* A healthy start for immune balance and skin health Developed especially for mother and baby

PureBabyProbiotic

The Hygiene HypothesisMore than ever, we are faced with the challenge of providing children with the best start to healthy immune defense. The hygiene hypothesis speculates that reduced microflora exposure at a very young age has a negative impact on immune balance, in both the short term and the long term. Ecologic® PANDA is a specially designed, multi-species probiotic developed to establish healthy immune balance and skin health early in life. It accomplishes this by supporting healthy T-cell balance and immune activity.*

IL-12, IL-5 and IL-13 IL-10

Balanced Immune System

Regulatory T cellsTh2 cells

Regulatory T cellsTh2 cells

Ecologic® PANDA at Young AgeMODE OF ACTION

Figure 1. Mode of Action. Ecologic® PANDA establishes healthy T-cell balance.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Manufacturers of Hypo-allergenic

Nutritional Supplements

490 Boston Post Road

Sudbury, MA 01776 USA

www.purecaps.com

800-753-2277

A healthy start for immune balance and skin health*

Developed Especially For Mother And Baby

PureBaby Probiotic

1 sachet (3 g) contains

calories ................................................................ 10total carbohydrate ................................................ 3 gproprietary blend Ecologic® PANDA .................... 3 billion CFU

providing: bifidobacterium bifidum, bifidobacterium lactis, lactococcus lactis

Contains milk, soy other ingredients: rice starch, maltodextrin, ascorbic acid

This product does not require refrigeration

serving size: ............................................................ 3 g (1 sachet)servings per container: ......................................... 30

Pregnant Women (starting at 34 weeks): As a dietary supplement, dissolve the contents of 1 sachet with water, juice or milk. Take once per day, preferably between meals.

Infant Dose (Bottle Fed): As a dietary supplement, dissolve the contents of 1 sachet in breast milk or formula through age 12 months. Children 12–24 months may continue with 1 sachet dissolved in water, juice or milk, preferably between meals.

Infant Dose (Breast Fed): Mother takes product according to recommendations for pregnant women.

QUANTITY ORDER CODE PureBaby Probiotic 30 sachets PPR3

Ecologic® PANDA is a multi-species probiotic product designed and produced by Winclove Bio Industries, BV in Amsterdam, the Netherlands.

Ecologic® PANDA lessened the incidence of skin sensitivity by 58% in 3 month

old infants. A beneficial effect persisted through 2 years of age, suggesting a lasting impact on immune balance.*

40

30

20

10

3 2412

Age In Months

58% reduction in incidence of skin

sensitivity at 3 months Cum

ulat

ive

Inci

denc

eIn

Abs

olut

e N

umbe

rs

45

40

35

30

25

20

15

10

5

0

% Skin Sensitivity (3 months)

Placebo

Placebo

Ecologic® PANDA

Parental-reported* Physician-confirmed*

*p<0.05 *p<0.05

Ecologic® PANDA

29

12

21

6

40

30

20

10

3 2412

Age In Months

58% reduction in incidence of skin

sensitivity at 3 months Cum

ulat

ive

Inci

denc

eIn

Abs

olut

e N

umbe

rs

45

40

35

30

25

20

15

10

5

0

% Skin Sensitivity (3 months)

Placebo

Placebo

Ecologic® PANDA

Parental-reported* Physician-confirmed*

*p<0.05 *p<0.05

Ecologic® PANDA

29

12

21

6

40

30

20

10

3 2412

Age In Months

58% reduction in incidence of skin

sensitivity at 3 months Cum

ulat

ive

Inci

denc

eIn

Abs

olut

e N

umbe

rs

45

40

35

30

25

20

15

10

5

0

% Skin Sensitivity (3 months)

Placebo

Placebo

Ecologic® PANDA

Parental-reported* Physician-confirmed*

*p<0.05 *p<0.05

Ecologic® PANDA

29

12

21

6

Ecologic® PANDAEcologic® PANDA is a proprietary blend of Lactococcus lactis, Bifidobacterium lactis and Bifidobacterium bifidum. These strains were specifically screened for their ability to support healthy T cell function. In addition, they were selected for their resistance against gastric pH, pancreatic digestive enzymes and bile salts. Ecologic® PANDA strains are also stable at room temperature.

The PANDA StudyThe results of the PANDA study reveal statistically significant support for immune balance and skin health in 3 month old infants. A beneficial effect was observed over a two year period.*

In this two year, double-blind, randomized, placebo-controlled trial, at Wilhelmina Children’s Hospital, in Utrecht, the Netherlands, 3 grams Ecologic® PANDA was administered prenatally to over 100 mothers (starting at 34 weeks) and then to their children for 12 months. Figure 3. At age 3 months, results indicate a 58% reduction in

incidence of skin sensitivity with Ecologic® PANDA.*

These effects are in part attributed to the ability of Ecologic® PANDA to enhance early colonization of beneficial microflora.*

Figure 4. Survival in the GI tract. Real Time PCR quantification of Lactococcus lactis in stool samples of eight randomly chosen participants from each of the placebo and intervention groups. Results are depicted as log gene copy numbers per gram stool.

REFERENCE: Adapted from Niers, et al. Allergy, 2009.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Figure 2. Real Time Stability of Ecologic® PANDA at 25°C (77°F ).

Real Time Stability @25°C

1,00E+05

1,00E+06

1,00E+07

1,00E+08

1,00E+09

1,00E+10

100 20

Time [months]

Tota

l Cel

l Cou

nt [

CFU/

gram

]

Placebo

Survival in the GI tract

1 2 3 4

Age (weeks)

12

Lc. l

actis

in fe

ces

Probiotics

Comprehensive Support for Mother and Child

PreNatal Nutrients

Provides a multivitamin/mineral complex designed for women of child-bearing age, pregnant women and lactating women. Provides 1 mg folic acid per serving for optimal neural and cellular development. Contains enhanced iron to meet pregnancy requirements.*

Neuromins™ 200 mg or DHA Ultimate

Offers DHA omega-3 fatty acid support for healthy prenatal development of brain and retinal tissue. Infants and children born to mothers who supplemented with DHA during pregnancy demonstrate healthy cognitive capacity and development.*

PureBaby Probiotic Ecologic® PANDA

Provides a clinically studied, multi-species probiotic blend that supports healthy microflora colonization, immune function and skin comfort for children through 2 years of age.*