r graphics outputcistrome.org/mageckflute/demo/mageckflute/flutemle/... · 2018. 4. 24. · tada1...
TRANSCRIPT
−2
−1
0
1
2
Control
Treatment
Sample
Bet
a S
core
Negative control normalized
−2
−1
0
1
2
Control
Treatment
Sample
Bet
a S
core
Cell cycle normalized
0.0
0.5
1.0
1.5
−2 −1 0 1 2
Beta Score
Den
sity
Control
Treatment
Negative control normalized
0.0
0.5
1.0
1.5
2.0
−2 −1 0 1 2
Beta Score
Den
sity
Control
Treatment
Cell cycle normalized
0
1
2
3
4
−1.0 −0.5 0.0 0.5 1.0 1.5
Treat−Control Beta Score
Den
sity
Negative control normalized
0
1
2
3
4
−0.5 0.0 0.5 1.0
Treat−Control Beta Score
Den
sity
Cell cycle normalized
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−2 −1 0 1 2
−0.
50.
51.
0
Cell cycle normalized
A
M
Median: 0.00322IQR: 0.122
−2
−1
0
Control
Treatment
Sample
Ess
entia
l.B.S
.Negative control normalized
−2.0
−1.5
−1.0
−0.5
0.0
0.5
Control
Treatment
Sample
Ess
entia
l.B.S
.
Cell cycle normalized
0.00
0.25
0.50
0.75
1.00
−2 −1 0
Essential.B.S.
Den
sity
Control
Treatment
Negative control normalized
0.0
0.3
0.6
0.9
1.2
−2.0 −1.5 −1.0 −0.5 0.0 0.5
Essential.B.S.
Den
sity
Control
Treatment
Cell cycle normalized
−2
−1
0
1
2
−2 −1 0 1 2
Control
Bet
a S
core
Control
Treatment
Negative control normalized
−2
−1
0
1
2
−1 0 1 2
Control
Bet
a S
core
Control
Treatment
Cell cycle normalized
−2
−1
0
−2 −1 0
Control
Ess
entia
l.B.S
.
Control
Treatment
Negative control normalized
−2.0
−1.5
−1.0
−0.5
0.0
0.5
−1.5 −1.0 −0.5 0.0 0.5
Control
Ess
entia
l.B.S
.
Control
Treatment
Cell cycle normalized
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GroupA: 3138
GroupB: 2143−2
−1
0
1
2
−2 −1 0 1 2
Control beta.score
Trea
tmen
t bet
a.sc
ore
Negative control normalized
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GroupA: 2813
GroupB: 2471−2
−1
0
1
2
−1 0 1 2
Control beta.score
Trea
tmen
t bet
a.sc
ore
Cell cycle normalized
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SLC35E2
UBE2M CUL3
CFC1
NF1
SLC35E2B
GADD45GIP1
SULT1A2
TADA1
POP7
OR52E2
MED12
ITGB2
CCL21
ORM1
NF2
KLF5
TADA2B
NOTCH2MCL1
0
5000
10000
15000
−0.5 0.0 0.5 1.0 1.5
Treatment−Control Beta Score
Ran
k
Negative control normalized
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PDCL2
IFI27L1
SLC35E2
UBE2MMETTL2B
CUL3
CFC1
NF1
GADD45GIP1
SULT1A2
ZSWIM1
TADA1
OR52E2
MED12ZBTB11
ORM1
NF2
KLF5TADA2B
MCL1
0
5000
10000
15000
−0.5 0.0 0.5 1.0
Treatment−Control Beta Score
Ran
k
Cell cycle normalized
●NANA
6.25 6.50 6.75 7.00
−log10(Adjust.pvalue)
Count ● 26
KEGG: GroupA
●NANA
5.8 6.0 6.2 6.4 6.6
−log10(Adjust.pvalue)
Count ● 48
KEGG: GroupA
●●●●
●●●●●●
●●
●●●●●●●●Iron−sulfur cluster assembly
Regulation of TOR signalingNucleic acid phosphodiester bond hydrolysis
Peptidyl−lysine modificationSRP−dependent cotranslational protein targeting ...
Endosome organizationRegulation of RNA stability
Mitochondrial RNA metabolic processSelenium compound metabolic process
RNA localizationNegative regulation of protein ubiquitinationMitochondrial respiratory chain complex I ...
Mitochondrial respiratory chain complex I assemblyNADH dehydrogenase complex assembly
DNA−templated transcription, initiationDNA−templated transcription, elongation
Cellular respirationMulti−organism metabolic process
Mitochondrial translationNcRNA metabolic process
5 10 15 20
−log10(Adjust.pvalue)
Count ● ● ● ●40 80 120 160
BP: GroupA
●●●●●●●
●●●
●●●●●
●
●
●RNA modificationRegulation of TORC1 signaling
TORC1 signalingMitochondrial RNA metabolic process
Selenium compound metabolic processDNA−templated transcription, initiation
RNA localizationDNA−templated transcription, elongation
Ribosome biogenesisRNA catabolic process
Multi−organism metabolic processMitochondrial respiratory chain complex assembly
Mitochondrial respiratory chain complex I ...Mitochondrial respiratory chain complex I assembly
NADH dehydrogenase complex assemblyCellular respiration
NcRNA metabolic processMitochondrial translation
5 10
−log10(Adjust.pvalue)
Count ● ● ● ● ●25 50 75 100 125
BP: GroupA
●NANA
1.75 2.00 2.25 2.50
−log10(Adjust.pvalue)
Count ● 66
KEGG: GroupB
No enriched terms
KEGG: GroupB
No enriched terms
BP: GroupB
No enriched terms
BP: GroupB
Group A
Negative control normalized
Group A
Negative control normalized
No multi pathview figures
Group B
Negative control normalized
No multi pathview figures No multi pathview figures
Group B
Negative control normalized
Group A
Cell cycle normalized
Group A
Cell cycle normalized
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514
741
276972
−0.50
−0.25
0.00
0.25
0.50
−0.6 −0.4 −0.2 0.0 0.2 0.4
Control Beta Score
Trea
tmen
t Bet
a S
core
● ● ●
● ●
Group1 Group2 Group3
Group4 Others
Negative control normalized
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517
749
278969
−0.25
0.00
0.25
0.50
−0.4 −0.2 0.0 0.2
Control Beta ScoreTr
eatm
ent B
eta
Sco
re
● ● ●
● ●
Group1 Group2 Group3
Group4 Others
Cell cycle normalized
●NANA
2.4 2.6 2.8 3.0 3.2
−log10(Adjust.pvalue)
Count ● 20
KEGG: Group1
●NANA
2.6 2.8 3.0 3.2 3.4
−log10(Adjust.pvalue)
Count ● 20
KEGG: Group1
●●
●
●
●●
●Multivesicular body organization
RNA splicing
NcRNA metabolic process
Transcription elongation from RNA polymerase II ...
Mitochondrial RNA metabolic process
RNA localization
Mitochondrial translation
2 4 6 8
−log10(Adjust.pvalue)
Count ● ● ● ●10 20 30 40
BP: Group1
●●
●
●
●●
●Multivesicular body organization
RNA splicing
NcRNA metabolic process
Transcription elongation from RNA polymerase II ...
Mitochondrial RNA metabolic process
RNA localization
Mitochondrial translation
2 4 6 8
−log10(Adjust.pvalue)
Count ● ● ● ●10 20 30 40
BP: Group1
No enriched terms
KEGG: Group2
No enriched terms
KEGG: Group2
No enriched terms
BP: Group2
No enriched terms
BP: Group2
No enriched terms
KEGG: Group3
No enriched terms
KEGG: Group3
No enriched terms
BP: Group3
No enriched terms
BP: Group3
No enriched terms
KEGG: Group4
No enriched terms
KEGG: Group4
No enriched terms
BP: Group4
No enriched terms
BP: Group4
●NANA
1.0 1.2 1.4 1.6 1.8
−log10(Adjust.pvalue)
Count ● 20
KEGG: Group1&3
●NANA
1.0 1.2 1.4 1.6 1.8
−log10(Adjust.pvalue)
Count ● 20
KEGG: Group1&3
●
●RNA localization
Mitochondrial translation
2 3 4 5 6
−log10(Adjust.pvalue)
Count ● ● ● ● ●29.00 29.25 29.50 29.75 30.00
BP: Group1&3
●
●RNA localization
Mitochondrial translation
2 3 4 5 6
−log10(Adjust.pvalue)
Count ● ● ● ● ●29.00 29.25 29.50 29.75 30.00
BP: Group1&3
No enriched terms
KEGG: Group1&4
No enriched terms
KEGG: Group1&4
●Mitochondrial translation
3.6 3.8 4.0 4.2 4.4
−log10(Adjust.pvalue)
Count ● 32
BP: Group1&4
●Mitochondrial translation
3.4 3.6 3.8 4.0 4.2
−log10(Adjust.pvalue)
Count ● 32
BP: Group1&4
No enriched terms
KEGG: Group2&3
No enriched terms
KEGG: Group2&3
No enriched terms
BP: Group2&3
No enriched terms
BP: Group2&3
No enriched terms
KEGG: Group2&4
No enriched terms
KEGG: Group2&4
No enriched terms
BP: Group2&4
No enriched terms
BP: Group2&4
No enriched terms
KEGG: Group1&2&3&4
No enriched terms
KEGG: Group1&2&3&4
No enriched terms
BP: Group1&2&3&4
No enriched terms
BP: Group1&2&3&4
Group 1
Negative control normalized
Group 1
Negative control normalized
Group 1
Cell cycle normalized
Group 1
Cell cycle normalized
No multi pathview figures
Group 1 & Group 3
Negative control normalized
No multi pathview figures No multi pathview figures
Group 1 & Group 3
Negative control normalized
No multi pathview figures
Group 1 & Group 3
Cell cycle normalized
No multi pathview figures No multi pathview figures
Group 1 & Group 3
Cell cycle normalized