+

Research Paths for Surgeon- Scientists Dolores J. Lamb, Ph.D. Lester and Sue Smith Chair in Urologic Research Director, Center for Reproductive Medicine Vice-Chairman for Research and Professor Scott Department of Urology Professor of Molecular and Cellular Biology Baylor College of Medicine

+ The Physician-Scientist

Physician-Scientists bring unique perspectives to biomedical science

Throughout history, physicians were “translators” of medical research

Over the last 30 years, physician-scientists are a dying breed

+ Why Did The Loss of Physician-Scientists Occur?

Progressive language barriers between basic and clinical scientists-

Technologic complexity

A reductionist approach to medical sciences suggested that complex systems can be understood by reducing the study to the smallest, individual, analyzable part Today “Systems Biology” provides a link between basic

science, clinical research and medical practice Schafer AI, Translational Research 155: 1-2, 2010.

+ The Cultural Chasm

Motivated by need for immediate action

Taught to adhere to Standards and Practice Guidelines

Respect hierarchy and expert authority

Errors are potentially mortal threats

Focus on the unique

Conditioned to avoid rushing to judgment

Taught to challenge existing paradigms

Critique and challenge accepted wisdom

Errors are a result of creative process

Look for generalizable principles

Physicians Basic Scientists

+ Gender Issues

Equivalent numbers of men and women graduate from medical school today

No increase of women in senior faculty and leadership positions Concerns regarding the challenges of a

medical research career with family life Concerns that women must be better then male

counterparts to be considered equal Few role models and little encouragement to

become physician-scientists Schafer AI, Translational Research 155: 1-2, 2010.

+ The Under-Represented Minority: Where Have All The Young Girls Gone? Howard Hughes Medical Research Institute (HHMI): less

then 2% are women with MD degrees (24% are men with MD degrees)

American Society for Clinical Investigation: less then 12% are women and less then 4% of emeritus and senior members are women (1 of 94 past presidents were women) Andrews, N, C., Nature Medicine 8, 439 - 441 (2002)

Flexible promotion systems that resemble corporate lattices rather than ladders will have a

competitive advantage for recruiting and retaining physician scientists

+ The Generation Gap

Different life priorities Work-life balance and controllable lifestyles

thought to be incompatible with research careers

Erosion in the quantity and quality of effective mentoring Mentor-mentee format

Schafer AI, Translational Research 155: 1-2, 2010.

+ Determine Your Nitch: Are you the Star or a Team Player?

? Can you be both a Star and a Team Player???

+ Research is a Team Sport

M.D.

PhD M.D.

PhD

Trainees Techs

Trainees Techs

M.D. PhD

Trainees Techs

There are many possible models

for the Team Leadership

+

Trainee Success Stories

+ Kirk Lo, M.D. (Urologist) Professor, U. Toronto School of Medicine

American Foundation for Urologic Disease Scholar and Canadian Urologic Association Scholarship

Staff Urologist, Professor, Surgeon Investigator, Mount Sinai Hospital, University of Toronto

Fertility Preservation Research and Semen Proteomic Analysis Funding NIH R01 A Novel Testicular Germ Cell Maturation

Model for Fertility Preservation in Pre-Puberal Boys

Physician Service Incorporated Foundation The Star

M.D.

PhD

Trainees Techs

+ Joseph Alukal, M.D. Asst. Professor Urology, NYU

American Urological Association Foundation Scholar

National Institutes of Health Loan Repayment Award for Research in Contraception and Male Infertility

Asst. Professor of Urology, NYU

Director of Reproductive Health and Benign Diseases of the Prostate

Co-Host of the “Men’s Health” show on Sirius Satellite Radio’s “Doctor Radio”

Collaborator (Team Player)

M.D.

PhD

Trainees Techs

+ Kathleen Hwang, M.D. Asst. Professor, Brown U, Rhode Island Hospital

Assistant Professor of Surgery (Urology) and Assistant Professor of Pathology and Laboratory Medicine

Elizabeth Pickett, MD Research Award, Society of Women in Urology, AUA

K12 Multidisciplenary Urologic Research Career Development Program Scholar

American Medical Women’s Association Award- Glasgow-Rubin Achievement Award

ASRM Research Grant Recipient.

Rising Star

M.D.

Trainees Techs

+ Richard Link, M.D., Ph.D. Assoc. Professor, Baylor College of Medicine

Professor of Urology (promotion in process)

Board-certified and fellowship-trained urologist specializing in the treatment of urologic disease affecting the kidney, ureter, and prostate.

Focuses on the use of laparoscopic, robotic-assisted, percutaneous, and endoscopic techniques to treat kidney tumors, renal and ureteral obstruction, and urinary tract stones.

Directs the BCM Division of Endourology and Minimally Invasive Surgery

Clinical Star- Rising Research Star

Busy, Successful

Clinician M.D., Ph.D.

Trainees Techs

New Research Investigator M.D., Ph.D.

20 Years After Graduate School at Stanford U.

+ Larry I. Lipshultz, M.D., Professor of Urology and Lester and Sue Smith Chair in Reproductive Medicine, Chief, Division of Male Reproductive Medicine and Surgery and Dolores J. Lamb, Ph.D., Professor of Urology and Molecular and Cellular Biology, Lester and Sue Smith Chair in Urologic Research, Director, Center for Reproductive Medicine, Vice-Chairman for Research, Scott Department of Urology

M.D. PhD

Trainees Techs

+ Take Home Message If you have the passion for research… Enjoy the thrill of discovery The satisfaction of advancing our field every day The creativity to think outside of the box The need to compete

The desire to be the “architect rather then the carpenter”

The love of writing, teaching, mentoring and presentation…

Then a career as a physician scientist is for you!

Trainee Trainee Trainee Mentors: Jeff Buch, M.D. Mark Sigman, M.D. Mike Coburn, M.D. Glenn Weitzman, M.D. Patrick O’Hollaran, M.D.

Marina Gvakharia, M.D., Ph.D. Richard Sutherland, M.D. Adel Essen, M.D. Tatiana Sheiko, Ph.D. Sarmistha Mukherjee, Ph.D.

Gerry Spotts, Ph.D. Dino DiConchini, M.D. John Houston, M.D. William Lin, M.D. Lei Chu, M.D.

Barbara M. Sanborn, Ph.D. Roy G. Smith, Ph.D. Larry Lipshultz, M.D. Arnold Belker, M.D.

Els Berns, Ph.D. Shubhada Sankararaman,Ph.D. Mounia Tannour-Louet, Ph.D.

Benjamin Tripp, M.D. Margaret Vereb, M.D. John S. Wiener, M.D. Shuo Han Alex Ridgeway

Edward Schatte, M.D. Jennifer Abidari, M.D. Michael Lewitton, M.D. Maurice Garcia, M.D. Jose Garcia, M.D.

David W. Bullock, Ph.D. John K. Hampton, Jr, Ph.D. Emil Steinberger, M.D.

Susan Marengo, Ph.D. Liang Ming Lee, M.D. Mohamed Salama, M.D. Aaron Bayne, M.D.

Thomas F. Kolon, M.D. William Huang, M.D. Edward D. Kim, M.D. Michael Hsieh, M.D., Ph.D.

Lixin Zhang, M.D., Ph.D. Laura Chelu, M.D. Joan Blanco, Ph.D. Abhi Seth, M.D.

Anna Steinberger, M.D. Eugene Carlton, M.D. Peter Scardino, M.D.

J. Lynn Teague, M.D. Maurus Glinz, M.D. Sang Kon Lee, M.D. Kirk C. Lo, M.D. Kathleen Hwang, M.D. Julie Stewart, M.D.

Chang So Kim, M.D. David Cozzolino, M.D. Sergio G. Moreira, M.D. Francesca Gordon, Ph.D. John Weedin, M.D. Shaye Lewis, Ph.D.

Natan Bar-Chama, M.D. Semih Ozkan, M.D. Steven King, Ph.D. Weber Chuang, M.D. Maria Rosa Maduro, Ph.D. Shannon Whirledge, Ph.D.

Edmond Gonzales, M.D. Bert O’Malley, M.D. Timothy Boone, M.D., Ph.D.

Madelyn Holzman, M.D. Craig Niederberger, M.D. Se Joong Kim, M.D. Meade Haller Arron Bayne, M.D. Sean Corbett, M.D.

Roberto Casella, M.D. Rodrigo Pagani, M.D. Eric A. Jones, M.D. Dung Quoc Pham, M.D. Ates Kadioglu, M.D. Rose Khavari, M.D.

Victor Trey Brugh, M.D. Joseph Hicks, M.D. Stefania Mariana, M.D. Alex Pastuszak, M.D, Ph.D. Jason Kovac, M.D., Ph.D. Ranjith Ramaswamy, M.D.

Alex Ridgeway. MS Lissette Gomez Sophie Fletcher, M.D. Adam Szafram, M.D., Ph.D. Mir Reza Bekhernia, M.D. Carolina Jorgez, Ph.D.

Past Fellows Who are In Leadership Positions Today: Michael Coburn, M.D., Chair of Urology Baylor College of Med. Adel Essen, M.D., Chair of Urology, Iszmir University School of Med William Huang, M.D. Chair of Urology Taipei Memorial U. Hospital Ates Kadioglu, M.D. Chair of Urology, University of Istanbul Andy Meachum, M.D. Chair of Urology, U. Colorado Craig Niederberger, M.D. Chair of Urology at UIC (co-Editor in Chief, Fertility and Sterility, SMRU Past-President, ASRM Program Chair ) Mark Sigman, M.D. Chair of Urology, Brown (SSMR, SMRU, SRS President, Editorial Editor, Fertility and Sterility) John Weiner, M.D. Past-Chair of Urology, U. Miss Shahrokh Shariat, M.D. Chair of Urology U. Vienna Edward Kim, M.D. (SMRU, SSMR Past-President) Kirk Lo, M.D. (ASRM Annual Meeting Post-Graduate Chair) Robert Oates, M.D. (SSMR, SRMU President, ASRM Annual Meeting Program Chair)