reu research program cancer and nanoparticle research dr. j. c. chiao
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By: Michael Lau [email protected]. REU Research Program Cancer and Nanoparticle research Dr. J. c. Chiao. Overview. The traditional cancer treatments tend to be harmful for the body: chemotherapy, surgery, etc. - PowerPoint PPT PresentationTRANSCRIPT
REU RESEARCH PROGRAMCANCER AND
NANOPARTICLE RESEARCH
DR. J. C. CHIAO
By: Michael Lau
UT Arlington REU Program Midterm 2
Overview The traditional cancer treatments tend to be
harmful for the body: chemotherapy, surgery, etc.
We are conducting experiments that work with different kinds of nanoparticles in breast cancer cells (MDAMB) and prostate cancer cells (PC-3).
The technique of microfluidics is used so that the control and variable experiments can be carried out with a small amount of resources.
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The PDMS device
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Nanoparticle Compatibility
How well did the cells thrive along with the nanoparticles?
Did the cells migrate across the channels?
Do the nanoparticles affect cell growth?
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Nanoparticle- Gold
X100
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Nanoparticles - Iron
X100
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Nanoparticles - Nickel
X100
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Nanoparticles - Comparison
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Example of Cell Migration
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Conclusion from Experiment
The cytotoxicity of gold and iron are at reasonable levels so that the cells will not lyse and die. (Good for experimentation)
However, the nickel NPs are cytotoxic, which makes the cells curl up and lyse. (Bad for experimentation)
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Possible Future Research Certain cancer cells metastasize in specific areas.
We would test to see how different tissues act as chemo-attractants to different cancer types (stemmed into another experiment).
Use magnets to see if magnetic fields affect migration across the channels.
Coating the nanoparticles with polymers so that drug molecule attachment could be possible (PEG).
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Side Project: Bacteria
Contamination in the experiment leads to a novel experiment.
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“Gating”
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“Gating” Process
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Applications
Possible creation of a nano-filter for bacteria.
A prevention of fluid dynamics or “backflow” in microfluidics.
Bacteria + nanoparticles results in…?
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Back Flow