role of validated and standardized herbal products ; a scientific approach
TRANSCRIPT
Dr Capt Tanweer AlamHead( AHP ) International Marketing
ROLE OF VALIDATED AND STANDARDIZED HERBAL PRODUCTS-A SCIENTIFIC APPROACH
25th Oct 2011Sun Moon Lake, Nantau, Taiwan
GROWING IMPORTANCE
Out of 252 drugs considered basic and essential by WHO , 11% are exclusively from plant origin and 28% are of synthetic origin but obtained from natural precursors
Eighty Five percent (85%) people in developing countries still rely on traditional medicines as first choice for human health care (WHO).
THE COMPARISON OF SCOPE!
Source: FAOSTAT website
Total world population Poultry : 19 BillionCattle : 1.5 billionSheep and goat : 1.6 billion
Total world population Human: 6.88 Billion
HERBAL MARKET: A COMPARISON
Source: FAOSTAT website & CLFMA REPORT 2009
1.5 Billion USD
Total Global Herbal Market 100 Billion USD
Total Animal Health
Herbal Market
HERBAL USAGE TRANSITION
Shhh… Shout!!!!From to
HERBAL USAGE TRANSITION
Don’t Ask ; Don’t Tell Usage with reasoning
POSITIVE TREND: ACROSS THE SEGMENT AND SPECIES
Digestive
Respiratory Dermal
Nutrient replacerStress care
GROWING CREDENTIALS : THE REASONS
GROWING CREDENTIALS : STANDARDIZATION & BETTER
ANALYTICAL METHODS
Standardization is the process by which one or more active ingredients of an herb are identified, and all batches of the herb produced by a single manufacturer contain the same amount of active
Standardisation and better analytical methods
TLC ProfilesA. paniculata Bacopa monnieri Zingiber officinale
GROWING CREDENTIALS : STANDARISATION & BETTER ANALYTICAL METHODS
GROWING CREDENTIALS:AVAILABLE TECHNICAL BACK-
UPS
Total number of research papers listed on PubMed containing the word "phytoconstituents."
GROWING CREDENTIALS:ARRAY OF HERBAL
MONOGRAPHS
Publication and availability of authoritative monographs by various organizations, improving the scientific credibility of herbs.
Indian HerbalPharmacopoeia
British Herbal Pharmacopoeia
English Translation of
German Commissions
E monographs
American Herbal Pharmacopoeia
( AHP )
Chinese Herbal Pharmacopoeia
Europe Scientific Cooperative
on Phytotherapy (ESCOP)
United States Pharmacopoeia
( USP )
Confluence of Herbal
Pharmacopoeia
GROWING CREDENTIALS:ARRAY OF HERBAL
MONOGRAPHS
2,50,000 flowering plants world wide
India – 8th largest country in natural plants
One of the largest flora bio diversity
75% of the medicinal plants grow naturally in India.
INDIA
Scientific approch of herbal product development
Ethnomedical information
Selection and standardization of in vitro
assays
Screening Program
(Selection of plants, parts,
solvent)
Bioactivity guided
fractionation
Standardization and
Chemical fingerprinting
Development of prototype/ formulation (Based on
compatibility studies)
Validation of safety and
efficacy using in vivo models
Field trials
Commercial production
4 cardinal focus points
Genuineness Safety Efficacy Consisten
cy
(i) Foreign organs: matter coming from
the source plant but not defined as the
drug.
(ii) Foreign elements: matter not coming
from the source plant and of either
vegetable or mineral origin. (viz,.
Moulds, insects and other animal
contamination.)
Free from contamination
Test for Foreign Matter
Contaminated
GENUINENESS
Coleus forskohlii Root (Dried)
Coleus forskohlii Root (Fresh)
Organoleptic analysis
• Colour
• Shape
• Odour
• Taste
GENUINENESS
Phytochemical profile checked by
Chromotographic techniques.
The samples are chromotographed reference standards
of marker constituents.
HPTLC Finger print
GENUINENESS
EFFICACY
Quantification of Markers / Actives using HPLC
High Performance liquid chromatography
Estimation of Forskolin using HPLC & TLC
EFFICACY
EFFICACY
LC/MS DETECTION:Powerful Tool for Organic Compound Analysis
Its application is oriented towards the specific detection and potential entification of phytomarkers in the presence of other phytochemical
SAFETY
• Physico-chemical [ Moisture, Ash, Acid insoluble ash,,Silica (Sand)]• Heavy metal residues (Pb, Cd, As, Hg)• Mycotoxin residues • Pesticide residues (organochloro pesticides and organophosphorous
pesticides).• Organic volatile impurities (solvent residues-wherever applicable)• Naturally occuring toxins (like pyrrolizidine, alkaloids, beta asarone,
cynogenic glycosides etc.) • Microbial Analysis for specific pathogens
CONSISTENCY
Batch to batch consistency
S – STANDARD MIX
T1- TEST SAMPLE (BATCH NO. AP/07, 24 MONTHS OLD SAMPLE)
T2- TEST SAMPLE (BATCH NO. AP/01005, 18 MONTHS OLD SAMPLE)
T3- TEST SAMPLE (BATCH NO. AP/02001, 12 MONTHS OLD SAMPLE)
T4- TEST SAMPLE (BATCH NO. AP/02006, 6 MONTHS OLD SAMPLE)
T5- TEST SAMPLE (BATCH NO. AP/02010, 1 MONTH OLD SAMPLE)
A BRIEF
India’s No 1 Herbal Veterinary company for the last 60 years
Pioneers in phyto-pharmaceuticals
State-of-the-Art R&D with more than 100 qualified scientists
OUR ACCREDITATIONS
OUR ACCREDITATIONS
CORPORATE SOCIAL RESPONSIBILITY
Quarterly journal called “Journal of Natural Remedies” dedicated to Medicinal Plant research across the globe.
A monthly magazine “Pashudhan”, dedicated to animal healthcare since 35 years and
Launched a web portal “vetsjobsindia.com”, developed exclusively for communicating employment opportunities to vets.
