purification challenge for drop-in bio-based chemicals · 2018-03-29 · purification challenge for...
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CLIB – 15 NOV 2012 Purification : a Challenge for Drop-In Bio-Based Chemicals 1
PurificationChallenge for Drop-In Bio-Based Chemicals
November 2012
CLIB – 15 NOV 2012 2
2 routes competing on :
� Technology
� Costs
� Life Cycle
Producing Bio-Based Drop-In Chemicals
Chemical
Intermediates
Purification : a Challenge for Drop-In Bio-Based Chemicals
CLIB – 15 NOV 2012
Transforming the Biomass into an Intermediate
Purification : a Challenge for Drop-In Bio-Based Chemicals 3
Theoretically!
Fractions
Chemical
Intermediate
CLIB – 15 NOV 2012 Purification : a Challenge for Drop-In Bio-Based Chemicals 4
In reality!
Fractions
+ +
Furfural, HMF, Furfural, HMF,
Organic acidsOrganic acidsChemical
Intermediate
++
Feed mat., side Feed mat., side
products, products,
biomass,biomass,……
Transforming the Biomass into an Intermediate
CLIB – 15 NOV 2012 Purification : a Challenge for Drop-In Bio-Based Chemicals 5
What is needed
industrially !
Fractions
Pu
rificatio
n
Furfural, HMF, Furfural, HMF,
Organic acids, Organic acids,
SaltsSalts
Pu
rificatio
n
•• Feed materialFeed material
•• Side productsSide products
•• SaltsSalts
•• ProteinsProteins
•• BiomassBiomass
Transforming the Biomass into an Intermediate
CLIB – 15 NOV 2012 Purification : a Challenge for Drop-In Bio-Based Chemicals 6
Which technologies for purification ?
New raw materials
New production routes
Mixtures / broths
Traditional Chemical
Industry Technologies
are not relevant !
Only
Advanced Purification Technologies
can do the job !
Combining the right technologies
into a complete process
is the key to be competitiveC5 Sugars
C6 Sugars
Di-alcohols
Organic acids
CLIB – 15 NOV 2012 Purification : a Challenge for Drop-In Bio-Based Chemicals 7
We develop processes and market equipment
to solve purification challenges
by using advanced technologies
Novasep Process
Novasep Process , Saint-Maurice-de-Beynost, France
CLIB – 15 NOV 2012 Purification : a Challenge for Drop-In Bio-Based Chemicals 8
Our Markets
BiopharmaFunctional
IngredientsBio-Industries
Food
Ingredients
Recombinant Proteins
Vaccines
mAbs - ADC
Blood Fractionation
Biomass Extracts
Cell Therapy
Sugar
Starch
Milk
Polyphenols
Anthocyanes
FOS
Sweeteners
Bio Based Chemicals
Organic Acids
Aminoacids
Antibiotics
Vitamins
CLIB – 15 NOV 2012 Purification : a Challenge for Drop-In Bio-Based Chemicals 99
Novasep Process Sales: 120 M€
Employees: 430� Process Development
# 20 purification processes per year in Industrial Biotechnology
# 30 purification processes per year in Biopharma
� Equipment and Systems
More than 2,000 units installed worldwide
� Design and Engineering Offices
Shanghai, Philadelphia, Lyon and Nancy
Sales by Segment
Industrial
BiotechPharma
Biopharma
50%
40%
10%
Facts and Figures
CLIB – 15 NOV 2012 Purification : a Challenge for Drop-In Bio-Based Chemicals 10Novasep Process: Your Purification Specialist for White Biotechnology 10
Membrane filtration
• Organic & Ceramic
• Clarification
• Concentration
Continuous chromatography
• Applexion® SSMB
• Separation of fractions
• Purification
Adsorption
Ion exchange
Membrane
filtration
Purity
Biobased Chemicals
Purification
Evaporation
Crystallization
Continuous
chromatography
An Unparalleled Breadth of Key Unit Operations
ElectrodialysisElectrodialysis
• Demineralization
• Salt Conversion
Evap/Crystallization
• Plate or tubular
• Multiple effect
• MVR
Adsorption/IEX
• Salt conversion
• Demineralization
• Decolorization
• Batch or Continuous
CLIB – 15 NOV 2012 Purification : a Challenge for Drop-In Bio-Based Chemicals 11
Working principles
Membranes + Chromatography + IEX + Electrodialysis
⇓⇓⇓⇓Efficient, cost-effective, reliable and scalable technologies
Allowing to reach high degrees of purity
& relying on the use of various physico-chemical properties :
pKa
Molar mass
Hydrogen bounds
Solvatation size
Isoelectric point
Hydrophobic/hydrophilic interactions
Polar/non polar interactions
Molecular Geometry configuration
CLIB – 15 NOV 2012 Purification : a Challenge for Drop-In Bio-Based Chemicals 12
Field of application
Novasep Process designs optimized and integrated process routes
by selecting among competitive technologies depending on local conditions
to build up processes that are applied industrially
to obtain products which market prices typically < 2€/kg
with units working 350 days/year on a 24/7 basis
with typical capacities of 100 kT / year
Citric Acid
Glucose1,4 BDO 1,3 PDO
Lysin
Succinic acid
CLIB – 15 NOV 2012
Ceramic Membranes - References
13Purification : a Challenge for Drop-In Bio-Based Chemicals 13
CLIB – 15 NOV 2012
Ion Exchange & Adsorption - References
14Purification : a Challenge for Drop-In Bio-Based Chemicals
CLIB – 15 NOV 2012
Chromatography references
15
0
1000
2000
3000
4000
5000
6000
1990
1995
2000
2005
2010
Ton
s T
S/d
ay
Year
Novasep Process Industrial Biotech Low pressure chromatography installed capacityExamples Product price Installed capacity
Fructose HFCS 0,7 €/kg 1710 kT / y
Citric acid 0,8 €/kg 135 kT / y
Purification : a Challenge for Drop-In Bio-Based Chemicals
CLIB – 15 NOV 2012
ED references
16
0
5
10
15
20
2006 2007 2008 2009 2010 2011
Total
Total
Year
Sum of Number of sites
Applications
�Sweet and lactic acid whey
�Lactulose syrup
�Casein whey
�Organic acid conversionPurification : a Challenge for Drop-In Bio-Based Chemicals
CLIB – 15 NOV 2012 Purification : a Challenge for Drop-In Bio-Based Chemicals 17
Success Stories
Novasep Process
CLIB – 15 NOV 2012 Purification : a Challenge for Drop-In Bio-Based Chemicals 18
Succinic Acid Purification
� Succinic acid is a key chemical intermediate
� Customer: JV ARD – BioAmber
� Process development work started in 2004
� Technology Screening
� Process Simulation
� Process integration
� Piloting work
� 1st industrial Bio Succinic Acid plant worldwide started in 2009, with
Capacity 3,000 t/year
� Other studies on-going (more than 6 routes studied)
CLIB – 15 NOV 2012 Purification : a Challenge for Drop-In Bio-Based Chemicals 19
Succinic Acid Purification
� Clarification by Kerasep® membrane filtration
� 2 different processes,
depending on local conditions:
� Applexion® CIEX
� Novasep – Mega® Electrodialysis
CLIB – 15 NOV 2012 Purification : a Challenge for Drop-In Bio-Based Chemicals 20
Chemical Polyol Purification
� Customer: confidential
� Molecule: chemical polyol, confidential
� Process development work started in 2007
� Technology Screening
� Process simulation
� Process integration
� Piloting work
� 1st industrial plant started in 2008
� Extension made in 2012
� Other studies on-going
CLIB – 15 NOV 2012 Purification : a Challenge for Drop-In Bio-Based Chemicals 21
Chemical Polyol Purification
� Separation of chemical polyol and salts by
Applexion® SSMB, on ion exclusion principle
� Concentration by reverse osmosis
� Separation of chemical polyol and sugar by
Applexion® SSMB, on affinity principle
0
20
40
60
80
100
120
140
160
0 1 2 3 4 5 6
Columns
Co
nce
ntr
atio
n g
/l
SaltsGlucosePolyol
CLIB – 15 NOV 2012 Purification : a Challenge for Drop-In Bio-Based Chemicals 22
Our References
Novasep Process
CLIB – 15 NOV 2012 Purification : a Challenge for Drop-In Bio-Based Chemicals 23
Main Experience With
Lactic Acid
Citric Acid
Gluconic acid
Succinic acid
Itaconic acid
Glucaric acid
Glucose
Mannose
Fructose Xylose
Arabinose
Oligosaccharides
Sorbitol
Mannitol
1,4 BDO1,3 PDO
Lysin
MSG
IMP
Threonin
GMPLignin
