Product InnovationJonathan Howard-BrandSupply Specialist, Innovation Unit

28 March 2017

© UNICEF/UNI197921/Schermbrucker

UNICEF Supply Division: Product Innovation

Need Development Scale

Need: in depth analysis of full context

4UNICEF Product Innovation – UNICEF for every child

Purpose is to communicate requirements for products which are currently not available

Less prescriptive than an RFP to allow for creativity and innovation flexibility. Not final procurement specifications

Useful tool to gain understanding of UNICEF and partners’ product needs and to gain internal buy-in for driving R&D

In 2016, 7 Target Product Profiles were published

Available online here: https://www.unicef.org/supply/index_91816.html

UNICEF Product Innovation – UNICEF for every child

Development: working non-exclusively with developers

Industry : • Dialogue with UNICEF on maturity of

technology• Ensure clinical and regulatory approvals

UNICEF

• Clarity on needs (e.g amendments to a TPP or industry consultations)

• Field trials in UNICEF context to prove value and inform scale

• Convene regulatory partners/advisory committees for feedback

Scale: incentivizing through volume guarantees and trials

UNICEF has a number of ways to incentivise (“pull”) developers to invest in R&D, regulatory and related to the product.

Concretely, UNICEF can do one of the following ranging from less to more committing:

• Indicate willingness to procure products meeting the TPP• Commit to carrying out field trials of selected products

meeting the TPP selected through competitive bidding• Commit to working with key actors and national agencies

(governments and implementing partners) to drive interest in uptake of products meeting the TPP

• Legally commit (through an Advanced Purchase Commitment or an Advanced Market Commitment) to procure a given amount of products

Convergence of Product Innovation and Influencing Markets

• Foster competition• Drive voloume• Strategic/transparent procurement

• Field Trials (FT)• Programmatic and technical guidance• Engagements with partners, such as WHO • Advocacy to end-users and implementing

partners

How we increase perceived value:

How we reduce cost

Marketpull

Sustainable Market

Tipping Point

*Supply Financing Mechanism

*

Field Developers/Suppliers

Supply Division

• Define & Communicate Field Needs

• Enable Product Development• Field Trial/Pilot• Implementation & Scale

• Communicate bottlenecks• Highlight Demand• Implementation/scale

• Product Development• Quality Assurance• Clinical Validation • Production

Our Value Add

Challenges

Need Development Scale

Working through the tradeoffs to create a TPP that matches the

field needs.

Designing a PULL that ensure the right R&D

gets pulled.

Ensuring impact actually happens.

Stage-Gate Process

UNICEF Product Innovation – UNICEF for every child

Product Innovation Example

11 Title of Presentation – UNICEF for every child

Zika Virus (ZIKV) Diagnostic

Key Activities:• Creation of TPPs to communicate the desired performance of products.

First time WHO, PAHO and UNICEF launched joint TPPs. • Zika Partner- Industry Consultation at SD with over 50 people subject

experts to share UNICEF’s Zika response strategy, exchange knowledge in an open and transparent forum, and communicate the need to accelerate product development through increased awareness of stakeholders’ challenges and needs.

• Initial forecast developed based on WHO classification of ZIKV transmission, environmental suitability for vector-borne transmission, potential target cohorts and various uptake scenarios.

• Coordination with USAID engaged in pull-mechanism, i.e. funding R&D to reduce time-to-market for POC diagnostics

What’s Next: • Continuous monitoring of the R&D landscape and consultations with

industry. Additionally, bilateral consultations with key pipeline manufacturers.

• Tendering• With Zika and market uncertainties, ensuring we share risk with industry

and make a balance to create a tipping point that makes a push-pull incentive that creates the right products and a healthy market.

Looking Ahead:Equipment for Injection Safety

13 Title of Presentation – UNICEF for every child

2005

Safe Injection Device DevelopmentJoint UNICEF, WHO, UNFPA Policy Issued Auto-Disable (AD) as a step-stage technology (added attribute to already established technology)

1999

AD @ start

RUP

SB

AD

RUP/SIP

UNICEF Expressed preference for early activation of the disabling mechanism (to reduce risk of reuse) leading to redefining technology and improve product design

AD

AD @ start

2009

Adequate Supply Available with preferred AD mechanism for full award - with multiple suppliers

2008

Introducing the RUP & RUP/SIP feature for reconstitution of freeze dried vaccines

RUP/SIP

RUP

2015

Introducing the RUP & RUP/SIP in therapeutic injections- participation in WHO expert group for new guideline recommendation

Needle-free devices

What we want: Innovation

What we are going to do? – our next steps

1. RFI / market analysis – what are you doing?2. If market does not meet UNICEF’s needs

a. Development of TPP(s)b. Industry Consultation (face-to-face/

online) c. Online transparency

3. If/when market meets UNICEF’s needsa. Field Trials (if needed) b. Share results and recommendations

4. Subject to FT results two routes: a. Positive results:

i. Procurement b. Negative results:

i. Work with industry on improvements

© U

NIC

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In the end, it’s all about getting to

Scale

/ UNICEFinnovation

@UNICEFinnovate

@UNICEFinnovate

www.unicef.org/innovation

www.unicefstories.org

Get in touch

www.unicefinnovationfund.org

www.unicef.org/supply