robert w. williams - the university of tennessee 1– robert w. williams department of genetics,...

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ROBERT W. WILLIAMSDepartment of Genetics, Genomics and Informatics University of Tennessee Health Science Center 71 South Manassas Street, Room 405 Memphis TN 38163 office: (901) 448-7050 cell: (901) 604-4752 email: [email protected], or [email protected] NIH Appl. ID and User: 8822179 eRA: RWILLIAM

www.genenetwork.org www.nervenet.org, www.mbl.org www.complextrait.org NCBI collection of publication at: www.ncbi.nlm.nih.gov/sites/myncbi/10G3rz0pE2tkz/bibliograpahy/47160705/public

DEGREES Ph.D. (1983) Physiology, University of California, Davis

B.A. (1975) Psychobiology, University of California, Santa Cruz

INTERESTS • Systems genetics, precision medicine, complex trait analysis • Genetics of aging, CNS diseases, and addiction • Visual system structure, function, development, aging, and glaucoma • Advanced methods in collaborative research, data sharing, web services

PROFESSIONAL EXPERIENCE 2013–present Chair: Department of Genetics, Genomics and Informatics, College of Medicine, UTHSC 2009–present UT-Oak Ridge National Laboratory Governor’s Chair in Computational Genomics 2008–present Director: UT Center for Integrative and Translational Genomics 1997–present Affiliated Professor: Department of Anatomy and Neurobiology and Center for

Neuroscience, UTHSC (secondary) 2014–present Affiliated Professor: Department of Ophthalmology, UTHSC 2001–present Affiliated Professor: Department of Pediatrics (secondary) 2013–2016 Visiting Professorship: University of Edinburgh, College of Medicine and Veterinary

Medicine, Scotland, UK 2001–2009 William and Dorothy Dunavant Chair of Excellence in Developmental Genetics:

Department of Pediatrics (secondary appointment), University of Tennessee Health Science Center (UTHSC)

2008–present Director: UT Center for Integrative and Translational Genomics (CITG) 2008–present Chief Scientific Officer: Varigenix Inc., Memphis TN 2000–2007 Codirector/Director: Center of Genomics and Bioinformatics, UTHSC 2001–present Member: Feinstone Center for Genomic Research, University of Memphis 1992–1997 Associate Professor: Department of Anatomy and Neurobiology and Center for

Neuroscience, UTHSC 1989–1992 Assistant Professor: Department of Anatomy and Neurobiology and Center for

Neuroscience, UTHSC 1986–1989 Assistant Professor: Yale University School of Medicine, Section of Neuroanatomy 1985–1986 Associate Research Scientist: Yale University School of Medicine, Section of

Neuroanatomy (P. Rakic, mentor) 1984–1989 Instructor: Neuroanatomy laboratory, Yale University School of Medicine, Section of

Neuroanatomy

RW Williams full CV (Nov 2015)

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1983–1985 Postdoctoral fellow: Yale University School of Medicine, Section of Neuroanatomy (P. Rakic, mentor)

1982–1983 Assistant Research Physiologist: University of California, Davis 1982 Instructor: University of California, Davis 1979–1982 National Institutes of Health Trainee: University of California, Davis (L.M. Chalupa, thesis

advisor) 1978–1981 Teaching Assistant and Teaching Associate: Animal Physiology and Psychology,

University of California, Davis

PROFESSIONAL SOCIETIES Complex Trait Consortium (founder and

director, 2001–2008) Research Society on Alcoholism (member) Molecular and Cellular Cognition Society

(member 2012) Society for Neuroscience (Chair,

Neuroinformatics Committee, 2003-2008, now ex-member)

International Society for Computational Biology (member 2009)

American Society for Human Genetics (member)

Association for Research in Vision and Ophthalmology (member)

International Behavioural and Neural Genetics Society (member, president 2005) International Mammalian Genome Society (ex-

member) Behavioural Neurogenetics Initiative (ex-

member) IEEE (ex-member)

GRANTS AND FELLOWSHIPS

2001–2017 Principal Investigator: INIA: Robust Systems Genetics of Alcohol and Stress Effects on CNS, National Institutes of Health U01AA13499. TDC ~$1.68 M over last 5 years (02.05.02–01.31.17)

2007–2017 Principal Investigator: INIA: Bioinformatics Core, National Institutes of Health U01AA016662. TDC ~$750K over last 5 years (02.05.12–01.31.17)

2013–2018 Principal Investigator: Translational Systems Genetics of Mitochondria, Metabolism, and Aging, National Institutes of Health R01AG043930. TDC ~ of $2.04 M over 5 years (06.01.13–05.30.18)

2015–2018 Principal Investigator: Research to Prevent Blindness Stein Innovation Award: $300,000 all years to study the genetics of glaucoma susceptibility using single cell genomics methods.

2013–2015 Principal Investigator: Advanced Data Mining subcontract to Mapping the Human Connectome: Structure, Function, and Heritability (David Van Essen PI) National Institutes of Health, 1U54MH091657. Subcontract TDC ~ of $128,726 over two years (06.01.13–05.30.15) 0.6 calendar months

Pasko Rakic (ca 2005) Dorys McConnell Duberg Professor, Director of the Kavli Institute for Neuroscience at Yale

Leo M Chalupa (ca 2007) VP Research at George Washington University.


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2013–2016 Participant, Work Package 1.1: Genome-to-Phenome; Human Brain Project, European Commission Future & Emerging Technologies flagship program. Estimated TCD ~200K Euros over first 2.5 years (ramp-up phase). All non-EU components funded as collaboration with the University of Edinburgh.

2011–2012 Memphis Research Consortium organizing member, State of Tennessee, ~$6 million, non-recurring for Genetics and Epidemiology of Pediatric Obesity

2007–2012 Principal Investigator: Systems Genetics of the HPA, National Institutes of Health U01AA017590. TDC ~$875K over 5 years (07.01.07–06.30.13)

2011–2013 Genetics of Stroke. 1R21NS066166 (PI: Nowak T) NINDS, Role: consultant, collaborator (unfunded)

2009–2011 Coinvestigator: Neuron-Specific Candidate Gene Expression and Adolescent Vulnerability to Smoking. 1RC2DA028962 (PI: Sharp B) 09.25.09–9.26.11; 0.50 calendar; NIDA $1,441,300 Role: coinvestigator

2007–2012 Coinvestigator: Modulators of Retinal Injury, National Institutes of Health R01 EY017841. TDC ~$1.0 over 5 years (10.01.07–9.31.11)

2005–2010 Coinvestigator: Dispersion Patterns for Retinal Neuroblasts, National Institutes of Health R01 EY0110871. TDC ~$1.0 over 5 years (07.01.05–06.30.10)

2008–2010 Lead contract with Eli Lilly and Co, Genes that Influence Diabetic Nephropathy. (DOE NFE-08-01254, $135K subcontract to UT-Battelle, LLC) (R07-3003-263)

2005–2009 Coinvestigator, Mouse Biomedical Informatics Research Network (BIRN), National Institutes of Health R24 RR021760. National Center for Research Resources, TDC ~$1.0 M over 5 years (04.01.05–03.31.09)

2006–2008 Principal Investigator: Huntingtin Transcriptome Analysis, High Q Foundation, $466,800 (02-01-06 to 01-31-08)

2004–2009 Coinvestigator: Integrative Genetics of Cancer Susceptibility, NCI 1U01CA105417. TDC $600,000 over 5 years (04.01.04–03.31.2009, with DW Threadgill)

2000–2010 Principal Investigator: Informatics Center for Mouse Neurogenetics, National Institutes of Health and National Science Foundation, Human Brain Project 2P20-DA21131, 1P20-MH62009, and IBN-0003982. TDC ~$5.4 M over 5 years (9.28.00–6.30.10, 32%)

2007–2010 Associated partner: German Network for Systems Genetics (GeNeSys). Helmholtz Centre for Infection Research. No funds

2010–present Associated partner of EU COST program: SYSGENET led by Prof Klaus Schughart (no funds)

2007–2011 Coinvestigator, subcontract: Gene Array Technology Center for Alcohol Research (the Rodent Gene Array Program) with Boris Tabakoff, University of Colorado Medical Center (08.01.07-07-31-11)

2005–2007 Coinvestigator: Development of Advanced Tools for Diagnosis and Triaging of Individuals Exposed to Select Pathogens, DOD/US W81XHW-05-01-0227

2005–2010 Coinvestigator: Dispersion Patterns for Retinal Neuroblasts, NEI R01EY011087-07A1. (B Reese, PI; RW Williams, coinvestigator)

2001–2006 Principal Investigator: INIA: Genotyping Core, National Institutes of Health 1U24AA13513. TDC ~$600,000 over 5 years (01.01.02–12.30.06)

2004–2007 Consultant: Conti Center, John Csernanski PI, Jim Cheverud, PI Project 5. Genetics of Schizophrenia-Related Traits in Mice, Washington University

2007–present Consultant: Consortium for Neuropsychiatric Phenomics–Coordinating Center (R Bilder PI, UCLA)


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2004–2007 External Advisory Board: P20 Exploratory Transdisciplinary Imaging Genetics Center and Function BIRN (Steve Potkin, PI, University of California, Irvine)

2000–2004 Principal Investigator: Genetic and Epigenetic Control of Eye Growth National Institutes of Health R01 EY12991. TDC $200,00 year 1, $800,000 all years (9.1.00–7.31.04, 30%)

1999–2002 Principal Investigator: Biometric and Functional Studies of the Eye and Retina, National Institutes of Health R01 EY13070. TDC $150,000 year 1, $444,381 all years (12.01.99–11.30.02, 25%)

2001 Principal Investigator: High Resolution QTL Mapping in Mice. NIHLB Mammalian Genotyping Service (7.1.01). Grant funded 350,000 genotypes.

2001 Collaborator: Sleep Patterns During Infectious Disease, NIH NL70522. TDC $225,00 year 1, $1.11M all years (9.19.01–7.31.05; Linda Toth, PI; no funded effort)

2000–2005 Eye Domain Coinvestigator: Targeted Mutagenesis of the Mouse Genome and Neural Phenotypes, NIH U01-MH61971. TDC, $2,664,000/year (D Goldowitz PI, RW Williams co-PI; funding from 7.1.00–6.30.05, RW 5%)

2000 Principal Investigator: An Advanced Intercross for Mapping Multigenic Morphometric Traits in Mice: A Community QTL Mapping Resource, NIHLB Mammalian Genotyping Service. (1.1.00) Grant funded ~190,000 genotypes.

1996–2000 Principal Investigator: Genetic Control of Neuron Populations, NIH R01 NS35485. TDC ~$733,000 all years (07.1.96 to 07.31.00, 20%)

1987–2000 Principal Investigator: Growth of Optic Nerve Fibers, NIH R01 EY06627-10. TDC, $437,500 (12.1.95 to 05.30.00)

1991–1994 Principal Investigator: Development and Clonal Structure of the Mammalian Retina, NIH R01 EY 08868–03. TDC $260,518

1992–1996 Coinvestigator: Genetic Basis of Retinal Development, NIH R01 EY09586-03 (Dan Goldowitz, PI). TDC $505,991 (4.1.92 to 3.31.96)

AWARDS Loren D. Carlson Prize in Physiology, 1982–83 Fellow Award, Winter Conference on Brain Research, 1987 Excellence in Teaching Award, University of Tennessee, 1995 Distinguished Scientist Award, 2007, International Behavioural and Neural Genetics

Society Distinguished Mentor Award, 2011, by the UT Postdoctoral Research Association Michael Gale Lecture: International Plant & Animal Genome Conference 2012

Bennett J. Cohen Award: University of Michigan for Biogerontology Research 2015

PATENTS Tissue Analyzer: Inventors Robert W. Williams, Pasko Rakic, U.S. Patent 4,932,044; filed November 4, 1988; issued June 5, 1990. See http://www.patents.ibm.com/claims?patent_number=4932044

Method for ultra-high resolution mapping of genes and determination of genetic networks among genes underlying phenotypic traits: Inventors David W. Threadgill (Chapel Hill NC) and Robert W. Williams (Memphis TN), U.S. Patent Application (EP 1543930) filed December 1, 2000.

Method for determining sensitivity to environmental toxins and susceptibility to Parkinson’s disease. Inventors: Richard Smeyne (Memphis TN) and Robert W. Williams (Memphis TN). U.S. Patent Application (EP Patent 1543930).


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Invention Disclosure: P2P-R cooperates with the MAD2, BUB3 and p55CDC/cdc20 mitotic checkpoint-associated proteins. Inventors: Dr. Robert E. Scott and Robert W. Williams, Memphis

TN

SYMPOSIA, CONFERENCES, CONSORTIA

2014 Series of six workshops on Systems Genetics and GeneNetwork in China: Shanghai-Fudan, Nantong, Nanjing, Chongqing, BGI-Shenzhen, and Shijiazhuang (March 17-28)

2013 Coorganizer: 13th IEEE International Conferences on Bioinformatics and Bioengineering: Chania, Greece, Nov 10-23

2013 Lead Organizer: INCF-CITG Neuroinformatics Jamboree: A week-long short course in neuroinformatics, neurogenomics, and brain disease. Germany, Sept 14-20

2013 Instructor: Introduction to R, R-QTL and GeneNetwork: A Joint COST Training School and King's College London (Leo Schalkwyk and colleagues) http://cost-sysgenet.iop.kcl.ac.uk/program.html

2012 Coorganizer with Paul Franken: Sinergia One-Day Short Course on Systems Genetics using GeneNetwork (UNIL and EPFL, Nov 26)

2012–13 Coorganizer with Martien Kas: International Neuroinformatics Coordinating Facility: Genetics Models of Psychiatric and Neurological Disease, Utrecht Feb 14-15

2012 Coorganizer with Paul Franken: Sinergia One-Day Short Course on Systems Genetics using GeneNetwork (UNIL and EPFL, Nov 26)

2010 Coorganizer: Mouse Genetics 2011, Washington DC, June 22-26

Course Instructor: Aug 14-16: GeNeSys program Helmholtz Foundation, Braunschweig Germany

2009 Coorganizer: 1st world-wide BXD scientific meeting (The BXD World), Braunschweig, (with Dr. Klaus Schughart). Nov 30 – Dec 1

Chair: INCF Digital Atlasing Taskforce meeting, Pilzen, Czech Republic (Sept 6, and 7)

2008* Organizer, International Neuroinformatics Congress, Stockholm, Workshop on Neurogenomics Meets Bioinformatics Meets Neuroinformatics (Sept 27-28)

Chair: SfN Task Force on Metadata and Linkage (with Jack Van Horn and David Van Essen). A follow-up to the PubMed Plus leadership conference

Lead organizer and chiar of Oversight Committee: INCF Workshop on Mouse and Rat Brain Atlasing Systems. March 5, UCLA

Organizer: UT-ORNL-UKY Bioinformatics Summit. Mar 28-30, Lake Barkley, KY

2007* Lead organizer: Consortium for Integrative and Translational Genomics, first meeting at the Oak Ridge National Laboratory, Sept 27-28


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Neurogenetics Terminology workshop leader: Neuroscience Informatics Framework sponsored workshop held at the SfN 2007 meeting. Jointly organized with Daniel Gardner

Lead organizer: PubMed Plus leadership conference, sponsored by the SfN, David Van Essen (President), St. Louis, June 14–16

Lead organizer: International Neuroscience Coordinating Facility Workshop on Mouse and Rat Brain Atlasing Systems. Feb 13–14, Karolinska Institute, Stockholm

2006* Multistrain Mouse Testing Strategy Advisory Working Group, NIEHS, Research Triangle Park, July 21 (with John Pritchard)

Databasing the Brain, European Union workshop, Oslo, Norway, June 25–27

Symposium honoring Dr. Lorraine Flaherty, Genomics Institute, Wadsworth Center, Albany Medical College, Albany, New York, June 19 Neurofederatie Keynote Lecture, Endo-Neuro-Psychopharmacology (ENP) annual meeting, Amsterdam, June 7 Genes Meet Behavior, a joint symposium of the International Behavioral Neuroscience Society and International Behavioural and Neural Genetics Society, Whistler, Canada, May 24

* Gordon Research Conference on Genes and Behavior, Ventura, California, Feb 11–17 * Blueprint LINC team member, NIH, Bethesda, March 30–31 2005* Human Brain Project Special Interest Social, presentation, SfN annual meeting, Washington,

Nov 14 German Genetics Society, Genetics of Infection, symposium presentation, Braunschweig, Germany, Sept 22 Opening lecture, 4th Annual Complex Trait Consortium (CTC) meeting, Groningen, Netherlands, June 27 Mouse Models of Human Cancers Consortium Glioblastoma Meeting, St. Louis, June 16–18 International Behavioural and Neural Genetics Society annual meeting, Sitges, Spain, June 9–13 GENSAT Gene Selection Advisory Meeting, Bethesda, June 7 High Q Foundation Meeting on Microarrays and Discovery of Therapeutic Targets for Huntington’s Disease, New York, May 19 2nd Annual Experimental Neurogenetics of the Mouse workshop, faculty member, Memphis, May 16–24 Plenary lecture, Data Sharing in the Age of Discovery Science, Human Brain Project, NIH, Natcher Center, April 25 Collaborative Cross Organizing Committee meeting, ORNL, March 24–25 Gordon Research Conference on Quantitative Genetics and Genomics, Ventura, California, Feb 19–24 Mouse Models of Human Cancers Consortium Committee Meeting, Vanderbilt, Jan 19–21 1st International Imaging Genetics Conference, UC Irvine, Jan 17

2004 NIEHS Toxicogenomics Research Consortium meeting, Chapel Hill, Dec 6–8 Mouse Resources Roundtable Conference, The Jackson Laboratory, Nov 19–21

Biomedical Informatics Research Network (BIRN) Symposium speaker, Boston, Oct 13 Co-organizer, 3rd Annual Complex Trait Consortium meeting, Bar Harbor, July 6–9 Organizer, 10th International Summer School on Behavioral Neurogenetics, Memphis, August

8–15 2003 Lecturer, NIDA Addiction Studies Workshop for Journalists, Tucson, Dec 8 Mouse Atlas Workshop, NIMH Office of Neuroinformatics, Nov 18

American Society of Human Genetics symposium speaker, Los Angeles, Nov 5


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Oregon Health Science symposium, Portland, Oct 9 Keynote, 9th International Summer School on Behavioral Neurogenetics, Aug 6–9, Toulouse,

France Joint Statistics Meeting symposium speaker, San Francisco, Aug 4–6 Mouse Initiatives V: Genomics of Complex System in Biomedical Research, July 31–Aug 2,

www.jax.org/courses/mi5_03.html Behavior Genetics Association Symposium, Chicago, June 27 2002 National Cancer Institute: Mouse Models of Human Cancers Consortium Roundtable, Newport

Beach, Dec 11–13 Host and organizer, 1st Complex Trait Consortium Meeting, Memphis, May 2–4 Spring Brain Conference Plenary Session organizer: Identifying Genes Controlling Brain Structure and Behavior Using Complex Trait Analysis, Sedona, March 12–15

Chair, Bioinformatics 2002, Society for Neuroscience Short Course, Orlando, Nov 2 Instructor, 8th International Summer School on Behavioral Neurogenetics, Worcester, Aug 5–9 2001 Chair, International Complex Trait Consortium, Edinburgh, Scotland, Oct. 23 Sponsor and organizing committee, 4th Annual Meeting, International Behavioral and Neural

Genetics Society, San Diego, Nov. 8–9 Workshop presentation, South-East Regional Meeting of the Society of Developmental Biology,

Montreat NC, May 24 Invited speaker, Neuroinformatics Faces Functional Genomics symposium: Tools for

Collaborative Analysis of Complex Neurodevelopmental and Behavioral Traits, Natcher Building, Bethesda, May 22

2000 NIAAA-sponsored QTL meeting, invited speaker, Washington, Dec 1 (organized by Robert Karp)

Human Brain Project: Neuroinformatics Satellite Symposium, invited participant, New Orleans, Nov 4 (presentation by GD Rosen)

1999 Co-organizer, Symposium on QTL Mapping, Behavior Genetics Association, Vancouver, July 1 Co-organizer and sponsor, Molecular Biology/Molecular Genetics of the Visual System, Center

for Vision Research, Memphis, Mar 26 Gordon Research Conference in Quantitative Genetics, Ventura, Feb 14–19 1998 Lecturer, Short Course in Quantitative Neuroanatomy, Society for Neuroscience

Chair, American Association of Anatomists, Experimental Biology 98: Symposium on Quantitative Neurobiology and the Human Brain Project

Presentation, Chautauqua Short Course for college teachers in neuroscience 1997 Chair, American Association of Anatomists, Experimental Biology 97: Mini-symposium on

Quantitative Neurobiology 1996–2000 Chair, Mouse Chromosome 7 Committee, International Mammalian Genome Society 1994–1996 Co-chair, Mouse Chromosome 7 Committee, International Mammalian Genome Society 1996 Co-organizer, Symposium on Cortical Development, Center for Neuroscience, University of

Tennessee, Memphis, June 1991 Participant, The Jackson Laboratory, Short Course in Medical and Experimental Mammalian

Genetics, Aug 1989 Organizer, Winter Brain Conference Workshop, Different Strategies of Brain Development, Jan

(co-organizer Karl Herrup) 1985 Participant, Gordon Research Conference, Central Nervous System, Tilton School, New

Hampshire, June 1983 Participant, Molecular Bases of Neuronal Development, Neuroscience Institute, Salk, La

Jolla, Oct


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1981 Participant, NATO Advanced Studies Institute, Formation of Neuronal Connections, Varenna, Italy, May

VIS IT ING SCIENTIST 2013 Host to Amelie Baud (Oxford Univ) working on GeneNetwork for large rat genomics

consortium in Europe (Feb 2-5) 2011 Sabbatical host to Dr. Klaus Schughart (HZI, Braunschweig, Germany) from Feb to May 2011 Host to Dr. Grant Morahan (U Western Australia) June 2007–2009 Visiting Professor, University of Utrecht (Prestige MSc Neuroscience Program hosted by

Martien Kas) 2006 University of California, San Diego, March (Dr. Mark Ellisman) 2000–2002 Advisory Professor, Fudan University, Shanghai, China 2000–present Collaborator, with Profs. Tan and Gu, Nantong Medical College, Nantong, China 1997 Harvard University, Beth Israel Hospital, June (Dr. Glenn Rosen) 1996 California Institute of Technology, Aug (Drs. John Allman and Scott Fraser) 1993 The Jackson Laboratory, July (Dr. Muriel Davisson)

SCIENTIF IC BOARDS 2014–present Scientific Advisory Board, VCU Alcohol Research Center P50 grant 2008–present Chairman of the Board and Chief Scientific Officer, Varigenix, Inc., Memphis TN (a biotech

startup with licenses from UTHSC and JAX to commercialize BXD strains of mice) 2009–present NIAAA Alcohol Research & Health Advisory Board Member, Editor of special issue on

Genetics of Alcoholism (2012) 2007–present Chair: Oversight Committee of the INCF Digital Brain Atlasing Program 2006–2007 Scientific Advisory Board, Institute Clinique de la Souris, Strasbourg, France (Prof. Johan

Auwerx) 2007–present Scientific Advisory Board, Conte Center: Genes Controlling Assembly and Function of

Serotonin Systems, Randy Blakely and colleagues, Vanderbilt University 2002–2008 NIAAA INIA-Stress Scientific Advisory Board 2006–present Scientific Advisory Board, National Center for Microscopy and Imaging Research

(NCMIR), UCSD, Mark Ellisman and colleagues 2006–2008 US Representative and Advisory Board member, International Neuroinformatics

Coordinating Facility (INCF), Stockholm, Sweden 2004–2009 Scientific Advisory Board, Portland Alcohol Research Center, VAM (PARC) Portland 2004–2007 External Advisory Board, Exploratory Transdisciplinary Imaging Genetics Center (Steven

Potkin, PI, UCI) 2001–2007 Genome Explorations Inc., Memphis

INVITED SEMINARS, WORKSHOPS, AND LECTURES ( INCOMPLETE) 2015 Presentation: University of Southern California Molecular and Computational Biology Program: Systems Genetics:

An Efficient Experimental Approach to Precision Medicine Using GeneNetwork, Nov 20 Presentations: 446h Residents' Day Conference in Ophthalmology, UTHSC: Precision Medicine and Genomics:

How Do We Get There? June 26 Keynote, AGE meeting, Systems Genetics of Lifespan and the Impact of a High Fat Diet, May 30 Keynote, Ninth Annual Biogerontology Research Symposium May 12, Recipient of the Bennett J. Cohen Award for

research on aging Workshop on Systems Genetics, University of Michigan, May 11 Lecture, Hudson Alpha Institute, Huntsville Alabama April 1 Organizer: 14th Annual UT-KBRIN Bioinformatics Summit, Paris Landing TN, March 20-22


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Lecture, participant: Replicability and Reproducability of Discoveries in Animal Phenotyping Conference, Tel Aviv Jan 5-7

2014 Lecture, Rat Genome Meeting, Hinxton GB, Dec 4 Workshop, NSF iNeuro, Nov 13-14 Lecture, German Genetics Society, Luxembourg Oct 2 Workshop: Single Cell Genomics, Stockholm, Sept 9-12 Seminar and workshop: University of North Dakota, School of Medicine, Aug 10-11 Symposium presentation: RSoA meeting, June 22 Symposium presentation: CTC Berlin, May 20 Symposium overview presentation: Stress and Alcohol meeting, Volterra, May 8 Seminar: National Biodefense Lab/Regional Biodefense Lab presentation on mouse resources (April 7) Presentation: St. Jude Children's Research Hospital: "Animal Models", Feb 7, 2014 Workshop: Vanderbilt University Postdoctoral Training Program: "Fun and Profit using GeneNetwork", Feb 5 2013 Plenary speaker: IEEE BIBE Conference, Chania, Greece, Nov 10 Plenary speaker: German Genetics Society, Berlin, Sept 23 Member: HBP Meeting, Madrid, May 6-7 Speaker: University of Virginia seminar, Apr 3 Speaker: NSF Systems Biology Workshop in Bioinformatics, Little Rock, Mar 2-5 Speaker, participant: INCF Mouse Models Workshop, Utrecht, Feb 14 Speaker: Systems Biology of Liver, Luxembourg, Feb 22 Speaker, instructor: University of Edinburgh, Feb 25, 26 2012 Member: INCF Atlasing Workshop, Stockholm, Dec 13-14, Plenary speaker: Swiss Laboratory Animal Sciences Association, Nov 19-20, Zurich Speaker: University of Texas San Antonio, Oct 22 Speaker: Pigment Society, Deer Valley Utah, Sept 20 Speaker: Bioinformatics and Systems Biology: Short course, Patras Greece, July 3 Plenary speaker: Complex Trait Community 11th annual meeting; Multiscalar Analysis & Integration of Phenotypes:

Power, Precision, and Priors, Paris, Jun 15 Speaker INCF Canadian Neuroinformatics, Atlases, Genomes, and Genetics: An International Tool Set to Help

Understand Brain Function: Vancouver Canada, May 24 Speaker The Urban Child Institute lecture: March 22 Speaker University of Memphis: Bioinformatics seminar series: March 2 Speaker UT Board of Trustees Research presentation: Feb 28 Plenary speaker (Michael Gale Lecture) at the International Plant & Animal Genome Conference (San Diego, CA):

Systems Genetics: Tools and Techniques to Link Genomes and Phenomes, Jan 16 2011 Speaker: Systems Genetics and Systems Neuroscience, University of Tennessee Health Science Center, Anatomy

and Neurobiology, Nov 1 Presentation on GeneNetwork: Seth Grant and colleagues: Sanger Institute, UK, Oct 17 Speaker: Next-Generation sequencing technologies: Medical sequencing approaches for complex disorders. NIAAA

Symposium, Sept 10, Washington DC Speaker: Max-Planck Institute, Gottingen, Germany, July 4: Systems level neurogenetics using isogenic populations

of immortal mice: a new collaborative landscape Speaker: Systems Biology Summit, Richmond VA, June 16, Genetic Control of Gene Networks in Complex Traits Speaker: BSEC Knoxville TN March 17 Speaker: Grand Rounds, University of Florida, Tallahassee, Feb 17 Instructor: University of Memphis, Bioinformatics Seminar, Feb 4 Speaker: Robust Systems Genetics for Physiologist. Department of Physiology, UTHSC, Jan 6 2010 Speaker: Sysgenet presentation on Mouse Reference Populations: Brussels, Belgium, Dec 6


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Speaker: ASHG NIAAA meeting: Tightening the Genotype-Phenotype Gap. Title: Functional Analysis of Candidate Genes for Alcoholism in Humans, An introduction to reverse complex trait analysis using rodent reference populations, Washington, Nov 2

Speaker: Mouse Development, Genetics & Genomics, Cold Spring Harbor Laboratory, Oct 26-30 Speaker: The Genomics of Common Diseases 2010, Baylor, Oct 6-9 Speaker: Japan Node Neuroinformatics: Title: Massive Image Collections and Pivot: Sept 2 Workshop organizer: GeneNetwork workshop: Braunschweig, Germany, Aug 16-18 Plenary speaker: BSEC IEEE Symposium: Neuroinformatics: Building an integrative framework to study brain

function, injury and regeneration. Oak Ridge, May 25 Speaker: Mouse models for human diseases (CASIMIR--European Commission meeting), London, May 19, London Speaker: A whole genome sequence for DBA/2J and its use in reverse complex trait analysis. IBANGS Halifax, May

16 Speaker: Next-generation Sequencing and Its Impact on Bioinformatics. University of Memphis, Bioinformatics

Program seminar, Feb 26 Speaker: Analysis of Complex Biological Networks using On-Line Resources. University of Memphis, Biology

Program Seminar Series, Feb 25 Speaker: Systems genetics of transcription in brain: Analysis of covariance, causality, and addiction using the

GeneNetwork platform. Gallo Center, UCSF, Nashville, Feb 17 Speaker: Systems genetics of gene transcription and disease susceptibility: What Genetic Reference Populations

and online databases can do for your research program. University of Cincinnati, Jan 22 2009 Workshop: INCF Workshop on Animal Models in Genetics (Stockholm, Dec 13,14) Workshop and speaker: BXD World meeting, Braunschweig, Nov 30-Dec2 Speaker: It’s the Network Stupid! Serotonin Symposium, Vanderbilt University, Nashville, Nov 11 Organizer and speaker: Workshop: Jump-Starting Genomics in Your Research Program. UTHSC, Nov 4 and Nov

10 Speaker: Genetics of Aging: Bandera Conference. UT San Antonio, Nathan Shock Center, Bandera, Oct 16 Speaker: Genetics of Neurodevelopmental Disorders: Use of New Mouse Models for High-Efficiency Translational

Research. Children’s Foundation Research Center seminar, Le Bonheur Hospital, Memphis, Sep 21 Presenter: Genetics of Nicotine Addiction, Lung Cancer, and COPD. GeneNetwork: a web resource to study gene

function and to evaluate candidate genes from GWAS studies. 1 hr. web seminar (hosted by J. Pollack), July 27

Speaker: International Society for Computational Biology, ISMB/ECCB, Highlights Special Session on eQTL, Stockholm, Sweden, Jun 28

Speaker: ICNF, Presentation on the Digital Brain Atlasing Program, Karolinska, Sweden, May 7 Speaker: EPFL, Lausanne, Switzerland, May 1 Speaker: International Waldenstrom’s Macroglobulinemia Foundation meeting, Memphis, April 20 Speaker: Buck Institute for Age Research, Novato, CA, Apr 20 Seminar: UTHSC Molecular Sciences: A practical guide to host genetics of infectious disease using mouse

reference populations, Apr 13. Seminar and workshop: University of Nebraska, Lincoln, Dept of Animal Science, Mar 30 - 31 Speaker and consultant: UCLA, Symposium on ultra high throughput biology, Feb 19 - 20 Two lectures and workshop: University of Utrecht, Rudolf Magnus Institute, Jan 5 - 9 2008 Speaker: Departments of Psychiatry and Neurology, VCU, Richmond, Dec 2 Speaker: NIDA Workforce Development, Philadelphia, Nov 16 Speaker: Departments of Pharmacology, University of Colorado, Denver, Richmond, Nov 3 Speaker: GeneSys Inaugural Meeting, Systems genetics of brain function and disease using the GeneNetwork

platform, Edinburg, Oct 1-3 Presentation: CHDI, High Q Foundation, New York and Princeton Aug 18-19 Speaker: GeNeSys 2nd Annual Meeting, Dresden Germany, Oct 24-25 Speaker and participant: Gordon Research Conference, Oxford UK, Aug 11-15 Participant: French-American Workshop on Multi-scale Modeling in Neuroscience, Bordeaux, June 8-10 Speaker: Eli Lilly and Co, May 22 Moderator: Genes, Brain, and Behavior: Symposium on Methodological considerations in the genetical genomics of

complex traits, Portland OR, May 7


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Speaker: Seminar, Northwestern University, Chicago, Apr 14 Speaker: Seminar and 1 day workshop leader, Dalhousie University, Department of Psychology. Halifax, Canada,

Apr 4–5 Speaker: Understanding the Brain through Informatics, INCF @ Karolinska (The Neuroinformatics of Gene

Expression: Collaborative Web Classes and Labs), Washington DC, Mar 7 Speaker: Université de Lausanne, UNIL-EPFL mini-symposium on mouse resources to map complex traits

(Collaborative Web Software Systems for Integrative Genomics), Lausanne, Switzerland, Feb 26 Speaker: University of Iowa, Department of Human Genetics seminar series, Cedar Rapids, Feb 19 Speaker: University of Alabama, Birmingham, Department of Molecular Biology seminar series (Genetics of Gene

Expression in Brain and Kidney: Problems and Prospects) Feb 15 Speaker: Mouse Models of Human Cancers Consortium Steering Committee satellite conference on the

Collaborative Cross, Washington DC, Jan 7 2007 Speaker: 11st Annual Meeting of GeneSys, Dresden, Germany, Dec 4–5 Co-organizer, New Directions in Data Mining: Synergies between Databases and Online Journal Publications,

Society for Neuroscience workshop, San Diego, Nov 7 Speaker: California Nanosystems Institute, UCLA, Sept 18 Speaker: Riken Brain Science Institute, Tokyo, Japan, Sept 13 Speaker: Neuro2007 Special Session on International Collaborations in Neuroinformatics (Large Scale Analysis of

Gene Expression in the CNS: A Rapidly Expanding Collaborative Landscape), Yokohama, Japan, Sept 10 Keynote speaker: 2nd Annual Department of Genetics Retreat, University of Alabama, Birmingham, Sept 6 Participant: International Neuroscience Coordinating Facility Workshop on Portals in Neuroinformatics, Karolinska

Institute, Stockholm, Sweden, Sept 3–4 Seminar: Institute for Systems Biology, Seattle, July 31 Seminar: Allen Institute for Brain Science, Seattle, July 30 Workshop: High Q Foundation, New York, July 17–18 Seminar: Vanderbilt University, Nashville, July 2 Organizer: SfN PubMed Plus Leadership Conference, Washington University, St. Louis, June 17–19 NIDA Workshop, Addiction, Microarrays, and Gene Discovery, May 30-June 1 Seminar: University of Wageningen, Netherlands, May 24 Distinguished Investigator award presentation: IBANGS, Doorwerth, Netherlands, May 23 Seminar: Genetics of Gene Expression in the Mouse Eye, GSF, Seminars on Genome Research, Institute for the

Environment and Health, Munich, Germany, May 15 Keynote lecture: 5th Annual Dean’s Symposium, UTHSC College of Medicine, (Personalized, Predictive and

Preventive Health Care: How the Mouse Will Make It Happen), April 13 Co-organizer: UT-UK-ORNL Bioinformatics Summit, Paris Landing, TN, April 13–15 Karolinska Institute, keynote seminar, Feb 15 Organizer: 1st International Neuroscience Coordinating Facility Workshop on Mouse and Rat Brain Digital Atlasing

Systems, Karolinska Institute, Stockholm, Sweden, Feb 13–14 Scripps Florida, seminar series presentation, Jupiter, Florida, Jan 9 2006 Panelist: Society for Scholarly Publishing: Washington DC, Nov 13 Workshop presentation: Application of Pharmacogenomics to Drug Development and Therapy, 14th ISSX Meeting,

Puerto Rico, Short Course presentation, Oct 22 Speaker: IIIe cycle, Lausanne Genome Day, Lausanne, Switzerland, Oct 4–5 Speaker: Unveiling Genome-Wide DNA Variation in 15 Diverse Mouse Strains: NIEHS, Sept 26 Speaker: West Virginia University Eye Institute, seminar, Sept 20 Instructor: Route 28 Meeting Adult Neurogenesis Course, Fraueninsel, Germany, Sept 2–8 Instructor: Plant Genome Short Course, Boston, Aug 1–3 Speaker: Eli Lilly Integrative Biology Research Group, Lectures, Indianapolis, June 12–13 Speaker: Workshop on Systems Genetics, University of Utrecht, Netherlands, June 6 Speaker: ARVO mini symposium, Ft. Lauderdale, May 3 Speaker: UT-UK-ORNL Bioinformatics Summit, Lake Barkley KY, April 22 Speaker: Society for Neuroscience Chapter lecture, University of Mississippi Medical Center, April 11 Speaker: SERCEB Infectious Disease Meeting, New York City, March 26–28 Speaker: Cold Spring Harbor, Systems Biology lecture, March 25


–12–

Speaker: Illumina Corp, La Jolla, March 15 Speaker: Cold Spring Harbor Laboratory, weekly seminar, Feb 24 Speaker: UCSB Engineering, seminar in imaging and genetics, Santa Barbara, Feb 14

2005 University of Texas at Austin, Department of Neurobiology, Nov 28 University of Colorado, Boulder, Institute for Behavior Genetics, Oct 14 Oxford University, Wellcome Trust, July 1 Lecture, Universidad Autonoma de Barcelona, Spain, June 8 SERCEB Annual Meeting seminar, Chapel Hill, May 5 NIEHS Seminar: Systems Genetics, Research Triangle Park, May 2 VA MC Memphis Seminar, March 11 UTHSC Pathogenesis Center Chalk talk, March 2 NIDA, Molecular Anatomy: Synergy by Informatics 2, Feb 15 UTHSC Department of Pharmacology, Genetic Modulation of Transcripts, Cells, and Behavior: Or, How I learned to

stop worrying and love complexity, Feb 9 St. Jude Children’s Hospital Danny Thomas Lecture Series: Genetic Variation in Transcriptional Activity, Jan 7

2004 Vanderbilt University: Seminar in Integrative Genomics, Nov 30 Department of Neuroscience, Vrije Universiteit, Amsterdam, Aug 27 Groningen Universiteit, Department of Stem Cell Biology, Aug 26 Route 28 Conference, Fraueninsel, Germany, Aug 23 Czech National Academy of Science, Prague, Aug 20 IGBMC Illkirch, France, Aug 18 Tübingen Neurocolloquium, Germany, May 27 GBF Braunschweig, Germany, May 25 Max-Delbrück-Centrum, Berlin-Buch, Germany, May 24 University of Kentucky, Lexington, April MGH/MIT Harvard, Feb 25

2003 Yale University, Department of Genetics, Dec 16 University of Chicago, Committee on Genetics, Dec 2 Department of Neuroscience, Vanderbilt University, Nashville, Oct 22 Nathan Kline Institute, New York, Oct 17 Special lecture: 9th international summer school on behavioral neurogenetics, Toulouse, Aug 5 Mouse Initiatives V meeting, Jackson Laboratory, Aug 1 Purdue University, June 19 Human Brain Project, Bethesda, Natcher Center, http://videocast.nih.gov/ram/brain051203.ram May 12 Pennsylvania State University, Genomics Spring Fever: Complex Genetics of Brain and Behavior, May 2, 3 Wadsworth Center, Albany, New York, Feb 2003 St Jude Children’s Research Hospital: Dissecting Transcriptional Networks (Affymetrix Memphis User Group

Meeting), Feb 6 University of Toronto, Mt. Sinai Hospital, Feb 4

2002 Wake Forest University, Drug Addiction Workshop for Journalists, Tucson, Dec Department of Physiology, University of California, Davis, Dec University of Memphis, Sept 13 Wilmer Eye Institute, Johns Hopkins University, The Complex Genetics of Eye and Brain Development: Gene

Network Analysis Using Microarrays, Aug 29 University of Tübingen, Neurobiology of Vision, Germany, July 9–10 King’s College, London, July 7 University of Alabama, Section of Statistical Genetics, June 17 New England College of Optometry, Boston, Apr 25 Southern Illinois University, School of Medicine, Mar 15 University of Tennessee Health Science Center, Grand Rounds in Pediatrics, Mar 13 Neuroinformatics, 35th Annual Winter Conference on Brain Research, Jan 27


–13–

2001 New Mouse Behavioral Phenotyping Assays: Half Moon Bay CA, Dec Society for Developmental Biology, Southeast Regional Meeting, Workshop presentation, May Human Brain Project Conference, NIH, Natcher Center, May Cornell University, Departments of Psychology and Neuroscience, Apr Stanford University, Apr 12 University of Alabama, Birmingham, Department of Medicine, Mar 21 MCP-Hahneman, Department of Neuroscience, Mar 14 UCLA, Neuroscience Grand Rounds, Feb 7

2000 Shanghai Medical University (Fudan), Department of Histology and Embryology, Nov Beijing Medical University, Department of Histology and Embryology, Nov Nantong Medical College, Neuroscience Institute, Nov University of North Carolina, Chapel Hill, Department of Genetics, Oct 23 University of Tennessee, Biomedical Engineering Joint Program, Sept 14 Cold Spring Harbor, Banbury Center, August 28 UCSB Neuroscience Research Institute, Quantitative Genetics of CNS Development: View from the Trailhead, Santa

Barbara, May 26 State University of New York at Buffalo, Roswell Park Cancer Institute, May 8

1999 and earlier Drexel University, Department of Biomedical Engineering, Nov 2, 1999 University of Michigan, Department of Genetics, Oct 5, 1999 Vanderbilt University, Vision Research Center: The genetics of brain evolution, Nashville, May 7, 1999 UCSB Neuroscience Research Institute, Santa Barbara, Feb 16, 1999 Case Western Reserve University, Department of Neurosciences, Cleveland, Jan 21, 1999 VA Medical Center, New Power of Forward Genetics: Analysis of Polygenic Traits that Control Disease and

Development, Memphis, Nov 20, 1998 Case Western Reserve University, Depts. of Ophthalmology and Genetics, Cleveland, Nov 18, 1998 Yale University, Department of Neuroanatomy, New Haven, July 1998 University of Southern California, Department of Anatomy & Neurobiology, June 1998 UCSD Department of Neuroscience, San Diego, June 1998 Pasteur Institute, Paris, France, Oct 1997 Mount Sinai Medical School, Department of Neuroscience, New York, NY, June 1997 Harvard University, Beth Israel Deaconess, Department of Neurology, June 1997 California Institute of Technology, Pasadena, Nov. 1995 Conference on Brain Evolution, Ithaca, New York, June 1995 National Cancer Institute (Steve O'Brien), Frederick, Maryland, June 9, 1995 The Jackson Lab Bioinformatics Group, Bar Harbor Maine, July 1993 25th Annual Meeting of the Biomedical Engineering Society, Memphis, Oct 24, 1993 University of Utah, Department of Biology, Salt Lake City, Jan. 1989 Winter Conference for Brain Research, Snowbird, Utah, Jan. 1989 University of Texas, Houston, Department of Neurobiology and Anatomy, Dec 1988 SUNY, Stony Brook, Department of Neurobiology, Oct 1988 Winter Conference for Brain Research, Vail, Colorado, Jan 1987 Conference on the Development of the Vertebrate Retina, Ithaca, New York, June 1987 New York University, Department of Physiology and Neuroscience, New York, Oct 1986


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University of Rochester, Center for Visual Sciences, Rochester, New York, Apr 1986 Rush-Presbyterian-St. Luke's Medical Center, Chicago, Nov 1986 University of California, Davis, Department of Psychology, June 1985 Stanford University, Department of Neurobiology, June 1985 SUNY Department of Biological Sciences, Albany, New York, Jan 1984

REVIEWER FOR Anatomy and Embryology, Behavior Genetics, Brain Behavior and Evolution, Behavioral Brain Sciences, Cerebral Cortex, Current Biology, Developmental Biology, European Journal of Neuroscience, Experimental Eye Research, Frontiers in Neuroscience, Frontiers in Genetics, Gene Expression Patterns, Genesis, Genomics, Investigative Ophthalmology and Vision Science, Journal of Comparative Neurology, Journal of Heredity, Journal of Neurobiology, Journal of Neurochemistry, Journal of Neurophysiology, Journal of Neuroscience, Journal of Neuroscience Methods, Molecular Vision, Nature, Nature Genetics, Nature Neuroscience, Neuroscience, Optometry and Vision Research, Proceedings of the National Academy of Science, Science, Visual Neuroscience, Vision Research

EDITORIAL BOARDS/COMMITEES 2015–2016 Guest Editor (Special Issue): Alcohol: Genetic models of alcohol use and stress-

alcohol interaction 2015–present Associate Editor: Experimental Biology and Medicine, Section on Genomics,

Proteomics, and Bioinformatics 2008–present Editor-in-Chief: Frontiers in Neurogenomics 2012–2016 Editorial board: Mammalian Genome 2012–present Editorial board: Physiological Genomics (Molecular Genetics of Complex Traits) 20010–2011 Editor: Special Issue on the Genetics and Alcoholism: Alcohol Research Current

Reviews 2007–2010 Editorial advisory board: Alcohol Research & Health (NIAAA) 2007–present Associate editor: Frontiers in Neuroinformatics (CRC Press) 2005–2008 Member: Executive Committee of the Collaborative Cross 2006–2008 NeuroCommons Working Group (Science Commons, Creative Commons); chaired

by John Wilbanks 2006–2008 US Representative and member of the Executive Committee of the International

Neuroinformatics Coordinating Facility (INCF, Stockholm) 2006–2008 Advisory board member of the NIH Blueprint Neuroinformatic Framework group (PI

Dan Gardner) 2004–2005 President: International Behavioural and Neural Genetics Society (executive

committee from 2003–2006) 2004–2010 Chair (2004-2008) and member: Neuroinformatics Committee, Society for

Neuroscience 2004–2005 Member: International Mouse Resource Centers Roundtable 2004–2009 Elected Member: International Committee on Standardized Genetic Nomenclature

for Mice 2003–2005 Member: Committee on Animals in Research, Society for Neuroscience 2004–2005 Member: Science Educator Award Selection Committee, SfN 2006–present Journal of Biomedical Discovery and Collaboration (www.j-biomed-discovery.com) 2005-present Alcohol: editorial board member 2002–present Genes, Brain & Behavior: editorial board member


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2002–present Neuroinformatics: editorial board member 2002 Gene Expression Patterns: board member 2001–present BioMed Central Neuroscience: core reviewer board member

www.biomedcentral.com/info/biologyeditorial.asp 2001–present Behavior Genetics: editorial board member 2000 Behavior Genetics: guest editor 1995–present Molecular Vision: board member 1993–present European Journal of Anatomy: board member

GRANT PROPOSAL REVIEWS 2013 Chair: ETTN-03: NIH Special Emphasis Panel: Emerging Technologies and Training

in Neuroscience, July 17 2013 Member (ad hoc): CMAD NIH Study Section, June 6-7, 2013 2013 Member (ad hoc): DER/NINHS NIH Study Section panel, 2013/05 NST-2, March 11-

12 2011-2012 Member, NIDA P30 Centers of Excellence review panel ZDA1 EXL-T (03) 1 2008–2010 Chair, Molecular Neurogenetics (MNG) Study Section 2009 Review for NWO: Netherlands Organisation for Scientific Research (TOP-Chemistry

in relation to biological and medical sciences 2008) 2007* Chair, MDCN-K(51) Special Emphasis Panel, NIH IRG: Neuroinformatics and

Neuroimaging, July 18–19 2007* Special Emphasis, NIH IRG: Conte Center: ZMH1-ERB-S-03, Feb 26 2006* Review Member, NIH IRG: Neuroinformatics and Neuroimaging: ZRG1 MDCN-K51

S, June 21 2005* ZRG1 MDCN-K (92), Neurogenetics 2004* Chair NIH ZRG1 IDM-K (04) Genetics of Viral Pathogenesis, Mar 15 2004–2005* Chair and member NIH MDCN-G (55) Human Brain Project 2004* American Institute of Biological Sciences: Disease Prevention & Epidemiology

review panel, USAMRMC 2003* MRC Program Review, July 2003 2002* BISTI SS-E(51) and Human Brain Project SS-E(95), Oct 22–25 2002* MCDN Special Review panel ZRG1 SSS-P 09 S, Sept 6 2002* NEI Special Review panel ZEY1 VSN 06 R, Aug 2002* Science Foundation Ireland reviewer, July 2002* NIH Mammalian Genetics IRG, June 2002 2002–2004* Mammalian Genotyping Advisory Panel, Apr 2002, 2003, 2004 2002* NIH Special Review, Feb 8 2001* NIH Innovations in Biomedical Science Tech ZRG1 SSS-7 21B, Nov 6 2001* NIH BISTI Panel Reviewer ZRG1 SSS-E01, July 1, Nov 2001* NIH CSR Reviewer ZRG1FCN-3 01 BISTI, July 19 2001* NIH Special Emphasis Panel ZRG1 SSS-R (02), July 2 2001* NIEHS Review Panel (Inbred Rodents) ES-01-05, June 29 2001* Medical Research Council (UK) Strategic Grants Reviewer 2000* Fonds voor Weterschappelijk Onderzoek - Vlaanderen (Belgian NIH) 2000* NIH VISB Study Section Ad Hoc Member, June 2000* NIMH Special Emphasis Panel Reviewer (Gene Array RFA MH-00-002, July 2000* UT System-wide Advisory Panel: Biotechnology and Biological Sciences Review,

July 1999* NIH VISC Study Section Ad Hoc Member, Feb


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1999* NIMH Center Grant Reviewer 1999* NIMH Special Emphasis Panel Reviewer ZMH1 BRB-I 1998* Department of Veterans Affairs: Merit Review Consultant 1995* Consultant to NIH VIS-B Study Section

TEACHING

2014 Teacher: Technique course: Pharmacogenetics session (April 14) for the Master Program in Pharmacology Program, UTHSC (Edward Park Ph.D. director)

2014 Organizer: Two-day Workshops (three) on Systems Genetics: Beijing Genomics Institute, China (March 23-24), and Shanghai Medical University, and Hebei Institute

2014 Organizer: Workshop on Systems Genetics: University of Edinburgh (Feb 26) 2013 Organizer: INCF Short Course on Neuroinformatics, Neurogenomics and Brain

Disease, Fraueninsel, Germany, Sept 14-20 2013 SysGenet Course, Sept 9-13, London 2013 Short Course in Systems Neurogenomics using GeneNetwork, University of

Edinburgh, Feb 2011-2012 UTHSC Pathology residents lecture 2010 GeNeSys workshop on systems genetics. HZI Braunschweig, Germany (14 student

participants): 16 contact hours. Aug 16–18. 2008–present UTHSC, Behavioral Neuroscience (ANAT 821), graduate student seminar in

neurogenetics 2007–present UTHSC, Bioinformatics Special Topics Course (Biochem 920), graduate student

seminar in genomics 2011–present UTHSC, Next Generation Sequence User’s Group: monthly 3 hour informal training

and seminar series on genomics (sponsored by the CITG and RW Williams) 2007–present University of Memphis, Research Seminars in Bioinformatics (BINF 7980). Four 90-

minute lectures (Feb and March) 2006* The Jackson Laboratory: Short Course in Vision Research NSF Plant Microarray Short Course, instructor, Boston, Aug 1–3

Third Annual Experimental Neurogenetics of the Mouse workshop, Memphis, May 16–24

Cold Spring Harbor, Systems Biology Short Course, March 23 2004–2006 Faculty, Annual Experimental Neurogenetics of the Mouse Workshop, 15–20

students/year (8-day short course at UTHSC and the University of Memphis) 2005 Course director: NIEHS Short Course on Systems Genetics (offered twice) at

NIEHS main campus, Sept 7–8 2005–present NS 825: Graduate School, Developmental and Molecular Neurobiology lecturer (fall) 2005–present NS212: School of Medicine, Neuroscience lecturer (fall) 2005* Society for Neuroscience, Meet the Expert Series leader, Microarray analysis, SfN

annual meeting, Washington, Nov 12 Memphis City Schools Middle/Secondary Science In-Service Session 15: The

Human Genome, August 11 (2 sessions) 2001–present Course member and co-director: International Summer School in Behavioral

Neurogenetics (Behavioral Neurogenetics Initiative). Annual course (one week, 15 to 30 grad and postdoctoral students/year)

2001–2003 Course co-director: Neuroscience Seminar Series (NS8): a graduate level course, 15–20 contact hours, ~15 students/year.

1992–2003 Course director: Morphological Neuroscience (NS822): a graduate level course, ~40 contact hours, ~ 8 students/year.

2003–2004 Lecturer: Comparative Medicine CM712, UTHSC: Mouse Genetics (graduate level) 2003–present Lecturer: Bioinformatics, University of Memphis (graduate level)


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2000–2002 Lecturer and Lab: Medical Neuroanatomy (M): ~20 contact hours, Lectures in CNS development. 150 students/year.

2002–2003 Short Course director: Society of Neuroscience, Bioinformatics 2003 Course co-director: Memphis Microarray Short Course, June 4–12 2002* Lecturer: NIDA Addiction Studies Workshop for Journalists, Tucson, Dec 8 2002* Short Course director: UAB Birmingham: Design and Analysis of Recombinant Inbred

Strain Experiments, all day course, June 18 1998* Course Lecturer: Short Course in Quantitative Neuroanatomy, Society for Neuroscience,

Los Angeles 1994–1996* Course director: Seminars in Neuroscience (NS821): Graduate level. 40 contact

hours, 10 to 15 students per year 1995* SGAEC Excellence in Teaching Award, University of Tennessee (for NS822) 1995* Short Course in Genetic Testing: Memphis city schools service training for science

high school teachers. 15 high school science teachers. 1994–1995* Human and Mouse Genetics: City Labs program for high school science teachers.

10 to 12 high school science teachers. 1990–1996* Medical Embryology, University of Tennessee, 8 lectures on development of

cardiovascular, urogenital, and gastrointestinal systems. 8 lecture hours, ~120 first-year medical students.

1983–1989* Neuroscience-Neuroanatomy laboratory instructor, Yale University. Team-taught first-year medical students, roughly 20 contact hours, 25 students per lab.

1982* Course Director: Sensory Psychology, University of California, Davis. 25 junior and senior psychology majors.

ADMINISTRATIVE 2001 – 2011 Founding Director: Complex Trait Community 2010 – 2012 Memphis Research Consortium: Task force member 2007 – present Scientific Director: Center for Integrative and Translational Genomics, UTHSC 2000 – 2008 Director (2007-2008) and codirector: UT Center of Excellence in Genomics and

Bioinformatics 2011–2012 Member: Search Committee: Statistical Genetics, UTHSC Preventive Med 2010 – 2011 Member: Search Committee; Executive Dean of UTHSC 2010 – 2011 Member: Search Committee; Vice Chancellor for Research. UTHSC 2003 – 2009 Member: Health Science Center Information Technology Committee 2004 – present Member: Biomedical Informatics Research Network (Mouse BIRN) 2001 – present The Center for Vision Research, UTHSC 2005 – 2006 Member: Search Committee; Executive Dean of UT Medical Colleges 2002 University of Tennessee Research Foundation Task Force Subcommittee (T.

Ballard, chair) 2001 – 2002 Section Coordinator for the Visual and Auditory Systems research section, Center

for Neuroscience, UTHSC 2002 – 2004 Member: Computing and Telecommunications Committee of the UTHSC Faculty

Senate (C. Russell, chair). Chair: Research Computing subcommittee, UTHSC 1999 – present Tennessee Mouse Genome Consortium, Scientific Steering Committee 1999 – 2001 Member: Promotion and Tenure Committee, Department of Anatomy and

Neurobiology, UTHSC 1999 – present Scientific Advisory Board: Tennessee Mouse Genome Consortium 1998 Chair: Promotion and Tenure Committee, Department of Anatomy and

Neurobiology, UTHSC 1998 – present Member: Department of Anatomy and Neurobiology Space and Research

Committee, UTHSC 1997 – present Member: Department of Anatomy and Neurobiology Advisory Council, UTHSC 1997 – present Member: Graduate Health Sciences Electronic Thesis and Dissertation Advisory

Committee, UTHSC


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1997 – 1999 Member: Center for Neuroscience: Graduate Student Recruitment Committee, UTHSC

1990 – 1997 Member: University of Tennessee, Graduate Health Science School, Policy Subcommittee

1995 – 1997 Member: University of Tennessee, Graduate Health Science School, Graduate Studies Council

1990 – 1994 Member, University of Tennessee library committee member 1990 – 1996 Member: Department of Anatomy and Neurobiology: Graduate student admissions

and policy committee

GRADUATE STUDENTS, POSTDOCTORAL FELLOWS, ADVISEES Sarah Neuner Ph.D. expected 2017, RWW is co-mentor (genetics) with Dr. Catherine

Kaczorowski

Ashutosh Pandey Ph.D. in 2015, currently Scientific Investigator in Computational Biology, Galaxo-Smith-Kline Inc., Philadelphia PA

Nourtan Abdeltawab Ph.D. in 2010, Assistant Professor, Faculty of Pharmacy, Cairo University)

Adrienne Adler 2011-2012: M.D. Ph.D. student, Wake Forest University

Megan Mulligan, Ph.D. Assistant Professor (tenure track), Department of Genetics, Genomics and Informatics, UTHSC

Khyobeni Mozhui Ph.D. in 2009, Assistant Professor (tenure track), Department of Preventive Medicine, UTHSC

Vida Abedi M.S., April 2011, Department of Electrical Engineering, U Memphis

Daniel Ciobanu, Ph.D. Postdoctoral fellow with RWW from 2007–Jan 2009. Now Associate Professor, University of Nebraska, Lincoln

Collin Hovinga, Pharm.D. K12 CTSI-sponsored research mentor. Collin is Director of Research at PSS/Dell Children’s Hospital, Austin TX(2011-present)

Jasgit (Jesse) C. Sachdev M.D. K12 CTSI-sponsored research mentor. Jesse is an assistant professor in the Department of Medicine at UTHSC (2008-2010)

John A. Capra, Ph.D. Undergraduate bioinformatics summer student. Ph.D. Princeton 2008, Now Assistant Professor, Vanderbilt University

Manjunatha N. Jagalur Ph.D. candidate, computer science. Primary mentor is Dr. David Kulp at University of Massachusetts, Amherst. My role is as a joint Ph.D. advisor.

Richelle C. Strom Ph.D. in 1999, University of Tennessee. Postdoctoral Fellow with Prof. Ruben Adler, Johns Hopkins University

Dennis S. Rice Ph.D. in 1996, University of Tennessee. Director of Ophthalmology at Lexicon Pharmaceuticals, The Woodlands, TX

Dale Hogan, Ph.D. NRSA NEI Postdoctoral fellow, 1992–1996; Research Associate with Mark Opp, Department of Psychiatry and Behavior, University of Texas Medical Branch, Galveston

Guomin Zhou, M.D., Ph.D. Research fellow, 1997–1999; Chairman and Professor of Histology and Embryology, Fudan University, Shanghai, China

Lu Lu, M.D. Research fellow, 1999–2001; Associate Professor, UTHSC; Professor in Histology and Embryology, Medical University of Nantong, China

David C. Airey, Ph.D. NRSA, NEI Postdoctoral fellow, April 1999–July 2001; Assistant Professor, Vanderbilt University


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Elissa J. Chesler, Ph.D. Research fellow, July 2002–2005; Associate Professor, The Jackson Laboratory Jeremy Peirce, Ph.D. Research fellow, June 2003–2006; staff scientist at Illumina Inc. Author of Attention-

Deficit/Hyperactivity Disorder (2008) by Chelsea House Publishers Anand Kulkarni, M.D. Research fellow, Nov 1999–Nov 2000; pathologist, UTHSC Siming Shou, Ph.D. Postdoctoral fellow, September 2001–2002 E. Gilissen, Ph.D. Postdoctoral fellow (1996–1997, with John Allman at Caltech); faculty Ph.D. of

paleontology, University of the Witwassersrand, South Africa Kathryn Ryder M.D. Dissertation, Yale University School of Medicine, 1987; associate professor,

Department of Medicine, UTHSC Michael Borodkin M.D. dissertation, Yale University School of Medicine, 1989

Ph.D. and M.S . COMMITTEES (M E N T O R E D B Y RW W U N L E S S N O T E D ) Sarah Neuner Ph.D. candidate, UTHSC (mentored by Catherine Kaczorowski) Sumana Chintalapudi Ph.D. candidate, UTHSC (mentored by Monica Jablonski) Neha Mehta Ph.D. candidate, Northwestern University, 2012–present (mentored by E. Redei) Ashutosh Pandey Ph.D. candidate, UTHSC (2011–present) Felecia D. Emery Ph.D. candidate, UTHSC (2011–present, mentored by Mark Miller) Suresh Kannan Ph.D. candidate, Univ Dresden, 2012–present (mentored by G. Kempermann) Khyobeni Mozhui Ph.D. in Neuroscience, UTHSC, May 2009 Rick Laughlin Ph.D. candidate, UCLA 2008 Nourtan Adeltawab Ph.D. candidate, UTHSC 2008 C. J. Jeon Ph.D. in Neuroscience, UTHSC 1992 Angela R. Howe Ph.D. in Neuroscience, UTHSC 1994 Vandana Menon Ph.D. in Physiology, UTHSC 1996 Qing Tang Ph.D. in Anatomy and Neurobiology, UTHSC June 1996 Loren Martin Ph.D. in Anatomy and Neurobiology, UTHSC Nov 2000 Toya H. Kimble Ph.D. in Anatomy and Neurobiology, UTHSC Jan 2003 Félix Vázquez-Chona Ph.D. in Anatomy and Neurobiology, UTHSC 2006 Kathryn Ryder, M.D. M.S. in Epidemiology, UTHSC 2002 A. Iannaccone, M.D. M.S. in Epidemiology, UTHSC 2002

ORIGINAL PAPERS

A substantial number of these papers are available online at www.nervenet.org.

1. Williams RW, Chalupa LM (1982) Prenatal development of retinocollicular projections in the cat: An anterograde tracer transport study. Journal of Neuroscience 2: 604–622 Revised and updated text at <http://nervenet.org/papers/SC1982.html>.

2. Stone, J, Rapaport DH, Williams RW, Chalupa LM (1982) Uniformity of cell distribution in the ganglion cell layer of prenatal cat retina: Implications for mechanisms of retinal development. Developmental Brain Research 2: 231–242

3. Williams RW, Bastiani MJ, Chalupa LM (1983) Loss of axons in the cat optic nerve following fetal unilateral enucleation: An electron microscopic analysis. Journal of Neuroscience 3: 133–144

4. Williams RW, Chalupa LM (1983) An analysis of axon caliber within the optic nerve of the cat: Evidence of size groupings and regional organization. Journal of Neuroscience 3: 1554–1564

5. Williams RW, Chalupa LM (1983) Development of the retinal pathway to the pretectum of the cat. Neuroscience 10: 1249–1267

6. Chalupa LM, Williams RW, Hughes MJ (1983) Visual properties of neurons in the tectorecipient zone of the cat’s lateral posterior-pulvinar complex: A comparison with the superior colliculus. Journal of Neuroscience 3: 2587–2596


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7. Chalupa, LM, Williams RW (1984) Organization of the cat’s lateral geniculate nucleus following interruption of prenatal binocular competition. Human Neurobiology 3: 103–107

8. Chalupa LM, Williams RW, Henderson Z (1984) Binocular interaction in the fetal cat regulates the size of the ganglion cell population. Neuroscience 12: 1139–1146 <nervenet.org/papers/SC1982.html>

9. Williams RW, Rakic P (1985) Dispersion of growing axons within the optic nerve of the embryonic monkey. Proceedings of the National Academy of Science USA 82: 3906–3910 <nervenet.org/papers/dispersion85.html>

10. Williams RW, Crabtree, JW, Chalupa LM, Spear PD, Kornguth SE (1985) Selectivity of antibody-mediated destruction of retinal ganglion cell axons. Brain Research 336: 57–66

11. Williams RW, Bastiani MJ, Lia B, Chalupa LM (1986) Growth cones, dying axons, and developmental fluctuations in the fiber population of the cat’s optic nerve. Journal of Comparative Neurology 246: 32–69 <nervenet.org/papers/Cat86.html>.

12. Lia B, Williams RW, Chalupa LM (1986) Does axonal branching contribute to the overproduction of optic nerve fibers during early development of the cat’s visual system. Developmental Brain Research 25: 296–301

13. Lia B, Williams RW, Chalupa LM (1987) Formation of retinal ganglion cell topography during prenatal development. Science 236: 848–851

14. Williams RW, Rakic P (1988) Elimination of neurons from the lateral geniculate nucleus of rhesus monkeys during development. Journal of Comparative Neurology 272: 424–436 <nervenet.org/papers/RHESUS_LGN.html>

15. Williams RW, Rakic P (1988) Three-dimensional counting: An accurate and direct method to estimate cell numbers in sectioned material. Journal of Comparative Neurology 278: 344–352 <nervenet.org/papers/3DCounting.html>

16. Wikler KC, Williams RW, Rakic P (1990) Photoreceptor mosaic: Number and distribution of rods and cones in the rhesus monkey retina. Journal of Comparative Neurology 297: 499–508

17. Williams RW, Borodkin M, Rakic P (1991) Growth cone distribution patterns in the optic nerve of fetal monkeys: Implications for mechanisms of axonal guidance. Journal of Neuroscience 11: 1081–1094 <nervenet.org/papers/GC91.html>

18. Rakic, P., Suñer I, Williams RW (1991) A novel cytoarchitectonic area induced experimentally within the primate visual cortex. Proceedings of the National Academy of Science USA 88: 2083–2087

19. Williams RW (1991) The human retina has a cone-enriched rim. Visual Neuroscience 6:403–406 20. Williams RW, Goldowitz D (1992) Structure of clonal and polyclonal cell arrays in chimeric mouse retina.

Proceedings of the National Academy of Science USA 89: 1184–1188 (PMC48413) 21. Williams RW, Cavada C, Reinoso-Suárez F (1993) Rapid evolution of the visual system: A cellular assay

of the retina and dorsal lateral geniculate nucleus of the Spanish wildcat and the domestic cat. Journal of Neuroscience 13: 208–228 <nervenet.org /papers/wildcat.html>

22. Williams RW, Hogan D, Garraghty PE (1994) Target recognition and visual maps in the thalamus of achiasmatic mutant dogs. Nature 367: 637–639; and see New and Views article by R.W. Guillery, Nature 367: 597–598 <nervenet.org/papers/DOGLGNNature.html>

23. Williams RW (1994) The Portable Dictionary of the Mouse Genome: A personal database for gene mapping and molecular biology. Mammalian Genome 5: 372-375. See <nervenet.org/main/dictionary.html>. This short paper’s main claim to fame is that it is the earliest publication in PubMed to list a web site URL (“http://”) in the abstract.

24. Brilliant MB, Williams RW, Conti C, Angel J, Holdener BC (1994) Mouse chromosome 7. Mammalian Genome 5: S104–S123

25. Dell'Osso LF, Williams RW (1995) Ocular motor abnormalities in achiasmatic mutant Belgian sheepdogs: Unyoked eye movements in a mammal. Vision Research 35: 109–116

26. Scheetz AJ, Williams RW, Dubin MW (1995) Severity of ganglion cell death during early postnatal development is modulated by neuronal activity and binocular competition. Visual Neuroscience 12: 605–610

27. Hogan D, Williams RW (1995) Analysis of the retinas and optic nerves of achiasmatic Belgian sheepdogs. Journal of Comparative Neurology 352: 367–380


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28. Rice DS, Williams RW, Goldowitz D (1995) Genetic control of retinal projections in inbred strains of albino mice. Journal of Comparative Neurology 354: 459–469

29. Rice DS, Williams RW, Harris B, Bailey PW, Davisson MT, Goldowitz D (1995) Mapping the Bst mutation on mouse Chromosome 16: A model for human optic atrophy. Mammalian Genome 6: 546–548 <nervenet.org/papers/Bst2.html>

30. Hogan D, Garraghty PE, Williams RW (1996) Lamination and visual topography in the lateral geniculate nucleus of normal and achiasmatic dogs. European Journal of Anatomy 1: 3–11

31. Ezer AD, Williams RW, Goldowitz D (1996) Arbitrary primer PCR of dog DNA with estimates of average heterozygosity. Journal of Heredity 87: 450–455

32. Goldowitz D, Rice DS, Williams RW (1996) Clonal architecture of the mouse retina. Progress in Brain Research 108: 2–15

33. Brilliant MH, Williams RW, Holdener BC, Angel JM (1996) Mouse chromosome 7. Mammalian Genome 6: S135–S150

34. Hamvas R, Trachtulec Z, Forejt J, Williams RW, Artzt K, Fischer-Lindahl K., Silver LM (1996) Mouse chromosome 17. Mammalian Genome 6: S281–S299

35. Williams RW, Strom RC, Rice DS, Goldowitz D (1996) Genetic and environmental control of retinal ganglion cell number in mice. Journal of Neuroscience 16: 7193–7205 <www.jneurosci.org/cgi/content/full/16/22/7193>

36. Rice DS, Tang Q, Williams RW, Harris B, Davisson MT, Goldowitz D (1997) Retinal ganglion cell loss and misdirect axon growth associated with fissure defects in Bst mutant mice. Investigative Ophthalmology and Visual Science 38:2112–2124

37. Williams RW, Strom RC, Goldowitz D (1998) Natural variation in neuron number in mice is linked to a major quantitative trait locus on Chr 11. Journal of Neuroscience 18: 138–146 <www.jneurosci.org/cgi/content/abstract/18/1/138>

38. Williams RW, Holdener BC, Angel JM, Oakey R, Hunter K (1998) Mouse chromosome 7. Mammalian Genome 8:S136–159. <www.informatics.jax.org/bin/ccr/index?year=1998>

39. Strom, RC, Williams RW (1998) Cell production and cell death in the generation of normal variation in neuron number. Journal of Neuroscience 18: 9948–9953 <www.jneurosci.org/cgi/content/abstract/18/23/9948>

40. Dell'Osso, LF Williams RW, Jacobs JB, Erchul DM (1998) The congenital and see-saw nystagmus in the prototypical achiasma of canines: comparison to the human achiasmatic prototype. Vision Research 38: 1629–1641

41. Zhou G, Williams RW (1999) Eye1 and Eye2: Gene loci that modulate eye size, lens weight, and retinal area in mouse. Investigative Ophthalmology and Visual Science 40: 817–825 <nervenet.org/papers/Eye1.html>

42. Williams RW (1999) A targeted screen to detect recessive mutations that have quantitative effects. Mammalian Genome 10:734–738 <nervenet.org/papers/consomic.html>

43. Zhou G, Williams RW (1999) Mouse models for the analysis of myopia: an analysis of variation in eye size of adult mice. Optometry and Vision Science 76: 408–418 <nervenet.org/papers/OVSMyopia.html>.

44. Williams RW, Angel JM, Holdener BC, Oakey R, Hunter K (1999) Mouse chromosome 7. Mammalian Genome 10:947 <www.informatics.jax.org/bin/ccr/index?year=1999>

45. Dell'Osso LF, Hertle RW, Williams RW, Jacobs JB (1999) A new surgery for congenital nystagmus: effects of tenotomy on an achiasmatic canine and the role of extraocular proprioception. J Amer Acad Ped Ophthal Soc 3:166–182

46. Toth LA, Williams RW (1999) Circadian patterns of locomotor activity in CXB recombinant inbred mice. Behavior Genetics 29:319–328

47. Toth LA, Williams RW (1999) Strain-related differences in slow wave sleep and rapid-eye-movement sleep in C57BL/6J and BALB/c mice. Behavior Genetics 29:329–337

48. Toth LA, Williams RW (1999) Circadian patterns of slow wave sleep in influenza-infected C57BL/6 and BALB/c mice: A genetic analysis using CXB recombinant inbred strains. Behavior Genetics 29:339–348

49. Rice DS, Goldowitz D, Williams RW, Hamre K, Johnson PT, Tan SS, Reese BE (1999) Extrinsic modulation of retinal ganglion cell projections: analysis of the albino mutation in pigmentation mosaic mice. Developmental Biology 216:41–56 <www.idealibrary.com/links/artid/dbio.1999.9467>


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50. Hogan D, Garraghty PE, Williams RW (1999) Asymmetric connections, duplicate layers, and reversed maps in the primary visual system. Journal of Neuroscience 19: RC38:1–6 <www.jneurosci.org/cgi/content/full/3657>

51. Kimble TDH, Williams RW (1999) Structure of the cone photoreceptor mosaic in the retinal periphery of adult humans: Analysis as a function of age, sex, and hemifield. Anatomy and Embryology 201:305–316

52 Dell'Osso LF, Hogan D, Jacobs JB, Williams RW (1999) Eye movements in canine hemichiasma: Does human hemichiasma exist? Neuro-ophthalmology 22:47–58

53. Angel JM, Williams RW (2000) Mouse chromosome 7. Mammalian Genome 11: 948–949 54. Williams RW, Lu L, Kulkarni A, Zhou G, Airey DC (2001) Genetic dissection of the olfactory bulbs of mice:

QTLs on chromosomes 4, 6, 11, and 17 modulate bulb size. Behavior Genetics 31:61–77 <nervenet.org/papers/OB/OB2000.html>

55. Cook MN, Williams RW, Flaherty L (2001) Anxiety-related behaviors in the elevated zero maze are affected by genetic factors and retinal degeneration. Behavioral Neuroscience 115:468–476

56. Lu L, Airey DC, Williams RW (2001) Complex trait analysis of the mouse hippocampus: Mapping and biometric analysis of two novel gene loci that modulate hippocampal size. Journal of Neuroscience, 21:3503–3514 <nervenet.org/papers/hipp1.html>

57. Rosen GD, Williams RW (2001) Complex trait analysis of the mouse striatum: Independent QTLs modulate volume and neuron number. BMC Neuroscience 2:5 (PMC31432)

58. Airey DC, Lu L, Williams RW (2001). Genetic control of the mouse cerebellum: identification of quantitative trait loci modulating size and architecture. Journal of Neuroscience 21: 5099–5109 <nervenet.org/papers/cerebellum2000.html>

59. Hardy CL, Lu L, Nguyen P, Woodland DL, Williams RW, Blackman MA (2001) Identification of quantitative trait loci controlling activation of TRBV4 CD8+ T cells during murine γ-herpes virus-induced infectious mononucleosis Immunogenetics 53: 395–400

60. Williams RW, Gu J, Qi S, Lu L (2001) The genetic structure of recombinant inbred mice: High-resolution consensus maps for complex trait analysis. Genome Biology 2: 46.1–46.18 <http://genomebiology.com/2001/2/11/research/0046/> (PMC59991)

61. Zhou G, Strom RC, Giguere V, Williams RW (2001) Modulation of retinal cell populations and eye size in retinoic acid receptor knockout mice. Molecular Vision 7, <www.molvis.org/molvis/v7/a36/>

62. Hsu, HC, Mountz JD, Williams RW, Shelton BJ, Yang P, Matsuki Y, Xu X, Zhang HG, Geiger H, van Zant G (2002) Age-related change in thymic T-cell development is associated with genetic loci on mouse chromosomes 1, 3, and 11. Mech Ageing Dev 123: 1145–1158

63. Geisert Jr EE, Williams RW, Geisert G, Maecker HT, Deng J, Levy S (2002) Increased brain size and glial cell number in CD81-null mice. Journal of Comparative Neurology 453: 22–32

64. Airey DW, Lu L, Shou S, Williams RW (2002) Genetic sources of individual differences in cerebellum. The Cerebellum 1: 233–240

65. Hitzemann R, Hitzemann B, Rivera S, Gatley J, Thanos P, Lu L, Shou S, Williams RW (2002) Dopamine D2 receptor binding, Drd2 expression and the number of dopamine neurons in the BXD recombinant inbred series: genetic relationships to alcohol and other drug associated phenotypes. Alcoholism: Clinical and Experimental Research 27: 1–11

66. Grizzle WE, Mountz JD, Yang PA, Xu X, Sun S, Van Zant GE, Williams RW, Hsu HC, Zhang HG (2002) BXD recombinant inbred mice represent a novel T-cell mediated immune response tumor model. International Journal of Cancer 101: 270–279

67. Cook R, Lu L, Gu J, Williams RW, Smeyne RJ (2003) Identification of a single QTL, Mptp1, for susceptibility to MPTP-induced substantia nigra pars compacta neuron loss in mice. Molecular Brain Research 110: 279–288

68. Hsu HC, Zhang HG, Li L, Yi N, Yang PA, Wu Q, Zhou J, Sun S, Xu X, Yang X, Lu L, Van Zant G, Williams RW, Allison DB, Mountz JD (2003) Age-related thymic involution in C57BL/6J X DBA/2J recombinant inbred mice maps to mouse chromosome 9. Genes and Immunity 4: 402–410

69. Hitzemann R, Malmanger B, Reed C, Lawler M, Hitzemann B, Coulombe S, Buck K, Rademacher B, Walter N, Polyakov Y, Sikela J, Williams RW, Flint J, Talbot C (2003) A strategy for integration of QTL, gene expression, and sequence analyses. Mammalian Genome 14: 733–747


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70. Schaeffel F, Burkhardt E, Howland HC, Williams RW (2004) Measurement of refractive state and deprivation myopia in two strains of mice. Optometry and Vision Science 81: 99–110

71. Peirce J, Chesler EJ, Williams RW, Lu L (2003) Genetic architecture of the mouse hippocampus: Identification of gene loci with regional effects. Genes, Brain & Behavior 2: 238–252

72. Wang J, Williams RW, Manly KF (2003) WebQTL: Web-based complex trait analysis. Neuroinformatics 1:299–308

73. Pollock GS, Robichon R, Boyd KA, Kerkel KA, Kramer M, Lyles J, Ambalavanar R, Khan A, Kaplan DR, Williams RW, Frost DO (2003) TRKB receptor signaling regulates dynamics of developmental retinal ganglion cell death but not final number. Journal of Neuroscience 23: 10137–10145

74. Rosen GD, La Porte NT, Diechtiareff B, Pung, CJ, Nissanov J, Gustafson C, Bertrand L, Gefen S, Fan Y, Tretiak OJ, Manly KF, Parks MR, Williams AG, Connolly MT, Capra JA, Williams RW (2003) Informatics center for mouse genomics: the dissection of complex traits of the nervous system. Neuroinformatics 1: 327–342

75. Chesler EJ, Wang J, Lu L, Qu Y, Manly KF, Williams RW (2003) Genetic correlates of gene expression in recombinant inbred strains: a relational model system to explore neurobehavioral phenotypes. Neuroinformatics 1: 343–357

76. Seecharan DJ, Kulkarni AL, Lu L, Rosen GD, Williams RW (2003) Genetic control of interconnected neuronal populations in the mouse primary visual system. Journal of Neuroscience 23: 11178–11188

77. Williams AG, Williams RW (2004) GenomeMixer: A complex genetic cross simulator. Bioinformatics 20: 2488–2490

2004 78. Jablonski MM, Lu L, Wang, XF, Chesler EJ, Carps E, Qi S. Gu J, Williams RW (2004) The ldis1 lens

mutation in RIIIS/J mice maps to chromosome 8 near cadherin 1. Molecular Vision 10: 577–587 79. Peirce J, Lu L, Gu J, Silver LM, Williams RW (2004) A new set of BXD recombinant inbred lines from

advanced intercross populations in mice. BMC Genetics 5: 7 (PMC420238) 80. Ponomarev I, Schafer GL, Blednov YA, Williams RW, Iyer VR, Harris A (2004) Convergent analysis of

cDNA and short oligomer microarrays, mouse null mutant, and bioinformatics resources to study complex traits. Genes, Brains & Behavior 3: 360–368

81. Schauwecker PE, Williams RW, Santos JB (2004) Genetic control of seizure-induced cell death susceptibility in mice. Journal of Comparative Neurology 477: 96–107

82. Simon P, Schott K, Williams RW, Schaeffel F (2004) Post-translational regulation of the immediate early gene EGR1 by light in the mouse retina. European Journal of Neuroscience 20: 3371–3377

83. Tan XL, Zhou Y, Cai KF, Shao YX, Zhu SX, Lu L, Williams RW, Gu XS (2004) Identification of QTLs for weight and cross-sectional area on cervical enlargement of spinal cord in mice. Yi Chuan Xue Bao 31: 801–806

84. Williams RW, Bennett B, Lu L, Gu J, DeFries JC, Carosone-Link P, Rikke B, Belknap JK, Johnson TE (2004) Genetic structure of the LXS panel of recombinant inbred mouse strains. Mammalian Genome 15: 637–647

2005 62. Baldwin NE, Chesler EJ, Kirov S, Langston MA, Snoddy JR, Williams RW, Zhang B (2005) Computational,

integrative and comparative methods for the elucidation of genetic co-expression networks. Journal of Biomedicine and Biotechnology 2: 172–180 (PMC1184052)

63. Bystrykh L, Weersing E, Dontje B, Sutton S, Pletcher MT, Wiltshire T, Su AI, Vellenga E, Wang J, Manly KF, Lu L, Chesler EJ, Alberts R, Jansen RC, Williams RW, Cooke M, de Haan G (2005) Uncovering regulatory pathways affecting hematopoietic stem cell function using “genetical genomics”. Nature Genetics 37: 225–232

64. Carlborg Ö, De Koning D-J, Chesler EJ, Manly KM, Williams RW, Haley CS (2005) Methodological aspects of the genetic dissection of gene expression. Bioinformatics 21: 2383–2393

65. Chesler EJ, Lu L, Shou S, Qu Y, Gu J, Wang J, Hsu HC, Mountz JD, Baldwin N, Langston MA, Threadgill DW, Manly KF, Williams RW (2005) Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function. Nature Genetics 37: 233–242


–24–

66. Jablonski MM, Dalke C, Wang XF, Lu L, Manly K, Pretsch W, Pardue M, Rinchik, Williams RW, Goldowitz D, Graw J (2005) An ENU-induced mutation in Rs1h causes disruption of retinal structure and function. Molecular Vision 11: 596–581

67. Jablonski MM, Wang, XF, Lu L, Miller DR, Rinchik EM, Williams RW, Goldowitz, D (2005) The Tennessee Mouse Genome Consortium: identification of novel ocular mutants. Visual Neuroscience 22: 595–604

68. Kerns RT, Ravindranathan A, Hassan S, Cage MP, York T, Williams RW, Miles MF (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. Journal of Neuroscience 25: 2255–2265

69. Li CX, Wei X, Lu L, Peirce JL, Williams RW, Waters RS (2005) Genetic analysis of barrel field size in the first somatosensory area (SI) in inbred and recombinant inbred strains of mice. Somatosensory and Motor Research 22: 141–150

70. Li HQ, Lu L, Manly KF, Wang J, Zhou M, Williams RW, Cui Y (2005) Inferring gene transcriptional modulatory relations: a genetical genomics approach. Human Molecular Genetics 14: 119–1125

71. Manly KF, Wang J, Williams RW (2005) Weighting by heritability for detection of quantitative trait loci with microarray estimates of gene expression. Genome Biology 6: R27.1-27.10 (PMC1088946)

72. Mountz JD, Yang PA, Wu Q, Zhou J, Tousson A, Fitgerald A, Allen J, Wang X, Cartner S, Grizzle WE, Yi N, Lu L, Williams RW, and Hsu H-C (2005) Genetic segregation of spontaneous erosive arthritis and generalized autoimmune disease in BXD2 recombinant inbred strain of mice. Scandinavian Journal of Immunology 61: 128–138

73. Scott RE, White-Grindley E, Ruley HE, Chesler EJ, Williams RW (2005) P2P-R expression is genetically coregulated with components of the translation machinery with PUM2, a translational repressor that associates with the P2P-R mRNA. Journal of Cellular Physiology 204: 99–105

74. Tsaih, SW, Lu L, Airey DC, Williams RW, Churchill GA (2005) Quantitative trait mapping in a diallel cross of recombinant inbred lines. Mammalian Genome 16: 344–355

75. Vazquez-Chona FR, Khan AN, Chan CK, Moore AN, Dash PK, Rosario Hernandez R, Lu L, Chesler EJ, Manly KF, Williams RW, Geisert Jr EE (2005) Genetic networks controlling retinal injury. Molecular Vision 11: 958–970 (PMC 2814057)

76. Zou F, Gelfond JA, Airey DC, Lu L, Manly KF, Williams RW, Threadgill DW (2005) Quantitative trait locus analysis using recombinant inbred intercrosses (RIX): theoretical and empirical considerations. Genetics 170: 1299–1311 (PMC 1451174)

2006 77. Aliesky HA, Pichurin PN, Chen CR, Williams RW, Rapoport B, McLachlan SM (2006) Probing the genetic

basis for thyrotropin receptor antibodies and hyperthyroidism in immunized CXB recombinant inbred mice. Endocrinology 147: 2789–2800

78. Bao L, Wei L, Peirce JL, Homayouni R, Li H, Zhou M, Chen H, Lu L, Williams RW, Pfeffer LM, Goldowitz D, Cui Y (2006) Combining gene expression QTL mapping and phenotype spectrum analysis to uncover gene regulatory relations. Mammalian Genome 17: 575–583

79. Kempermann G, Chesler EJ, Lu L, Williams RW, Gage FH (2006) Natural variation and genetic covariance in adult hippocampal neurogenesis. Proceedings of the National Academy of Science USA 103: 780–785 (PMC 1325968)

80. Lan H, Chen M, Byers JE, Yandell BS, Stapleton DS, Mata CM, Mui TK, Flowers MT, Schueler KL, Manly KF, Williams RW, Kendziorski, CM, Attie AD (2006) Combined expression trait correlations and expression quantitative trait locus mapping. PLoS Genetics 2: 51–61 (PMC1331977)

81. Li H, Chen H, Bao L, Manly KF, Chesler EJ, Lu L, Wang J, Zhou M, Williams RW, Cui Y (2006) Integrative genetic analysis of transcription modules: towards filling the gap between genetic loci and inherited traits. Human Molecular Genetics 15: 481–492

82. Martin M, Dong H, Vallera D, Lee D, Lu L, Williams RW, Rosen GD, Cheverud J, Csernansky J (2006) Independent quantitative trait loci influence ventral and dorsal hippocampal volume in recombinant inbred strains of mice. Genes, Brain & Behavior 5: 614–623

83. Peirce JL, Lu L, Li H, Wang J, Manly KF, Hitzemann RJ, Belknap JK, Rosen GD, Goodwin S, Sutter TR, Williams RW (2006) How replicable are mRNA expression QTLs. Mammalian Genome 17: 643–642

84. Radcliffe RA, Lee MJ, Williams RW (2006) Prediction of cis-QTLs in a pair of inbred mouse strains with the use of expression and haplotype data from public databases. Mammalian Genome 17: 643–642


–25–

85. Shifman S, Bell JT, Copley RR, Taylor M, Williams RW, Mott R, Flint J (2006) A high resolution single nucleotide polymorphism genetic map of the mouse genome. PLoS Biology 4: 2227–2237 (PMC1635748)

2007 86. Aziz, R, Kanal R, Abdeltawab NF, Rowe SL, Su Y, Carrigan D, Nooh MM, Attia RR, Brannen C, Gardner

LA, Lu L, Williams RW, Kotb M (2007) Susceptibility to severe streptococcal sepsis: a mouse reference population to study genetic and environmental factors. Gene and Immunity 8: 404–415 (PMID: 17525705)

87. Bao L, Peirce JL, Lu L, Zhou M, Li H, Goldowitz D, Williams RW, Cui Y (2007) An integrative genomics strategy for systematic characterization of genetic loci modulating phenotypes. Human Molecular Genetics 16: 1381–1390

88. Bao L, Zhou M, Wu L, Lu L, Goldowitz D, Williams RW, Cui Y (2007) PolymiRTS database: linking polymorphisms in microRNA target sites with complex traits. Nucleic Acids Research (database issue): D51–54 (PMC1669716)

89. Bhave SV, Hornbaker C, Phang TL, Saba L, Lapadat R, Kechris K, Gaydos J, McGoldrick D, Dolbey A, Leach S, Soriano B, Ellington A, Ellington E, Jones K, Mangion J, Belknap JK, Williams RW, Hunter LE, Hoffman PL, Tabakoff B (2007) The PhenoGen Informatics website: tools for the analysis of complex traits. BMC Genetics 8: 59 (PMC 2034588)

90. Bug W, Wong WW, Gustafson C, Johnson GA, Martone ME, Price DL, Rosen GD, Williams RW, Zaslavsky I, Nissanov J (2007) Brain atlasing tool interoperation: NeuroTerrain-Smart Atlas synergistic visualization and analysis environment. Neural Engineering, 2007 3rd International IEEE/EMBS Conference (ISBN 1-4244-0792-3)

91. Dong H, Martin M, Colvin J, Ali Z, Wang L, Lu L, Williams RW, Rosen GD, Csernansky JG, Cheverud JM (2007) Quantitative trait loci linked to thalamic and cortical gray matter volumes in BXD recombinant inbred mice: implications for the genetics of schizophrenia. Heredity 99: 62–69

92. Gatti D, Maki A, Chesler EJ, Kosyk O, Kirova R, Lu L, Manly KF, Qu Y, Williams RW, Perkins A, Langston ME, Threadgill DW, Rusyn I (2007) Genome-level analysis of genetic regulation of liver gene expression networks. Hepatology 46: 548–557

93. Miyairi I, Tatireddigari A, Mahdi OS, Belland RJ, Lu L, Williams RW, Byrne GI (2007) The p47 GTPases Iigp2 and Irgb10 regulate innate immunity and inflammation to murine Chlamydia psittaci infection. Journal of Immunology 179: 1814–1824 (free article)

94. Mozhui K, Hamre KM, Holmes A, Lu L, Williams RW (2007) Genetic and structural analysis of the basolateral amygdala complex in BXD recombinant inbred mice. Behavior Genetics 37: 223–243 (featured article in Nature Neuroscience Gateway: http://www.neuroscience-gateway.org/2007/070215/full/aba1717.shtml)

95. Peirce JL, Broman KW, Lu L, Williams RW (2007) A simple method for combining genetic mapping data from multiple crosses and experimental designs. PLoS One 2: e1036 (PMC2001185)

96. Vázquez-Chona F, Lu L, Williams RW, Geisert EE (2007) Genetic influences on retinal gene expression and wound healing. Gene Regulation and Systems Biology 1: 327-348

97. Yang J, Zhu J, Williams RW (2007) Mapping the genetic architecture of complex traits in experimental populations. Bioinformatics 23: 1527–1536

2008 98. Abdeltawab NF, Aziz RK, Kansal R, Rowe SL, Su Y, Gardner L, Brannen C, Nooh MM, Attia RR,

Abdelsamed HA, Taylor WL, Williams RW, Kotb M (2008) An unbiased systems genetics approach to mapping genetic loci modulating susceptibility to severe streptococcal sepsis. PLoS Pathogens 4: e1000042 (PMC2277464)

99. Chesler EJ, Miller DR, Branstetter L, Galloway L, Jackson B, Philip VM, Voy B, Culiat CT, Threadgill DW, Williams RW, Churchill GA, Johnson DK, Manly KF (2008) The Collaborative Cross at Oak Ridge National Laboratory: developing a powerful resource for systems genetics. Mammalian Genome 19: 382-389 (PMC2745091)

100. Crawford, NPS, Walker RC, Officewala JS, Lukes L, Williams RW, Hunter KW (2008) The diasporin pathway: a tumor progression-related network that predicts breast cancer survival. Clinical and Experimental Metastasis 25: 357-369 ()

101. Danciger M, Ogando D, Yang H, Matthes MT, Yu H, Ahern K, Yasumura D, Williams RW, LaVail MM (2008) Genetic modifiers of retinal degeneration in the rd3 mouse. Investigative Ophthalmology and Visual Science 49: 2863-2869 (PMC2574750)


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102. Druka A, Potokina E, Luo Z, Bonar N, Druka I, Zhang, L, Marshall DF, Steffenson BJ, Close TJ, Wise RP, Kleinhofs A, Williams RW, Kearsey MJ, Waugh R (2008) Exploiting regulatory variation to identify genes and loci underlying quantitative resistance to the wheat stem rust pathogen Puccinia graminis f. sp. tritici in barley. Theoretical and Applied Genetics 117: 261-272

103. Druka A, Druka I, Centeno AG, Li H, Sun Z, Thomas WTB, Bonar N, Steffenson BJ, Ullrich SE, Kleinhofs A, Wise RP, Close TJ, Potokina E, Luo Z, Wagner C, Schweizer GF, Marshall DF, Kearsey MJ, Williams RW, Waugh R (2008) Towards systems genetic analyses in barley: Integration of phenotypic, expression and genotype data into GeneNetwork. Manuscript. BMC Genetics 9: 73 (PMC2630324)

104. Gardner D, Akil H, Ascoli AG, Bowden DM, Bug W, Donohue DE, Goldberg DH, Grafstein B, Grethe JS, Gupta A, Halavi M, Kennedy DN, Marenco L, Marton ME, Miller P, Muller HM, Robert A, Shepherd GM, Sternberg PW, Van Essen DC, Williams RW (2008) The Neuroscience Information Framework: a data and knowledge environment for neuroscience. Neuroinformatics 6: 149-160 (PMC2661130)

105. Hsu H-C, Yang PA, Wu Q, Myers R, Wang J, Guentert T, Chen J, Yi J, Tousson A, Stanus AL, Le TVL, Lorenz RG, Xu H, Kolls HK, Carter RH, Chaplin DD, Williams RW, Mountz JD (2008) Interleukin 17–producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice. Nature Immunology 9: 166–175

106. Jan TA, Lu L, Li CX, Williams RW, Waters RS (2008) Genetic analysis of posterior medial barrel subfield (PMBSF) size in somatosensory cortex (SI) in recombinant inbred strains of mice. BMC Neuroscience 9: 3 (PMC2254631)

107. Lu L, Wei L, Peirce JL, Wang X, Zhou J, Homayouni R, Williams RW, Airey DC (2008) Using gene expression databases for classical trait QTL candidate gene discovery in the BXD recombinant inbred genetic reference population: mouse forebrain weight. BMC Neuroscience 9: 444 (PMC2570693)

108. McLachlan SM, Aliesky H. Pichurin PN, Chen CR, Williams RW, Rapoport B (2008) Shared and unique susceptibility genes for Graves’ disease induced by thyrotropin receptor adenovirus immunization in BXH and CXB recombinant inbred mice. Endocrinology 149: 2001-2009 (PMC2276708)

109. Mozhui K, Ciobanu DC, Schikorski T, Wang X, Lu L, Williams RW (2008) Dissection of a QTL hotspot on mouse distal chromosome 1 that modulates neurobehavioral phenotypes and gene expression. PLoS Genetics 4: e1000260 (PMC2577893)

110. Mulligan MK, Ponomarev I, Boehm SL, Owen JA, Levin PS, Berman AE, Blednov YA, Crabbe JC, Williams RW, Miles MF, Bergeson SE (2008) Alcohol trait and transcriptional genomic analysis of C57BL/6J substrain. Genes, Brain & Behavior 7: 677-689

111. Pardue MT, Faulkner AE, Fernandes A, Yin H, Schaeffel F, Williams RW, Pozdeyev N, Iuvone PM (2008) High susceptibility to experimental myopia in a mouse model with a retinal on pathway defect. Investigative Ophthalmology and Visual Science 49: 706-712 (PMC2752325)

112. Peirce JL, Broman KW, Lu L, Chesler EJ, Zhou G, Airey DC, Birmingham AE, Williams RW (2008) Genome reshuffling for advanced intercross permutation (GRAIP): A permutation method for quantitative advanced intercross population analysis. PLoS One 3: e1977 (PMC2295257)

113. Reiner DJ, Jan TA, Boughter JD, Li CX, Lu L, Williams RW, Waters RS (2008) Genetic analysis of tongue size and taste papillae number and size in recombinant inbred strains of mice. Chemical Senses 33: 693-707 (PMC2565774)

114. Yang RJ, Mozhui K, Karlsson RM, Cameron HA, Williams RW, Holmes A (2008) Variation in mouse basolateral amygdala volume is associated with differences in stress reactivity and fear learning. Neuropsychopharmacology 33: 2595-2604

2009 115. Badea A, Johnson GA, Williams RW (2009) Genetic dissection of the mouse brain using high-field magnetic

resonance microscopy. Neuroimaging 45: 1067-79 (PMC2667384) 116. Boon ACM, deBeauchamp J, Hollmann A, Luke J, Kotb M, Rowe S, Finkelstein D, Neale G, Lu L, Williams

RW, Webby RJ (2009) Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice. Journal of Virology 83: 10417-10426 (PMC2753106)

117. Brigman JL, Mathur P, Lu L, Williams RW, Holmes A (2009) Genetic relationship between anxiety- and fear-related behaviors in BXD recombinant inbred mice. Behavioral Pharmacology 20: 204-209 (PMC2701299)

118. Davies MN, Lawn S, Whatley S, Fernandes C, Williams RW, Schalkwyk LC (2009) Is blood a reasonable surrogate for brain in gene expression studies? Frontiers in Neuroscience 3: 54 (PMC2858613)


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119. Gaglani SM, Lu L, Williams RW, Rosen GD (2009) The genetic control of neocortex volume and covariation with patterns of gene expression in mice. BMC Neuroscience 10: 44 (PMC2685397)

120. Geisert EE Jr, Lu L, Freeman-Anderson NE, Templeton JP, Nassr M, Wang X, Gu W, Jiao Y, Williams RW (2009) Gene expression in the mouse eye: an on-line resource for genetics using 103 strains of mice. Molecular Vision 15: 1730-1763 (PMC2736153)

121. Koutnikova H, Markku L, Lu L, Combe R, Paananen J, Kuulasmaa T, Kuusisto J, Häring H, Hansen T, Pedersen,O, Smith U, Hanefel M, Williams RW, Auwerx J (2009) Identification of UBP1 as a critical blood pressure determinant. PLoS Genetics 5: e1000591 (PMC2715105)

122. Overall RW, Kempermann G, Peirce J, Lu L, Goldowitz D, Gage FH, Goodwin S, Smit G, Airey DC, Rosen GD, Schalkwyk LC, Sutter TR, Nowakowski R, Whatley S, Williams RW (2009) Systems genetics of the hippocampal transcriptome in 99 mouse strains. Frontiers in Neuroscience 3: 55 (PMC2858614)

123. Rosen GL, Pung C, Owens C, Caplow J, Kim H, Lu L, Williams RW (2009) Genetic modulation of striatal volume in BXD recombinant inbred mice. Genes, Brain & Behavior 8: 296-308 (PMC2706028)

124. Templeton JP, Nassr M, Vazques-Chona, Freeman-Anderson NE, Orr WE, Williams RW, Geisert EE (2009) Differential response of C57BL/6J mouse and DBA/2J mouse to optic nerve crush. BMC Neuroscience 10: 90 (PMC2727955)

125. Whitney IE, Raven M, Ciobanu DC, Williams RW, Reese BE (2009) Multiple genes on chromosome 7 regulate dopaminergic amacrine cell number in the mouse retina. Investigative Ophthalmology and Visual Science 50: 1996-2003 (PMC2672967)

2010 126. Ciobanu DC, Lu L, Mozhui K, Wang X, Morris JA, Taylor WL, Dietz K, Simon P, Williams RW (2010)

Detection, validation, and downstream analysis of allelic variation in gene expression. Genetics 184: 119-128 (PMC2802080)

127. Hoffman P, Bennett B, Saba L, Bhave S, Carosone-Link P, Hornbaker C, Kechris K, Williams RW, Tabakoff B (2010) Using the Phenogen website for ‘in silico’ analysis of morphine-induced analgesia: identifying candidate genes. Addiction Biology 16: 393-404. (PMID 21054686)

128. Li, Z., Mulligan MK, Wang X, Miles MF. Lu L, Williams RW (2010) A mutation in Comt generates mRNA isoforms and causes widespread expression and behavioral differences among inbred mice. PLoS One 5: e12181

129. Lionikas A, Carlborg O, Lu L, Peirce JL, Williams RW, Yu F, Vogler GP, McClearn GE, Blizard DA (2010) Genomic analysis of variation in hindlimb musculature of mice from the C57BL/6J and DBA/2J lineage, Journal of Heredity 101: 360-367 (PMC 2855676)

130. Mozhui K, Karlsson RM, Kash TL, Ihne J, Norcross M, Patel S, Farrell MR, Hill EE, Martin KP, Camp M, Fitzgerald P, Ciobanu DC, Sprengel R, Mishina M, Wellman CL, Winder DG, Williams RW, Holmes A (2010) Genetically-driven variation in behavioral responses to stress is associated with divergent glutamate plasticity. Journal of Neuroscience 30: 5357-5367 (PMC 2866495)

131. Mulligan MK, Rogers Jr. GL. Lu L, Langston MA. Williams RW (2010) Genetic analysis of BDNF expression cliques and adult neurogenesis in the hippocampus. 2010 Annual ORNL Biomedical Science & Engineering Conference. (IEEE Catalog Number: CFP1047G-ART)

132. Peidis P Giannakouros T, Burow ME, Williams RW, Scott RE (2010) Systems genetics analyses predict a transcription role for P2P-R: molecular confirmation that P2P-R is a transcriptional co-represssor. BMC Systems Biology 4: 14 (PMC 2843647)

133. Poon A, Li Z, Wolfe GW, Lu L, Williams RW, Hayes NL, Nowakowski RS, Goldowitz D (2010) Identification of a Chr 11 quantitative trait locus that modulates proliferation in the rostral migratory stream of the adult mouse brain. European J Neuroscience 32: 523-37

134. Rapoport B, Williams RW Chen CR, McLachlan SM (2009) Evidence from recombinant inbred CXB and BXH mice that immunoglobulin heavy chain variable region genes contribution to induction of thyroid stimulating antibodies. Genes and Immunity 11: 254-263 (PMID 20407472)

135. Reinius B, Shi C, Hengshuo L, Sandhu KS, Radomska KJ, Rosen GD, Lu L, Kullander K, Williams RW, Rosen GD, Jazin E (2010) Female-biased expression of long non-coding RNAs in domains that escape X-inactivation in mouse. BMC Genomics 11: 614 (PMC 3091755)


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136. Ziebarth JD, Cook MN, Li B, Williams RW, Lu L, Cui Y (2010) Systems genetics analysis of molecular pathways underlying ethanol-induced behavioral phenotypes. 2010 Annual ORNL Biomedical Science & Engineering Conference. (IEEE Catalog Number: CFP1047G-ART DOI 10.1109/BSEC.2010.5510821)

2011 137. Alberts R, Chen H, Pommerenke C, Smit AB, Spijker S, Williams RW, Geffers R, Bruder D, Schughart K

(2011) Expression QTL mapping in regulatory and helper T cells from the BXD family of strains reveals novel cell-specific genes, gene-gene interactions and candidate genes for auto-immune disease. BMC Genomics 12: 610

138. Chen H, Liu Z, Gong S, Wu X, Taylor WL, Williams RW, Matta SG, Sharp BM (2011) Genome-wide gene expression profiling of nucleus accumbens neurons projecting to ventral pallidum using both microarray and transcriptome sequencing. Frontiers in Neuroscience 5: 98 (PMID 21886604)

139. Gatti DM, Lu L, Williams RW, Sun W, Wright FA, Threadgill DW, Rusyn I (2011) MicroRNA expression in the livers of inbred mice. Mutation Research 714: 126-133

140. Freeman NE, Templeton JP, Orr WE, Lu L, Williams RW, Geisert EE (2011) Genetic networks in the mouse retina: Growth Associated Protein 43 and Phosphate Tensin Homology network. Molecular Vision 17: 1355-1372 (PMC 3108897)

141. Furlotte N, Xu L, Williams RW, Homayouni R (2011) Literature-based evaluation of microarray normalization procedures. IEEE Bioinformatics and Biomedicine Conference 608-611 (DOI 10.1109/BIBM.2011.114)

142. Jablonski MM, Freeman NE, Orr WE, Templeton JP, Lu L, Williams RW, Geisert EE (2011) Genetic pathways regulating glutamate levels in retinal Müller cells. Neurochemical Research 36:594-603 (PMID 20882406)

143. Krebs J, Römer D, Overall RW, Fabel K. Babu H, Brandt M, Williams RW, Jessberger S, Kempermann G (2011) Adult hippocampal neurogenesis and plasticity in the infrapyramidal bundle of the mossy fiber projection: II. Genetic covariance and identification of Nos1 as a linking candidate gene. Frontiers in Neuroscience 5: 106 (PMID 21960957)

144. Laughlin RE, Grant TL, Williams RW, Jentsch JD (2011) Genetic dissection of behavioral flexibility: reversal learning in mice. Biological Psychiatry 69:1109-1116 (PMID 21392734)

145. Lu, H, Wang X, Pullen M, Guan H, Chen H, Sahu S, Zhang B, Chen H, Williams RW, Geisert EE, Lu L, Jablonski MM (2011) Genetic dissection of the Gpnmb network in the eye. Investigative Ophthalmology and Visual Science 52: 4132-4142 (PMID 21398278)

146. Lu H., Li L, Watson ER, Williams RW, Geisert EE, Jablonski MM, Lu L (2011) Complex interactions of Tyrp1 in the eye. Molecular Vision 17: 2455-2468 (PMID 21976956)

147. McLachlan SM, Lu L, Aliesky HA, Williams RW, Rapoport B (2011) Distinct genetic signatures for variability in total and free serum tyroxine levels in four sets of recombinant inbred mice. Endocrinology 152: 1172-1179 (PMID 21209025)

148. McLachlan SM, Aliesky HA, Chen CR, Williams RW; Rapoport B (2011) Exceptional hyperthyroidism and a role for both major histocompatiblity class I and class II genes in a murine model of Graves' disease. PLoS One 6: e21378 (PMC 3124500)

149. Mozhui K, Wang X, Chen J, Mulligan MK, Li Z, Ingles J, Chen X, Lu L, Williams RW (2011) Genetic regulation of Nrxn1 expression: an integrative cross-species analysis of schizophrenia candidate genes. Translational Psychiatry 1: e25

150. Poot M, Badea A, Williams RW, Kas MJ (2011) Identifying human disease genes through cross-species gene mapping of evolutionarily conserved processes. PLoS One 6: e18612 (PMC 3087714)

151. Porcu P, O’Buckley Tk, Song SC, Harenza JL, Lu L, Wang X, Williams RW, Miles MF, Morrow AL (2011) Genetic analysis of the neurosteroid deoxycorticosterone and its relation to alcohol phenotypes: identification of QTLs and downstream gene regulation. PLoS One 6: e18405 (PMC 3072994)

152. Römer B, Krebs J, Overall RW, Fabel K, Babu H, Overstreet-Wadiche L, Brandt MD, Williams RW, Jessberger S, Kempermann G (2011) Adult hippocampal neurogenesis and plasticity in the infrapyramidal bundle of the mossy fiber projection: I. Co-regulation by activity. Frontiers in Neuroscience 5:107 (PMID 21991243)

153. Whitney IE, Raven MA, Lu L, Williams RW, Reese BE (2011) A QTL on chromosome 10 modulates cone photoreceptor number in the mouse retina. Investigative Ophthalmology and Visual Science 52: 3228-3236 (PMC 3109025)


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154. Whitney IE, Raven MA, Ciobanu DC, Poché RA, Ding Q, Elshatory Y, Gan L, Williams RW, Reese BE (2011) Genetic modulation of horizontal cell number in the mouse retina. Proceedings of the National Academy of Sciences USA 108: 9697-9702 (PMID 21576457)

155. Yan L, Zhou X, Lu L, Centeno A, Kuan L, Hawrylycz M, Larimer M, Rosen GD, Williams RW (2011) Global exploratory analysis of massive neuroimaging collections using Microsoft Silverlight PivotViewer. ORNL Biomedical Science & Engineering Conference 1-4. IEEE Bioinformatics and Biomedicine Conference (DOI 10.1109/BSEC.2011.5872323)

2012 156. Alberts R, Lu L, Williams RW, Schughart K (2012) Genome-wide analysis of the mouse lung transcriptome

reveals novel molecular gene interaction networks and cell-specific expression signatures. Respiratory Research 12: 61 (PMID 21535883)

157. Andreux PA, Williams EG, Koutnikova H, Houtkooper RH, Champy MF, Schoonjans K, Williams RW, Auwerx J (2012) Systems genetics of metabolism — the use of the BXD reference panel for multiscalar integration of traits. Cell 150: 1287-1299

158. Boughter Jr JD, St. John SJ, Tokita K, Lu L, Heck D, Williams RW (2012) A QTL on chromosome 1 contributes to rhythmic oromotor movement in mice. PLoS One 7: e38169 (PMC 3364982)

159. Brunschwig H, Levi L, Ben-David E, Williams RW, Yakir B, Shifman S (2012) Fine-scale map of recombination rates and hotspots in the mouse genome. Genetics 191: 757-764

160. Cao Y, Zhang J, Jiao Y, Yan J, Jiao F, Liu XY, Williams RW, Hasty K, Stuart J, Gu W (2012) Genomic dissection and prioritizing of candidate genes of QTL for regulating spontaneous arthritis on chromosome 1 in mice deficient for interleukin-1 receptor antagonist. Journal of Genetics 91: 119-128

161. Cao Y, Jiao Y, Wang L, Huang Y, Postlethwaite A, Stuart J, Kang A, Williams RW, Gu W (2012) Anakinra as an interleukin 1 receptor antagonist, complicated genetics and molecular impacts- from the point of view of mouse genomics. Int Immunopharmacol 13: 28-36 (PMID 22425556)

162. Collaborative Cross Consortium (2012) The genome architecture of the Collaborative Cross mouse genetic reference population. Genetics 190: 389-401 (PMC 22345608)

163. Jellen LC, Unger EL, Lu L, Williams RW, Rousseau S, Wang X, Earley CJ, Allen RP, Miles MF, Jones BC (2012) Systems genetic analysis of the effects of iron deficiency in mouse brain. Neurogenetics 13: 147–157 (PMID 22457016)

164. Jiao Y, Lu L, Williams RW, Smeyne RJ (2012) Genetic dissection of strain dependent paraquat-induced neurodegeneration in the substantia nigra pars compacta. PLoS One 7: e29447 (PMID 22291891)

165. Hager R, Lu L, Rosen GD, Williams RW (2012) Genetic architecture supports mosaic brain evolution and independent brain-body size regulation. Nature Communications 3: 1079

166. McKnite AM, Perez-Munoz, PE, Lu L, Williams EG, Brewer S, Andreux P, Bastiaansen JWM, Wang X, Kachman SD, Auwerx J, Williams RW, Benson AK, Peterson DA, Ciobanu DC (2012) Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits. PLoS One 7: e39191 (PMC 3377628)

167. Miyairi I, Ziebarth J, Laxton JD, Wang X, van Rooijen N, Williams RW, Lu L, Byrne GI, Cui Y (2012) Prediction and validation of causal pathways of Chlamydia disease susceptibility. PLoS One 7: e33781 (PMID 22438999)

168. Mozhui K, Lu L, Armstrong WE, Williams RW (2012) Sex-specific modulation of gene expression networks in murine hypothalamus. Frontiers in Neuroscience 6: 63 (PMC 3350311)

169. Mulligan MK, Wang X, Adler AL, Mozhui K, Lu L, Williams RW (2012) Complex control of GABA(A) receptor subunit mRNA expression: Variation, covariation, and genetic regulation. PLoS One 7: e34586 (PMID 22506031)

170. Nedelko T, Kollmus H, Klawonn F, Spijker S, Lu L, Heszmann M, Alberts R, Williams RW, Schughart K (2012) Distinct gene loci control the host response to influenza H1N1 virus infection in a time-dependent manner. BMC Genomics 13: 411 (PMID 22905720)

171. Rosen GD, Azoulay N, Griffin E, Newbury A, Koganti L, Fujisaki N, Takahashi E, Grant E, Truong D, Fitch R, Lu L, Williams RW (2012) Bilateral subcortical heterotopia with partial callosal agenesis in a mouse mutant. Cerebral Cortex 23: 859–872 (PMID 22455839)


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172. Reinius B, Johansson MJ, Radomska KJ, Morrow EH, Pandey GK, Kanduri C, Williams RW, Jazin E (2012) Abundance of female-biased and paucity of male-biased somatically expressed genes on the X-chromosome. BMC Genomics 13: 607

173. Wang X, Mozhui K, Li Z, Mulligan MK, Ingels JF, Zhou X, Hori R, Chen H, Cook MN, Williams RW, Lu L (2012) A promoter polymorphism in the Per3 gene is associated with alcohol and stress response. Translational Psychiatry 2: e73 (PMC 3309544)

174. Wolen AR, Phillips CA, Langston MA, Vorster PJ, Bruce NA, York TP, Williams RW, Miles MF (2012) Genetic dissection of acute ethanol responsive gene networks in prefrontal cortex: Functional and mechanistic implications. PLoS One 7: e33575

175. Ziebarth J, Cook MN, Wang X, Williams RW, Lu L, Cui Y (2012) Treatment- and population-dependent activity patterns of behavioral and expression QTLs. PLoS One 7: e31805 (PMID 22359631)

2013 176. Detti L, Martin DC, Williams RW, Schlabritz-Loutsevich, Williams LJ, Uhlmann RA N (2013) Somatic and

reproductive outcomes in mice treated with cyclophosphamide in pre-pubertal age. Systems Biology in Reproductive Medicine 59: 140-145

177. Hamidi S, Aliesky HA, Williams RW, Rapoport B, McLachlan SM (2013) Genetic linkages of thyroxine released in response to thyrotropin stimulation in three sets of recombinant inbred mice provide evidence for shared and novel genes controlling thyroid function. Thryoid 23: 360–370

178. Houtkooper RH, Mouchiroud L, Ryu D, Moullan N, Katsyuba E, Knott G, Williams RW, Auwerx J (2013) Mitonuclear protein imbalance as a conserved longevity mechanism. Nature 497: 451-457

179. Huang Y, Wang L, Bennett B, Williams RW, Wang YJ, Gu WK, Jiao Y (2013) Potential role of Atp5g3 in epigenetic regulation of alcohol preference or obesity from a mouse genomic perspective. Genet Mol Res 12: 3662-3674

180. Jiao Y, Chen H, Yan J, Wang L, Huang Y, Liu X, Williams RW, Lu L, Wang Y, Gu W (2013) Genome-wide gene expression profiles in antioxidant pathways and their potential sex differences and connection to vitamin C in mice. International Journal of Molecular Science 14: 10042-10062

181. Jellen LC, Wang X, Williams RW, Lu L, Jones BC (2013) Iron deficiency alters expression of dopamine-related genes in the ventral midbrain in mice. Neuroscience 252: 13-23.

182. Jones BC, Miller DB, O'Callaghan JP, Lu L, Unger EL, Alam G, Williams RW (2013) Systems analysis of genetic variation in MPTP neurotoxicity in mice. Neurotoxicology 37: 26-34

183. Liebe R, Hall R, Williams RW, Dooley S, Lammert F (2013) Systems genetics of hepatocellular damage in vivo and in vitro: Identification of a critical network on chromosome 11 in mouse. Physiological Genomics 45: 931-939

184. Munguba GC, Geisert EE, Williams RW, Tapia ML, Lam D, Bhattacharya SK, Lee RK (2013) Effects of glaucoma on Chrna6 expression in the retina. Current Eye Research 38: 150-157

185. Skobowiat C, Nejati R, Lu L, Williams RW, Slominski AT (2013) Genetic variation of the cutaneous HPA axis: an analysis of UVB-induced differential responses. Gene 530: 1-7

186. Swaminathan S, Lu H, Williams RW, Lu L, Jablonski, M (2013) Genetic modulation of the iris transillumination defect: A systems genetics analysis using the expanded family of BXD glaucoma strains. Pigment Cell & Melanoma Research 38: 150-157

187. Templeton J, Freeman-Andersen N, Nickerson J, Jablonski M, Williams RW, Geisert EE (2013) Innate immune network in the retina activated by optic nerve crush. Investigative Ophthalmology and Visual Science 54: 2599-2606

188. Uhlmann RA, Ogwo C, Williams RW, Osborne SE, Williams LJ, Detti L (2013) Somatic and reproductive development in pre-pubertal mice treated with cyclophosphamide and subsequent estrogen replacement. Syst Biol Reprod Med 59: 337-341

189. Wang, R, Li JJ, Diao S, Kwak YD, Liu L, Shi L, Bueler H, Bhat NR, Williams RW, Park EA, Liao FF, (2013) Metabolic stress modulates Alzheimer's beta-secretase gene transcription via SIRT1-PPARgamma-PGC-1 in neurons. Cell Metabolism 17: 685-694

2014 190. Ashbrook DG, Williams RW, Lu L, Stein JL, Hibar DP, Nichols TE, Medland SE, Tompson PM, Hager R

(2014) Joint genetic analysis of hippocampal size in mouse and human identifies novel genes linked to neurodegenerative disease. BMC Genomics 15: 850


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191. Boon ACM, Williams RW, Sinasac DS, Webby RJ (2014) A novel genetic locus linked to pro-inflammatory cytokines after virulent H5N1 virus infection in mice. BMC Genomics 15: 1017

192. Emery FD, Parvathareddy J, Pandey AK, Cui Y, Williams RW, Miller MA (2014) Genetic control of weight loss during pneumonic Burkholderia pseudomallei infection. Pathogens and Disease 71: 247-62

193. Graybeal C., Bachu M, Mozhui K, Saksida LM, Bussey TJ, Sagalyn E, Williams RW, Holmes A (2014) Strains and stressors: An analysis of touchscreen learning in genetically diverse mouse strains. PLoS One 9: e87745

194. Hall RA, Liebe R, Hochrath K, Kazakov A, Alberts R, Laufs U, Böhm M, Fischer HP, Williams RW, Schughart K, Weber SN, Lammert F (2014) Systems genetics of liver fibrosis: identification of fibrogenic and expression quantitative trait loci in the BXD murine reference population. PLoS One 9: e89279

195. Jones BC, O'Callaghan JP, Lu L, Williams RW, Alam G, Miller DB (2014) Genetic correlational analysis reveals no association between MPP+ and the severity of striatal dopaminergic damage following MPTP treatment in BXD mouse strains. Neurotoxicol Teratology S0892-0362(14)00159-7

196. Keeley PW, Whitney IE, Madsen NR, St. John A, Williams RW, Reese BE (2014) Independent genomic control of neurons number across retinal cell types. Developmental Cell 30: 103-109

197. Keeley PW, Zhou C, Lu L, Williams RW, Melmed S, Reese BE (2014) Pituitary Tumor-Transforming Gene 1 regulates the patterning of retinal mosaics. Proceedings of the National Academy of Science USA 111: 9295-300

198. Lotan A, Fenckova M, Bralten J, Alttoa A, Dixson L, Williams RW, van der Voet M (2014) Neuroinformatic analyses of common and distinct genetic components associate with major neuropsychiatric disorders. Frontiers in Neuroscience 8: 331

199. McLachlan SM, Hamidi S, Aliesky H, Williams RW, Rapoport B (2014) Sex, genetics and the control of thyroxine and thyrotropin in mice. Thyroid 24: 1080-1087

200. McLachlan SM, Aliesky H, Banuelos B, Magana J, Williams RW, Rapaport B (2014) Immunoglobulin heavy chain variable region and major istocompatibility region genes are linked to induced Graves’ disease in two large families of recombinant inbred mice. Endocrinology 155: 4094–4103

201. Pandey A. Lu L, Wang, X, Homayouni R, Williams RW (2014) Functionally enigmatic genes: A case study of the brain ignorome. PLoS One 9: e88889

202. Shin DL, Pandey AK, Ziebartth JD, Williams RW, Geffers R, Hatesuer B, Schughart K, Wilk E (2015) A spontaneous KLRD1 (CD94) mutation in the DBA/2J mouse strain. G3: Genes, Genomes, Genetics 5: 235–239

203. Thompson RL, Williams RW, Kotb M, Sawtell NM (2014) A forward phenotypically driven unbiased genetic analysis of host genes that moderate herpes simplex virus virulence and stromal keratitis in mice. PLoS One 9: e92342

204. Toth L, Trammell R, Williams RW (2014) Mapping complex traits using families of recombinant inbred strains: an overview and example of mapping susceptibility to Candida albicans induced illness phenotypes. Pathogens and Disease 71: 232-446

205. Wang L, Lu W, Zhang L, Huang Y, Scheib R, Liu X, Myers L, Lu L, Farber CR, Liu G, Wang CY, Deng H, Williams RW, Wang Y, Gu W, Jiao Y (2014) Trps1 differentially modulates the bone mineral density between male and female mice and its polymorphism associates with BMD differently between women and men. PLoS One 9: e84485

206. Wang L, Jiao Y, Huang Y, Bennett B, Williams RW, Li D, Zhao H. Gelernter J, Kranzler HR, Farrer LA, Gu W. Ttn as a likely causal gene for QTL of alcohol preference on mouse chromosome 2. BMC Bioinformatics 15 (Suppl 10): P12

207. Ye R, Carneiro AM, Airey D, Sanders-Bush E, Williams RW, Lu L, Wang J, Zhang B, Blakely RD (2014) Evaluation of heritable determinants of blood and brain serotonin homeostasis using recombinant inbred mice. Genes Brain & Behavior 13: 247-260

208. Ye R, Carneiro A, Giao H, Airey DC, Zhang B, Lu L, Williams RW, Blakely RD (2014) Quantitative trait loci mapping and gene network analysis implicate protocadherin-15 as a determinant of brain serotonin transporter expression. Genes, Brain & Behavior 13: 247–260

2015 209. Ashbrook DG, Williams RW, Lu L, Hager R (2015) A cross-species genetic analysis identifies gene for

mouse anxiety and human bipolar disorder. Frontiers in Behavioral Neuroscience 9:171


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210. Chintalapudi SR, Morales-Tirado VM, Williams RW, Jablonski MM (2015) Multipronged approach to identify and validate a novel upstream regulator of Sncg in mouse retinal ganglion cells. In submission

211. Cook M, Baker J, Heldt S, Williams RW, Hamre K, Lu L (2015) Identification of candidate genes that underlie the QTL on chromosome 1 that mediates genetics differences in stress-ethanol interactions. Physiological Genomics 47:308-317

212. Swaminathan S. Lu H. Lu L, Williams RW, Jablonski MM (2015) Iris transillumination defect and it gene modulators do not directly influence intraocular pressure in the BXD family of mice, in submission

213. Hibar DP, Stein JL,...Rosen GD, Lu L, Hager R, Williams RW,... Thompson PM, Medland SE (2015) Common genetic variants influence human subcortical brain structure. Nature 520:224-229

214. Padula AE, Griffin III, WT, Lopez MF, Nimitvilai S, McGuier NS, Chesler EJ, Miles FN Williams RW, Randall P, Woodward J, Becker HC, Mulholland PJ (2015) KCNN genes that encode small-conductance Ca2+-activated K+ channels influence alcohol and drug addiction. Neuropsychopharmacology in press

215. Zhao W, Zhao T, Chen Y, Zhao F, Gu Q, Williams RW, Bhattacharya SK, Lu L, Sun Y (2015) A murine hypertrophic cardiomyopathy model: The DBA/2J strain. PLoS One 10:e0133132

216. Wang X, Pandey AK, Mulligan MK, Williams EG, Mozhui K, Li Z, Jovaisaite V, Quarles LD, Xiao Z, Huang J, Capra JA, Chen Z, Taylor WL, Bastarache L, Niu X, Pollard KS, Ciobanu DC, Reznik AO, Tishkov AV, Zhulin IB, Peng J, Nelson SF, Denny JC, Auwerx J, Lu L, Williams RW (2016) Joint mouse-human phenome-wide association to test gene function and disease risk. Nature Communications in press

Legend: Illustration of the embryonic mammalian visual system in the style of da Vinci (by RWW 1985)

REVIEWS, LETTERS, BOOK CHAPTERS

1. Chalupa LM, Williams RW (1984) Prenatal development and reorganization in the visual system of the cat. In Development of Visual Pathways in Mammals. Stone J, Dreher B, Rapaport DH (eds): Alan R Liss Inc, New York, pp 89–102. Full text <nervenet.org/papers/CatRev84.html>


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2. Chalupa LM, Williams RW (1985) Formation of retinal projections in the cat. In Advances in Neuronal and Behavioral Development. Vol 1. Aslin RN (ed): Ablex Publishing, Norwood, New Jersey, pp 1–32

3. Williams RW, Herrup K (1988) The control of neuron number. Annual Review of Neuroscience 11:423–453 <nervenet.org/papers/NUMBER_REV_1988.html>.

4. Williams RW. Goldowitz D (1992) Lineage versus environment in embryonic retina: A revisionist perspective. Trends in Neuroscience 15: 368–373

5. Williams RW, Goldowitz D (1993) Lineage versus environment in embryonic retina: Letters to the editor. Trends in Neuroscience 16: 96–98 <nervenet.org/papers/TINS_1992.html>

6. Williams RW (1990) The primary visual system does not care about Previc’s near-far dichotomy. Why not? Behavioral and Brain Sciences 13: 557

7. Williams RW (1992) A very rare congenital eye movement disorder in Belgian sheepdogs. National Belgian Newsletter 44: 75

8. Williams RW, Strom RC, Zhou G, Yan Z (1998) Genetic dissection of retinal development. Seminars in Cell and Developmental Biology 9: 249–255 <nervenet.org/papers/retinarev98.html>

9. Williams RW (1998) Neuroscience meets quantitative genetics: Using morphometric data to map genes that modulate CNS architecture. Short Course in Quantitative Neuroanatomy (Morrison J, and Hof P, eds) pp 66-78 <nervenet.org/papers/ShortCourse98.html>

10. Toth LA, Williams RW (1998). Genetic analysis of complex quantitative traits using inbred mice. Sleep Research Society Bulletin 4: 50–56

11. Williams RW (2000). Mapping genes that modulate mouse brain development: a quantitative genetic approach. In Mouse Brain Development. Goffinet AF, Rakic P (eds). Springer, New York, pp 21–49 <nervenet.org/papers/brainrev99.html>

12. Belknap JK, Crabbe JC, Phillips TJ, Hitzemann R, Buck KJ, Williams RW (2001) Quantitative trait loci and genome-wide mutagenesis: two phenotype-driven approaches to the dissection of complex murine traits. Behavior Genetics 31: 5–15

13. Mountz JD, van Zant G, Zhang H, Grizzle WE, Ahmed R, Williams RW, Hsu HC (2001) Genetic dissection of age-related changes in immune function in mice. Scandinavian Journal of Immunology 54: 10–20

14. Airey DC, Williams RW. (2002) Quantitative genetic perspectives. Commentary to Finlay BL, Darlington RB, and Nicastro N (2002) Developmental structure in brain evolution. Behavioral and Brain Sciences 24: 279–280

15. Hunter K, Williams RW (2002) Quantitative trait locus analysis in cancer research. ILAR J 43:80–88 16. Threadgill DW, Hunter K, Williams RW (2002) Genetic dissection of complex and quantitative traits: from

fantasy to reality via a community effort. Mammalian Genome 13: 175–178 17. Williams RW, Dubnau J, Enoch MA, Flaherty L, Sluyter F, Gannon KS, Maxson SC, Riedl CAL, Williams KD,

Holmes A, Bolivar VJ, Crusio WE (2002) Hot topics in behavioral and neural genetics. Gene, Brain and Behavior 1: 1–10

18. Williams RW, Glueck SB (2002) New views of gene expression in the brain: Focus on “Gene expression tomography.” Physiological Genomics 8: 79

19. Williams RW (2002) Everyday bioinformatics: map, microarrays and beyond. Bioinformatics 2002, A Society for Neuroscience Short Course (Williams RW, Goldowitz D, eds), Society for Neuroscience, pp 1–10

20. Dell’Osso LF, Williams RW, Jacobs JB, Hertle RW, FitzGibbon EJ, Thompson MA, Yang D (2002) Novel surgery for nystagmus: initial trial results. Research to Prevent Blindness 16: 56–57

21. Williams RW, Flaherty L, Threadgill DW (2003) The math of making mutant mice. Genes, Brain and Behavior 2: 191–200

22. Williams RW, Moody SA (2003) Developmental and genetic control of cell number in the retina. In The Visual Neurosciences. Chalupa LM , Werner JS (eds). MIT Press, Cambridge MA, pp 65–78

23. Williams RW, Broman KW, Cheverud JM, Churchill GA, Hitzemann RW, Hunter K, Mountz JD, Pomp P, Reeves RH, Schalkwyk LC, Threadgill DW (2002) A collaborative cross for high-precision complex trait analysis. 1st Workshop Report of the Complex Trait Consortium: Sept 2002. http://www.complextrait.org/Workshop1.pdf

24. von Bartheld CS, Williams RW (2003) Measurement of differential shrinkage or compression in the z-axis of tissue sections. Current Protocols in Neuroscience Unit 11.11–1.11.29 Suppl 24


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25. von Bartheld CS, Williams RW (2003) Calibration of counting methods by a limited and simple 3-D reconstruction of serial sections. Current Protocols in Neuroscience Unit 11.11–1.11.29 Suppl 24

26. Williams RW, von Bartheld CS, Rosen GD (2003) Counting cells in sectioned material—3D counting, the optical disector, and Abercrombie’s two-section comparison method. Current Protocols in Neuroscience Unit 1.11.1–1.11.29 Suppl 24

27. Rosen GD, Williams RW (2003) Celloidin embedding and cresyl violet staining. Current Protocols in Neuroscience Unit 11.11–1.11.29 Suppl 24

28. Rosen GD, Williams RW (2003) Estimation of regional volume from serial sections using point counting and Cavalieri’s rule. Current Protocols in Neuroscience Unit 1.11

29. Williams RW, Rosen GD (2003) Providing researchers access to tissue banks. American Laboratory 35: 42

30. Gardner D, Toga AW, Ascoli GA, Beatty J, Brinkley AF, Dale AM, Fox PT, Gardner EP, George JS, Goddard N, Harris KM, Herskovits EH, Hines M, Jacobs GA, Jacobs RE, Jones EG, Kennedy DN, Kimberg DY, Mazziotta JC, Miller P, Mori S, Mountain DC, Reiss AL, Rosen GD, Rottenberg DA, Shepherd GM, Smalheiser NR, Smith KP, Strachan T, Van Essen DC, Williams RW, Wong STC (2003) Toward effective and rewarding data sharing. Neuroinformatics 1: 288–295

31. Schaeffel F, Simon P, Feldkaemper M, Ohngemach S, Williams RW (2003) Molecular biology of myopia. Clinical and Experimental Optometry 86: 295–307

32. The Complex Trait Consortium: Flaherty L, Abiola O, Angel JM, Avner P, Bachmanov AA, Belknap JK, Bennett BB, Blankenhorn EP, Blizard DA., Bolivar V, Brockmann GA, Buck KJ, Bureau J-F, Casley, WL, Chesler EJ, Cheverud JM, Churchill GA, Cook M, Crabbe JC, Crusio WE, Darvasi A, de Haan G, Demant P, Doerge RW, Elliott RW, Farber CR, Flint J, Gershenfeld H, Gibson JP, Gu W, Himmelbauer H, Hitzemann R, Hsu H-C, Hunter K, Iraqi F, Jansen RC, Johnson TE, Jones BC, Kempermann G, Lammert F, Lu L, Manly KF, Matthews DB, Medrano JF, Mehrabian M, Mittleman G, Mock BA, Mogil JS, Montagutelli, X, Morahan G, Mountz JD, Nagase H, Nowakowski RS, O'Hara BF, Osadchuk AV, Paigen B, Palmer AA, Peirce JL., Pomp D, Rosemann M, Rosen GD, Schalkwyk LC, Seltzer Z, Settle S, Shimomura K, Shou S, Sikela JM, Siracusa LD, Spearow JL, Teuscher C, Threadgill DW, Toth LA, Toye AA., Vadasz C, Van Zant G, Wakeland E, Williams RW, Zhang H-G, Zou F (2003) The nature and identification of quantitative trait loci: a community’s view. Nature Genetics Reviews 4: 911–916 (PMC2063446)

33. Nissanov J, Williams RW (2003) Mouse neuroinformatic public resources. An invitation to end-users. Neuroinformatics 1: 297–298

34. Williams RW (2003) A neuroscientist’s guide to genomic resources. In: The Bioinformatics of Brains: From genes and proteins to behavior (Williams RW, ed) Society for Neuroscience, Washington, DC, pp 1–8.

35. Williams RW (2003) WebQTL: a tour of transcriptional networks. In: The Bioinformatics of Brains: From genes and proteins to behavior (Williams RW, ed) Society for Neuroscience, Washington, DC, pp 51–59

36. Williams RW (2003) Managing your lab data flux: getting beyond Excel. In: The Bioinformatics of Brains: From genes and proteins to behavior (Williams RW, ed) Society for Neuroscience, Washington, DC, pp 83–92

37. Zareparsi S, Hero A, Zack DJ, Williams RW, Swaroop A (2004) Seeing the unseen: microarray-based gene expression profiling in vision. Investigative Ophthalmology and Vision Science 45: 2457–2462

38. Chesler EJ, Lu L, Wang J, Williams RW, Manly KF (2004) WebQTL: Rapid exploratory analysis of gene expression and genetic networks for brain and behavior. Nature Neuroscience 7: 485–486

39. Chesler EJ, Williams RW (2004) Brain gene expression: genomics and genetics. In: DNA Arrays in Neurobiology (ed. Miles M) Academic Press, International Review of Neurobiology 60: 59–95

40. The Complex Trait Consortium: Churchill GA, ... Williams RW and many coauthors (2004) The Collaborative Cross: a community resource for the genetic analysis of complex traits. Nature Genetics 36: 1-5

41. de Haan G, Williams RW (2005) A genetic and genomic approach to identify longevity genes in mice. Mechanisms of Aging and Development 126: 133–138

42. Johnson DK, Rinchik EM, Moustaid-Moussa N, Miller DR, Williams RW, Michaud EJ, Jablonski MM, Goldowitz D (2005) Phenotype screening for genetically-determined age-onset disorders and increased longevity in ENU-mutagenized mice. AGE 27: 75–90


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43. Matthews DB, Bhave SV, Belknap JK, Brittinham C, Chesler EJ, Hitzemann RJ, Hoffmann PL, Lu L, McWeeney S, Miles MF, Tabakoff B, Williams RW (2005) Complex genetics of interactions of alcohol and CNS function and behavior. Alcoholism: Clinical and Experimental Research 29: 1706–1719

44. Williams RW (2006) Genomics and dyslexia: Bridging the gap (2006) In: The Dyslexic Brain: New Pathways in Neuroscience Discovery, Rosen GD, ed. Lawrence Erlbaum Associates, pp. 167–190

45. Williams RW (2006) Animal models in biomedical research: ethics, challenges, and opportunities. In: Principles of molecular medicine, 2nd ed. Runge MS, Patterson C eds, Chapter 8, Humana Press, Totowa, New Jersey, pp. 53–60

46. Williams RW (2006) Expression genetics and the phenotype revolution. Mammalian Genome 17: 496–502 47. Peirce JL, Williams RW (2006) Expression and brain structure: black boxes between genes and behaviors.

Neurobehavioral Genetics: Methods and Applications, 2nd ed (Jones B, Mormede P, eds). Taylor and Francis, Boca Raton

48. Chesler EJ, Bystrykh L, Cooke M, de Haan G, Manly KF, Williams RW (2006) Normalization procedures and detection of linkage signal in genetical-genomics experiments. Reply to RBH Williams et al., Nature Genetics 38: 856–858

49. Miles M, Williams RW (2007) Meta-analysis for microarray studies of the genetics of complex traits. Trends in Biotechnology 25: 45–47

50. Shifman S, Tzenova Bell J, Copley RR, Taylor MS, Mott R, Flint J, Williams RW (2007) Evidence of a large-scale functional organization of mammalian chromosomes; Authors’ reply. PLoS Biol 5: e128

51. Hsu HC, Lu L, Yi N, Van Zant G, Williams RW, Mountz JD (2007) Quantitative trait locus (QTL) mapping in aging systems. In: Methods in Molecular Biology (Biological Aging: Methods and Protocols), Tollefsbol TO (ed), Chapter 23, Humana Press, Totowa, New Jersey, Vol 371: 321–348

52. Morahan G. Williams RW (2007) Systems genetics: the next generation in genetics research? Novartis Foundation Symp 281: 181–188

53. Rosen GD, Chesler EJ, Manly KF, Williams RW (2007) An informatics approach to systems neurogenetics. Neuroinformatics. Crasto CJ (ed), Humana Press, New York. Methods in Molecular Biology 401: 287-303

54. Boline J, Hawrylycz M, Williams RW (2007) 1st INCF workshop on mouse and rat digital atlasing systems. http://precedings.nature.com/documents/1046/version/1 http://www.incf.org/med/incf_report_digitalatlasing_070915.pdf%20

55. Chalupa LM, Williams RW (2008) Eye, Retina, and Visual System of the Mouse (2008) MIT Press. 754 pp

56. Geisert EE, Williams RW (2008) The mouse eye transcriptome: cellular signatures, molecular networks, and candidate genes for human disease. In Eye, Retina, and Visual System of the Mouse, Chalupa LM, Williams RW (eds), MIT Press, pp. 659–674.

57. Kotb M, Fathey N, Aziz R, Rowe S, Williams RW, Lu L (2008) Unbiased forward genetics and systems biology approaches to understanding how gene-environment interactions work to predict susceptibility and outcomes of infections. Novartis Found Symp 293: 156-65; discussion165-7, 181-3 (PMID: 18972751)

58. Morahan G, Peeva V, Munish M, Williams R (2008) Systems genetics can provide new insights in to immune regulation and autoimmunity. Journal of Autoimmunity 31: 233-236

59. Williams RW, Lu L (2008) Integrative genetic analysis of alcohol dependence using the GeneNetwork web resources. In Pathways to Alcohol Dependence: Alcohol Research & Health 31: 275-277

60. Beiter T, Reich E, Williams RW, Simon P (2009) Antisense transcription: a critical look in both directions. Cellular and Molecular Life Sciences 66: 94-112

61. Badea A, Johnson GA, Williams RW (2009) Genetic dissection of the mouse CNS using magnetic resonance microscopy. Current Opinion in Neurology 22: 379–386 (PMC2734144)

62. Williams RW (2009) Herding cats: the sociology of data integration. Frontiers in Neuroscience 3: 151-154 (PMC2751652)

63. Williams RW (2010) Headlong into a genomics singularity. Frontiers in Neuroscience 4: 25 (PMC2858621)

64. Wang X, Agarwala R, Capra JA, Chen Z, Church DM, Ciobanu DC, Li ZS, Lu L, Mozhui K, Mulligan MK, Nelson SF, Pollard KS, Taylor WL, Thomason DB, Williams RW (2010) High-throughput sequencing of the DBA/2J mouse genome. BMC Bioinformatics 11 (Suppl 4): O7

65. Houtkooper RH, Williams RW, Auwerx J (2010) Metabolic networks of longevity. Cell 142: 9-14


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66. Williams RW (2012) Genetic and genomic web resources for research on alcohol use and abuse. Alcohol Research, Current Reviews 34: 378–380

67. Williams RW, Norohna A (2012) A watershed year for an update on the genetics of alcoholism. Alcohol Research, Current Reviews 34: 263

68. Williams RW, Mulligan MK (2012) Genetic and molecular network analysis of behavior. International Review of Neurobiology: Bioinformatics of Behavior 104:135-157

69. Williams RW (2013) Recombinant inbred strain. In Brenner’s Encyclopedia of Genetics 2nd ed. Maloy S. Hughes K (eds), Academic Press, San Diego, 6: 82–86

70. Jones BC, Lu L, Williams RW, Unger EL, Yin L (2013) Response to Breckenridge et al. (2013) Neurotoxicology 38: 23-4

71. Mozhui K, Williams RW (2012) Multidimensional databases of model organisms. In The OMICs: Applications in Neuroscience, G Coppola, ed., Oxford University Press, New York, pp. 333–344

72. Jones BC, Huang X, Mailman RB, Lu L, Williams RW (2014) The perplexing paradox of Paraquat: The case for host-based susceptibility and postulated neurodegenerative effects. Journal of Biochemistry and Molecular Toxicology 28: 191-197

73. Pandey A, Williams RW (2014) Genetics of gene expression in the CNS. International Review of Neurobiology 116: 195-231

74. Akay M, Fotiadis DI, Nikita KS, Williams RW (2015) Biomedical informatics in clinical environments. IEEE Journal of Biomedical and Health Informatics 19:149-150

75. Mulligan MK, Williams RW (2015) Systems genetics of behavior: A prelude. Current Opinions in Behavioral Sciences in press

76. Heimel JA, Overall RW, Williams RW (2014) Workshop report: INCF short course on neuroinformatics, neurogenomics and brain disease, 14-21 September 2013. Frontiers in Neuroscience 8: 499

77. Akay M, Fotiadis DI, Nikita KS, Williams RW (2015) Guest editorial: Biomedical informatics in clinical environments. IEEE J Biomed Health Inform 19: 149-150

78. Mulligan MK, Williams RW (2015) Systems genetics of behavior: a prelude. Current Opinion in Behavioral Sciences 2:108–115

79. Overall RW, Williams RW, Heimel JA (2015) Collaborative mining of public data resources in neuroinformatics. Frontiers in Neuroscience 9: 90

RESEARCH WEB SITES 1. www.genenetwork.org, GeneNetwork (GN) and WebQTL were created by Manly KF, JT Wang, and RW

Williams in 2001, initially as part of a Human Brain Project. GN and a number of specialized code modules (GenomeGraph, SNP Browser, QTL Reaper) are being developed by RW Williams and colleagues (2001-present). GeneNetwork is a major genomics resource site that receives ~12,000 hits per day and ~ 1200 hosts per week (see http://www.genenetwork.org/webqtllog/). GN has reciprocal links with UCSC’s Genome Browser, NCBI, The Allen Brain Atlas, NEIBank, and The BIRN MBAT project. A full mirror site of GN is maintained at the Helmholtz Zentrum für Infektionsforschung in Germany (http://genesys.helmholtz-hzi.de/search.html). Approximately 1000 publications referenced GeneNetwork and WebQTL. Please search https://scholar.google.com/ for "genenetwork.org" OR "webqtl" to get more up-to-date numbers.

2. www.nervenet.org. Nervenet was initiated by RW Williams, January 1994. It is one of the oldest neuroscience web sites and now serves as the Williams lab portal. It predecessor, mickey.utmem.edu originally housed the Portable Dictionary of the Mouse Genome. The earliest “http” reference in a PubMed abstract is associated with this portal: see http://www.ncbi.nlm.nih.gov/pubmed/8043953

3. www.mbl.org and pivotcollections.org : The Mouse Brain Library was initiated by Williams RW, Rosen GD, Williams, A.G., May 1997. The Mouse Brain Library and the Internet Atlas of the Mouse Brain have been in continuous operation since May 1997. This is a growing and well-used Internet database with histological image data for over 2000 mouse brains imaged at low, intermediate, and high resolution. It includes several stereotaxic atlases of the brains of mice. The MBL was included in ISI Current Web Contents (CC Connect TM) starting in Jan 2001. The site was reviewed by Kaiser J (2000) in Science. Mouse Brain Library: Netwatch Images selection. Science 289:211.


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4. www.complextrait.org. The main web site for the Complex Trait Consortium. Founded in 2002 by RW Williams and colleagues. The site is housed in the Williams lab.

5. www.ibangs.org (hosted 2002-2010). The main web site for the International Behavioural and Neural Genetics Society. This site was initiated by Dr. Wim Crucio. It was rebuilt most recently by Arthur Centeno and RW Williams.

6. <iscope.nervenet.org> Initiated by Williams RW, Cruz B, Connolly M; Capra JA (1999) iScope. A software suite for telemicroscopy. <www.mbl.org > Aug 1999–2005. As of 2006, this project and web site has been retired.

7. http://pivotcollections.org. Initiated by Lei Yan, G Rosen, R Williams and colleagues in 2011 as an upgraded and radically revised version of the Mouse Brain Library. While this is a fully funcational site, it is still a pilot project in the sense that the database system only includes a subset of several hundred cases from the MBL.

NEWS AND COVERAGE New York Times. Blakeslee S (1993) Evolution of tabby cat mapped in brain study. Tuesday January 12,

Section B5. Il Corriere Della Sera (Milan newspaper). Simion L (1993) Al micio si e rimpicciolito il cervello. Jan 31 issue. Discover Magazine. Oliwenstein L (1993, May issue) Brain Donors. Discover 14:18. Nature. Guillery RW (1994) No crossing at the crossing. A New and Views article. Nature 367:597–598 (This

review considers a paper by Williams et al. 1994.) Human Genome News. Mansfield BK (1994) Mouse gene data files available from UT Memphis. Human

Genome News, May 1994. Science. Takahashi JS (1994) Forward and reserve genetic approaches to behavior in the mouse. Science 264:

1724–1733. (This review contains a brief description of the Portable Dictionary of the Mouse Genome.) Science. Kaiser J (2000) Mouse Brain Library: Netwatch Images selection. Science 289: 211 Commercial Appeal (Memphis newspaper). July 9, 2001. Front page photo of Abigail Haynes working in R.

Williams laboratory (by Lance Murphey). Memphis Business Journal. Jan 15–21, 2002. Vol. 24 No. X. RW cited in article on Genome Explorations. Commercial Appeal. May 15, 2002: World’s scientists sniff trail of complex traits. RW cited in article as organizer.

Page A11. Apple Computer, Inc. Providing Broad Access to Tissue Banks: on the Science & Technology site at

http://www.apple.com/scitech/appletech/dv/utic/ (posted 2002) AAAS News Release. Feb 17, 2003 by Monica Amarelo. iScope, you scope, we all scope a mouse brain DataDescription Inc. Which gene influences what? Data Desk aids in gene mapping: DataDescription Inc., by

Holly M. Bailey, July 2003, http://www.datadesk.com/company/profiles/williams.shtml Bio IT World. June 15, 2003 issue. Building a better mouse database. http://www.bio-

itworld.com/archive/061503/mouse_sidebar_2646.html and see http://www.bio-itworld.com/archive/061503/mouse.html

Vogel G (2003) Geneticists Dream of 1001 Complex Mice. Science 301:456–457 Bio-IT World (2004) Mouse Brains — FileMaker & Excel by Mike Nelson Memphis Business Journal. Aug 12–18, 2005, by Scott Shepard. Mouse engineer: Williams leads project to

revolutionize genomics research BIRNing Issues: Biomedical Informatics Research Network: August 2005. “Williams helps integrate diverse

mouse data.” www.nbirn.net/Publications/Newsletter/ pp 5-6 Memphis Business Journal. July 7–13, 2006, pp. 9–10 by Scott Shepard. Focus on Biotech. Biotech debate:

Share or covet knowledge. pp. 9-10. This article includes an interview with RWW. “The key concept is to recognize the areas of science and areas of industry that we all regard as pre-competitive.”

Time Magazine (Jan 2007) “What the Mouse Brain Tells Us,” by Alice Park. Jan 29, 2007, p. 93. Neuroscience Gateway (Feb 2007) Pump up the volume. Genes associated with basolateral amygdala

morphology are involved in neuronal development. Feb doi:10.1038/aba1717 http://www.neuroscience-gateway.org/2007/070215/full/aba1717.shtml [An article about a paper by Mozhui, Hamre, Holmes, Lu, and Williams on loci modulating volume of the amygdala.]


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Snow, D (April 2008) The Million Dollar Mouse: a statewide consortium provides a model of collaboration and research. Business TN, www.businesstn.com/pub/5_4/features/8506-1.html

Memphis Business Journal, April 24, 2012: University of Tennessee research awarded $2.1 M NIH grant, http://www.bizjournals.com/memphis/news/2012/04/25/ut-researcher-awarded-21m-nih-grant.html?ana=e_du_pub&s=article_du&ed=2012-04-25

Marketplace Tech (Jan 29, 2013) National Public Radio with David Brancaccio on the Human Brain Project: http://www.marketplace.org/topics/tech/human-brain-project-and-recruiting-more-cyberwarriors and the audio is here http://download.publicradio.org/podcast/marketplace/tech_report/2013/01/29/marketplace_tech_report20130129_64.mp3?_kip_ipx=583527999-1359652979

Future Tense radio program, Australian Broadcasting Corporation on the Human Brain Project (RWW interviewed Feb 6, 2013 by Anthony Funnell, http://www.abc.net.au/radionational/programs/futuretense/

Wolff S, Dillin A (2013) Beneficial miscommunication. Nature 497:442. A commentary on our article in Nature on longevity that exploited BXD strain data and validation studies with C. elegans

Richards, Sabina (2013) Inhibit mitochondria to liver longer? The Scientist: http://www.the-scientist.com/?articles.view/articleNo/35673/title/Inhibit-Mitochondria-to-Live-Longer-/

UTHSC forms new Department of Genetics, Genomics an Informatics in High Ground http://www.highgroundnews.com/innovationnews/UTHSCFormsNewGGIDepartment071614.aspx

Sheffield M (2015) UTHSC researchers part of worldwide brain study. Memphis Business Journal. http://www.bizjournals.com/memphis/news/2015/03/02/uthsc-researchers-part-of-worldwide-brain-study.html

WREG television appearance, April 23, 2015, https://youtu.be/m094-‐5lSA70


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Synopsis. Robert (Rob) W. Williams received a BA in neuroscience from UC Santa Cruz (1975) and a Ph.D. in physiology at UC Davis with Leo M Chalupa (1983). He did postdoctoral work in developmental neurobiology at Yale with Pasko Rakic and moved to the University of Tennessee in 1989. He is chair of the Department of of Genetics, Genomics and Informatics at UTHSC. Williams holds the UT Oak Ridge National Laboratory Governor’s Chair in Computational Genomics. He was a past president of the International Society for Behavioural and Neural Genetics and founding director of the Complex Trait Community (www.complextrait.org). He is editor-in-chief of Frontiers in Neurogenomics, and serves on the editorial boards of Genes, Brain & Behavior, Neuroinformatics, Mammalian Genome, Molecular Vision, European Journal of Anatomy, Alcohol, BiomedCentral Neuroscience, the Journal of Biomedical Discovery and Collaboration, and Behavior Genetics. One of Williams’ more notable contributions is in the field of systems genetics and expression genetics (eQTL analysis). He and his research group have built GeneNetwork (www.genenetwork.org), an online resource and suite of gene mapping code that is used widely by the genetics and molecular biology communities.

Abstract on science. Mendelian genetics is the study of single gene variants associated with specific traits. Systems genetics is the analysis of many gene variants, networks of interacting traits, and multiple environments. Neuroscience is a perfect field in which to apply systems genetics. However, it is difficult to acquire large numbers of related traits for populations of humans in an experimentally controlled setting (e.g., gene expression in hippocampus following stress). In the case of mice, it is not difficult; we have acquired and curated hundreds of thousands of micro-traits (mRNA expression levels) for a panel of up to 100 highly diverse lines of mice that model some of the complexity of human populations. The genetic covariance among these traits and transcripts provides remarkable insights into molecular and higher order phenotypes, up to and including behavioral variation, addiction, and disease susceptibility. Abstract on models. A Paradigm Shift in Mouse Genetics: Merging Reductionist and Holistic Approaches to Model Pervasive Diseases in Human Populations ABSTRACT: The analysis of human disease has profited enormously from systematic application of reductionist methods. But as we learn more about disease susceptibility and the impressive range of natural variation among humans, we realize that final outcomes are due to complex interactions among systems that are essentially irreducible. How do we model and test such complexity and take into account the major roles played by genetic variation and environmental perturbations such as changes in diet, stress level, and exercise? We need experimental systems with tightly controlled genomes and environments, but with a level of genetic complexity that mirrors human population diversity. This is now possible using Genetic Reference Populations of mice, rats, and fruit flies. These new resources promise to revolutionize our ability to deliver personalized and predictive health care to humans in the next 100 years. In this talk I will review how Reference Populations are being used to study brain function, aging, and disease. I will also introduce a powerful on-line resource called GeneNetwork that is used for systems genetics research. You should come away from this presentation with new and easy ways to study traits, diseases, and molecular network that interest you.

Abstract on Center for Integrative and Translational Genomics. Virtually all human disease is due to complex interactions between genetic and environmental (epigenetic) factors. Our group in Memphis has developed novel murine disease models that incorporate a level of genetic complexity that mirrors that of human populations. We are using these new Reference Populations to build and test quantitative models of disease mechanisms, with a special focus on neurodegeneration and aging, addiction, and neurological/psychiatric disease. We also develop powerful web services, such as GeneNetwork (www.genenetwork.org) used by many groups world-wide to study brain structure, function, aging, and disease in mouse, rat, and human.

Abstract for neuroscience talk. Systems Neurogenetics and Genetic Control of Expression in the Mouse Brain. Many neuroscientists are interested in understanding complex networks of molecules and cellular processes that modulate structural and behavioral variation in the brain. Over the past several years our team has produced unique tissue and transcriptome resources and companion on-line analytic and stereological tools as part of the Mouse Brain Library (www.mbl.org) and GeneNetwork (www.genenetwork.org). This set of neuroinformatics resources is now being used by neuroscientists and geneticists to systematically study the complex genetics of the mammalian brain in terms of development, architecture, function, and pathology. In this presentation I will review these online resources, and demonstrate how they can be used to elucidate functions of gene networks


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that modulate variation in both the hippocampus and striatum by exploiting multiscale data generated using a panel of 100 diverse strains of mice. Systems Genetics and Genomics Workshop Instructor: Robert W. Williams, Chair of Genetics, Genomics and Informatics, UTHSC, Memphis Date and Time: 12 noon to 3 PM Place: Purpose: Over the last decade, there has been an exponentially growth in open access data and online analysis tools that can be used to study gene function and disease susceptibility. In this half-day short course, Rob Williams will provide a hands-on tour of how you can access and use enormous mouse and human genetic, genomic, and phenotype data sets to help answer questions in many areas of biomedical research. Bring your research questions or a set of favorite genes/protein/receptors to the course, along with a portable computer. We will focus on learning how to exploit the GeneNetwork web resource (www.genenetwork.org) to test ideas or to generate new hypotheses that link the genome to phenotype and disease. We welcome anyone, including bench scientists, clinicians, programmers, and bioinformaticists. No background in genetics is required. Please see the attached documents for further background.

robert w. williams - the university of tennessee 1– robert w. williams department of genetics,...

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