principles of neural science discussion section€¦ · principles of neural science discussion...
TRANSCRIPT
Principles of Neural Science Discussion Section
Lauren Walker
Office Hours: Thursday 5:30-6:30
Life Sciences 111
Contralateral Neglect Syndrome
Neuroscience. Purves et al. 2nd edition
Capgras Delusion
• Delusion that a loved one has been replaced by an identical- looking imposter
• Mrs. D, a 74 year old married housewife, believed “that her husband had been replaced by another unrelated man. She refused to sleep with the impostor, locked her bedroom and door at night, asked her son for a gun, and finally fought with the police when attempts were made to hospitalise her. At times she believed her husband was her long deceased father. She easily recognised other family members and would misidentify her husband only.”
Passer and Warnock 1991
Upcoming Seminars
• John D. York, Ph.D.
– Inositol phosphate Communication: insights into the Cell's 'iPhone’
– Wednesday, Sept 14 @ 4, Moore Auditorium
• Andrew Schwartz, Ph.D.
– "Progress Toward a High-performance Brain-controlled Prosthetics“
– Friday, Sept 16 @ 4, FLTC Connor Auditorium
Other terms
• Rostral- ‘towards the head’
• Caudal- ‘towards the tail’
– Caudal=tail
• Medial- ‘towards the middle’
• Lateral- ‘towards the side’
Famous Neuroscientists
Camillo Golgi Santiago Ramon y Cajal
Camillo Golgi • Silver nitrate staining
labels limited number of neurons at random
• Reticular theory
Santiago Ramon y Cajal
• Neuroanatomical studies
• Neuron Theory
• Realized nerve conduction had a ‘direction’
Llinas 2003 Nature
Neurons come in all shapes and sizes
http://www.mind.ilstu.edu/curriculum/neurons_intro/neurons_intro.php
Glia
Macroglia Astrocytes
Oligodendrocytes/ Schwann Cells
Microglia Macrophage-like
Astrocytes
Haydon 2001 Nat. Rev. Neurosci.
• Wrap synaptic terminals, associate w/neurons
– Modulate synaptic transmission
• Support endothelial cells of blood brain barrier
• Maintain ionic milieu
• Neurotransmitter uptake (Glu, GABA)
• Repair damage to CNS (glial scar)
• Connected by gap junctions
Calcium signaling in astrocytes
Fields 2010 Sci. Signal.
Myelin
Poliak and Peles 2003 Nat Rev Neurosci
Myelin
Microglia
• Scavenge CNS for damaged neurons and microbes
In your neuroscience textbook:
http://www.sinauer.com/neuroscience4e/animations22.1.html