protein structure. biology/chemistry of protein structure primary secondary tertiary quaternary...
TRANSCRIPT
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Protein Structure
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Biology/Chemistry of Protein Structure
Primary
Secondary
Tertiary
Quaternary
Assembly
Folding
Packing
Interaction
S T
R U
C T
U R
E P R O
C E S S
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Primary Structure - Sequence
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FOLDING
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Basic Secondary structureBasic Secondary structure
α-helix β-sheet
Secondary structures, α-helix and β-sheet, have regular hydrogen-bonding patterns.
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Tertiary structure
Quaternary structure
1’ > 2’ > 3’ > 4’ > …
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X - Ray
X-ray Diffraction Pattern for a Protein
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X-Ray
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NMR – there is no right answer
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THE database of experimentally-derived structures of proteins, nucleic acids, and complexes
•Access to structural information•Visualization•Analysis
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Experimental Methods: X-Ray Crystallography NMR more…
Macromolecules: Proteins Nucleic acids Carbohydrates
Protein-nucleic acid complexes Protein-carbohydrate complexes
PDB Growth and Content
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PDB Homepage
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An Example – 2ARA
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Search Methods
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Advanced Search
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Sequence Search
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Example Results