review of ingredients added to cigarettes overview kara lewis, ph.d. staff scientist
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Review of Ingredients Added to Cigarettes Overview Kara Lewis, Ph.D. Staff Scientist. Epidemiology shows that cigarette smoking associates with premature human mortality Effect of added ingredients is unknown. Introduction. A substance other than tobacco that is added to a cigarette. - PowerPoint PPT PresentationTRANSCRIPT
Review of Ingredients Added to Cigarettes
Overview
Kara Lewis, Ph.D.
Staff Scientist
Introduction
• Epidemiology shows that cigarette smoking associates with premature human mortality
• Effect of added ingredients is unknown
Definition of Added Ingredient
A substance other than tobacco that is added
to a cigarette
LSRO Approach
Assess relative risk of adverse health effects
Relative Risk
sdx
NS sd
xNS sd
xNS Risk (+)
ingredient Risk (-)ingredient
LSRO approachExpert Panel
Carroll E. Cross, M.D.
Division of Pulmonary and Critical Care Medicine
University of California, School of Medicine
Shayne C. Gad, Ph.D., D.A.B.T.
Gad Consulting Services
Donald E. Gardner, Ph.D., F.A.T.S.
Inhalation Toxicology Associates
Louis D. Homer, M.D., Ph.D.
Holladay Park Medical Center
Rudolph J. Jaeger, Ph.D., D.A.B.T.
Environmental Medicine, Inc.
Robert Orth, Ph.D.
Apis Discoveries, LLC.
Resha M. Putzrath, Ph.D., D.A.B.T. (Retired)
Georgetown Risk Group
Emanuel Rubin, M.D.
Department of Pathology, Anatomy, and Cell Biology
Thomas Jefferson University
James L. Schardein, M.Sc., F.A.T.S.
Independent consultant
Thomas J. Slaga, Ph.D.
AMC Cancer Research Center and
Center for Causation and Prevention
LSRO Approach
• Convened 11 times to date
• Reviewed more than 3000 publications• Worldwide literature
• Clinical studies
• Government reports
• Books
• Received 21 scientific presentations
Project Structure
Phase I: Determination of Feasibility
Phase II: Development of Scientific Criteria
Phase III: Reviews of Individual Ingredients
• Determined whether testing ingredients
added to cigarettes is feasible
• Reviewed published literature covering•Smoke chemistry and physics
•Exposure
•Adverse health effects
•Issues and methods in testing
Phase I - Feasibility
Phase I - Conclusions
• Testing is feasible and worthwhile.
• Publication of the Phase I report is imminent.
Framework to guide the process of testing ingredients added to cigarettes
Phase II – Scientific Criteria
Phase III - Reviews of Individual Ingredients
•Use the criteria developed in Phase II
•Process:
–Literature review
–Data analysis
• Compare cigarettes with and without added
ingredients
• This approach is feasible
• Phase II is underway
Summary