respiratory failure s/t hcap

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    CASE PRESENTATION:

    RESPIRATORYFAILURE

    2 TO HCAP

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    PRESENTED BY: GROUP 2

    Aramburo, Cristina

    Binag, La! "i

    Caba#o, $%an%tt%

    Diron, Ann%

    Es%o, &ir' I(an

    &it, A#!ssa

    Lai, &i%rst%in

    Largo, Ni)o#%

    L%a, Ri)*an

    Samuio, $o*n Car#o

    Toma)ru+, Samant*a

    Traba#, T*omas C*ar#%s

    Ua!an, E#ain% $%an

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    INTRODUCTION:

    D%g%n%rati(% is) is%as% in t*% #umbar sin%, or #o-%r ba)' arti)u#ar#! in t*% L.

    /L0 r%1%rs to a s!nrom% in -*i)* a )omromis% is) )aus%s #o- ba)' ain r%1%rr%

    to as #umbago3 or irritation o1 a sina# n%r(% to )aus% ain raiating o-n t*% #%g

    s)iati)a3, numbn%ss in %rmatom%s istribution an ositi(% straig*t #%g raising t%st

    S)iati) ain aggra(at%s on staning, -a#'ing, b%ning, straining an )oug*ing4 Ot*%

    s!mtoms o1 #umbar is) %g%n%ration ar% s%nsor! isturban)%s in #%gs, )#aui)ation

    r%#i%1 o1 ain -*%n b%ning 1or-ar an -%a'n%ss4

    As -% ag%, t*% -at%r an rot%in )ont%nt o1 t*% )arti#ag% o1 t*% bo! )*ang%s4 T*is

    )*ang% r%su#ts in -%a'%r, mor% 1ragi#%, an t*in )arti#ag%4 B%)aus% bot* t*% is)s an

    t*% 5oints t*at sta)' t*% (%rt%bra% 1a)%t 5oints3 ar% art#! )omos% o1 )arti#ag%, t*%s

    ar%as ar% sub5%)t to -%ar an t%ar o(%r tim% %g%n%rati(% )*ang%s34

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    T*% is) its%#1 o%s not *a(% a b#oo su#!, so i1 it sustains an in5

    )annot r%air its%#1 t*% -a! ot*%r tissu%s in t*% bo! )an4 An ot*%rinsigni1i)ant in5ur! to t*% is) )an start a %g%n%rati(% )as)a% -*

    is) -%ars out t*us )aus%s (arious )om#i)ations su)* as immobi#i

    to r%sirator! )om#i)ations as #ungs ar% unab#% to %6an ro%r#

    T*% #ungs )an b% a11%)t% a1t%r (%r! s*ort %rios o1 immobi#it! #%

    r%sirator! )om#i)ations4 E(%n a a! or t-o t*% )*%st mus)#%s b%-%a'%n% r%su#ting in %)r%as% #ung %6ansion an s*a##o- br%at

    Coug*ing an imortant rot%)ti(% 1un)tion to )#%ar t*% air-a!s, b%

    -%a'%r an #%ss %11%)ti(%4

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    S%)r%tions bui# u in t*% #ungs, in)r%asing t*% ris' o1 n%umonia an #at%r on -i## #%a

    r%sirator! 1ai#ur% -*i)* r%su#ts 1rom ina%7uat% gas %6)*ang% b! t*% r%sirator! s!st%mt*at t*% art%ria# o6!g%n, )arbon io6i% or bot* )annot b% '%t at norma# #%(%#s4 A ro

    )arri% in b#oo is 'no-n as *!o6%mia8 a ris% in art%ria# )arbon io6i% #%(%#s is )a##%

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    T*% r%(a#%n)% o1 D%g%n%rati(% Dis' is%as% r%#at% r%sirator! )om#i)ations is *ig*%

    t*% %r)%ntag% o1 99 an 9; in -om%n ag%s 1rom 0< !%ars o# an abo(%4 T*% *ig*

    r%(a#%n)% o1 an int%r(%rt%bra# sa)% -it* %g%n%rati(% is) is%as% is in L. = L0 abouan ob%sit! -%r% asso)iat% -it* t*% r%s%n)% o1 %g%n%rati(% is) is%as% in a## r%gion

    In t*% )as% o1 t*% ati%nt D4A, 9. !%ars o#, ma#%, )*i%1 )om#ain i11i)u#t! o1 br%at*ing

    uration an amitt% u% to s%sis s%)onar! to *osita# a)7uir% n%umonia an )om

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    Pati%nt -as iagnos% -it* %g%n%rati(% is) is%as% arti)u#ar#! in L. an L0 an

    %6%ri%n)% s!mtoms su)* as bi#at%ra# 'n%% ain, an g%n%ra# bo! -%a'n%ss,

    #%aing to immobi#i+ation4 Du% to immobi#i+ation, t*% ati%nt *a a )ommunit!

    a)7uir% n%umonia t*%n -as amitt% to UER@ *osita# an it -as r%so#(%4 Lat%r

    on, t*% ati%nt *a *osita# a)7uir% n%umonia at t*% sam% tim% -it* )om#i)at%

    UTI4 rom )om#i)at% UTI, an t*% %stru)tion o1 L. an L0 it r%su#ts to as)%ning

    in1%)tion #%aing to t*% a)ut% 'in%! in5ur! t*%n going to s!st%mi) )ir)u#ation -*i)*

    r%su#ts to s%sis4

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    DE@OGRAPIC DATA

    Name: D4A

    Gender: @a#%

    Age: 9. !%ars o#

    Status: Sing#%

    Occuat!"n: R%tir% @@DA O11i)%r

    Nat!"na#!t$: i#iino

    Address: Cubao, u%+on Cit!

    Re#!g!"n: Cat*o#i)

    %ate "& '!rt(:

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    DE@OGRAPIC DATA

    Adm!tt!ng %!agn"s!s: S%sis s%)onar! to *osita# a)7uir% n%umonia an )om#i)at%

    UTI4

    Past Hea#t( H!st"r$:

    Status ost r%na# ston%s ;

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    ANATO@Y AND PYSIOLOGY

    T(e Res!rat"r$ S$stemT*% r%sirator! s!st%m is ma% u o1 organs an tissu%s t*at *%# !ou br%at*%4 T*% mai

    s!st%m ar% t*% air-a!s, t*% #ungs an #in'% b#oo (%ss%#s, an t*% mus)#%s t*at %nab#%

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    Figure A shows the location of the respiratory structures in the body. Figure Benlarged view of the airways, alveoli (air sacs), and capillaries (tiny blood veC is a closeup view of gas exchange between the capillaries and alveoli. COdioxide, and O is oxygen.

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    ANATO@Y AND PYSIOLOGY

    Airways

    The airways are pipes that carry oxygen-rich air to your lungs. They also carry cara waste gas, out of your lungs. The airways include your:

    Nose and linked air passages (called nasal cavities)

    outh

    !arynx (!"#-ingks), or voice box

    Trachea (T#"-ke-ah), or windpipe Tubes called bronchial tubes or bronchi, and their branches

    "ir $rst enters your body through your nose or %outh, which wets and war%s the air can irritate your lungs.) The air then travels through your voice box and down ywindpipe. The windpipe splits into two bronchial tubes that enter your lungs.

    " thin 'ap of tissue called the epiglottis (ep-ih-!T-is) covers your windpipe wheswallow. This prevents food and drink fro% entering the air passages that lead to

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    ANATO@Y AND PYSIOLOGY

    *xcept for the %outh and so%e parts of the nose, all of the airways have special hairs callecilia (+!-e-ah) that are coated with sticky %ucus. The cilia trap ger%s and other foreignparticles that enter your airways when you breathe in air.

    These $ne hairs then sweep the particles up to the nose or %outh. ro% there, theyreswallowed, coughed, or snee/ed out of the body. Nose hairs and %outh saliva also trapparticles and ger%s.

    Lungs and Blood Vessels

    0our lungs and linked blood vessels deliver oxygen to your body and re%ove carbon dioxid

    fro% your body. 0our lungs lie on either side of your breastbone and $ll the inside of yourchest cavity. 0our left lung is slightly s%aller than your right lung to allow roo% for yourheart.

    1ithin the lungs, your bronchi branch into thousands of s%aller, thinner tubes calledbronchioles. These tubes end in bunches of tiny round air sacs called alveoli (al-2**-uhl-eye).

    *ach of these air sacs is covered in a %esh of tiny blood vessels called capillaries. The

    capillaries connect to a network of arteries and veins that %ove blood through your body.

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    ANATO@Y AND PYSIOLOGY

    The pul%onary (34!!-%un-ary) artery and its branches deliverblood rich in carbon dioxide (and lacking in oxygen) to thecapillaries that surround the air sacs. nside the air sacs, carbondioxide %oves fro% the blood into the air. "t the sa%e ti%e, oxyge%oves fro% the air into the blood in the capillaries.

    The oxygen-rich blood then travels to the heart through the

    pul%onary vein and its branches. The heart pu%ps the oxygen-richblood out to the body.

    The lungs are divided into $ve %ain sections called lobes. +o%epeople need to have a diseased lung lobe re%oved. 5owever, theycan still breathe well using the rest of their lung lobes.

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    ANATO@Y AND PYSIOLOGY

    Muscles Used for Breathing

    uscles near the lungs help expand and contract (tighten) the lungto allow breathing. These %uscles include the:

    6iaphrag% (6-ah-fra%)

    ntercostal %uscles

    "bdo%inal %uscles uscles in the neck and collarbone area

    The diaphrag% is a do%e-shaped %uscle located below your lungst separates the chest cavity fro% the abdo%inal cavity. Thediaphrag% is the %ain %uscle used for breathing.

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    ANATO@Y AND PYSIOLOGY

    The intercostal %uscles are located between your ribs. They alsoplay a %a7or role in helping you breathe.

    8eneath your diaphrag% are abdo%inal %uscles. They help youbreathe out when youre breathing fast (for exa%ple, duringphysical activity).

    uscles in your neck and collarbone area help you breathe in when

    other %uscles involved in breathing dont work well, or when lungdisease i%pairs your breathing.

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    ANATO@Y AND PYSIOLOGY

    What are the kidneys and what do they do?

    The kidneys are two bean-shaped organs, each about the si/e of a$st. They are located 7ust below the rib cage, one on each side ofthe spine. *very day, the two kidneys $lter about 9; to 9

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    ANATO@Y AND PYSIOLOGY

    The urinary tract

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    ANATO@Y AND PYSIOLOGY

    Why are the kidneys important?

    The kidneys are i%portant because they keep the co%position, or%akeup, of the blood stable, which lets the body function. They

    prevent the buildup of wastes and extra 'uid in the body

    keep levels of electrolytes stable, such as sodiu%, potassiu%,and phosphate

    %ake hor%ones that help

    regulate blood pressure

    %ake red blood cells

    bones stay strong

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    ANATO@Y AND PYSIOLOGY

    How do the kidneys work?

    The kidney is not one large $lter. *ach kidney is %ade up ofabout a %illion $ltering units called nephrons. *ach nephron$lters a s%all a%ount of blood. The nephron includes a $ltercalled the glo%erulus, and a tubule. The nephrons workthrough a two-step process. The glo%erulus lets 'uid and

    waste products pass through it> however, it prevents bloodcells and large %olecules, %ostly proteins, fro% passing. The$ltered 'uid then passes through the tubule, which sendsneeded %inerals back to the bloodstrea% and re%oveswastes. The $nal product beco%es urine.

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    ANATO@Y AND PYSIOLOGY

    *ach kidney is %ade up of about

    %illion $ltering units called

    nephrons.

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    ANATO@Y AND PYSIOLOGY

    Points to emem!er *very day, the two kidneys $lter about 9; to 9 however, itprevents blood cells and large %olecules, %ostly proteins, fro%

    passing. The $ltered 'uid then passes through the tubule, whichsends needed %inerals back to the bloodstrea% and re%oves

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    PYSICAL ASSESS@ENTA##$##M$%& A%A

    +?N and

    N"!+

    *venly colored skin tone, dry and war% to

    touch. There is presence of peeling of the

    skin on both upper and lower extre%ities

    with poor skin tugor, presence of grade four

    pitting ede%a, both upper and lower

    extre%ities. There are four pressure sores

    that are present. 3ressure sore @9 is on

    sacral %edial> grade A with %easure%ent of

    grade with %easure%ent of 9.< x

    ;.B c%. 3ressure sore @A on %alleolus

    (right)> necrotic and dry with %easure%ent

    of 9.< x 9 c% and pressure sore @D on

    %alleolus (left)> grade with %easure%ent

    of x c%. Nails are clean and intact.

    " dry ski

    pressure

    present d

    prolonge

    i%%obilit

    &apilliary

    %ore tha

    seconds

    skin tugo

    decrease

    oxygena

    body sys

    3resence

    four pitti

    is due to

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    PYSICAL ASSESS@ENT

    A##$##M$%& A%AL'#

    5*"6 "N6N*&? 5ead is round with s%ooth skullcontour. 5ard and s%ooth, no

    tenderness upon palpation. No

    bleeding and lesions noted.

    3resence of white hair. ree fro%

    lice. acial features are

    sy%%etrical. No swelling of ly%ph

    nodes below the angle of the 7aw

    and along the sternocleido%astoid

    %uscle. No bruits heard upon

    auscultation. &lient has li%ited

    range of %otion of the neck.

    !i%ited range oof neck is due to

    atrophy and pro

    i%%obility.

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    PYSICAL ASSESS@ENT

    A##$##M$%& A%AL'#

    *0*+ "N6 *"#+ *yebrows are sy%%etrical in shape

    and eyelashes are si%ilar in

    =uantity and distribution. *ye has

    no redness, and tenderness

    *yeballs are feels $r%. No ede%a

    or tearing of the lacri%al sac.

    &on7unctiva is %oist and clear. *ars

    are sy%%etrical in shape> externalauditory %eatus is patent with no

    drainage. &olor of ear %atches the

    surrounding area and face, no

    redness, nodules, swelling and

    lesions noted. 5earing is intact and

    able to recogni/ed voices and

    N#"!

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    PYSICAL ASSESS@ENT

    A##$##M$%& A%AL'

    N+* "N6 +N4+*+ Nose is straight, nares are

    e=ual in si/e, and skin is

    intact. No tenderness,

    swelling upon palpation.

    NT is intact.

    N#"!

    4T5 !ips are sy%%etrical, nolesions, dry but %oist

    buccal %ucosa. 3atientEs

    teeth are loose. +urface

    of the tongue is s%ooth

    and %oist.

    " dry lip is dueopening of the

    because of the

    endotracheal t

    3ositive for de

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    PYSICAL ASSESS@ENT

    A##$##M$%& A%AL'#

    #*+3#"T#0 &lientEs chest color is consistent

    with the rest of the body. +ternu%is in %idline. 5as tachypnea,

    positive labored breathing and used

    of accessory %uscles. &rackles are

    heard on lower left lung upon

    auscultation. "ssisted with

    %echanical ventilator with whiningtherapy every after %orning care

    %aintained with oxygen tank at one

    liter per %inute. #espiratory rate of

    F bp%. 3resence of purulent

    sputu% greenish in color upon

    suctioning thick in consistency.

    "ssess%ent sho

    client has been with 5&"3.

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    PYSICAL ASSESS@ENT

    A##$##M$%& A%AL'

    &"#62"+&4!"# ood heart tone with noabnor%al sounds heard.

    No %ur%urs or bruits

    heard during auscultation

    83: 9;GC; %%5g

    3#: FB bp%

    N#"!

    "+T#NT*+TN"! No lesions, scars

    observed on the

    abdo%en. "bdo%en is

    sy%%etric and 'at.

    Nor%o active bowel

    sounds. *%pty bladder is

    not palpable or

    N#"!

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    PYSICAL ASSESS@ENT

    A##$##M$%& A%AL'#

    #*+3#"T#0 &lientEs chest color is consistent

    with the rest of the body. +ternu%is in %idline. 5as tachypnea,

    positive labored breathing and used

    of accessory %uscles. &rackles are

    heard on lower left lung upon

    auscultation. "ssisted with

    %echanical ventilator with whiningtherapy every after %orning care

    %aintained with oxygen tank at one

    liter per %inute. #espiratory rate of

    F bp%. 3resence of purulent

    sputu% greenish in color upon

    suctioning thick in consistency.

    "ssess%ent sho

    client has been with 5&"3.

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    PYSICAL ASSESS@ENT

    A##$##M$%& A%AL'#(

    4#N"#0 oley catheter inserted and

    attached to a oley catheterbag. Nor%al yellow urine color

    passes through the bag in

    %ini%al a%ounts

    onitor urinary ou

    evaluate hydrationand collection of u

    sa%ples for diagno

    procedures.*IT#*T*+ *xtre%ities are sy%%etrical in

    si/e and shape with li%ited

    range of %otion. 3resence ofgrade pitting ede%a on shin

    and ankle. No presence of

    pedal pulses. &apillary re$ll

    seru% returns to nor%al less

    than two seconds. No signs of

    cyanosis noted

    3itting ede%a is as

    with acute kidney

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    PYSICAL ASSESS@ENTA##$##M$%& A%AL'#(

    N*#24+ +0+T* No di//iness, tre%or or sei/ure.

    5ard to awaken. !i%ited %otor

    function. Nu%bness and

    weakness in the lower

    extre%ities

    Nu%bness and we

    the legs is one of

    of herniated disc

    4+&4!+?*!*T

    "!

    &lient has 9G< %uscle strength

    of 'exion and extension on bothupper and lower extre%ities.

    &anEt do the cross over hand

    grip. +tiJness in trape/ius, ar%

    and hand %uscles. orward

    shoulder, downward scapular

    rotation and increased kyphosis.

    1eak %uscle tone

    strength

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    PATOPYSIOLOGY

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    LABORATORY RESULTS

    )H$M(#&' *MA)H +,- +./01

    &$#& $#UL& $2$$%)$ (%&$P$&

    A%AL)reatinine C< u%olG! DD K 9;B u%olG! N#Al!min Mass ) gG! AF K

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    LABORATORY RESULTS

    BL334 )H$M(#&' *AP(L +- +./01

    &$#& $#UL& $2$$%)$ (%&$P% A%4 A

    #odium 9AB %%olG! 9A< K 9

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    LABORATORY RESULTS

    )3MPL$&$ BL334 )3U%& *AP(L /6- +./01

    &$#& $#UL& $2$$%

    )$

    (%&$P$&A&(3% A%4 A%AL

    Hemoglo!

    in Mass )

    9;< 9D;-9B; !ow 5b indicates anemia, rec

    he%orrhage, or 'uid retention, can cause he%odilution

    Hematocri

    t

    A; D;-

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    )3MPL$&$ BL334 )3U%& *AP(L /6- +./01

    &$#& $#UL& $2$$%)$ (%&$P

    A%4 A%WB) 99.;

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    DRUG ANALYSIS

    4rug M3A (ndication8 )(9 #ide

    $7ects

    %ursing esponsi!i

    &lexane

    &lassi$ca

    tion:

    "nticoag

    ulants

    " low %oleculer

    weight heparin

    derivative that

    acceleratesfor%at

    ion of anti-

    thro%bin -

    thro%bin co%plex

    and deactivates

    thro%bin,preventing

    conversion of

    $brinogen to

    $brin. 5as higher

    anti-factor Ia

    toantifactor a

    activity ratio.

    :

    patients with

    acute illness

    who are at

    increased risk

    because of

    decreased

    %obility.

    &:

    &onditions with

    high risk of

    uncontrolled

    he%orrhage

    including %a7or

    bleeding

    -ede%a

    -ane%ia

    - onitor 2+ and asses

    of bleeding

    -ive only by deep +&

    down

    -6o not give

    -"ssess for 5eparin pr

    hypersensitivity

    -6ocu%ent baseline h

    para%eters, liver funccoagulation studies

    -#eport unusual bleed

    weakness

    -"void T& agents con

    aspirin

    -4se an electronic ra/o

    -4se a bandage to pre-

    4rugs M3A ( and )( #$ %(l l l i ki k i l l

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    etropolol

    &lassi$catio

    n:

    8eta

    8locker

    " selective

    beta blocker

    that

    selectively

    blocks beta9

    receptors>decreases

    cardiac

    output,

    peripheral

    resistance,

    and cardiac

    oxygenconsu%ption>

    and

    depresses

    rennin

    secretion.

    :

    -hypertension

    &:

    -right

    ventricularfailure

    secondary to

    pul%onary

    hypertension.

    6ry skin,

    pruritus, skin

    eruptions.

    +pecial

    +enses: 6ry

    %outh and%ucous

    %e%branes.

    Take apical puls

    ad%inistering dr

    physician signi$c

    rate, rhyth%, or

    or variations in 8

    ad%inistration.

    onitor 83, 5#,

    carefully during

    ad%inistration..

    !ab tests: btai

    periodic evaluat

    cell counts, blooand kidney func

    onitor M, da

    auscultate daily

    rales.

    1ithdraw drug i

    presents sy%pto

    4U5# M3A )3%&A(%: #(4$ %U#

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    (%4()A&(3%

    #

    4()A&(3%# $22$) $#P3

    &linda%y

    cin

    &lassi$cation:

    "nti

    neJectiv

    e

    nhibits

    protein

    synthesis in

    susceptiblebacteria at the

    level of

    hinders or kills

    susceptiblebacteria

    / To treat

    serious

    respirator

    y tractinfection

    caused by

    pneu%on

    ococci

    / nfection

    in skin

    and soft

    tissuein7ury

    / &ontraindi

    cated to

    patient

    hypersensitive to

    drugs

    / 4se

    cautiously

    in patient

    with renal

    or hepatic

    dse.

    +evere skin

    reaction

    that causes

    blisteringand

    peeling.

    / "ss

    pat

    con

    appthe

    spu

    / bt

    for

    sen

    to i

    the

    / onand

    ant

    trea

    / "ss

    for

    hyp

    4U5# M3A )3%&A(% #(4$ %U#(

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    4U5# M3A

    (%4()A&(3

    %#

    )3%&A(%

    :

    4()A&(3%#

    #(4$

    $22$)

    %U#(

    $#P3

    '!ansopra

    /ole

    &lassi$ca

    tion:

    33

    8ind en/y%e

    in presence

    of acidicgastric 35

    3reventing

    $nal

    transport of

    hydrogenions to

    gastric

    lu%en

    / "ctive

    benign

    hastriculcer

    / 3rolonge

    d *T and

    NT

    tube

    5ypersens

    itivity to

    the drug

    6ry %outh

    3eripheral

    ede%a

    / "sse

    rout

    epigabdo

    pain

    / "d%

    drug

    %ea

    / #epo

    headwors

    sy%

    / ral

    ice c

    prev

    dryn

    %U#(%5 )A$ PLA%

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    %U#(%5 )A$ PLA%P(3(&' ;/

    Assessment

    4iagnosi

    s

    Planni

    ng

    (nter

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    %U#(%5 )A$ PLA%P(3(&' ;/

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    Assessment 4iagnosis Planb7ective:

    &lientEs chest color is consistent with the rest

    of the body. +ternu% is in %idline. 5astachypnea, positive labored breathing and

    used of accessory %uscles. &rackles are

    heard on lower left lung upon auscultation.

    "ssisted with %echanical ventilator with

    whining therapy every after %orning care

    %aintained with oxygen tank at one liter per

    %inute. #espiratory rate of F bp%. 3resence

    of purulent sputu% greenish in color upon

    suctioning thick in consistency.

    neJective

    breathing pattern

    related tohypoventilation as

    %anifested by ##

    of F bp% and

    crackles upon

    auscultation

    +hort ter%:

    "fter -A hour

    intervention tbe able to i%p

    pul%onary ve

    oxygenation.

    !ong ter%:

    "fter -Adays

    intervention t

    breathing pat

    %aintain as n

    respiratory ra

    %U#(%5 )A$ PLA% P(3(&'

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    (nter

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    $

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    =3U%AL9 $#P(A&3'2A(LU$

    #espiratory failure occurs due %ainly either to lung failure resulting inhypoxe%ia or pu%p failure resulting in alveolar hypoventilation andhypercapnia. 5ypercapnic respiratory failure %ay be the result of%echanical defects, central nervous syste% depression, i%balance ofenergy de%ands and supplies andGor adaptation of central controllers.

    5ypercapnic respiratory failure %ay occur either acutely, insidiously oracutely upon chronic carbon dioxide retention. n all these conditions,pathophyisiogically, the co%%on deno%inator is reduced alveolarventilation for a given carbon dioxide production.

    "cute hypercapnic respiratory failure is usually caused by defects in thcentral nervous syste%, i%pair%ent of neuro%uscular trans%ission,%echanical defect of the ribcage and fatigue of the respiratory %uscle

    =3U%AL9 $#P(A&3'

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    =3U%AL9 $#P(A&3'2A(LU$

    The pathophysiological %echanis%s responsible for chronic carbon dioxide retention are no

    yet clear. The %ost attractive hypothesis for this disorder is the theory of Onatural wisdo%P3atients facing a load have two options, either to push hard in order to %aintain nor%al

    arterial carbon dioxide and oxygen tensions at the cost of eventually beco%ing fatigued anexhausted or to breathe at lower %inute ventilation, avoiding dyspnea, fatigue andexhaustion but at the expense of reduced alveolar ventilation. 8ased on %ost recent work,the favored hypothesis is that a threshold inspiratory load %ay exist, which, when exceederesults in in7ury to the %uscles and, conse=uently, an adaptive response is elicited toprevent andGor reduced this da%age. This consists of cytokine production, which, in turn,

    %odulates the respiratory the respiratory controllers, either directly through the blood or

    probably the s%all aJerents or via the hypothala%ic-pituitary-adrenal axis. odulation of thpattern of breathing, however, ulti%ately results in alveolar hypoventilation and carbondioxide retention.

    #**#*N&*:

    #oussos, &., M ?outsoukou, ". (;;A). #espiratory failure Q"bstractR. *uropean #espiratorySournal, A-9D. #etrieved ay ;, ;9B.