AMGEN Sustainability Program

VCEDA Business Outlook Conference

October 2011

2

Amgen Is a Pioneer in Discovery and

Delivery of Vital Medicines

• World’s leading independent

biotechnology company, with a

mission to serve patients

– Amgen medicines have reached 20

million patients

– Presence in nearly 50 countries

• More than 30 years of pioneering

science and vital medicines

• Focus solely on discovering,

developing, and making human

therapeutics

– Specializing in innovative medicines

for serious illness

– Pioneer and world leader in protein

therapeutic manufacturing

• Broad and deep pipeline of novel

product candidates

Marketed Products

For additional information about Amgen products, including

important safety information, visit www.amgen.com

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Amgen Launched a Formal Environmental

Sustainability Program in 2007

• Know where you are

• Have a strategy

• Set goals

• Improve what you have

• Plan for the future

• Build sustainability into the core of your business

• Announce results

What we’ve found that leads to success:

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Know Where You Are: Compare

Performance With Industry Peers

0

0.5

1

1.5

Amgen Average

Gig

ajo

ule

s /

Sq

Feet

Total Energy

Note: 2009 Pharmaceutical Environmental Group Benchmarking;

0

2

4

6

Average Amgen

MC

M /

Sq

Feet

Water Intake

0

0.03

0.06

0.09

0.12

Amgen Average

Metr

ic T

on

s / S

q F

eet

Carbon Dioxide

0

1500

3000

4500

6000

7500

Average Amgen Metr

ic T

on

s / M

M S

q F

eet

Total Routine Waste

Availability of data allows focus on things that are most impactful

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Have a Strategy: High Level Direction to

Achieve Awareness, Consensus and Action

Pillars Strategic Direction

Conservation

• Environmental impacts are understood, managed and measured for continuous improvement

• Supply chain impacts are clearly understood, measured, and reduced where feasible

Design for Environment • Sustainable products, facilities, and processes

through use of green design principles

Transparency

• Amgen reputation enhanced through communications; publish annual Environmental Sustainability report

• Staff embrace environmental stewardship

• Accurate data collected, available in timely manner

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Set Goals: Specific, Measurable,

Attainable, Relevant, Time-Bound

Reduction to date: 520,000 GJ Target met

Reduction to date: 46,000 MT 62% of

target met

Results of conservation projects through 2010

Reduction to date: 435 MT 62% of

target met

Reduction to date: 660,000 m3 Target met

Reduction to date: 58% Target met

Reduction to date: 3 mpg 75% of

target met

2012 target

Energy Reduce 500,000 GJ

Carbon dioxide Reduce 75,000 MT

Water Reduce 235,000 m3

Waste Reduce 700 MT

Recycling Divert more than 40%

Fuel efficiency Improve by 4 mpg

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Improve What You Have: Pick the Best

Conservation and Efficiency Opportunities

8

Pure Water Is Critical to Our Industry

Recycling Significantly Reduces Use

Recycled

water

Cooling towers Reverse osmosis

water treatment

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Work with your Utility Partners to

Maximize Benefits

Technical Assistance Programs

• Benchmarking & Energy Audits

– Trane Cube Program

– Data Center Audit

– Building Re-commissioning

• Equipment Efficiency Studies

– Hydraulic Pumps

– Air Compressors

– Boiler Efficiency

– Steam Trap and Condensate Return Analyses

Rebate and Incentive Program

• Incentivized Projects

– HVAC Airflow Reductions

– Lighting Fixture Upgrades

– Chilled Water Plant Optimization

– Pump Efficiency

– High Efficiency Window Film

• Equipment Rebates

– Boiler Economizer Replacement

• Construction/Renovation Incentives

– Energy Saving Measures (From Energy Models)

Energy Efficiency Calculated Incentive

Program (EECIP)

Continuous Energy Improvement

Program (CEI)

Energy Efficiency Rebates for Business

Steam and Condensate Audit

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Our Recycling Program Has a Long

History of Success

• Amgen’s recycling program

has been in place since

mid-1990s

• Since 2007, Amgen has

recycled more than 16,000

MT of waste

– 3200 garbage truck loads of

recyclable materials

• Diversion rates continue to

increase

• Waste minimization reduces

both purchase and disposal

costs 0

10

20

30

40

50

60

70

2007 2008 2009 2010

Diversion (Recycle) Rate (%)

We are recycling more and disposing less…

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Plan For the Future: Testing concepts to be

built into Next Generation Laboratories

• Worked with peers in our

industry to develop new

standards for air flow and set

backs

• Tested automated sash

closures that reduce both

energy use and improve safety.

• Integrated occupancy sensors

for lighting and fume hood

control

• Next generation labs – more

automation, more efficient use

of space,

Amgen CONFIDENTIAL Facilities and Engineering

Fume Hood With ASPS Fume Hood With ASPS

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Workplace of the Future Integrates

Sustainability

• High Performance HVAC, Intelligent Lighting

System (25% Energy Reduction)

• Waterless Urinals / Efficient Water Fixtures

(40% Water Reduction)

• Extensive Daylighting in Workspace,

Exposed and Reflective Ceilings

• Recycled Content & Low Emitting Materials

• Forest Stewardship Council Certified Wood

• Reuse of Existing Core & Shell

• Demolition and Construction Waste

Recycling Program

• Reflective Roofing

• Landscaping 50% More Water Efficient

• Enhanced Commissioning Process

• Active Utility Performance Measurement &

Occupant Engagement Dashboards

LEED Registered, Project Tracking to LEED Gold

Highly efficient use of collaborative, tech-enabled space greatly

increases environmental benefits from sustainable building systems.

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Build sustainability into the core of your

business: Manufacturing of the Future

• Improved productivity - smaller plants and equipment for same results

• Portable, reconfigurable equipment: - improved plant effectiveness

• Isolator technology - reduces size of clean space

• Improved cleanability - reduce energy, water and chemicals

Significantly improves:

• Energy use

• Emissions

• Water usage

• Waste water volume

• Solid waste generation

Advances in technology promise to improve plant efficiency –

both business and environmental performance improvements

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Announce Results: Your Stakeholders

Want to Know How You Are Doing

• Customers

– B2B

– Retail

• Neighbors

• Peers

• Shareholders

• Employees

Amgen’s first environmental sustainability report:

http://wwwext.amgen.com/about/environment/espublications.html

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Amgen Has Been Recognized For Its

Environmental Sustainability Efforts

• 2010 Waste Reduction Award Program (WRAP)

award was given to Amgen in South San Francisco by

the California Integrated Waste Management Board

• 2010 Puerto Rico Manufacturers Association

Environmental Accomplishment Award, PRMA's

highest honor, awarded to Amgen Puerto Rico for

outstanding and consistent environmental compliance

• 2010 WasteWatch Award was given to Amgen

Thousand Oaks for outstanding achievements in waste

reduction and recycling.

• 2011 U.S. Environmental Protection Agency (EPA)

Environmental Quality Award , presented to Amgen

Puerto Rico; category: business and industry, Region 2

• 2011 Colorado Energy Partner of the Year awarded to

Amgen Colorado for outstanding efforts in making

Colorado a world leader in energy efficiency.

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Every Company, At any Scale, Can

Achieve Sustainability Success

Know where you are

Have a strategy

Set goals

Improve what you have

Plan for the future

Build sustainability into the core of your business

Announce results