protein structure prediction - dr. m. jazayeri...all lig n emall a f rin t all el. co or alignments...
TRANSCRIPT
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Protein structure predictionProtein structure prediction((HBsAgHBsAg)) 25
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((HBsAgHBsAg)) 2
ByMansour PoorebrahimMansour Poorebrahim
PhD, Medical Biotechnology Tehran University of Medical Sciences 2Tehran University of Medical Sciences 2
Hierarchicalnatureofproteinstructure
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HBsAg
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Methodsforproteinstructureprediction
Comparative modeling
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Comparative modeling
Threading
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Ab initio prediction
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HHpred serverHHpred server
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Threading(structuralfoldrecognition)g g
Protein threading predicts the 3D structure for a new
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protein by aligning its primary sequence to proteins in thePDB to see if a similar structure can be found
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A method of protein modeling to model proteins which donot have homologous proteins and have the same fold asproteins of known structuresproteins of known structures.
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Threading(structuralfoldrecognition)g g
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PHYRE2serverhttp://www.sbg.bio.ic.ac.uk/phyre2/html/page.cgi?id=index
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Modelvisualization
UCSF chimera
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1010
ProteinvalidationServer
RAMPAGE
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1111
PredictedmodelsofHBsAgbyPHYRE2g y
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HBsAg
T123I (9/31)
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( / )
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PredictedmodelsofHBsAgbyPHYRE2g y
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1414
3/05
/201
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