8/14/2019 Preventive Action of Vitamin C on Nit Rosa Mine Form...[Int J Vitam Nutr Res Suppl. 1989] - PubMed Result

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Preventive action of vitamin C on nitrosamine formation.

Tannenbaum SR.

N-Nitroso compounds are known to form endogenously in the human stomach from the precursors nitrite as well

as secondary and tertiary amines. Ascorbic acid has been found to be an effective blocking agent for this process

of formation of carcinogenic substances, both in vitro and in vivo. The mechanism by which ascorbic acid reacts

is chemical in nature and results in the formation of NO and dehydroascorbic acid. Since NO can be recycled in

the presence of O2 to form [NO]x, which is capable of additional nitrosation, greater than stoichrometric

amounts of ascorbate are required for effective inhibition in vivo. The efficacy of ascorbic acid for inhibition of

nitrosamine formation in humans has been demonstrated both clinically and epidemiologically through the use of

"Nitrosoproline Test"--of Ohshima and Bartsch.

1: Int J Vitam Nutr Res Suppl. 1989;30:109-13.

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Preventive action of vitamin C on nitrosamine formation.

Prolongation of survival times of terminal cancer patients by administration

of large dose...

Vitamin C and cancer: an overview.

The influence of ascorbic acid on the growth of solid tumors in mice and on

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Vitamin C lowers mutagenic and toxic effect of hexavalent chromium in

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Patient Drug Information

Source: AHFS Consumer Medication Information

Ascorbic Acid (Cecon Drops, Cenolate , Cevi-Bid , ...) Ascorbic acid is used

to prevent and treat scurvy, a disease caused by a lack of vitamin C in the body.