1.PsychopharmachologyIntroduction and Overview

2. Vingette - IntroductionJoe is a 55 year old African American man. He quite smoking6 years ago but has moderate symptoms of COPD. He hasdifficulty cathcing his breath and is often fatigued.He comes into the clinic to address sleep problems. Hereports waking up in the early morning and having difficultygetting back to sleep. He also describes being highly irritablewith his wife and feeling like his job is pointless. He is havingdifficulty remembering things and reports being distractable.He has two boys 15 and 17. He reports that he is having moretrouble breathing lately so he has stopped coaching hisyoungest sons baseball team. He likes to play sports butreports gaining weight over the last six years. He reports thathe feels hopeless about his future ability to be able to have anormal life. 3. Dr. Mary Bernheim, "Molly," wasborn Mary Hare in 1902 inGloucester, England. She spent herchildhood in India. She received aBA, MA, and PhD from Cambridgein England, the latter in 1928.Mary Hare, while a graduatestudent, also in 1928, discoveredthe enzyme tyramine oxidase. Theenzyme was eventually renamedmonoamine oxidase (MAO) and waslater found to play a significant rolein mood regulationDr. Mary Bernheims discovery,which Theodore Slotkin calls "oneof the seminal discoveries intwentieth century neurobiology." 4. Living With Half a Brain When Cameron Mott was three years old, she contracted a rareand deadly brain disorder; Rasmussens Encephalitis. Her parents are desperate and have opted for the only availablecure, a radical high-risk operation to remove the diseased half ofher brain. Cameron lives with her sister Caroline and her parents Casey andShelley in Jamestown, North Carolina.http://today.msnbc.msn.com/id/36032653/ns/today-today_health/t/meet-girl-half-brain/#.UFAJEBjfMtc 5. Story of a Smile 6. Biopsychosocial BrainBiological SocialEpigeneticsEnvironmentalGeneticsPsychological 7. Adverse GADPTSD ChildhoodLifeCoping EventsStress Chronic Style Pain Depression PersonalityPoor SocialSleep Support InflammatoryCortisolOxytocin ANS Balance ResponseAnd HRVHeart Disease 8. Depression Visualized 9. Depression TreatmentSSRI Compared with CBT 10. CBT and OCD 11. NeurotransmittersDopamine (DA): Five major transmiter systems.Motor function, appititive behaviors, reward, andworking memory.Serotonin (5-HT): Feeling satisfied, pain reduction,mood, basic okness, body temp and mood.GABA: Inhabitory neurotransmitter.Glutamate (Glu): Excititory neurotransmitter. 80-90% of all synapses.Acytalcholine (ACh): Learning, memory, arousallevels and concentraition.Norepinephrine (NE): Arousal, reward, and mentalfilter.Oxytocin: Social bonding, romantic love, andsexual intamacy.Histomine: Activation and arousal.Melatonin: Sleep and nacturnal rythums.Substance P: Pain response from body to thebrain.