respimat ® dry inhaler technology

8/12/2019 RESPIMAT dry inhaler technology

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RESPIMAT dry inhaler

technology


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What is Respimat Soft Mist

Inhaler?Respimat soft mist inhaler (SMI) is propellent Free

inhaler by Boehringer Ingelheim as innovative approach

to inhalation therapy.

Respimat soft mist inhaler helps to improve lung

disposition is easy to use and preferred by patients than

conventional MDI and DPIs


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Benefits of respimat SMI innhaler Results

Unique soft mist resulting in decreased in

Cloud velocity

Less impaction in the oropharynx

decreased cloud velocity*

Unique soft mist resulting in

increased cloud duration

Simplifies co-ordination of activation

with inspiration

Increased lung deposition Better drug targeting, allowing

reduction of the nominal dose

Propellant-free Less impact on the environment

Easy to use * Simple for the patient

High fine particle fraction Greater amount of respirable particles

Why respimat inhaler useful???


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Key features of Respimat soft mist

inhaler

1) High Fine-Particle Fraction :The RESPIMAT inhaler generates a medicationcloud with a high fine-particle fraction (FPF). The size of drug particles is a keyfactor in ensuring penetration of the medication into lungs.

2) Long Cloud Duration:The RESPIMAT inhaler has demonstrated a longer cloud

duration than pressurized metered dose inhalers (pMDIs)RESPIMAT inhaler mean cloud duration: 1.5 seconds

pMDI cloud duration: 0.15 to 0.36 seconds

3) Slow-Moving Aerosol Cloud :The RESPIMAT inhaler has demonstrated a slowercloud velocity (mean 0.8 m/sec) relative to pMDIs (range 2.0 m/sec to 8.4

m/sec).4) Consistent Drug Dose : The RESPIMAT inhaler delivers a consistent drug dose

throughout the life span of the cartridge.

5) Higher Lung Deposition :achieve high therapeutic effect compared with othertypes of inhalers.


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No Propellant :

The RESPIMAT inhaler contains no chlorofluorocarbons

(CFCs). This eliminates the problems associated with thevolatile propellants in pMDIs.

Multidose Canister :

The RESPIMAT inhaler cartridge delivers 120 metered

actuations after preparation and priming for first-time use.The RESPIMAT inhaler includes a dose indicator combined

with a locking mechanism that engages when the dose

indicator has reached the end of the scale (after 120

actuations).


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External components of Respimat inhaler


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Internal components of Respimat

inhaler


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HOW IT WORKS?

A 180 twist of the device base compresses the spring.

This draws a metered dose of drug solution through the

capillary tube to the dosing chamber

When the dose release button is pressed, the power from the spring

moves the capillary tube into the dosing chamber The drug solution is forced through the uniblock

The uniblock produces two fine jets of liquid that converge at a selected

angle and then collide.

The collision aerolizes the liquid to form a slow-moving cloud of

inhalable particles, the Soft Mist


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Storage conditions for Respimat

inhaler

Store RESPIMAT inhaler at Room Temperature

between 59F to 86F (15C to 30C).

Do not freeze your RESPIMAT cartridge and inhaler.


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Marketed formulations:

Combivent respimat inhaler: It contains ipratonium and albuterol astwo bronchodilators for treatment of bronchitis and ephysema.

Dosing:2 inhalations 4 times daily.

Spiriva respimat inhaler: It contains tiotripium (long actingmuscarinic receptor antagonist) 2.5 micrograms per actuation.it is used

for COPD diseases.


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Advantages:

No propellant

Slow moving medicament cloud

Consistent drug dose Cloud with high particle fraction

Dose indicator

Higher lung disposition than pMDIs


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Disadvantages

Not available in most countries.

Not breath actuated.


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Conclusion:

Respimat inhaler is efficient technology as

pulmonary drug delivery system .

It has higher lung disposition of drug .

No propellants are used so, it is environmental

friendly


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Referances:

1) www.google.com

2) www.wikipedia.in
http://www.google.com/http://www.wikipedia.in/http://www.wikipedia.in/http://www.google.com/


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respimat ® dry inhaler technology

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