preventing the development and spread of antimicrobial resistance

Public Health Research Programme

Preventing the development and spread of Antimicrobial Resistance

10-11 am - 2 October 2013

NIHR Public Health Research Programme

Dr Claire Kidgell, Senior Programme ManagerDr Andrew Cook, Consultant Advisor

www.themedcalls.nihr.ac.uk/amr


• Introduction to the AMR Themed Call• Introduction to the PHR Programme• Tips for success• Questions

Webinar overview



• NIHR themed calls are issued to meet an identified health challenge or government priority

• Calls are generally issued once a year• Cross NIHR initiative involving all NIHR research programmes• Previous calls have focused on:

– Dementia– Surgery– Primary Care Interventions– Very Rare Diseases

What is a themed call?


• Part of coordinated response by the NIHR to the publication of the 2nd volume of the 2011 Annual Report of the Chief Medical Officer: Infections and the rise of antimicrobial resistance.

• For research into the evaluation of public health measures, health care interventions and health services to reduce the development and spread of antimicrobial resistance and consequent morbidity

• Provides opportunities to evaluate interventions which cross NIHR programme boundaries and applications which span the remit of one or more NIHR programme will be considered.


NIHR Antimicrobial Resistance themed call



AMR Website


EME – exploratory trials, less pragmatic, phase 2-3, efficacy, mechanisms if possibleHTA – systematic reviews, large multicentre pragmatic trials or other studies (phase 3-4), effectiveness in the NHSHS&DR – organisational, patient experience, qualitative or otheri4i - translation of bright ideas for new high-tech products into methods of prevention, diagnosis and treatmentPHR – effectiveness and cost effectiveness of non-NHS interventions to improve public healthPGfAR- £2m for up to 5 years, awards made to NHS bodiesRfPB – max £350k for up to 36 months. Encourages proposals for projects covering a wide range of health service issues and challenges which translate into patient benefit locally and for the wider NHS.


Which NIHR programme?


www.phr.nihr.ac.uk

NIHR Funding Programme Closing date

Efficacy and Mechanism Evaluation Closed

Health Services & Delivery Research 30 January 2014

Health Technology Assessment 30 October 2013

Invention for Innovation Opening October 2013

Programme Grants for Applied Research Opening December 2013

Public Health Research 19 November 2013

Research for Patient Benefit Opening October 2013

NIHR Fellowships Programme Opening October 2013

http://www.phr.nihr.ac.uk/


Purpose and Remit

To evaluate public health interventions, providing new knowledge on the benefits, costs, acceptability and wider impacts of non-healthcare interventions intended to improve the health of the public and reduce inequalities in health

The scope of the programme is multi-disciplinary and broad covering a range of public health interventions.

Introduction to PHR Programme

www.phr.nihr.ac.uk



Possible Areas for Research• Better prevention• Improved surveillance, monitoring and diagnosis• More effective use of existing antibiotics• Behavioural issues that can affect antibiotic use, the

development or spread of AMR• Organisation-wide initiatives in hospitals, practices and the

community to improve stewardship of antibiotics• Improved education and training• Evaluations of the efficacy and mechanisms of interventions• Public health measures outside of healthcare settings to

prevent the occurrence and transmission of antimicrobial resistance.

www.themedcalls.nihr.ac.uk/amr/resources


www.themedcalls.nihr.ac.uk/amr/resources/specificationdocument/possible-research


• Applications should meet the remit of the AMR specification document and the PHR Programme

• Applications received to the PHR Programme but not in remit will be transferred to other participating NIHR Programmes where appropriate

• Provides opportunities to evaluate interventions which cross NIHR programme boundaries and applications which span the remit of one or more NIHR programme will be considered

• Closing date for applications to the PHR Programme in response to the NIHR AMR themed call 1pm, 19 November 2013

• However, the PHR programme will continue to welcome applications in this area after the call has closed

Applying to the AMR call



Screening assessment:• remit

Programme Advisory Board:• public health importance

Research Funding Board:• scientific quality• feasibility• value for money

Process for Assessment of Applications


Tips For Success


Keep to the remit

Or carefully justify deviations


Give sufficient detail

But not too much


Pick a design to minimise bias

A non-randomised design is a very hard sell if a randomised design is

possible.


Have the right team

Two psychologists are not a multidisciplinary team, even if they

trained at different universities.


Value for Money

We’ll pay a lot to answer an important question – but we will

consider overall value and opportunity cost


…and at full proposal

You will get feedback on your outline proposal. Respond to every point.

You may disagree with the board, but don’t ignore them.


NIHR Support Available

http://www.themedcalls.nihr.ac.uk/amr/resources/support


For more information visit: www.phr.nihr.ac.uk & www.themedcalls.nihr.ac.uk/amr

Enquiries welcome: [email protected] or +44 (0)23 8059 9697 (24 hour answer phone)

Closing date for applications to the PHR Programme in response to the NIHR AMR themed call 1pm, 19 November 2013

Questions?


http://www.themedcalls.nihr.ac.uk/amr

http://www.themedcalls.nihr.ac.uk/amr

preventing the development and spread of antimicrobial resistance

Documents

public health research19

health care interventions

health technology assessment

identified health challenge

public healthpgfar

applied research opening

nhs interventions

yearcross nihr initiative