real-time monitoring technology of mass spectrometry
DESCRIPTION
Real-time Monitoring technology of Mass spectrometry. Speaker : Achong. Outline. IMS PTR-MS SIFT-MS Application of IMS IMS-TOF IMS-IMS-TOF Application of PTR-MS PIT-MS. Real-time Monitoring Mass spectrometry. Environmental science Biochemical and medical diagnosis - PowerPoint PPT PresentationTRANSCRIPT
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Real-time Monitoring technology of Mass spectrometry
Speaker : Achong
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Outline
IMS
PTR-MS
SIFT-MS
Application of IMS
IMS-TOF
IMS-IMS-TOF
Application of PTR-MS
PIT-MS
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Real-time Monitoring Mass spectrometry
Environmental science
Biochemical and medical diagnosis
Workplace safety
Security check
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EI source
Analysis of atmospheric air is especially challenging using electron ionization mass spectrometry, because the gas loading of the ion source by N2 and O2 (as well as water vapor) can be excessive.
70 ev
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Real-time Monitoring MS
Soft chemical ionization
Measurement in Real-Time
Without pre-concentration system
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I. IMS (ion mobility spectrometer)
Ion mobility mass spectrometry (Eiceman,1991; Baumbach, 2001)
Analytical Chemistry, A390-A397, November 1, 2004
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Ion mobility (K)
Journal of Bimolecular Technique, Vol.13, Issue 2, June, 2002
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Ion Mobility-Mass Spectroscopy
Witt & Bowers: JACS. 2000, 122, 3458.
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Ion mobility mass spectrometry
Advantages:Multiform ion source could be applied.Some isomer could be separated.Real-time measurement
Disadvantages:Lower mass resolutionLower sensitivity to allow accurate analysis of complex mixtures.Standard is requisite
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II. PTR-MS (proton-transfer reaction)
Proton-transfer reaction-mass spectrometry (Lagg A, Taucher J, Hansel A, Lindinger W. 1994.)
http://info.uibk.ac.at/c/c7/c722/umwelt/html/animation.html
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proton-transfer reaction
H3O+ + R → RH+ + H20
[RH+]
= [H3O+]o(1 - e-k[R]t)
= [H30+]o[R]kt
J. Mass Spectrom Ion Processes, 173 (1998) 191-241
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J. Mass Spectrom Ion Processes, 173 (1998) 191-241
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J. Mass Spectrom Ion Processes, 173 (1998) 191-241
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PTR mass spectrometry
Advantages:Soft ionization and low matrix effectReal-time measurementLow limit of detection (0.5 ppbv for 1-min measurements)
Disadvantages:A large number of VOCs could not be identified and
quantified.
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III. SIFT-MS (selected ion flow tube)
http://www.syft.com/
Adams NG, Smith D. 1976. Spanel P ,Smith D. 1995.
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SIFT mass spectrometry
Advantages:application of multiple reagent ions (H3O+, NO+ and O2+)quantification in real-time discriminate isomers in Real-Time
Disadvantages:The kinetic parameters of the reagent ion and the analyte ion must be known.
Selected ion flow tube mass spectrometry for no-line trace gas analysis David Smith and Patrik SpanelReference : Mass Spectrometry Reviews, 2005, 24, 661– 700
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Application of IMS
IMS/TOF
IMS/IMS/TOF
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Ion Mobility/TOFMS
Anal. Chem. 2003, 75,6202-6208
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Pulse sequence of IMS & TOF
Anal. Chem. 2003, 75,6202-6208
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example spectrum
Analytical Chemistry, 1998 Vol. 70, No. 11, June 1,
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Anal. Chem. 2003, 75,6202-6208
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collision-induced dissociation
http://proteomics.med.ncku.edu.tw/proteomicsweb/Liao_94_1007.ppt
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IMS/IMS/TOF
Anal. Chem. 2006, 78,4161-4174
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operational mode A
Anal. Chem. 2006, 78,4161-4174
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operational mode B
Anal. Chem. 2006, 78,4161-4174
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operational mode C
Anal. Chem. 2006, 78,4161-4174
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Application of PTRMS
PIT-MS
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PIT-MS
http://cires.colorado.edu/~gouw/Instruments/PITMS/PITMS.html
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PIT-MSproton-transfer ion trap-mass spectrometry
J Am Soc Mass Spectrom 2005, 16, 1316–1324
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CID process on ion-trap MS
http://www.chem.agilent.com/cag/Other/IonTrap_fig2.gif
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calibration measurement of the PIT-MS
J Am Soc Mass Spectrom 2005, 16, 1316–1324
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single CID measurement of m/z 59
ambient air pure acetone pure propanal
J Am Soc Mass Spectrom 2005, 16, 1316–1324
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CID of propanal and acetone
m/z=59 m/z=41 m/z=31
J Am Soc Mass Spectrom 2005, 16, 1316–1324