principles of magnetic resonance imaging david j. michalak presentation for physics 250 03/13/2007
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![Page 1: Principles of Magnetic Resonance Imaging David J. Michalak Presentation for Physics 250 03/13/2007](https://reader030.vdocuments.site/reader030/viewer/2022032800/56649d3b5503460f94a1594e/html5/thumbnails/1.jpg)
Principles of Magnetic Resonance Imaging
David J. Michalak
Presentation for Physics 25003/13/2007
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Motivation
Principles of NMR
Interactions of spins in B0 field
Principles of 1D MRI
Principles of 2D MRI
2D MRI using the atomic magnetometer.
Applications in progress
o Earth-field MRI for microfluidics
Summary
Outline
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Magnetic Resonance Imaging provides a non-invasive imaging technique.Pros:
-No injection of potentially dangerous elements (radioactive dyes)-Only magnetic fields are used for imaging – no x-rays
Cons:-Current geometries are expensive, and large/heavy
Motivation
www.nlm.nih.gov
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B0
Principles of NMR
Application of prepolarizing magnetic field, B0, aligns the spins in a sample to give a net magnetization, M. M rotates about B0 at a Larmor precession frequency, = B0
M = Mi
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RFPulse
B0
Principles of NMR
Application of prepolarizing magnetic field, B0, aligns the spins in a sample to give a net magnetization, M. M rotates about B0 at a Larmor precession frequency, = B0
y
x
zB0
Application of a rf pulse 0=2f0 along the x-axis will provide a torque that displaces M from the z axis towards y axis. A certain pulse length will put M right on xy plane
M = Mi
M
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RFPulse
B0
Principles of NMR
Application of prepolarizing magnetic field, B0, aligns the spins in a sample to give a net magnetization, M. M rotates about B0 at a Larmor precession frequency, = B0
y
x
zB0
y
x
zB0
M = Mi
M precesses in the transverse plane. In the absence of any disturbances, M continues to rotate indefinitely in xy plane.
MM
Time
Application of a rf pulse 0=2f0 along the x-axis will provide a torque that displaces M from the z axis towards y axis. A certain pulse length will put M right on xy plane
exp[-it]
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RFPulse
B0
Principles of NMR
Application of prepolarizing magnetic field, B0, aligns the spins in a sample to give a net magnetization, M. M rotates about B0 at a Larmor precession frequency, = B0
y
x
zB0
y
x
zB0
M = Mi
M precesses in the transverse plane. In the absence of any disturbances, M continues to rotate indefinitely in xy plane.
Detector
MM
Time
Application of a rf pulse 0=2f0 along the x-axis will provide a torque that displaces M from the z axis towards y axis. A certain pulse length will put M right on xy plane
exp[-it]
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RFPulse
B0
Principles of NMR
Application of prepolarizing magnetic field, B0, aligns the spins in a sample to give a net magnetization, M. M rotates about B0 at a Larmor precession frequency, = B0
y
x
zB0
y
x
zB0
M = Mi
M precesses in the transverse plane. In the absence of any disturbances, M continues to rotate indefinitely in xy plane.
Detector
MM
Time
Assume: 1) All spins feel same B0.2) No other forces on Mi
(including detection).
Application of a rf pulse 0=2f0 along the x-axis will provide a torque that displaces M from the z axis towards y axis. A certain pulse length will put M right on xy plane
exp[-it]
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RFPulse
B0
Principles of NMR
Application of prepolarizing magnetic field, B0, aligns the spins in a sample to give a net magnetization, M. M rotates about B0 at a Larmor precession frequency, = B0
y
x
zB0
y
x
zB0
M = Mi
Detector
MM
Time
time, t
sign
al,
s r(t
)Application of a rf pulse 0=2f0 along the x-axis will provide a torque that displaces M from the z axis towards y axis. A certain pulse length will put M right on xy plane
(0/2)-1
exp[-it]
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RFPulse
B0
Principles of NMR
Application of prepolarizing magnetic field, B0, aligns the spins in a sample to give a net magnetization, M. M rotates about B0 at a Larmor precession frequency, = B0
y
x
zB0
y
x
zB0
M = Mi
Detector
FT
MM
Time
s r(t
)s r
()
t
Application of a rf pulse 0=2f0 along the x-axis will provide a torque that displaces M from the z axis towards y axis. A certain pulse length will put M right on xy plane 0 = 2f
exp[-it]
(0/2)-1
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RFPulse
B0
Principles of NMR
Application of prepolarizing magnetic field, B0, aligns the spins in a sample to give a net magnetization, M. M rotates about B0 at a Larmor precession frequency, = B0
y
x
zB0
y
x
zB0
M = Mi
Detector
(0/2)-1
FT
MM
Time
Boring Spectrum!
0 = 2fs r
(t)
s r(
)
t
Application of a rf pulse 0=2f0 along the x-axis will provide a torque that displaces M from the z axis towards y axis. A certain pulse length will put M right on xy plane
exp[-it]
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Principles of NMR
y
x
zB0
In Reality:
1) Relaxation (Inherent even if B0 is homogeneous)1) T1: Spins move away from xy plane towards z.2) T2: Spins dephase from each other.3) Chemical Shift.
2) Experimental Design Effects.1) T2*: Field inhomogeneity in B0(x, y, z, t)
1) Could be intentional (e.g., gradient) or not.
Complexity Makes Things Interesting
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Principles of NMR
y
x
zB0
T1 Spin Relaxation: return of the magnetization vector back to z-axis.
1) Spin-Lattice Time Constant:1) Energy exchange between spins and
surrounding lattice.2) Fluctuations of B field (surrounding dipoles ≈
receivers) at 0 are important. Larger E exchange necessary for larger B0 → lower T1.
2) Math: dM/dt = -(Mz-M0)/T1
1) Solution: Mz = M0 + (Mz(0)-M0)exp(-t/T1)2) After 90 pulse: Mz = M0 [1-exp(-t/T1)]
M0 = net magnetization based on B0.Mz = component of M0 along the z-axis.t = time
T1 Spin Relaxation
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Principles of NMR
y
x
zB0
T2 Spin Relaxation: Decay of transverse magnetization, Mxy.
1) T1 plays a role, since as Mxy → Mz, Mxy → 01) But dephasing also decreases Mxy: T2 < T1.
2) T2: Spin-Spin Time Constant1) Variations in Bz with time and position.2) Pertinent fluctuations in Bz are those near dc
frequencies (independent of B0) so that 0 is changed.
3) Molecular motion around the spin of interest.1) Liquids: High Temp more motion, less B, high
T2
2) Solids: slow fluctuations in Bz, extreme T2.3) Bio Tissues: spins bound to large molecules vs.
those free in solution.
3) Math: dM/dt = -Mxy/T2
1) After 90 pulse: Mxy = M0 exp(-t/T2)]
y
x
z
B0+B(r,t)
T2 Spin Relaxation
Mxy
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Principles of NMR
y
x
zB0
Comparison of T1 and T2 Spin Relaxation:
y
x
z
B0+B(r,t)
Tissue T1 (ms) T2 (ms)
Gray Matter 950 100
White Matter 600 80
Muscle 900 50
Fat 250 60
Blood 1200 100-200*
*200 for arterial blood, 100 for venous blood.B0 = 1.5 T, 37 degC (Body Temp)Magnetic Resonance Imaging: Physical Principles and Sequence Design, Haacke E.M. et al., Wiley: New York, 1999.
T1/T2 Spin Relaxation
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Principles of NMR
y
x
zB0
Comparison of T1 and T2 Spin Relaxation:
y
x
z
B0+B(r,t)
Tissue T1 (ms) T2 (ms)
Gray Matter 950 100
White Matter 600 80
Muscle 900 50
Fat 250 60
Blood 1200 100-200*
Detector
T1/T2 Spin Relaxation
*200 for arterial blood, 100 for venous blood.B0 = 1.5 T, 37 degC (Body Temp)Magnetic Resonance Imaging: Physical Principles and Sequence Design, Haacke E.M. et al., Wiley: New York, 1999.
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Principles of NMR
y
x
zB0
Comparison of T1 and T2 Spin Relaxation:
y
x
z
B0+B(r,t)
Tissue T1 (ms) T2 (ms)
Gray Matter 950 100
White Matter 600 80
Muscle 900 50
Fat 250 60
Blood 1200 100-200*
*200 for arterial blood, 100 for venous blood.Magnetic Resonance Imaging: Physical Principles and Sequence Design, Haacke E.M. et al., Wiley: New York, 1999.
FID 0
Spectrum
T2 << T1
Mxy decays~exp(-t/T2)
Detector
FT 2/T2
Because T2 is independent of B0, higher B0 gives better resolution
T1/T2 Spin Relaxation
s r(t
)
t
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Principles of NMR
y
x
zB0
y
x
z
B0+B(r,t)
Inclusion of T1 and T2 Spin Relaxation:
1) Inclusion of mathematical expression:1) Bloch Equation
1
0
2
)(
T
MM
T
MMBM
dt
dM zyx kji
= gyromagnetic ratioT1 = Spin-Lattice (longitudinal-z) relaxation time constantT2 = Spin-Lattice (longitudinal-z) relaxation time constantM0 = Equilibrium Magnetization due to B0 field.i, j, k = Unit vectors in x, y, z directions respectively.
T1/T2 Spin Relaxation
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Principles of NMR
y
x
zB0
y
x
z
B0+B(r,t)
Inclusion of T1 and T2 Spin Relaxation:
1) Inclusion of mathematical expression:1) Bloch Equation
1
0
2
)(
T
MM
T
MMBM
dt
dM zyx kji
= gyromagnetic ratioT1 = Spin-Lattice (longitudinal-z) relaxation time constantT2 = Spin-Lattice (longitudinal-z) relaxation time constantM0 = Equilibrium Magnetization due to B0 field.i, j, k = Unit vectors in x, y, z directions respectively.
Precession TransverseDecay
LongitudinalGrowth
Net magnetization is not necessarily constant: e.g., very short T2, long T1.
T1/T2 Spin Relaxation
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Principles of NMR
y
x
zB0
Chemical Shift: Nuclei are shielded (slightly) from B0 by the presence of their electron clouds.
1) Effective field felt by a nuclear spin is B0(1-).1) Larmor precession freq, = B0(1-).
1) Shift is often in the ppm range.1) ~500,000 precessions before Mxy = 0
2) Chemical environment determines amount of .1) H2O vs. Fat (fat about 3.5 ppm lower 0)
y
x
z
B0(1-)
Discrete Shift
H HO
+ +
-
H HC
Less Shielding More Shielding
Chemical Shift
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Principles of NMR
y
x
zB0
Chemical Shift: Nuclei are shielded (slightly) from B0 by the presence of their electron clouds.
1) Effective field felt by a nuclear spin is B0(1-).1) Larmor precession freq, = B0(1-).
1) Shift is often in the ppm range.1) ~500,000 precessions before Mxy = 0
2) Chemical environment determines amount of .1) H2O vs. Fat (fat about 3.5 ppm lower 0)
y
x
z
B0(1-)
Discrete Shift
H HO
+ +
-
H HC
Detector Less Shielding More Shielding
Chemical Shift
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Principles of NMR
y
x
zB0
Chemical Shift: Nuclei are shielded (slightly) from B0 by the presence of their electron clouds.
y
x
z
B0(1-)
Discrete Shift
0
2/T2
Because T2 is independent of B0, higher B0 gives better resolution
Detector
0(1-)
Ability to resolve nuclei in different chemical environments is key to NMR
Chemical Shift
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Principles of NMR
y
x
zB0
T2*: B0 Inhomogeneity: Additional decay of Mxy.
1) In addition to T2, which leads to Mxy decay even in a constant B0, application of B0(x, y, z, t) will cause increased dephasing: 1/T2* = 1/T2 + 1/T’, where T’ is the dephasing due only to B0(x, y, z, t).1) T2
* < T2, and depends on B0(x, y, z, t).2) Additional loss of resolution between peaks.
y
x
z
B0+B(r,t)
time,
Field Inhomogeneity
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Principles of NMR
y
x
zB0
T2*: B0 Inhomogeneity: Additional decay of Mxy.
1) In addition to T2, which leads to Mxy decay even in a constant B0, application of B0(x, y, z, t) will cause increased dephasing: 1/T2* = 1/T2 + 1/T’, where T’ is the dephasing due only to B0(x, y, z, t).1) T2
* < T2, and depends on B0(x, y, z, t).2) Additional loss of resolution between peaks.
2) If B0(x, y, z) is not time dependent, then it can be corrected by an echo pulse.
y
x
z
B0+B(r,t)
time,
Field Inhomogeneity
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Principles of NMR
y
x
zB0
T2*: B0 Inhomogeneity: Additional decay of Mxy.
1) In addition to T2, which leads to Mxy decay even in a constant B0, application of B0(x, y, z, t) will cause increased dephasing: 1/T2* = 1/T2 + 1/T’, where T’ is the dephasing due only to B0(x, y, z, t).1) T2
* < T2, and depends on B0(x, y, z, t).2) Additional loss of resolution between peaks.
2) If B0(x, y, z) is not time dependent, then it can be corrected by an echo pulse.
y
x
z
B0+B(r,t)y
x
z
B0+B(r,t)y
x
z
B0+B(r,t)
180x pulse
(x → x, y → –y)
time,
time,
Field Inhomogeneity
Echo!
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Principles of NMR
y
x
zB0
T2
T2*
Field Inhomogeneity
T2*: B0 Inhomogeneity: Additional decay of Mxy.
3) If echo pulse applied at time, , then echo appears at 2. 1) Only T’ can be reversed by echo pulsing, T2
cannot be echoed as the field inhomogeneities that lead to T2 are not constant in time or space.
4) Signal after various echo pulsed displayed below.
180 pulse
applied
Echo
t 90
pulse
’180 pulse
applied
’Echo
s r(t
)
t
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Principles of 1DMRI Single B0 – No Spatial Information
Measured response is from all spins in the sample volume. Detector coil probes all space with equal intensity
90 pulse
B0 B0
FID 0
Spectrum
FT 2/T2
If only B0 is present (and homogeneous) all spins remain in phase during precession (as drawn).
- B(x, y, z, t) = B0; thus, (x, y, z) = 0 = B0
time
B0
No Spatial Information(Volume integral)
Detectorcoil
s r(t
)
t
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Principles of 1DMRI Slice Selection: z-Gradient
Slice selection along z-axis. Gradient in z and selective excitation allows detection of a single slice.
B(z) = B0 + Gzz
Field strength indicated by line thickness
Gz
Gz = dBz/dzintegrateBz=Gzz
It follows that:B(z=0)=B0
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Principles of 1DMRI Slice Selection: z-Gradient
Slice selection along z-axis. Gradient in z and selective excitation allows detection of a single slice.
Selective90 pulse
rf=0+Gzz
B(z) = B0 + Gzz
Field strength indicated by line thickness
Gz
Gz = dBz/dzintegrateBz=Gzz
It follows that:B(z=0)=B0
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Principles of 1DMRI Slice Selection: z-Gradient
Slice selection along z-axis. Gradient in z and selective excitation allows detection of a single slice.
B(z) = B0 + Gzz
Field strength indicated by line thickness
1) Larmor Precession frequency is z-dependent: (z) = B(z) (z) =(B0 + Gzz)(z) = 0 + Gzz
Gz Selective90 pulse
rf=0+Gzz
2) Excite only one plane of z ± z by using only one excitation frequency for the 90 pulse. For example, using B0 for excitation: only spins at z=0 get excited. All other spins are off resonance and are not tipped into the transverse plane.Gz = dBz/dz
integrateBz=Gzz
It follows that:B(z=0)=B0
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FT
Principles of 1DMRI Slice Selection: z-Gradient
Slice selection along z-axis. Gradient in z and selective excitation allows detection of a single slice.
B(z) = B0 + Gzz
Field strength indicated by line thickness
Gz
3) In practice, you must bandwidth match the frequency of the 90 pulse with the desired thickness (z) of the z-slice. (i.e., with a linear gradient, the Larmor precession of spins within z = 0 ± z oscillate with frequency 0 ± Gzz. Thus, BW = 2Gzz.)
4) To apply a “boxcar” of frequencies ± Gzz, we need the 90 deg excitation profile to be a sinc function in time.1) FT(sinc) = rect
Selective90 pulse
rf=0+Gzz
t 90° z ± z
Gz = dBz/dzintegrateBz=Gzz
It follows that:B(z=0)=B0 sinc = (sinx)/x
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Principles of 1DMRI Slice Selection: z-Gradient
Pulse Sequence. Shows the relative timing of the RF and gradient pulses.
Selective90
pulse
B(z) = B0 + Gzz
Gz
Pulse Sequence
RF
Gz
0 3 time
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0-Gzz
Principles of 1DMRI Slice Selection: z-Gradient
Gradient Echo Pulse. Gradient Echo pulse restores all spins to have the same phase within the slice z.
Selective90
pulse
B(z) = B0 + Gzz
Gz
Pulse Sequence
RF
Gz
Gradient Echo
0
0+Gzz
Before Gradient Echot =
0 3 time
Spins out of phase on xy plane
z
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0-Gzz
Principles of 1DMRI Slice Selection: z-Gradient
Gradient Echo Pulse. Gradient Echo pulse restores all spins to have the same phase within the slice z.
Selective90
pulse
B(z) = B0 + Gzz
Gz
Pulse Sequence
RF
Gz
Gradient Echo
z
0
0+Gzz
Before Gradient Echot =
0 time
Spins out of phase on xy plane
Top View of xy plane
t=
0 0+Gzz0-Gzz
3
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Principles of 1DMRI Slice Selection: z-Gradient
Gradient Echo Pulse. Gradient Echo pulse restores all spins to have the same phase within the slice z.
Selective90
pulse
B(z) = B0 + Gzz
Gz
Pulse Sequence
RF
Gz
z
z
Before Gradient Echot =
After Gradient Echot = 3/2
0 time
Spins out of phase on xy plane
Spins all IN phase
Gradient Echot=
t=3
0 0+Gzz0-GzzTop View of xy plane
0-Gzz0
0+Gzz
3
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Principles of 1DMRI Slice Selection: z-Gradient
Slice selection along z-axis. Gradient in z and selective excitation allows detection of a single slice.
Selective90
pulse
B(z) = B0 + Gzz
Gz
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Principles of 1DMRI Slice Selection: z-Gradient
Slice selection along z-axis. Gradient in z and selective excitation allows detection of a single slice.
Selective90
pulse
B(z) = B0 + Gzz
Gz
Detectorcoil
time
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Principles of 1DMRI Slice Selection: z-Gradient
Slice selection along z-axis. Gradient in z and selective excitation allows detection of a single slice.
Selective90
pulse
B(z) = B0 + Gzz
Gz
Detectorcoil
time
FID 0
Spectrum
FT 2/T2No x, y Information, but only spins from the z ± z slice contribute to the signal.
exp(-t/T2)
s r(t
)
t
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Principles of 1DMRI Slice Selection: z-Gradient
Slice selection along z-axis. Gradient in z and selective excitation allows detection of a single slice.
Selective90
pulse
B(z) = B0 + Gzz
Gz
Detectorcoil
time
FID 0
Spectrum
FT 2/T2No x, y Information, but only spins from the z ± z slice contribute to the signal.
exp(-t/T2)
If we can encode along x and y dimensions, we can iterate for each z slice.
s r(t
)
t
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Principles of 1DMRI Frequency Encoding
Perform z-slice. Now only look at 2D plane from now on. Use Gradient along x to generate different Larmor frequencies vs. x-position.
Selective90
pulse in z ± z
z y
xz
z y
x
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Principles of 1DMRI Frequency Encoding
Perform z-slice. Now only look at 2D plane from now on. Use Gradient along x to generate different Larmor frequencies vs. x-position.
Selective90
pulse in z ± z
time
z y
xz
Apply x-GradientGx = dBz/dx
Precession Frequency varies with x
z y
x
z
xBz(x) - B0
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Principles of 1DMRI Frequency Encoding
Perform z-slice. Now only look at 2D plane from now on. Use Gradient along x to generate different Larmor frequencies vs. x-position.
Selective90
pulse in z ± z
time
z y
xz
Apply x-GradientGx = dBz/dx
Precession Frequency varies with x
z y
x
z
xBz(x) - B0
0 0 + Gxx0 - Gxx
(x)
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Principles of 1DMRI Frequency Encoding
Perform z-slice. Now only look at 2D plane from now on. Use Gradient along x to generate different Larmor frequencies vs. x-position.
Selective90
pulse in z ± z
time
z y
xz
Apply x-GradientGx = dBz/dx
Precession Frequency varies with x
z y
x
z
x
0 0 + Gxx0 - Gxx
(x)
Frequency Encoding along x
Bz(x) - B0
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Principles of 1DMRI Frequency Encoding
Perform z-slice. Now only look at 2D plane from now on. Use Gradient along x to generate different Larmor frequencies vs. x-position.
z
xBz(x) - B0
0 0 + Gxx0 - Gxx
(x)
Pulse Sequence
RF
Gz
0 time
Gx
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Principles of 1DMRI Frequency Encoding
Perform z-slice. Now only look at 2D plane from now on. Use Gradient along x to generate different Larmor frequencies vs. x-position.
z
xDetector
coil
Pulse Sequence
RF
Gz
0 time
Gx
Detect Signal “readout”
Gx on while detecting
Bz(x) - B0
0 0 + Gxx0 - Gxx
(x)
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Principles of 1DMRI Frequency Encoding
Perform z-slice. Now only look at 2D plane from now on. Use Gradient along x to generate different Larmor frequencies vs. x-position.
z
xDetector
coil
Apply x-Gradient DURING acquisition.Precession Frequency varies with x.
Bz(x) - B0
0 0 + Gxx0 - Gxx
(x)
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Principles of 1DMRI Frequency Encoding
Perform z-slice. Now only look at 2D plane from now on. Use Gradient along x to generate different Larmor frequencies vs. x-position.
Apply x-Gradient DURING acquisition.Precession Frequency varies with x.
z
xDetector
coil
FID
exp(-t/T2*)T2* is based on the intentionally applied gradient.s r
(t)
t
Bz(x) - B0
0 0 + Gxx0 - Gxx
(x)
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Principles of 1DMRI Frequency Encoding
Perform z-slice. Now only look at 2D plane from now on. Use Gradient along x to generate different Larmor frequencies vs. x-position.
Apply x-Gradient DURING acquisition.Precession Frequency varies with x.
z
xDetector
coil
FID FT
exp(-t/T2*)T2* is based on the intentionally applied gradient.
0
2/T2*
0 - Gxx 0 + Gxx
s r(t
)
t
Bz(x) - B0
0 0 + Gxx0 - Gxx
(x)
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0 + Gxx
Principles of 1DMRI Frequency Encoding
Perform z-slice. Now only look at 2D plane from now on. Use Gradient along x to generate different Larmor frequencies vs. x-position.
Apply x-Gradient DURING acquisition.Precession Frequency varies with x.
Spins at various x positions in space are encoded to a different precession frequency
z
xDetector
coil
FID FT
exp(-t/T2*)T2* is based on the intentionally applied gradient.
0
2/T2*
0 - Gxx 0 + Gxx
s r(t
)
t
Bz(x) - B0
00 - Gxx
(x)
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Principles of 1DMRI
90 pulse
Imaging Example
Two Microfluidic Channels. Water only exists in two microfluic channels as shown.
z y
xz
z y
x
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Principles of 1DMRI
90 pulse
time
z
xBz(x)
Imaging Example
Two Microfluidic Channels. Water only exists in two microfluic channels as shown.
z y
xz
z y
x
Application of Gx
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Principles of 1DMRI
90 pulse
time
z
xBz(x)
1) No spins exist at x=0 where Gx=0 (0): FT of signal has no intensity at 0.
2) Signal is the line integral along y. (Still no info about y distribution of spins.)
Imaging Example
Two Microfluidic Channels. Water only exists in two microfluic channels as shown.
z y
xz
00 - Gxx 0 + Gxx
Image
z y
x
Application of Gx
![Page 53: Principles of Magnetic Resonance Imaging David J. Michalak Presentation for Physics 250 03/13/2007](https://reader030.vdocuments.site/reader030/viewer/2022032800/56649d3b5503460f94a1594e/html5/thumbnails/53.jpg)
Principles of 1DMRI
90 pulse
time
z
xBz(x)
1) No spins exist at x=0 where Gx=0 (0): FT of signal has no intensity at 0.
2) Signal is the line integral along y. (Still no info about y distribution of spins.)
Imaging Example
Two Microfluidic Channels. Water only exists in two microfluic channels as shown.
z y
xz
00 - Gxx 0 + Gxx
Image
z y
x
x y
xtGitir dxdyeeyxmts x0),()(
m(x,y) = spin density(x,y)
Application of Gx
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Principles of 1DMRI 1DFT Math
Signal is the 1DFT of the line integral along y.
x y
xtGitir dxdyeeyxmts x0),()(
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Principles of 1DMRI 1DFT Math
Signal is the 1DFT of the line integral along y.
x y
xtGitir dxdyeeyxmts x0),()(
x y
xtGi dxdyeyxmts x),()(
Homodyne the signal (from 0 to 0).
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Principles of 1DMRI 1DFT Math
Signal is the 1DFT of the line integral along y.
x y
xtGitir dxdyeeyxmts x0),()(
x y
xtGi dxdyeyxmts x),()(
Homodyne the signal (from 0 to 0).
x
xtGi dxexgts x)()( y
dyyxmxg ),()(
Let g(x) = Line integral along y for a given x position.
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Principles of 1DMRI 1DFT Math
Signal is the 1DFT of the line integral along y.
x y
xtGitir dxdyeeyxmts x0),()(
x y
xtGi dxdyeyxmts x),()(
Homodyne the signal (from 0 to 0).
x
xtGi dxexgts x)()( y
dyyxmxg ),()(
Let g(x) = Line integral along y for a given x position.
2
22
FT)()( tGkx
xtG
i
xx
x
g(x)dxexgts
The homodyned signal is thus the Fourier Transform (along x) of the line integral along y.
Spatial frequencyGxt ~ kx
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0 + Gxx
Principles of 1DMRI k-vector perspective
Time Evolution of Spins in an x-Gradient. Spatial frequency, k-vector, changes.
Pulse Sequence
RF
Gz
0 time
Gx
t1 t2
x
Mi(x)
t1
Dephasing across x in time. Rotating frame 0 or relative to x=0
time
00 - Gxx
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0 + Gxx
Principles of 1DMRI k-vector perspective
Pulse Sequence
RF
Gz
0 time
Gx
t1 t2
x
Mi(x)
t1
Dephasing across x in time. Rotating frame 0 or relative to x=0
time
00 - Gxx
Time Evolution of Spins in an x-Gradient. Spatial frequency, k-vector, changes.
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0 + Gxx
Principles of 1DMRI k-vector perspective
Pulse Sequence
RF
Gz
0 time
Gx
t1 t2
x
Mi(x)
t1
Dephasing across x in time. Rotating frame 0 or relative to x=0
time
00 - Gxx
Time Evolution of Spins in an x-Gradient. Spatial frequency, k-vector, changes.
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0 + Gxx
Principles of 1DMRI k-vector perspective
Pulse Sequence
RF
Gz
0 time
Gx
t1 t2
x
Mi(x)
t1
Dephasing across x in time. Rotating frame 0 or relative to x=0
time
00 - Gxx
Time Evolution of Spins in an x-Gradient. Spatial frequency, k-vector, changes.
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Principles of 1DMRI k-vector perspective
Pulse Sequence
RF
Gz
0 time
Gx
t1 t2
Mi(x)
t1
Dephasing across x in time. Rotating frame 0 or relative to x=0
time
Time Evolution of Spins in an x-Gradient. Spatial frequency, k-vector, changes.
0 + Gxx00 - Gxxx
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Principles of 1DMRI k-vector perspective
Pulse Sequence
RF
Gz
0 time
Gx
t1 t2
Mi(x)
t1
Dephasing across x in time. Rotating frame 0 or relative to x=0
time
Time Evolution of Spins in an x-Gradient. Spatial frequency, k-vector, changes.
0 + Gxx00 - Gxxx
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Principles of 1DMRI k-vector perspective
Pulse Sequence
RF
Gz
0 time
Gx
t1 t2
Mi(x)
t1
Dephasing across x in time. Rotating frame 0 or relative to x=0
time
Time Evolution of Spins in an x-Gradient. Spatial frequency, k-vector, changes.
0 + Gxx00 - Gxxx
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Principles of 1DMRI k-vector perspective
Pulse Sequence
RF
Gz
0 time
Gx
t1 t2
Mi(x)
t1
Dephasing across x in time. Rotating frame 0 or relative to x=0
time
Time Evolution of Spins in an x-Gradient. Spatial frequency, k-vector, changes.
0 + Gxx00 - Gxxx
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Principles of 1DMRI k-vector perspective
Pulse Sequence
RF
Gz
0 time
Gx
t1 t2
Mi(x)
Homo-dynes(t)
t1
Dephasing across x in time. Rotating frame 0 or relative to x=0
time
FID
Time Evolution of Spins in an x-Gradient. Spatial frequency, k-vector, changes.
0 + Gxx00 - Gxxx
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0 + Gxx00 - Gxx
Principles of 1DMRI k-vector perspective
Pulse Sequence
RF
Gz
0 time
Gx
tGk xx
2
t1 t2
Mi(x)
Homo-dynes(t)
t1
Dephasing across x in time. Rotating frame 0 or relative to x=0
time
k FID
Spatial frequency encoded by phase
k=0
k: one spatial period
Time Evolution of Spins in an x-Gradient. Spatial frequency, k-vector, changes.
x
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Principles of 1DMRI k-vector perspective
Pulse Sequence
RF
Gz
0 time
Gx
t1 t2
Mi(x)
Homo-dynes(t)
t1
Dephasing across x in time. Rotating frame 0 or relative to x=0
time
k FID
k=0
k: one spatial period
Each Point on FID is a different value of kx
Time Evolution of Spins in an x-Gradient. Spatial frequency, k-vector, changes.
tGk xx
2
0 + Gxx00 - Gxx
Spatial frequency encoded by phase
x
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Principles of 1DMRI k-vector perspective
Pulse Sequence
RF
Gz
0 time
Gx
t1 t2
Mi(x)
Homo-dynes(t)
t1
Dephasing across x in time. Rotating frame 0 or relative to x=0
time
k FID
k=0
k: one spatial period
Each Point on FID is a different value of kx
Time Evolution of Spins in an x-Gradient. Spatial frequency, k-vector, changes.
tGk xx
2
0 + Gxx00 - Gxxk-vector ~ amount of
spin warping over distance
Spatial frequency encoded by phase
x
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Principles of 1DMRI 2 Approaches to Understand FTThe imaging in 1D can be understood in 2 ways:
1) From the received signal perspective: The spins, spatially separated along the x-dimension, are distinguished by the application of a gradient field that makes their Larmor precession vary along x. The FT resolves the difference in frequency and hence position.
2) Homodyned (baseband) signal perspective: As time passes during the application of the gradient, the spins dephase from each other. The amount of dephasing can be represented as a spatial frequency, kx, that increases with measurement time.
tGk xx
2
2/T2*
00 - Gxx 0 + Gxx
Frequency EncodingPrecession: (x)
Phase EncodingPhase(t) ~ Spatial Freq.
FT of FID (time) gives frequency, . depends on position
FT of spatial frequency data, kx, data gives position data, x.Different values of kx are probed over time, t.
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Principles of 2DMRI 2DFT Principles
Again perform z-slice. Only look at 2D plane. Want to now distinguish spins along x- and y-directions.
z
y
x90 pulsed
Plane
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Principles of 2DMRI 2DFT Principles
Again perform z-slice. Only look at 2D plane. Want to now distinguish spins along y-direction also.
z
y
x
z
y
x90 pulsed
Plane Apply y-Gradient for time ty
Gy = dBz/dy
Gy
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Principles of 2DMRI 2DFT Principles
Again perform z-slice. Only look at 2D plane. Want to now distinguish spins along y-direction also.
z
y
x
z
y
x90 pulsed
Plane Apply y-Gradient for time ty
Gy = dBz/dyThen Gy turned off
Gy
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Principles of 2DMRI 2DFT Principles
Phase Encoding. Gy is turned on for a certain time, ty, then off. This generates a difference in phase over y.
All precess
at 0
z
y
x
z
y
x90 pulsed
Plane Apply y-Gradient for time ty
Gy = dBz/dyThen Gy turned off
Gy z
y
x
But spin warped along y by an amount determined by Gyty ~ single ky value
yyy tGk
2
Phase encoding along y
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z
y
x
Principles of 2DMRI 2DFT Principles
Detect Using Gx. As usual detection occurs with Gx.
All precess
at 0
z
y
x
Bz(x)
z
y
x90 pulsed
Plane Apply y-Gradient for time ty
Gy = dBz/dyThen Gy turned off
Gy z
y
x
Detectorcoil
Detect with Gx
Usual frequency encoding along x
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z
y
x
Principles of 2DMRI 2DFT Principles
Detect Using Gx. As usual detection occurs with Gx.
All precess
at 0
z
y
x
Bz(x)
z
y
x90 pulsed
Plane Apply y-Gradient for time ty
Gy = dBz/dyThen Gy turned off
Gy z
y
x
Detectorcoil
Detect with Gx
This time, the magnitude of the signal at each (x-position), corresponds to the intensity of the spatial frequency, ky, encoded by Gy phase encoding step.
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z
y
x
Principles of 2DMRI 2DFT Principles
Detect Using Gx. As usual detection occurs with Gx.
All precess
at 0
z
y
x
Bz(x)
Frequency Encoding along x (Gxt)Phase Encoding along y (Gyty)
z
y
x90 pulsed
Plane Apply y-Gradient for time ty
Gy = dBz/dyThen Gy turned off
Gy z
y
x
Detectorcoil
Detect with Gx
This time, the magnitude of the signal at each (x-position), corresponds to the intensity of the spatial frequency, ky, encoded by Gy phase encoding step. (for ky=0 it’s the line integral)
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Bz(x) - B0
z
x
Principles of 2DMRI 2DFT Principles
Again perform z-slice. Only look at 2D plane. Want to now distinguish spins along y-direction also.
Phase
Enc
oded
Pulse Sequence
RF
Gz
0 time
Gx
ty
Gy
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z
x
Principles of 2DMRI 2DFT Principles
Again perform z-slice. Only look at 2D plane. Want to now distinguish spins along y-direction also.
Bz(x)Detector
coil
Phase
Enc
oded
Pulse Sequence
RF
Gz
0 time
Gx
Detect Signal
ty
PhaseEncode
Gy
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z
x
Principles of 2DMRI 2DFT Principles
Again perform z-slice. Only look at 2D plane. Want to now distinguish spins along y-direction also.
Bz(x)Detector
coil
Repeat experiment multiple times varying the Gy gradient strength (or time ty) so that ky receives the same sampling as kx (FID sampling rate).
Phase
Enc
oded
Pulse Sequence
RF
Gz
0 time
Gx
Detect Signal
ty
PhaseEncode
Gy
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Principles of 1DMRI 2DFT Math
Signal is the 2DFT of the image.
x y
xtGiytGi dxdyeeyxmts xyy ),()( Baseband (Homodyned) signal.
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Principles of 1DMRI 2DFT Math
Signal is the 2DFT of the image.
x y
xtGiytGi dxdyeeyxmts xyy ),()( Baseband (Homodyned) signal.
Phase EncodingStep
Gx during recording
of FID
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Principles of 1DMRI 2DFT Math
Signal is the 2DFT of the image.
x y
xtGiytGi dxdyeeyxmts xyy ),()( Baseband (Homodyned) signal.
For any given FID, ty is fixed and t is running variable.
Phase EncodingStep
Gx during recording
of FID
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Principles of 1DMRI 2DFT Math
Signal is the 2DFT of the image.
x y
xtGiytGi dxdyeeyxmts xyy ),()( Baseband (Homodyned) signal.
2
,2
,FTD2)( yyy
xx
tGk
tGk
y)m(xts
For any given FID, ty is fixed and t is running variable.
Phase EncodingStep
Gx during recording
of FID
00 - Gxx 0 + Gxx
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Principles of 1DMRI 2DFT Math
Signal is the 2DFT of the image.
x y
xtGiytGi dxdyeeyxmts xyy ),()( Baseband (Homodyned) signal.
2
,2
,FTD2)( yyy
xx
tGk
tGk
y)m(xts
For any given FID, ty is fixed and t is running variable.
Phase EncodingStep
Gx during recording
of FID
00 - Gxx 0 + Gxx
Intensities at each x correspond to intensity of the ky spatial frequency (applied during phase encoding) at that x position. In other words, the intensity corresponds to 1 pt on the FID taken in the y direction
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Principles of 2DMRI 2DFT Principles
k-space perspective. Want to map k-space then take 2DFT. (Each FID samples line in k-space along kx)
kx
ky
Set of data points along the kx axis corresponds to the sampled FID taken with no Gy phase encoding gradient.
Set of data points sampled from the FID with a phase encoding of a given ky (Gyty).
yyy tGk
2 tGk xx
2
Measure FIDkx measured in time
Cha
nge
Gyt
y
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Principles of 2DMRI 2DFT Principles
k-space perspective. Want to map k-space then take 2DFT. (Each FID samples line in k-space along kx)
kx
ky
Thus, it is evident that a column of data (at a given x position) on the collection of points in k-space represents the FT of the various Gy values. The data along a line is the FT of the signal in the y direction.
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Principles of 2DMRI 2DFT Principles
k-space perspective. Want to map k-space then take 2DFT. (Each FID samples line in k-space along kx)
kx
ky
Thus, it is evident that a column of data (at a given x position) on the collection of points in k-space represents the FT of the various Gy values. The data along a line is the FT of the signal in the y direction.
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Principles of 2DMRI 2DFT Principles
k-space perspective. Want to map k-space then take 2DFT. (Each FID samples line in k-space along kx)
kx
ky
Thus, it is evident that a column of data (at a given x position) on the collection of points in k-space represents the FT of the various Gy values. The data along a line is the FT of the signal in the y direction.
Rotate forviewing
“FID” along y.
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Principles of 2DMRI 2DFT Principles
k-space perspective. Want to map k-space then take 2DFT. (Each FID samples line in k-space along kx)
kx
ky What does this data look like?
Image
Rect function
Rec
t fu
nctio
n
Sinc function
Sin
c fu
nctio
n
x
y
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Principles of 2DMRI 2DFT Principles
k-space perspective. Want to map k-space then take 2DFT. (Each FID samples line in k-space along kx)
kx
ky What does this data look like?
x
Image
Circle function(radially symmetric rect)
Jinc functionRadially symmetric sinc)
y
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Principles of 2DMRI 2DFT Principles
Updated Pulse Sequence. Want to map k-space then take 2DFT. (Each FID samples line in k-space along kx)
kx
ky Pulse Sequence
RF
Gz
0 time
Gx
tyGy
ty
2ty
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Principles of 2DMRI 2DFT Principles
Updated Pulse Sequence. Want to map k-space then take 2DFT. (Each FID samples line in k-space along kx)
kx
ky Pulse Sequence
RF
Gz
0 time
Gx
tyGy
ty
ty
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Principles of 2DMRI 2DFT Principles
Updated Pulse Sequence. Want to map k-space then take 2DFT. (Each FID samples line in k-space along kx)
kx
ky Pulse Sequence
RF
Gz
0 time
Gx
tyGy
ty
ty
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Principles of 2DMRI 2DFT Principles
Updated Pulse Sequence. Want to map k-space then take 2DFT. (Each FID samples line in k-space along kx)
kx
ky Pulse Sequence
RF
Gz
0 time
Gx
Gy
ty
ty
Representation
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Principles of 2DMRI Discrete FT Imaging Issues
Sampling Rate Issues: Real time FID is sampled at various times of interval, t, which leads to a sampling rate in the kx dimension of (kx). Interval on ky is determined by the change in gradient area (Gyty) between different runs
kx
ky
Sampling rate of k-space
We know that we need enough data to adequately sample the FID in time (kx) dimension
Same principle applies for ky (Gyty) dimension
t, kx
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Principles of 2DMRI Field of View
Field of View: Sampling rate of k-space determines the field of view in the object-oriented domain.
kx
ky
Sampling rate of k-space
x
y
ky
kx
FOVy
=1/ky)
FOVx = 1/kx)
FOV > Image size!Prevent Aliasing
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Principles of 2DMRI
kx
ky
Sampling rate of k-space
ky
kx
Aliasing Issues
Aliasing: If sampling rate is not sufficient, the Field of view will overlap.
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Principles of 2DMRI
kx
ky
Sampling rate of k-space
x
y
ky
kx
FOVy
=1/ky)
FOVx = 1/kx)
FOV > Image size!Prevent Aliasing(Image Overlap)
Aliasing Issues
Aliasing: If sampling rate is not sufficient, the Field of view will overlap.
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Principles of 2DMRI Resolution
Resolution: Resolution in the object-oriented domain is determined by the extent of k-space measured.
kx
ky
Sampling rate of k-space
x
y
kyNpe
kxNread
y = FOVy/Npe
=(kyNpe)-1
x = FOVx/Nread
=(kxNread)-1
Field of View/Resolution ~ # points need to sample
(e.g., 25.6 cm image, 1mm resolution:256 points/dimension, 65.5k points)
Nread: # of readout points during FIDNpe: # of phase encoding steps
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Summary
1. MRI is based on the spatial encoding of spins either through a difference in phase (y) or a difference in Larmor frequency (x):
1. FID in the presence Gx, after a given phase encoding in y, gives a line of points in k-space. FIDs are repeated for a variety of ky values to fill up k-space.
1. 2DFT of k-space gives the image of spin density m(x,y)
2. Limitations.
1. Detection is based on the signal received in a coil.1. Coil inductor has an impedance, Zcoil= iL, ~ frequency. Thus
significant voltage signals are observed only at high frequencies. (Mxy → icoil. icoil = vsignal/Zcoil.)
2. Requires Large Magnetic fields – cryogenics, homogeneity.1. Large Fields can lead to signal distortion. Samples containing
metals cannot be imaged
3. Atomic magnetometry – large fields not necessary. Remote detection can be used so that imaging can be performed in the presence of metals.
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Remote Detection
Flow In
1) Spatial Encoding (90 pulse, Gx, Gy, Gz)
2) Storage of one component (Mx, My) along z.
FlowOut
Detector(Analyze stored
component)
Region of Interest(Flow profile, etc.)
Spatial information carried by flow of liquid (H2O) to the detection region.
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MRI using the atomic magnetometer
Nitrogen
Magnetometer
Pre-polarization Field (~ 3 kG)
Encoding Field (B0, Bx, By, Bz)
Water Out
H2O
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RFPulse
TravelTime
StoragePulse
π/2 π/2 Mt
B0
Remote Detection of NMR/MRIRemote Detection of NMR/MRI
1) dc magnetometer means NO FID recorded.
2) k-space in must be measured point-by-point.-Very slow! Imaging takes much more time!-But z-slice obtained all at once by flow profile.
Encoding Region
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Remote Detection
Flow In
FlowOut
No z-slice performed – use flow and detection time to obtain z-slice.
Detector
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Remote Detection
Flow In
FlowOut
No z-slice performed – use flow and detection time to obtain z-slice.
Pulse
t
Det
ecto
rs(
t)
Detector
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Remote Detection
Flow In
FlowOut
No z-slice performed – use flow and detection time to obtain z-slice.
Flow
t
Det
ecto
rs(
t)
Detector
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Remote Detection
Flow In
FlowOut
No z-slice performed – use flow (and detection time) to obtain z-slice.
Flow
t
Det
ecto
rs(
t)
Detector
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Remote Detection
Flow In
FlowOut
No z-slice performed – use flow and detection time to obtain z-slice.
Flow
ttflow
Det
ecto
rs(
t)
Detector
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Remote Detection
Flow In
FlowOut
No z-slice performed – use flow and detection time to obtain z-slice.
Flow
ttflow
Det
ecto
rs(
t)
Detector
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Remote Detection
Flow In
FlowOut
No z-slice performed – use flow and detection time to obtain z-slice.
Flow
ttflow
Det
ecto
rs(
t)
Detector
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Remote Detection
Flow In
FlowOut
No z-slice performed – use flow and detection time to obtain z-slice.
Flow
ttflow
Det
ecto
rs(
t)
Detector
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Remote Detection
Flow In
FlowOut
No z-slice performed – use flow and detection time to obtain z-slice.
Flow
ttflow
Det
ecto
rs(
t)
Detector
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Remote Detection
Flow In
FlowOut
No z-slice performed – use flow and detection time to obtain z-slice.
Flow
ttflow
Det
ecto
rs(
t)
Detector
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Remote Detection
Flow In
FlowOut
No z-slice performed – use flow and detection time to obtain z-slice.
Flow
ttflow
Det
ecto
rs(
t)
Detector
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Remote Detection
Flow In
FlowOut
No z-slice performed – use flow and detection time to obtain z-slice.
Flow
ttflow
Det
ecto
rs(
t)
Detector
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Remote Detection
Flow In
FlowOut
No z-slice performed – use flow and detection time to obtain z-slice.
Flow
ttflow
Det
ecto
rs(
t)
Detector
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Remote Detection
Flow In
FlowOut
No z-slice performed – use flow and detection time to obtain z-slice.
Flow
ttflow
Det
ecto
rs(
t)
Detector
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Remote Detection
Flow In
FlowOut
No z-slice performed – use flow and detection time to obtain z-slice.
Flow
ttflow
Sig
na
l (n
G)
Time (s)
In absence of diffusion, s(t) is the average of the z-slices in the detection region
Det
ecto
rs(
t)
Detector
In reality, diffusion-weighted z-slice
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Encoding2
2
Detection
GPE(x, y)
=(x,-x,y,-y)
a. Pulse sequence: phase encoding
MRI results
x = xt = Gxxt
y = yt = Gyyt
Granwehr, J., et al., PRL 95, 075503 (2005).
kx
kytx,y
tx,y
Sig
na
l (n
G)
Time (s)
Obtain a flow profile for each (kx, ky) point and repeat for all points in k-space- Actually, 4 flow profiles are obtained for each point in k-space…
For x,y dimensions:
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a. Phase Cycling (90 storage pulse along x or y)
MRI results
Granwehr, J., et al., PRL 95, 075503 (2005).
x
y
z For a given k-space point, the net magnetization, Mxy, is rotated to a given point on the x,y plane. Need to convert this to a Mz for measurement.
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a. Phase Cycling (90 storage pulse along x or y)
MRI results
Granwehr, J., et al., PRL 95, 075503 (2005).
x
y
z
x
y
z
2 y Mx → Mz
For a given k-space point, the net magnetization, Mxy, is rotated to a given point on the x,y plane. Need to convert this to a Mz for measurement.
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a. Phase Cycling (90 storage pulse along x or y)
MRI results
Granwehr, J., et al., PRL 95, 075503 (2005).
x
y
z
x
y
z
2 y Mx → Mz
For a given k-space point, the net magnetization, Mxy, is rotated to a given point on the x,y plane. Need to convert this to a Mz for measurement.
But this only tells you the x-component of Mxy. Need to repeat for y to get the vector Mxy.
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a. Phase Cycling (90 storage pulse along x or y)
MRI results
Granwehr, J., et al., PRL 95, 075503 (2005).
x
y
z
x
y
z
x
y
z
2 y
2 x
Mx → Mz
My → -Mz
My component of Mxy stored along z for detection
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a. Phase Cycling (90 storage pulse along x or y)
MRI results
Granwehr, J., et al., PRL 95, 075503 (2005).
x
y
z
x
y
z
x
y
z
2 y
2 x
Mz component detected. Vector addition of signal from /2(x) and /2(y) describes vector Mxy for each point in k-space. This must be repeated for each Gx, Gy (point in k-space) desired. (So far, 2 points per k-space, but why 4?...)
Mx → Mz
My → -Mz
My component of Mxy stored along z for detection
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MRI results
x
y
z
x
y
z
2 y Mx → Mz
a. Phase Cycling (Can do storage pulse along y or -y)
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MRI results
Granwehr, J., et al., PRL 95, 075503 (2005).
x
y
z
x
y
z
2 y 1) Repeating the 90 storage pulse along y and –y
allows for data averaging. (Similar to gradiometer; common mode noise rejected)
Mx → Mz
a. Phase Cycling (Cand do storage pulse along y or -y)
x
y
z2 -y
Mx → -Mz
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MRI results
Granwehr, J., et al., PRL 95, 075503 (2005).
x
y
z
x
y
z
2 y 1) Repeating the 90 storage pulse along y and –y
allows for data averaging. (Similar to gradiometer; common mode noise rejected) - Set Mz(z=0)=0, then add Mz(y pulse) – Mz(-y pulse)
Mx → Mz
a. Phase Cycling (Cand do storage pulse along y or -y)
x
y
z2 -y
Mx → -Mz Sig
na
l (n
G)
Time (s)
Mz=-M0
Mz=M0
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MRI results
Granwehr, J., et al., PRL 95, 075503 (2005).
x
y
z
x
y
z
2 y 1) Repeating the 90 storage pulse along y and –y
allows for data averaging. (Similar to gradiometer; common mode noise rejected) - Set Mz(z=0)=0, then add Mz(y pulse) – Mz(-y pulse)
2) Repeat for x and –x storage pulses to get 4 flow profiles (x, y, -x, -y) for each point in k-space.
Mx → Mz
a. Phase Cycling (Cand do storage pulse along y or -y)
x
y
z2 -y
Mx → -Mz Sig
na
l (n
G)
Time (s)
Mz=-M0
Mz=M0
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a
x
yz
1 mm
z
yx •
b
b. Images of the encoding volume
H2O
MRI results
Images along z are obtained by using the magnetization magnitude from the flow profile after a given flow time.
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0.5 s 0.7 s 0.9 s 1.1 s 1.3 s
1.5 s 1.7 s 1.9 s 2.1 s 2.3 s
c. Time-resolved flow images
Sig
na
l (n
G)
Time (s)
H2O
Temporal resolution: 100 msSpatial resolution: 1.6 mm x 1.6 mm x 4.7 mm
MRI results
Z-sampling
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Resolution: z, 5mm; y, 2.5mm
z
y
0.4 s 0.6 s 0.8 s 1.0 s 1.2 s
1.4 s 1.6 s 1.8 s 2.0 s 2.2 s
c. Time-resolved flow images
MRI results
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c. Time-resolved flow images
MRI results
Resolution: z, 5mm; y, 2.5mm
z
y
0.4 s 0.6 s 0.8 s 1.0 s 1.2 s
1.4 s 1.6 s 1.8 s 2.0 s 2.2 s
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c. Time-resolved flow images
MRI results
z
y
0.4 s 0.5 s 0.6 s 0.7 s 0.8 s
Flow Mixing Region
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c. Time-resolved flow images
MRI results
High-field MRI (300 MHz) of flow in a porous metallic sample.The images show only the inlet and outlet, while imaging of the sample region (marked by the red box) is not possible.
LMRI of flow in a porous metallic sample in the Earth’s field
1.4 s1.2 s1.0 s0.8 s0.6 s0.4 s
In-plane resolution: 2.5mm x 2.5mmObject size: 12 mm diameter, 12 mm length
Stainless Steel Porous Sample
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Summary
1. MRI is based on the spatial encoding of spins either through a difference in phase (y) or a difference in Larmor frequency (x):
1. FID in the presence Gx, after a given phase encoding in y, gives a line of points in k-space. FIDs are repeated for a variety of ky values to fill up k-space.
1. 2DFT of k-space gives the image of spin density m(x,y)
2. MRI can be performed using the atomic magnetometer.
1. Image takes much longer to achieve! Measurement of FID in Gx not yet possible.
2. Hopefully rf magnetometry can solve this problem.
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AcknowledgementsShoujun Xu
Louis Bouchard
Pines Group
Alex PinesChristian HiltyJosef GranwehrSabieh AnwarElad HarelAlyse JacobsonAll current ‘nuts
Budker Group
Dmitry BudkerSimon RochesterValeriy YashchukJames HigbieDerek KimballJason StalnakerMisha Babalas
Physics Department Machine ShopChemistry Department Electronic ShopChemistry Department Glass Shop
Good Books: 1) Principles of Magnetic Resonance Imaging, Dwight G. Nishimura, Stanford University2) Magnetic Resonance Imaging: Physical Principles and Sequence Design, Haacke E.M. et al., Wiley: New York, 1999.