review of cleanroom microflora

Upload: vpnarashimman

Post on 03-Jun-2018

237 views

Category:

Documents


0 download

TRANSCRIPT

  • 8/12/2019 Review of Cleanroom Microflora

    1/8

    ..

    ://..

    C

    C

    C

    C : M

    ://..

    C, , ,

    ://..

    C:

    ,

    . A A , HEPA ,

    , C , .

    C IO 14644.O E GMP.

    ://..

    ://..

    1,000,000,000

    10%

    P ( ) .

    ://..

  • 8/12/2019 Review of Cleanroom Microflora

    2/8

    .

    , 100,000 0.3

    (2 ), 5

    (5 ), 7.5 .

    ://..

    #C:

    P .

    G : ,

    A

    ://..

    #A

    DAF

    B :I AB

    K

    C

    ://..

    E

    .

    C .

    M: .

    P .

    C , , .

    C , .

    ://..

    :

    A :

    P :

    : (ODAC)

    P : F

    M .

    N .

    ://.. ://..

  • 8/12/2019 Review of Cleanroom Microflora

    3/8

    M

    () .

    :

    C

    P

    C .

    A .

    ://..

    :

    M ,

    L ,

    ,

    D ,

    I ,

    I ,

    I .

    ://..

    ://..

    H M P (2008)

    D ( ).

    M: .

    10 : 1012 ,

    1010 ,

    1014

    200

    ://..

    M

    .

    A (16 NA DNA).

    N :C

    O .

    ://..

    ://..

  • 8/12/2019 Review of Cleanroom Microflora

    4/8

    ://..

    D

    B

    L M

    N , H

    A ,

    ://..

    A

    H

    G

    M .

    ://..

    H

    500 1000

    EL

    .

    .O

    A , .

    B .

    ://..

    #1

    A 1.82

    : 2537C

    (36.6C) (29.5C).

    H , F: H 4.8 : H 6.9.

    M H : , , =

    O

    ://..

    #2

    C

    .

    ://..

  • 8/12/2019 Review of Cleanroom Microflora

    5/8

    #3 M 4 :

    A: G ..M, C P

    F : G .. C B

    P: G ..E, ,, H

    B: O G

    ://..

    #4

    G?

    D .

    G ( ).

    H, ( ), , G .

    ://..

    #5

    ,

    F & D

    O :

    H :, , A .

    A D L : .

    H .

    M

    M C, A .

    ://..

    #6

    :

    E, .

    :

    , , , .

    :

    , ( ), .

    ://..

    #7

    :B:

    ., .

    , , .

    F: ,

    ,

    ://.. ://..

  • 8/12/2019 Review of Cleanroom Microflora

    6/8

    :

    A

    C

    C

    C

    C

    P

    L

    G

    ://..

    A

    ://..

    D

    .

    : C

    G,

    G

    G

    C .

    ://..

    :

    M P

    D , ( )

    P

    L EM EM

    C 10%

    ://..

    .

    A :

    , . (2011): A C M:, , P, , . 65, N.4, JA 2011, 392403

    ://..

    P E

    :

    40 G B ( G A)

    35 G C

    20 G D

    EM A :

    3035C 2 2025C 5

    : 2001 2010

    ://..

  • 8/12/2019 Review of Cleanroom Microflora

    7/8

    E GMP G A B = 6,729

    ://..

    G A B

    , M ( M ) >90%

    ://..

    E GMP G C D

    = 2, 500

    M

    ://..

    A

    ( ) .

    L .,

    P ,

    , .O,

    .

    , .

    ://..

    L

    .. , , HAC

    :P : G

    A : G ( )

    : G . H G ( ) G ,

    ://..

    M

    .

    .

    .C

    :

    ://..

  • 8/12/2019 Review of Cleanroom Microflora

    8/8

    .. G?

    C

    C

    ://..

    C .

    I 50% .

    I ?

    ,

    N,

    ://..

    O

    C

    M .

    K :

    : ,

    ,

    .

    ://.. ://..