Progression of CML

Complications of CML

• Unexplained fever• Significant weight loss• Increasing dose requirement of the drugs

controlling the disease• Bone and joint pain• Bleeding• Thrombosis• Infections

Source: p. 684

Disease Acceleration

Blast Crisis (Acute

Leukemia)

Complications of CML

• Fatigue• Excess bleeding• Pain• Enlarged spleen• Stroke or excess clotting• Infection• Death

Source: http://www.mayoclinic.com