RESULTS

INTRODUCTIONOF THE CLINIC

In the eleven years of its existence, more than 15 000 couples from over 90 coun-tries around the world have chosen REPROFIT for their treatment. Our centre of assisted reproduction focuses on all available methods of infertility treatment.

We put the very latest equipment in the capable hands of a professional team of physicians, embryologists and andrologists. ČSN ISO 9001 and ČSN ISO 15189 Quality Certificates, as well as accreditations for the education of physicians and clinical embryo-logists, are testimony to the high quality of our services.

We know how important is the information about the success of treatments for patients coming to us for the first time. This is the prime indicator of the quality of laboratory work, the quality of our physicians and the whole team.

In 2017 we implemented 5 006 cycles, of which 768 were cycles of artificial fertilisa-tion using donated eggs, and 1 478 cycles using the patients’ own eggs.

MORE THAN

10.000CHILDREN BORN THANKS

TO THE CLINIC

The REPROFIT Clinic was founded in 2006 and thanks to positive results has become the largest and most successful clinic in the Czech Republic. Reprofit also belongs among the top European clinics and provides the highest standard in care to an ever increasing number of patients

POSITION IN THE CZECH REPUBLIC

SUCCESS OF THERAPY

CUTTING-EDGE TECHNOLOGYThanks to advanced medical procedures and technologies such as Preimplantation Ge-netic Diagnostics, Time-lapse or Polarization Microscopy we achieve the above standard of treatment outcomes.

Average number of good embryos per cycles

Average age

Average number of embryos per ET

Number of embryo transfers

Number of embryo transfers

Clinical Pregnancy rate (cPR) [%]

Clinical Pregnancy rate (cPR) [%]

Average number od embryos per ET

FRES

HEM

BRYO

S FR

OZE

N

EMBR

YOS

41,1 28,1 32,5 37,0 41,2 45,2 28,2 33,0 37,6 41,3 44,5 38,5

< 30 31 - 34 35 - 39 40 - 43 44 > < 30 31 - 34 35 - 39 40 - 43 44 >

3,81 3,98 3,4 2,51 1,75 0,9 1,54 1,24 1,13 0,84 0,61 0,2

641 113 171 211 64 7 9 25 73 77 15 28

1,3 1,2 1,1 1,2 1,3 1,1 1,1 1,2 1,2 1,2 1,1 1,0

54,7 47 50 37,7 17,9 0 22,2 32 21,9 19,1 7,7 34,8

750 120 185 217 47 4 7 40 53 22 5 130

1,2 1,1 1,1 1,0 1,1 1,5 1,1 1,1 1,1 1,0 1,0 1,0

35,8 33,7 43,4 35,7 31,8 66,7 60,0 52,0 37,3 35,4 20,0 37,2

32,8

NATIV OTHERDIVF IVF IVF min

Number of cycles 768 171 255 339 113 20 13 46 126 177 41 178 332

DIVF IVF

465 175 466 100

50,1 68,4 40,9 39,6

Number of embryo transfers

Clinical Pregnancy rate (cPR) [%]

FRES

HEM

BRYO

S

SINGLE DOUBLE SINGLE DOUBLE

DIVF IVF

570 134 401 44

34 45,0 37 47,2

Number of embryo transfers

Clinical Pregnancy rate (cPR) [%]

FRO

ZEN

EM

BRYO

S

SINGLE DOUBLE SINGLE DOUBLE

5 006 CYCLES CYCLES WITHDONOR EGGS768 CYCLES WITH

PATIENT’S OWN EGGS1 478

< 1 43,5 < 1 41,9 Multiple Pregnancy rate [%] < 1 44,7 < 1 37,5 Multiple Pregnancy rate [%]

DIVF – Treatment with donor eggs. IVF – Treatment with own eggs and normal stimulation. IVF min – Treatment with own eggs and minimal stimulation. IVF nativ – Treatment with own eggs without stimulation. ET – Frozen Embryo Transfer.

Hlinky 48/122, 603 00 Brno

www.reprofit.cz

info@reprofit.cz+420 543 516 001

IVF WITH DONOR EGGS (DIVF, OD) IVF WITH PATIENT’S OWN EGGS (IVF)

PRE-IMPLANTATIONDIAGNOSTICS (PGD)

FROZEN EMBRYO TRANSFER (FET)

In our laboratory the latest technology is being combined with the great skills of our experienced embryologists. The Result of this is creating high quality embryos at our clinic. The high quality of these emb-ryos enables us to transfer only one emb-ryo in more than a half of all cycles. It also decreases the risk of multiple pregnancies. A slight decrease in the success rate using single embryo transfer balances the overall success of treatment with all embryos from one cycle.

The success rate of our IVF treatment with own eggs reaches up to 50% and also we manage to keep increasing the success rate for patients between 40-43 years. Egg qu-ality decreases with age and therefore ob-taining good-quality eggs in such age is suc-cessful just in about half of all the patients. However, then the success rate of embryo-transfer is up to 22%. Our clinic continues with a long-term strategy; transferring only one embryo in order to prevent health risks associated with multiple pregnancies.

The success rate of frozen embryo transfer with thawed embryos is close to the success of a treatment with fresh embryos and in some cases it is even higher. This is more likely to be seen within IVF cycle with own eggs due to the better preparation of en-dometrium lining, while the stimulation of ovaries does not occur at the same time. We are among the world’s best clinics with our result which pleases not only us, but mainly our patients.

Thanks to using a PGD we increase the su-ccess of achieving pregnancy rate by 10 % (61.4 % after using PGD techniques in IVF with own oocytes). The main reason for this examination is the fact that up to 44 % of morphologically good duality embryos have an unsatisfactory distribution of genetic in-formation. Such embryos may stop to deve-lop, and inappropriate genetic information may be the reason for the fail of embryos nesting in the womb.

The patient have one embryo trans-ferred during a fresh cycle, and other embryos are frozen (average is 2.54 fro-zen embryos). Should the patient not become pregnant during the fresh cycle, the other embryos could be transferred through Frozen Embryo Transfer. This will increase the chance of successful pregnancy, and cumulative success of those 3 embryos is more than 91 %.