PYTHIOSISPYTHIOSIS

http://www.pythiosis.com/images/rusty1.JPG

What is it?!What is it?!

pythium insidiosumpythium insidiosum

Class OomyceteClass Oomycete Aquatic pathogenAquatic pathogen Not true fungiNot true fungi

http://www.mycology.adelaide.edu.au/images/pithium.gif

http://www.pf.chiba-u.ac.jp/gallery/img/fungi/p/Pythium_insidiosum_colonies.jpg

http://www.pythiosis.com/fieldtrial_files/image002.jpg

http://www.pf.chiba-u.ac.jp/gallery/img/fungi/p/Pythium_insidiosum_microscopy.jpg

Life CycleLife Cycle

In nature In nature

Infective process Infective process

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC266174/

Who gets it?Who gets it?

RarelyRarely CutaneousCutaneous G.I.G.I.

Increasing prevalenceIncreasing prevalence G.I.G.I. Rarely cutaneousRarely cutaneous

Cutaneous Cutaneous

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http://lh6.ggpht.com/_yElYiq7gRbk/RyfBMDU6W3I/AAAAAAAAAdM/PoYIiiBBa7k/IMG_0582.JPG

http://msnbcmedia.msn.com/j/ap/4f71e2f6-c001-46ad-afee-e7cf6dab8b4e.hlarge.jpg

What does it look like?What does it look like?

http://school.discoveryeducation.com/clipart/images/look---.gif

http://pythium.pavlab.com/images/Cat%20leg.jpg

http://pythium.pavlab.com/images/cat%20abdomen.jpg

http://pythium.pavlab.com/images/Dog%20leg%20pythiosis.jpg

http://pythium.pavlab.com/images/dog%20pythiosis.jpg

http://pythium.pavlab.com/images/respiratory.jpg

http://www.ecmagazine.net/spring2008/photos/pythiosis1.jpg

http://pythium.pavlab.com/images/horse%20neck%20leg.jpg

http://www.userltriangle.org/Cisco%20June%2019,%202007%20-%20pic%201.jpg

http://www.scielo.br/img/fbpe/pvb/v21n4/7481f3.jpg

http://img.tfd.com/vet/thumbs/gr297.jpg

http://upload.wikimedia.org/wikipedia/commons/thumb/b/b9/Pythiosis_2.jpg/120px-Pythiosis_2.jpg

http://bld.msu.edu/images/bonepith.jpg

http://www.merckvetmanual.com/mvm/htm/bc/genfg30.htm

http://www.scielo.br/img/revistas/pvb/v29n11/a13fig01.gif

What about intestinal What about intestinal pythiosis?pythiosis?

Anywhere Anywhere Thickening (U/S & Barium)Thickening (U/S & Barium) Granulomatous + hyphaeGranulomatous + hyphae Clinical signs vagueClinical signs vague

How will I diagnose this?How will I diagnose this?

Non-healing granulomatous cutaneous Non-healing granulomatous cutaneous lesionslesions

Fungal cultureFungal culture PCRPCR Serum ELISASerum ELISA

treatment optionstreatment options

Surgical resection Surgical resection +/- Itraconazole+/- Itraconazole Immunotherapy in horses (and dogs?)Immunotherapy in horses (and dogs?) Early diagnosis KEYEarly diagnosis KEY

What is it?

Necrotic and purulent foci within the sole of the hoof

Clinical signs: Acute Severe lameness Pointing toe Blocks sound Positive to hoof testers Increased digital pulse +/- fever Draining tracts

What causes it?What causes it?

Puncture wounds (big hole vs little hole)Puncture wounds (big hole vs little hole)

http://www.foxtailforge.com/images/abscess_1.jpg

Also…Also…

Sub-solar abscess Sub-solar abscess

http://www.farriervet.com/images/lam6.jpg

More?More?

Result of bruising Result of bruising

http://i.ehow.com/images/a04/bn/cj/thoroughbred-racehorses-200X200.jpg

Poor trimming techniquePoor trimming technique

http://www.eponashoe.com/Documents/On%20the%20Comments_files/thumb012.jpg

http://easycareinc.typepad.com/.a/6a00d83451606969e2010536c67fce970b-320wi

Radiographically?Radiographically?

May see draining tracts May see draining tracts Solar defectsSolar defects Septic osteitisSeptic osteitis

Treatment options?Treatment options?

Benign neglectBenign neglect Soaking/PoulticingSoaking/Poulticing LancingLancing Surgical resectionSurgical resection Antibiotics Antibiotics

www.vin.com

www.equinepodiatry.com