8/14/2019 Preventive Effect of Vitamin C (L-Ascorbic Acid) Oncology. 1986] - PubMed Result

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PMID: 3763128 [PubMed - indexed for MEDLINE]

Preventive effect of vitamin C (L-ascorbic acid) on methylcholanthrene-induced soft tissue sarcomasin mice.

Abdel-Galil AM.

The effect of vitamin C (L-ascorbic acid) on methylcholanthrene (MCA)-induced local malignant sarcomas in

mice was investigated. Four groups of mice were given single intramuscular application of MCA at a dose level

of 0.5 mg/0.1 ml olive oil for each animal. Doses of 6, 25, and 35 mg vitamin C (VC)/mouse were given to

animals of groups B, C and D, respectively. VC was applied in drinking water by intragastric administration 5

times weekly for the first 20 weeks. Animals of group A served as carcinogenic controls. The application of VC

statistically prevented the induction of sarcomas in mice of groups B, C and D compared to carcinogenic

controls (group A). VC supplementation did not significantly reduce the diameters and weights of tumors. It

was concluded that, under the experimental conditions conducted, VC significantly prevented the induction of

sarcomas in mice providing a good prophylactic activity; however, it did not achieve a significant therapeutic

level.

1: Oncology. 1986;43(5):335-7.

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Source: AHFS Consumer Medication Information

Ascorbic Acid (Cecon Drops, Cenolate , Cevi-Bid , ...) Ascorbic acid is used

to prevent and treat scurvy, a disease caused by a lack of vitamin C in the body.