radiation therapy in wilms tumour
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31st July 2010
Radiation therapy in Wilms Tumor
Dr. Lokesh Viswanath M.DProfessor, Department of Radiation
OncologyKidwai Memorial Institute of Oncology
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Radiation Therapy Wilms Tumors - high sensitivity – ionizing
radiation
1940`s (all stages) 5yr survival Surgery alone : 15-20% Post OP RT : 47%
1970`s CT - Distant relapses
typically - large T size at presentation propensity for metastasis (hematogenous)
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Roles of Radiotherapy Historical
Definitive radiation therapy Contemporary
Preoperative Radiation Flank Whole Abdomen
Postoperative Radiation Flank Whole Abdomen Lung bath
Treatment of recurrence Abdomen (localized abdominal recurrence)
Treatment of metastasis Lung Brain Bone Liver Lymph nodes
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Indications Multimodality, stage and risk adapted
approach is the standard of care Radiation therapy is now a days indicated in
a selected few to eliminate the risk of local recurrence
RT Management varies according to: Age of patient (avoided in < 6 months infants /
<2yrs FH) Preoperative extent on imaging Operative stage Post operative histology
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RT - Indications : Post OP RT
WT - Favourable Histology Stage III:
residual T Gross/Micro +ve Margin Local Infiltration Vital Structures
Abd/Pelv -Ly N + peritoneal surface
Penetration Tumour implants T Spillage (pre / intro OP)
Bx – trucut, Bx, FNAC T removed in Pieces : eg - extn adrenal
, T thrombus in renal vein Standard Risk FH WT without LOH at
1p & 16q Higher Risk FH with LOH at 1p & 16q
Stage IV Rapid responders of lung metastasis at
week 6 on DD4A (Possibility of no-RT to rapid complete
responders on CT scan) Slow responders (lungs) & non-
pulmonary metastasis
WT Unfavourable Histology Anaplasia
Stage I – diffuse Stage II-IV – diffuse Stage I-IV - Focal
Clear cell CCSK Stage I-III Stage IV
Rhabdoid RTK Stage I -IV
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RT Technique
Timing of RT : not later than 9 days after surgery (max 14 days)
Delay of >10dys – significantly higher abdominal relapse rate , particularly UH.
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RT Machines
Telecobalt Linear Accelerator
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RT Techniques Flank RT Whole Abdomen RT (WAI):
Indicated – diffuse tumor spillage - Pre-OP / Intra OP Tumor Rupture Peritoneal T seeding Ascites +ve Cytology
Whole Lung RT Localized foci of lung disease persisting 2 weeks
after 12 Gy can be excised or given additional 7.5 Gy Treat both lungs regardless of the number or
location of visible metastases Patients with CT only pulmonary mets – at the
discretion of the treating institution
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General Principles : RT planning Pt position : Supine Immobilization: Vacuum Cushion Sedation / Anesthesia during RT / Simulation Simulation:
Simulator – X –Ray + IVP (to Exclude Opposite kidney) CT Simulation
Ensure – Anesthesia & Patient monitoring equipments in the RT Bunker
Opposed AP:PA fields Field Shaping : 3DCRT / Contouring Shielding opposite kidney & selected normal
structures Complete Vertebrae to be included in the RT field
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RT DoseStage III FH FLANK RT :
10.8Gy, 180cGy/fx
Stage I-III Focal anaplasia
Diffuse anaplasia
CCSKStage III Diffuse anaplasia
FLANK RT : 19.8Gy (Infants -10.8Gy), 180cGy/fxStage I-III RTK
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Whole Abdomen RT
FH 10Gy, 150cGy/Fx
Residual Boost
+ 10GyRenal Shielding / Limit the dose to remaining kidney <14.4Gy
Lung (mets.) FH / UH 12Gy WLI in 8#
Liver (mets.) 19.8Gy WLivI in 11#
Brain (mets.) 36.6Gy WB in 17#Or 21.6Gy WB + 10.8Gy IMRT /SRST Boost
Unresected Lymph nodes
19.8Gy in 11#
Bone (mets.) 25.2 Gy in 14#
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Flank Radiation Treatment Portal design :
Should encompass the tumor bed and the site of the excised kidney
2-3 cm margins should be given circumferentially
3D Plans: PreOP CT/MRI – CTV : kidney + Tumor with 1cms Margin
Field sizes ~ 10 x 10 / 12 x 12 cms Beam energy : 4-6 MV
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Treatment Fields - Flank
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Whole Abdomen Radiation Indicated in few patients now a days energy - 4-6 MV photons Shielding :
Opposite kidney : Posterior 5 HVL shield Acetabulum and femoral heads – both AP-PA shields
Superior border : dome of diaphragm (nipples) Inferior border : inferior border of the
obturator foramen( pubis symphysis ) Lateral border : to the lateral peritoneal
reflection
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Lung Irradiation Superior border : 3cm above the
middle 1/3 rd of clavicle Inferior border : ( below the
costophrenic angles) Below the xiphisternum / level of L1 (transpyloric plane)
Lateral borders : Lateral border of areola of nipple
Shielding humeral head larynx
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bilateral Wilms’
Dose to more than 1/3 of the contralateral kidney or residual kidney should not exceed 14.4 Gy
Inoperable Bilateral WT- role of Cyber Knife, Tomotherapy, Rapid Arc, True Beam, IMRT to be conscidered . PET based planning.
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Long-term results of NWTS-3 and -4
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Results – 4yrs – FH (NWTS 5)Stage RFS OS EFS
I 92% 98%
II 83% 92%
III 85.3% 93.9%
IV 74.6% Lung Mets,Pulm RT
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Results UH (NWTS 5) Diffuse Anaplasia 2 y
EFS Stage I 64.3 % Stage II 79.5% Stage III 62.7% Stage IV 33.6%
CCSK Stage I –IV 4y RFS
77.6% 6/9 Stage IV patients
relapsed
Rhabdoid Tumors Stage I 50% Stage II 33.3% Stage III 33.3% Stage IV 21.4 % Stage V 0%
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Conclusion WT at presentation is a large tumor and
has a high propensity for distant metastasis
However the prognosis is excellent with modern day Multimodality Management
Surgery with chemotherapy is the mainstay of treatment
Radiation therapy given judiciously can reduce recurrences and improve QOL
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Thank You