réponse non spécifique ou innée (2h) les cellules natural killers et leurs déficits (1h) :...
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Réponse non spécifique ou innée (2h)Les cellules Natural Killers et leurs déficits (1h) :
Cellules NK & Immunité Innée
Part I. Innate Immunity
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Echinodermata
Urochordata
Vertebrata
ChondrichtyesMammalia
Chordata
MHC +TCR +NK cells +Complement system +Complement receptors (SCR) +
MHC -TCR -NK cell receptors +Complement (Bf,C3, C6-C9) +Complement receptors (SCR) +
Agnatha
CionaBotryllusHalocynthia
Petromyzon
innate+ adaptiveimmunity
innate immunity only
Cephalochordata
MHC
NK receptors-570 myr
-525 myr
Innate + adaptive immunity
Innate immunity only
From Thomas C. G. Bosch (Kiel)
Histoire d’une découverte
« The dirty little trick »
A paradigm:Self vs. Non-self
« The structure of scientific revolutions » Thomas S. Kuhn 1962
- « Their achievement was sufficiently unprecedented to attract an enduring group of adherent away from competing modes of scientific activity »
- « Simultaneously, it was sufficiently open-ended to leave all sorts of problems for the redefined group of practitioners to resolve »
Paradigm shift:
Une expérience simple
Cold Spring Harb Symp Quant Biol. 1989;54 Pt 1:1-13.
Approaching the asymptote? Evolution and revolution in immunology.
Insects have an open circulatory system
BrainBrainGutGut
Dorsal blood Dorsal blood vesselvessel
Nervous chainNervous chain
Hematopoietic Hematopoietic tissuestissues
VirusesVirusesBacteriaBacteria
FungiFungi
ProtozoaProtozoa
Induction of antimicrobial activity by immune challenge
Injection of bacteriaInjection of bacteria
ControlControl
AntimicrobialAntimicrobialactivity in the activity in the
cell-free cell-free hemolymphhemolymph
Time (h) Time (h) 0 0 6 6 9 9 1212 24 24 48 48 3 3