responsible conduct of animal research at uthsch meredith l. moore, ph.d. assistant director, iacuc...

Responsible Conduct of Animal Research at UTHSCH

Meredith L. Moore, Ph.D.Assistant Director, IACUC Office

http://www.uthouston.edu/animal-research/index.htm

http://www.uthouston.edu/animal-research/index.htm

Objectives

Federal laws Overview of the UTHSC Animal Care

and Use Program Ethical considerations in planning

an animal activity UTHSC resources for animal

activities

UTHSC ANIMAL PROGRAM METRICS

3.0 million dollar CLAMC budget 15% of all active and pending

UTHSC grants include animals 175 UTHSC scientists use animals 475 approved animal protocols 16,000 animals cared for daily

Federal Laws

UTHSC-Animal Care and Use Program

Federal Laws

AWCAWCOffice

Animal Care Program (CLAMC)

Animal Care ProgramCLAMC

Veterinarian Dr. Mary Robinson

AWC Office

AWC

ChairDr. C. Ambrose

Research Staff

InstitutionalTrainingEnviron. SafetyOccup. Health

Federal RegulationsAnd Policies

Institutional OfficialDr. George Stancel

Dr. M. Moore

Investigator

Federal LawsFederal Laws

AWCAWCOffice


Veterinarian Dr. Brad Goodwin

ChairDr. C. Ambrose

Research Staff




Dr. M. Moore

investigator


Federal LawsFederal Regulations

And Policies

Animal Welfare Act

Health ResearchExtension Act

USDA

PHS

Animal Welfare Regulations

PHS Policy and Guide

Federal Agencies

Federal Laws RegulatingAnimal Research

Covered Animal Activities

All animal activities performed at UTHSC facilities.

All animal activities, even off site, where UTHSC funds are used to purchase the research animals.

Animal research activity involving UT personnel but not approved by any other animal committee.

Federal Laws


AWCAWCOffice



ChairDr. C. Ambrose

Research Staff




Dr. M. Moore

Investigator

Federal Laws


AWCAWCOffice



AWC OFFICEAWC

ChairDr. C. Ambrose

Research Staff




Dr. M. Moore

Investigator

UTHealth Animal Welfare Committee

Mandated committee Appointed by the

President Composition of

membership Responsibilities

Protocols Inspections Concerns Authority

AWC Office - Resources

Office Hours Tuesdays, CLAMC Thursdays, BBSB

Statistical Help Office Visits for

protocol planning or returned response

Navigating iRIS

Classes offered monthly and posted on the AWC website

AWC Animal Protocol

Form available online in iRIS and the final submission must be comprehensive and well written

Consult with an AWC Coordinator and a CLAMC veterinarian

Approval is for three years, but USDA protocols require review on an annual basis

Modifications of approved protocols must be approved before implementation and can be submitted using the change request form.

Animal Protocol Ethical Considerations:Justification

Research should be justified Purpose is sufficient to justify the use of

animals Model system is the best suited to

answer the scientific question Reasonable expectation that the

research methods employed will provide valid results

Animal Protocol Ethical Considerations:Personnel

Must be qualified through training or experience to accomplish experimental manipulations in a humane and scientifically acceptable manner

Institutional Training in Animal Care and Use

Coordinated by CLAMC

Institutional courses Introductory Species specific Offered 2X month

One-on-one training

Animal Protocol Ethical Considerations:Species Selection and Quantity

The animals selected for a procedure should be of an appropriate species and quality and the minimum number required to obtain valid results.

Animal Protocol Ethical Considerations:Proper Use of Animals

• It is imperative to utilize methods that will avoid or minimize discomfort, distress and pain, when consistent with sound scientific practices.

Animal Protocol Ethical Considerations:Painful Procedures

Procedures that are known to cause more than momentary pain or distress, should be performed with appropriate sedation, analgesia, and/or anesthesia.

Animal Protocol Ethical Considerations:Unrelieved Pain or Distress

Animals that would otherwise suffer severe or chronic pain or distress that cannot be relieved, should be euthanized at the end of the procedure or if appropriate, during the procedure.

Animal Protocol Ethical Considerations:Environment and Well-being

The living conditions of animals should be appropriate for their species and contribute to their health and comfort.

Federal Laws


AWCAWCOffice


Animal Care ProgramCLAMC

Veterinarian Dr. Mary Robinson

ChairDr. C. Ambrose

Research Staff




Dr. M. Moore

Investigator

Center for Laboratory Animal Medicine and Care

Centralized program for animal housing, care, and use

40 staff members including 5 veterinarians and 7 veterinary health and surgery technicians

CLAMC managed resources located in 5 UTHSC buildings


Locations- MSB/E- IMM- BBSB- UCT

Shared Location- SCRB 3 (CABIR)


Services and resources Animal housing and husbandry Veterinary consultation & care Surgical resource & support Clinical laboratory Technical assistance Import and export Transportation Canine breeding program Whole animal irradiator

Other UTHSC Animal Resources:Genetically Manipulated Rodent Models

IMM - Development of transgenic and knockout mouse strains

IMM –Cryopreservation of embryos

Dr. Rick WetselDr. Eva Zsigmond

Other UTHSC Animal Resources:FMR Imaging Research Resource

3.0 and 7.0 T dedicated for research

Dr. Ponnada Narayana – Radiology, MS

Internal Medicine Preclinical CT Imaging GE eXplore Ultra CT• The GE eXplore Ultra is a volume CT system designed

for high resolution, high speed imaging in research.

• 24 cm bore and large transaxial field of view designed to accommodate rodent to rabbit sized animals.

• Variable energy X-ray tube (up to 140 kVp) permits optimization of scanning protocols for varying objects of interest.

• Gantry speeds as fast as 1 rotation per second can be used for dynamic imaging applications.

• The eXplore Ultra allows exceptional CT imaging of clinical specimens at resolutions not possible in standard clinical systems.Contact Information

The Preclinical CT imaging suite is located on the fifth floor of the Medical School Building in room 5.302.

For additional information, specifics, or to submit an imaging request, email:

[email protected]

Federal Laws


AWCAWCOffice



ChairDr. C Ambrose

Research Staff




Dr. M. Moore

Investigator

Occupational Health Environmental Health and Safety

Health and environmental risks are identified Personnel are aware of the risks Practices in place to minimize the risks Procedures in place to monitor exposure and to

provide medical intervention, if needed.

Federal Laws

AWCAWCOffice



ChairDr. C. Ambrose

Research Staff




Dr. M. Moore

Investigator


Good Animal Care = Good Science

responsible conduct of animal research at uthsch meredith l. moore, ph.d. assistant director, iacuc...

Documents

animal research slide

animal committee

uthsc animal care

daily slide

animal research activity

approved animal protocols

covered animal activities

awc website slide