Questions for knowledge creators

richard j. bookmanrbookman@miami.edu

2012 Bootcamp Courseuniversity of miami12 September 2012

disclosures

• I have no financial interest in any of the content presented today.

• I have no direct experience in translational or clinical research

objectives

leave you with questions

How do you pick a problem?

Research is a human activity

http://www.stanford.edu/group/vista/cgi-bin/FOV/wp-content/uploads/2012/02/tables1.png

Which offer do you want?

Which offer do you want?

results

68%16%

32%84%

Dan Ariely, Predictably Irrational

Hypothesis-driven vs.

discovery-driven research

Let’s play a game

basic applied

fundamental

useful

?D.E. Stokes, Pasteur’s Quadrant, 1997

fundamental

useful

From G. Dyson, Turing’s Cathedral, 2012

the internet of things

big bang

the internet of things

big data

^

every

\

http://doi.ieeecomputersociety.org/10.1109/MIS.2009.36

research 3.0de

sign

spe

c

Terms of UseSee this page for info, including copyright

how are these trends playing out in clinical research ??

http://www.patientslikeme.com

http://www.pnas.org/content/105/6/2052

Methods

http://www.pnas.org/content/105/6/2052

http://www.nature.com/nbt/journal/v29/n5/full/nbt.1837.html

AbstractPatients with serious diseases may experiment with drugsthat have not received regulatory approval. Online patient communities structured around quantitative outcome datahave the potential to provide an observational environmentto monitor such drug usage and its consequences. Herewe describe an analysis of data reported on the website PatientsLikeMe by patients with amyotrophic lateral sclerosis (ALS) who experimented with lithium carbonate treatment.To reduce potential bias owing to lack of randomization, we developed an algorithm to match 149 treated patients to multiple controls (447 total) based on the progression of their disease course. At 12 months after treatment, we found no effect of lithium on disease progression. Although observational studies using unblinded data are not a substitute for double- blind randomized control trials, this study reached the same conclusion as subsequent randomized trials,

http://www.nature.com/nbt/journal/v29/n5/pdf/nbt.1837.pdf

http://artisopensource.net/cure/

Salvatore IaconesiFounder, Art is open source

“Patient engagement is the blockbuster drug of the 21st

century”Leonard Kish

http://www.hl7standards.com/blog/2012/08/28/drug-of-the-century/

summary

What problem do you want to work on?

How can you empower patients so as to accelerate discovery?

In a digitally enabled world, can you think of better ways to create useful knowledge?

Are you looking for black swans?

Have you fallen in love with your own ideas?

How does your own brain limit your ability to reason?