profert male forte
TRANSCRIPT
Profert Male
POTENT NUTRIENTS AND ANTIOXIDANTS FOR OPTIMUM SPERM HEALTH
The role of nutraceuticals as vitamins , minerals and antioxidants is very well documented and
accepted in Male Infertility , resulting in Enhance male fertility with regard to higher semen volumes,
sperm concentrations, the percentage of normal sperm morphology and sperm motility in male
partners of sub-fertile couples with idiopathic infertility.
Reactive oxygen species, such as
superoxide anion and hydrogen
peroxide, are known to impair sperm
motility and membrane integrity by
inducing membrane lipid peroxidation
(LPO). Infertile men have higher levels
of semen reactive oxygen species
(ROS) than do fertile men.
High levels of semen ROS can cause
sperm dysfunction, sperm DNA
damage and reduced male
reproductive potential. This observation has led clinicians to treat infertile men with antioxidant
supplements.
To date, most clinical studies suggest that dietary antioxidant supplements are beneficial in terms of
improving sperm function and DNA integrity. The improvement of clinical symptoms, as sperm
indexes (semen liquefied duration, motility, viability, density and abnormal morphology is seen by
giving nutritional and antioxidant support.
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Semen Analysis
Male factor infertility is assessed based upon the following values:
(1) Deficient sperm count (less than 10 million per milliliter; volume should be 1 - 5 ml. of
ejaculate)
(2) Insufficient sperm motility (over 60% should be motile and demonstrate purposeful forward
movement), and/or (3) poor sperm morphology (more than 50-60% abnormal in form)
Infertility is defined as the inability to fertilize the ovum; whereas sterility is defined as the lack
of sperm production.
The average ejaculate sample contains almost 200 million sperm. Amazingly enough, only a few
dozen sperm actually reach the egg for a chance at penetration. This makes for some pretty
ominous statistics for sperm overall. It is for this reason that sperm numbers must be so high,
just to have a modicum of hope of reaching the vicinity
of the egg traveling down the fallopian tube. If both
partners have fertility issues, it seems truly a miracle
that conception ever even takes place. Luckily, there are
methods to improve sperm count, motility, and
morphology.
An Overview of Sperm Production
Sperm production begins during puberty in response to
the same hormones (LH and FSH) as in the female. But
the LH signals cells within the leydig cells of the testes to
produce testosterone, and FSH signals sertoli cells to produce sperm. Estrogen is also important
in sperm formation, but too much dietary
synthetic sources of estrogen can be harmful.
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The seminal vesicles secrete substances which nourish the sperm, including fructose (which
feeds the sperm), fibrinogen (which holds or coagulates the fluid together) and prostaglandins
(which help the sperm penetrate the cervix). The prostate adds an alkaline fluid to the
ejaculate. It is extremely important to keep the sperm in a more alkaline environment because
the vaginal pH is relatively acidic.
Seminal fluid in normal, fertile men contains antioxidant factors. In many sub fertile men the
seminal fluid may not contain the protective elements or the
circulating free radicals may be so abundant that the seminal
fluid is not capable of scavenging the damaged reactive oxygen
species. Therefore, men with suboptimum sperm counts
should include dietary sources of antioxidants.
The plasma membrane of human sperm contains high levels of
polyunsaturated fatty acids, making them extremely
susceptible to peroxidative changes. Free radical damage leads
to functional impairment in the sperm, lowering motility and
morphology.
Most vaginal lubricants are hostile to sperm. The only vaginal
lubricants which have been found to support sperm longevity
are egg whites (yes, really) and canola oil.
Male reproductive potential and lifestyle factors :
Infection: The role of infection in idiopathic male infertility has
been underestimated, in particular chronic asymptomatic
chlamydial infections.1 Chlamydia can reside in the epididymis
and vas deferens, affecting sperm development and fertility.
One study suggests approximately 28-71 percent of infertile
men have evidence of a chlamydial infection. The presence of
anti-sperm antibodies may indicate an undiagnosed infection,
and is estimated to be a relative cause of infertility in 3-7 percent of cases. In a study designed
to examine the effects of antioxidants on anti-sperm antibodies, there was a significant
correlation between beta carotene levels and antibody titers, suggesting dietary antioxidants
are involved in mediating immune function in the male reproductive system.
Potential Contributing
Factors in Male Infertility
Infection
Hormonal imbalances
Hepatic cirrhosis
Infection
Excessive heat
Radiation exposure
Heavy metal toxicity
Cigarette smoking & Alcohol
Obesity
Xeno-estrogen exposure
Pesticide exposure
High intake of cottonseed
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Declining Sperm Counts There is a growing body of scientific evidence supporting the idea that sperm counts have
declined considerably over the last 50 years. Carlsen et al analyzed a total of 61 studies
including 14,947 men from the years 1938 to 1991, for mean sperm density and mean seminal
volume. Their results show a significant decline in mean sperm density from 113 million/ml in
1940 to 66 million/ml in 1990. (p<0.0001). Seminal volume decreased from an average of 3.40
ml to 2.75 ml (p=0.027).6,7 .This demonstrates a 20-percent drop in volume and a substantial
58-percent decline in sperm production in the
last 50 years. Three other recent reports also
found semen quality has declined among
donors over the last 20 years.8-10 Because
the decline in sperm production is relatively
recent, one must suspect a combination of
environmental, lifestyle, and dietary factors
might be interfering with spermatogenesis.
Environmental Risk Factors:
Current evidence suggests there may be environmental reasons for deteriorating sperm quality, including occupational exposure to various chemicals, heat, radiation, and heavy metals. In addition, exposure to environmental estrogens and pesticides has been linked to alterations in spermatogenesis. Lifestyle risk factors are also significant, including cigarette smoking, alcohol consumption, chronic stress, and nutritional deficiencies. Xeno-Estrogens and Pesticides Increased exposure to estrogens is thought to be responsible for not only prenatal testicular
damage, but may also contribute to post-natal depression of testicular function and
spermatogenesis. Exogenous estrogens impact fetal development by inhibiting the
development of Sertoli cells, which determine the lifelong capacity for sperm production.
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Circulating estrogens also inhibit enzymes involved in testosterone synthesis and may directly
affect testosterone production.
The synthetic estrogen, diethylstilbestrol (DES), is a well-documented example of this problem.
DES was prescribed from 1945 to 1971 to millions of women during pregnancy. Male offspring
from those women had a higher incidence of developmental problems of the reproductive
tract, as well as diminished sperm volume and sperm count.
Synthetic estrogens are still widely used in the livestock, poultry, and dairy industries. Men
wishing to improve their fertility and sperm quality probably should avoid hormone-containing
dairy products and meats and opt instead for organic or hormone-free foods.
Many commonly-used pesticides, such as organochloride compounds, have estrogenic effects
within the body. Chemicals such as dioxin, DDT, and PCBs are known to interfere with
spermatogenesis. One study which examined the effect of DDT on male rat sexual development
found low levels of DDT caused degeneration in sperm production, a decrease in the total
number of sperm, and a reduced number of Leydig cells. DDT acts as an hormonal disrupter,
damaging the seminiferous epithelium and lowering local testosterone levels.
Dietary and Lifestyle Factors In addition to avoiding exogenous estrogens and pesticides, there are other dietary factors to
consider. Adequate intake of essential fatty acids is important to ensure proper membrane
fluidity and energy production in sperm cells. High dietary intake of hydrogenated oils,
particularly cottonseed oil, has been shown to have a negative impact on sperm cell function.
Not only does cottonseed oil contain toxic pesticide residues, it also contains high levels of the
chemical gossypol, which can interfere with spermatogenesis.
In Nigeria, a randomized, controlled trial was designed to evaluate the effect of dietary
aflatoxin on infertile men. Forty percent of the 50 infertile men in the study had aflatoxin in
their semen samples, compared to eight percent of the fertile control group. Infertile men
exposed to dietary aflatoxin had a 50-percent higher number of abnormal sperm.
Heavy Metals Numerous environmental pollutants have been linked with testicular oxidative stress. Among these are air pollutants such as diesel particulate matter. Cadmium and lead have been specifically linked with sperm oxidative damage; mercury and arsenic are also toxic to sperm [33]. The male reproductive system is also adversely affected by agricultural pesticides and industrial chemicals, and illustrates the importance of recording potential occupational exposures in the clinical history. Hyperthermia, whether from tight clothing or from working in a continuous sedentary position (e.g., truck driving, computer work), has also been implicated
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in the production of elevated levels of ROS and RNS, since germinal cells respond to increased temperature by production of heat-shock proteins. Cigarette Smoking Cigarette smoking has been associated with decreased sperm count, alterations in motility, and an overall increase in the number of abnormal sperm. A study designed to evaluate seminal zinc levels in smokers and non-smokers found that although smokers did not have significantly lower zinc levels than non-smokers, seminal cadmium levels were significantly increased, especially in those smoking more than one pack per day. Experimental evidence also Suggests nicotine can alter the function of the hypothalamic-pituitary axis, affecting Growth hormone, cortisol, vasopressin, and oxytocin release, which then inhibits the Release of luteinizing hormone (LH) and prolactin.21 Cigarette smokers were also shown to have higher levels of circulating estradiol and decreased levels of LH, follicle stimulating hormone (FSH), and prolactin than non-smokers, all of which potentially impact spermatogenesis. Smokers with low prolactin levels also demonstrated defects in sperm motility.
Alcohol
Excessive consumption of alcohol increases ROS levels and many alcohol abusers consume
insufficient dietary amounts of protective antioxidants. Dietary deficiencies have been linked to
oxidative damage in spermatozoa.
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Extreme Exercise :
Extremes of exercise have also been linked with oxidative stress . Muscle-aerobic metabolism is
the cause of ROS in those who exercise regularly . ROS therefore may be heightened in those
employed in strenuous occupations where physical exertion is routine (i.e., agricultural
workers, day laborers, construction, etc).
Obesity :
Among the obese, adipose tissue releases pro-inflammatory cytokines that increase leukocyte
production of ROS . Several recent population-based studies have shown an increased
likelihood of abnormal semen parameters among obese men .The increasing worldwide
prevalence of obesity is of concern to all medical professionals, especially as it is a risk factor for
Type II diabetes mellitus. Hyperglycemia increases ROS and adversely affects spermatic
parameters.
Medications :
Several medications, chemotherapeutic agents, antimicrobials, and radiation may affect
gonadal function and can possibly result in azoospermia . Cannabis, heroin, and cocaine
adversely affect spermatic parameters, but the extent to which they do so is dependent upon
the quantity and frequency of use [.
Aging & Stress:
Sperm DNA damage increases with advancing age in both fertile and infertile men, possibly
because of normal increases in ROS levels over time [. Psychological stress reduces semen
quality with a central underlying mechanism being impairment of gonadotropin drive . Stress
also reduces sperm quality by increasing plasma ROS generation and decreasing antioxidant
protection .
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Dietary Vitamins & antioxidants Minerals : Carotenoids , Vitamin C , E ,B complex , Zinc and
selenium have well documented role as antioxidants in protecting oxidation induced damage to
spermatozoa. Outcome of Numerous clinical studies have proven the beneficial role of these
dietary nutrients in improving fertility and protecting spermatozoa from oxidative damage.
Tribulus terrestris L. extract, : A non-hormonal plant-derived extract, has been successfully
used in Europe and Asia to treat sexual dysfunctions. Active components of this extract were
determined to be a furostanol saponin, named protodioscin. Oral administration of this extract
to laboratory animals resulted in the stimulation of spermatogenesis and the proliferation of
the spermatogonia, which involved cell divisions of the spermatocytes and spermatids. In
addition to the increased mitotic activity of the spermatozoa and the increased number of
Sertoli cells, sperm viability and survival were also significantly increased. Detailed clinical trials
found that protodioscin was not toxic and had no undesirable side-effects.
Protodioscin, a furostanol saponin as the active ingredient has beneficial effects on the
improvement of spermatogenesis, and on the increase in sperm mobility. Tribulus terrestris L.
treatment has clinically positive effect on sperm morphology and acrosome reactions in
subjects with oligoasthenoteratozoospermia.
Mucuna Prureins Extract : M. pruriens seed powder not only reactivates the enzymatic activity
of metabolic pathways and energy metabolism but also rejuvenates the harmonic balance of
male reproductive hormones in infertile men. These findings open more opportunities for
infertility treatment and management by improving semen quality. Treatment with M. pruriens
regulates steroidogenesis and improves semen quality in infertile men.
Withania Somnifera Extract : It inhibited lipid peroxidation and protein carbonyl content and
improved sperm count and motility. Treatment of infertile men recovered the seminal plasma
levels of antioxidant enzymes and vitamins A, C, and E and corrected fructose. Moreover,
treatment also significantly increased serum T and LH and reduced the levels of FSH and PRL.
The treatment with W. somnifera effectively reduced oxidative stress, as assessed by decreased levels of various oxidants and improved level of diverse antioxidants. Moreover, the levels of T, LH, FSH and PRL, good indicators of semen quality, were also reversed in infertile subjects after treatment with the herbal preparation.
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Lycopene : Lycopene seems to have a role in the management of idiopathic male infertility. In
a trial with lycopene patients (66%) showed an improvement in sperm concentration, (53%)
had improved motility and fourteen (46%) showed improvement in sperm morphology .
Co Q 10 : Three-month supplementation with CoQ10 in OAT infertile men can attenuate oxidative stress in seminal plasma and improve semen parameters and antioxidant enzymes activity. Coenzyme Q10 supplementation results significant improvement in certain semen parameters. Elevated seminal plasma CoQ10 levels are associated directly with good semen parameters and inversely with the oxidative stress.
L-carnitine :L-carnitine, capable of significantly improving sperm motility and raising the rate of
pregnancy, is a safe and effective therapeutic option for asthenozoospermia.
Indications: Profert Male is useful in Azospermia , Oligospermia & Decrease motility leading to male
infertility
Dosage: ADULTS: The recommended dosage 1-2 capsules a day.
Profert Male should be taken for 2-6 months or even more to have the desired sperm health. Its use is
found to be safe and can be used regularly as a male health supplement. When used as a fertility
supplement use of loose undergarments and garments are recommended to avoid pressure on testis.
Precautions :None
Pack Size: 10 capsules ( strip) x 2 per Box
For further Details Please Write to Product Management AHL Herbal Pharma .
Full Prescribing Information is available on request.
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Profert Forte
SUPPLEMENT FACTS
Mixed carotenoids : 10 mg
Vitamin C : 50 mg
Vitamin E : 10 mg
Thiamine B1 :1.4 mg
Riboflavine B2 : 2.2 mg
Niacin B3 : 18 mg
Pyridoxin B6 : 2 mg
Panthonic Acid : 60 mg
Follic Acid : 400 mcg
B 12 : 2 mcg
Zinc as Gluconate : 20 mg
Selenium : 50 mcg
Saffron : 2 mg
Piper Longum Extract : 30 mg
Ginseng Extract : 50 mg
Tribulus Terrestris Extr : 200 mg
Gingko Biloba Extract : 40 mg
curculigo orchioides : 50 mg
Chlorophytum borivilianum Ext: :50 mg
Mucuna Prureins Ext : 50 mg
Withania Somnifera Ext : 50 mg
L Arginine : 50 mg
Lycopene : 10 mg
Co Q 10 : 20 mg
L-carnitine : 100 mg
Profert
SUPPLEMENT FACTS
Mixed carotenoids : 10 mg
Vitamin C : 50 mg
Vitamin E : 10 mg
Thiamine B1 :1.4 mg
Riboflavine B2 : 2.2 mg
Niacin B3 : 18 mg
Pyridoxin B6 : 2 mg
Panthonic Acid : 60 mg
Follic Acid : 400 mcg
Zinc as Gluconate : 20 mg
Selenium : 50 mcg
Saffron : 2 mg
Piper Longum Extract : 30 mg
Ginseng Extract : 50 mg
Tribulus Terrestris Extr : 200 mg
Gingko Biloba Extract : 40 mg
curculigo orchioides : 50 mg
Chlorophytum borivilianum Ext: :50 mg
Mucuna Prureins Ext : 50 mg
Withania Somnifera Ext : 50 mg
L Arginine : 50 mg
Lycopene : 10 mg
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