Digestive, Kidney and Urological Sciences

Reorganization of DKUS IRG.

2

• CONVERT A SUCCESSFUL RECURRENT SEP TO A CHARTERED STUDY SECTION

• CONVERT A CHARTERED STUDY SECTION WITH VERY LOW WORKLOAD TO A RECURRENT SEP.

NO NET CHANGE IN NUMBER OF CHARTERED STUDY SECTIONS

SUMMARY

– CSR Agreement to run a test SEP focused on environmental health and toxicology for three Council rounds (2009) and then evaluate the review outcomes.

– Although SIEE was successful, CSR terminated the SEP and assigned environmental health and toxiology applications to 4 other study sections

– Working Group meeting (2012) recommended Chartering SIEE.

– SIEE was reconstituted as a recurrent SEP in 2012 for further testing and analysis

Recurrent SEP - Systemic Injury from Environmental Exposure (SIEE) :

CHERYL L WALKER (Chair) UNIVERSITY OF TEXASDAVID C CHRISTIANI HARVARD UNIVERSITYGWEN COLLMAN NIEHSILA COTE EPAJOSEPH H GRAZIANO COLUMBIA UNIVERSITYJOHN D GROOPMAN JOHNS HOPKINS UNIVERSITYF PETER GUENGERICH VANDERBILT UNIVERSITYRONALD N HINES MEDICAL COLLEGE OF WISCONSINDEBRA LYNN LASKIN RUTGERS UNIVERSITYPAUL J LIOY UMDNJSTEPHEN B PRUETT MISSISSIPPI STATE UNIVERSITYALVARO PUGA UNIVERSITY OF CINCINNATIKENNETH S RAMOS UNIVERSITY OF LOUISVILLESTEPHEN H SAFE TEXAS A AND M UNIVERSITYMARTYN T SMITH UNIVERSITY OF CALIFORNIA-BERKELEY

Environmental Health Toxicology Workgroup

Council Round TOTAL R01s %ES

Jan-09 54 42 76May-09 62 47 77Oct-09 60 45 60May-13 92 50 96Oct-13 45 24 83Jan-14 84 47 89

May-14 72 47 89Oct-14 71 41 83AVERAGE 68 43 82

Application Numbers in SIEE SEP

Chapman, Eli Stress response, p97, and Nrf2 in arsenic-mediated toxicity

University Of Arizona Phipps, Richard P. Environmental obesogens reduce Thy1 expression and University Of Rochester promote obesity

Totah, Rheem Angela Role of Cyp2J2 in Xenobiotic Induced Qt-Prolongation University of Washington

Li, Yong Convergence of MicroRNAs and P53 Signaling in Multiple

University Of Louisville Myeloma: Environmental Cofactors

Gilbert, Kathleen M Determining How Trichloroethylene Alters Cd4+ Arkansas Children's Hospital T Cell Function

Pestka, James J Trichothecene Toxicity and the Ribotoxic Stress Response

Michigan State University

Examples of Awarded Grants from SIEE

2012 05 2012 10 2013 01 2013 05 2013 10 2014 01 2014 050

20

40

60

80

100

120

EFFECT OF SIEE ON RELATED SRGs

SIEELIRRLCMIXNDAIII

ROUND

APPLICATI

ONS

EFFECT OF SIEE ON RELATED SRGs

• History of low application numbers• Difficulty in reviewer recruitment• General agreement not to merge with kidney

based study sections (Community groups and NIDDK staff

• Agreement from NIDDK Program staff to convert to a recurrent SEP

Urologic and Genitourinary Physiology and Pathology (UGPP)

Council Round TOTAL R01s %DK

Oct-12 32 21 67Jan-13 47 32 81May-13 39 24 71Oct-13 39 24 83Jan-14 44 24 85May-14 43 26 69

Application Numbers in UGPP

• Convert SIEE to a Chartered Study Section• Convert UGPP to a Recurrent SEP• Continue to monitor SIEE and related study

sections for any problems• Continue to work with the Urology research

community to find ways to encourage greater participation

PROPOSAL

PTHE - 100% NIAIDBACP - 98% NIAIDVIRA - 90% NIAIDVIRB - 95% NIAIDCRFS - 90% NIAIDDDR - 97% NIAID

KMBD - > 90% NIDDKPBKS - 82% NIDDKCIMG - 77% NIDDKVB - 100% NIAIDHIBP - 90% NIAID

IMM IRG > 85% NIAID

Degree of IC capture of other SRGs in DPPS