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ions and lineshapeof the included p

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A). The minimum acond frequency di

Maximum echo samn the reconstructedmolecular baseline

mum echo sampledthe same acquisimolecular baselinesis set (Fig B). T0b, The MathWorkarameters were eser of metabolites a-free two dimensiolf-deconvolution spline baseline anal fit. The new alg

me in-vivo data setts & Discussion t results using the

fitted spectrum, tively. Figures D, ed improved verson of macromolec

ape model (Fig. I &of the problems

omolecular contribnd also residual tlearly identified ms are drasticallyvement on the fitH). Another refine to handle enveduring the wholebe shown that

molecule signals c

ences Schulte et al., NMRSchulte et al., NMRaudsley, JMR (199M Sima et al., Mea

nstitute for Biomed

ous detection and qke Glutamate, Glchiatric diseases is

pectroscopy showeding the spectral innsion. A software lows two dimensisimilar to LCMo

version of ProFit. roblems like mace distortions. In adrior knowledge redes of the resonanoriginal version of

re acquired from achievable echo timimension was encmpling was used tod spectrum to preve was measured ud basis set of 20 ition parameters e was denoised an

The revised versioks, Inc., Natick, Mtimated from preland degrees of freonal lineshape wa[3, 4]. Finally allnd the spline-basegorithm was compt.

old ProFit tool arethe residual and

F and H show thesion of ProFit. Excular baseline sign& J). From the cos of the previoubutions at about tails of spectral co

within the noiy reduced in the quality is clearly

nement comes froelope distortions e duration of an e

including featurcan significantly i

R in Biomed (2006R in Biomed (20065), 106(B): 47–57

as. Sci. Technol. (2

Aledical Engineering,

quantification of mutamine or GABAs impeded by speced to significantlynformation of couptool called ProFit

ional prior knowlodel. However, soThe aim of this

cromolecular baseddition possibilitieegarding phase andnce lines are provProFit.

the human brain me was 31ms and

coded by 100 stepso improve SNR anvent overlap [2].

using a double invmetabolites was

as for the in-vivnd included as an on of ProFit was

MA, USA). Startingliminary fit iteratieedom. Prior to thas calculated basedl metabolites toged lineshape modepared to the old P

e shown in Fig. C,d a projection ae results from the

xcellent fit qualitynals as shown in Fomparison of the s version of Pro1ppm could not bomponents like cse (Fig. E). Alrevised version (

y visible in the prom the complex li

and also phase experiment (Fig. res like 2D modimprove fitting re

6), 19: 255–263 6), 19: 264–270

7 2009)

Prxander Fuchs1, PeUniversity and ET

metabolites represA, which are of sctral overlap at 3T.y reduce the problpled spin systems t [1] was introducledge fitting usingome drawbacks ars work was to imelines, residual bas for more flexibld frequency offsetvided. The fit qua

on a Philips 3T sthe TR was set 16s with a t1 incremnd to produce tiltedA metabolite nullversion sequence. simulated in GA

vo scan. The meadditional metaboimplemented in M

g values for the difons using an incr

he last fitting iterad on regularized sether with an addl were used to cal

ProFit version app

, E and G correspoalong the t1 dim

same data set usiy is achieved due Fig. B and a modresiduals (Fig. E

oFit become appbe handled suffic

creatine at 3ppm cl these systemat(Fig. F) and the orojection spectra ineshape model,deviations, whicI & J). In concludel-free lineshapesults for 2 dimen

oFit revised ter Boesiger2, and TH Zurich, Zurich

senting special . Two-lem of into a

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system 600ms. ment of

d peak led 2D A 2D

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d Anke Henning2 h, Zurich, Switzerla

ures (A-J): (A) unteer. In (B) the ace splines as ctrated. In the left

ether with the residOn the right side

posed ProFit versioimaginary part of

and, 2University an

D

H

B

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shows the meafinal contribution

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dual and t1 projecte (D, F & H) the on are presented. the spline based li

J

nd ETH Zurich

asured spectrum n of macromolecul

the proposed Prspectrum of the oted spectrum are scorresponding plSubplots (I & J)

ine shape model u

from a healthy les together with roFit version is

old ProFit version shown in (C, E & ots of the newly finally show real sed.

1758Proc. Intl. Soc. Mag. Reson. Med. 20 (2012)