Regenerative Medicine Selected Bibliography

Journal Articles

(2016) Blaschczok, Katharina; Steiger, Nina; Jurkiewicz, Elke; Husemann, Ute; Faulstich, Franziska; Eibl, Regine; Greller, Gerhard: Evaluating New Film for Single-Use Bags: Growth Performance Studies with Animal and Human Cells.

In Bioprocess International 14 (Suppl 1).

(2016) Buclez, Pierre-Olivier; Dias Florencio, Gabriella; Relizani, Karima; Beley, Cyriaque; Garcia, Luis; Benchaouir, Rachid: Rapid, scalable, and low-cost purification of recombinant adeno-associated virus produced by baculovirus expression vector system.

In Molecular therapy. Methods & clinical development 3, p. 16035. DOI: 10.1038/mtm.2016.35.

(2016) Jossen, Valentin; Schirmer, Cedric; Mostafa Sindi, Dolman; Eibl, Regine; Kraume, Matthias; Portner, Ralf; Eibl, Dieter: Theoretical and Practical Issues That Are Relevant When Scaling Up hMSC Microcarrier Production Processes.

In Stem cells international 2016, p. 4760414. DOI: 10.1155/2016/4760414.

(2016) Nienow, Alvin W.; Hewitt, Christopher J.; Heathman, Thomas R.J.; Glyn, Veronica A.M.; Fonte, Gonçalo N.; Hanga, Mariana P. et al.: Agitation conditions for the culture and detachment of hMSCs from microcarriers in multiple bioreactor platforms.

In Biochemical Engineering Journal 108, pp. 24–29. DOI: 10.1016/j.bej.2015.08.003.

(2015) Chan, Lesley; Prowse, Andrew; Zandstra, Peter W.; Timmins, Nicholas: Aggregate-based human pluripotent stem cell manufacturing with the ambr®15 platform.

In Cytotherapy 17 (6), S69-S70. DOI: 10.1016/j.jcyt.2015.03.544.

(2015) Chen, Allen Kuan-Liang; Chew, Yi Kong; Tan, Hong Yu; Reuveny, Shaul; Weng Oh, Steve Kah: Increasing efficiency of human mesenchymal stromal cell culture by optimization of microcarrier concentration and design of medium feed.

In Cytotherapy 17 (2), pp. 163–173. DOI: 10.1016/j.jcyt.2014.08.011.

(2015) Silva, Ana Carina; Simao, Daniel; Kuppers, Claudia; Lucas, Tanja; Sousa, Marcos F. Q.; Cruz, Pedro et al.: Human amniocyte-derived cells are a promising cell host for adenoviral vector production under se-rum-free conditions.

In Biotechnology journal 10 (5), pp. 760–771. DOI: 10.1002/biot.201400765.

(2014) Fenge, Christel; Jurkiewicz, Elke; Husemann, Ute; Adams, Thorsten; Delaunay, Lucy; Greller, Gerhard; Barbaroux, Magali: Consistently Superior Cell Growth. Achieved with New Polyethylene Film Formulation.

In Bioprocess International Volume 12 Suppl 5.

(2014) Hupfeld, Julia; Gorr, Ingo H.; Schwald, Christian; Beaucamp, Nicola; Wiechmann, Kornelius; Kuentzer, Karin et al.: Modulation of mesenchymal stromal cell charac-teristics by microcarrier culture in bioreactors. In Biotechnology and bioengineering 111 (11), pp. 2290–2302. DOI: 10.1002/bit.25281.

(2014) Schirmaier, Carmen; Jossen, Valentin; Kaiser, Stephan C.; Jüngerkes, Frank; Brill, Silke; Safavi-Nab, Agnieszka et al.: Scale-up of adipose tissue-derived mesenchymal stem cell production in stirred single-use bioreac-tors under low-serum conditions. In Eng. Life Sci. 14 (3), pp. 292–303. DOI: 10.1002/elsc.201300134.

(2014) Weymann, Alexander; Patil, Nikhil Prakash; Sabashnikov, Anton; Jungebluth, Philipp; Korkmaz, Sevil; Li, Shiliang et al.: Bioartificial heart: a human-sized porcine model--the way ahead.

In PloS one 9 (11), e111591. DOI: 10.1371/journal.pone.0111591.

(2013) Glen, Katie E.; Workman, Victoria L.; Ahmed, Forhad; Ratcliffe, Elizabeth; Stacey, Adrian J.; Thomas, Robert J.: Production of erythrocytes from directly isolated or Delta1 Notch ligand expanded CD34+ hematopoi-etic progenitor cells: process characterization, monitoring and implications for manufacture.

In Cytotherapy 15 (9), pp. 1106–1117. DOI: 10.1016/j.jcyt.2013.04.008.

(2013) Goh, Tony Kwang-Poh; Zhang, Zhi-Yong; Chen, Allen Kuan-Liang; Reuveny, Shaul; Choolani, Mahesh; Chan, Jerry Kok Yen; Oh, Steve Kah-Weng: Microcarrier culture for efficient expansion and osteogenic differentiation of human fetal mesenchymal stem cells.

In BioResearch open access 2 (2), pp. 84–97. DOI: 10.1089/biores.2013.0001.

(2013) Jossen, Valentin; Kaiser, Stephan C.; Schirmaier, Carmen; van den Bos, Christian; Eibl, Dieter; Eibl, Regine: Investigations of fluid flow and microcarrier sus-pension for hMSC expansion in single-use stirred bioreactors. BioTech, Single-Use Technology in Biopharma-ceutical Manufacturing, Wädenswil, Switzer-land.

(2013) Rafiq, Qasim A.; Brosnan, Kathryn M.; Coopman, Karen; Nienow, Alvin W.; Hewitt, Christopher J.: Culture of human mesenchymal stem cells on mi-crocarriers in a 5 l stirred-tank bioreactor. In Biotechnology letters 35 (8), pp. 1233–1245. DOI: 10.1007/s10529-013-1211-9.

(2012) Galvez, J.; Lecina, M.; Sola, C.; Cairo, J. J.; Godia, F.: Optimization of HEK-293S cell cultures for the pro-duction of adenoviral vectors in bioreactors using on-line OUR measurements. In Journal of biotechnology 157 (1), pp. 214–222. DOI: 10.1016/j.jbiotec.2011.11.007.

Regenerative Medicine Selected Bibliography

(2012) Ratcliffe, E.; Glen, K. E.; Workman, V. L.; Stacey, A. J.; Thomas, R. J.: A novel automated bioreactor for scalable process optimisation of haematopoietic stem cell culture. In Journal of biotechnology 161 (3), pp. 387–390. DOI: 10.1016/j.jbiotec.2012.06.025.

(2012) Timmins, N. E.; Kiel, M.; Gunther, M.; Heazlewood, C.; Doran, M. R.; Brooke, G.; Atkinson, K.: Closed system isolation and scalable expansion of human placental mesenchymal stem cells. In Biotechnology and bioengineering 109 (7), pp. 1817–1826. DOI: 10.1002/bit.24425.

(2011) Spanholtz, Jan; Preijers, Frank; Tordoir, Marleen; Trilsbeek, Carel; Paardekooper, Jos; Witte, Theo de et al.: Clinical-grade generation of active NK cells from cord blood hematopoietic progenitor cells for immu-notherapy using a closed-system culture process.

In PloS one 6 (6), e20740. DOI: 10.1371/ journal.pone.0020740.

(2011) Timmins, Nicholas E.; Athanasas, Stavrosia; Gunther, Marko; Buntine, Penelope; Nielsen, Lars K.: Ultra-high-yield manufacture of red blood cells from hematopoietic stem cells. In Tissue engineering. Part C, Methods 17 (11), pp. 1131–1137. DOI: 10.1089/ten.TEC.2011.0207.

(2010) Serra, Margarida; Brito, Catarina; Sousa, Marcos F. Q.; Jensen, Janne; Tostoes, Rui; Clemente, Joao et al.: Improving expansion of pluripotent human embryonic stem cells in perfused bioreactors through oxygen control. In Journal of biotechnology 148 (4), pp. 208–215. DOI: 10.1016/j.jbiotec.2010.06.015.

(2009) Timmins, Nicholas E.; Palfreyman, Emma; Marturana, Flavia; Dietmair, Stefanie; Luikenga, Sanna; Lopez, Genghis et al.: Clinical scale ex vivo manufacture of neutrophils from hematopoietic progenitor cells. In Biotechnology and bioengineering 104 (4), pp. 832–840. DOI: 10.1002/bit.22433.

(2016) Toueille, Magali: Pre-Industrial Manufacturing of Lentiviral Vectors by Transient Transfection in Single Use Systems. Genethon. Cell Therapy Manufacturing & Gene Therapy Congress. Brussels, Belgium, 2/4/2016.

(2015) Chan, Lesley; Panchalingam, Krishna; Prowse, Andrew; Zandstra, Peter W.; Timmins, Nicholas E.: Aggregate-based human pluripotent stem cell (hPSC) manufacturing with the ambr®15 platform. Sartorius Stedim Biotech, Centre for Commer-cialization of Regenerative Medicine.

(2014) Prowse, Andrew; Chatha, Sukhmani; Norman, Andreea; Chan, Lesley; Keller, Gordon; Zandstra, Peter; Timmins, Nick: hPSC Derived Cardiomyocyte Therapy for Heart Related Disorders: Process Optimization and Defining the Product Profile. Centre for Commercialization of Regenerative Medicine, Sartorius Stedim Biotech.

(2014) Swihart, JoAnne; Bure Kim; Drake, Rosemary; Zoro, Barney: Novel Platform Technology for Scale Down and Process Optimisation for Regenerative Medicine. Sartorius Stedim Biotech, Centre for Commer-cialization of Regenerative Medicine.

(2013) Schirmaier, Carmen; Kaiser, Stephan C.; Jossen, Valentin; Brill, Silke; Jüngerkes, Frank; van den Bos, Christian et al.: Expansion of mesenchymal adipose-tissue derived stem cells in a stirred single-use bioreactor under low-serum conditions.

23rd European Society for Animal Cell Tech-nology (ESACT) Meeting: Better Cells for Better Health.

(2013) Steiger, Nina; Imseng, Nicole; Schirmaier, Carmen; Jurkiewicz, Elke; Husemann, Ute; Eibl, Regine; Greller, Gerhard: Towards a standardized biological test for the identification of cell growth influencing leachables. Zurich University of Applied Sciences, Sartorius Stedim Biotech GmbH. European Society for Animal Cell Technology (ESACT) Meeting, Lille, France.

(2016) Nienow, A. W.; Coopman, K.; Heathman, T.R.J.; Rafiq, Q. A.; Hewitt, C. J.: Bioreactor Engineering Fundamentals for Stem Cell Manufacturing.

In Joaquim S. Cabral (Ed.): Stem cell manufacturing: Elsevier, pp. 43–75.

(2016) Rafiq, Qasim A.; Heathman, Thomas R. J.; Coopman, Karen; Nienow, Alvin W.; Hewitt, Christopher J.: Scalable Manufacture for Cell Therapy Needs: John Wiley & Sons.

In Biotechnology Letters; August 2013, Volume 35, Issue 8, pp 1233–1245

(2014) Jossen, Valentin; Pörtner, Ralf; Kaiser, Stephan C.; Kraume, Matthias; Eibl, Dieter; Eibl, Regine: Mass Production of Mesenchymal Stem Cells – Im-pact of Bioreactor Design and Flow Conditions on Proliferation and Differentiation.

In Daniel Eberli (Ed.): Cells and biomaterials in regenerative medicine. Rijeka, Croatia: InTech Europe.

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