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    PROJECT WORK INDEPARTMENT OFCOMMUNITYMEDICINE

    PREVALENCE OF

    Rheumatic Heart Disease

    in School-Children ofShimla.

    2007-2008.

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    DEPARTMENT OF Community

    Medicine

    Indira Gandhi Medical College

    Shimla, Himachal

    CERTIFICATEDept. of Community Med. IGMC/Batch 2004/ Prevalence of RHD in SchoolChildren of Shimla

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    This is to certify that the work contained in

    the project entitled Prevalence of Rheumatic Heart

    Disease in School-Children of Shimla has been carried

    out by Mr. Vaibhav Sharma, Mr. Vikrant Sharma, Mr.

    Vikrant Thakur, Mr. Vineet Bhardwaj, Mr. Virat Kuntalam

    & Mr. Virender Chauhan of batch 2004 themselves under

    one direct supervision and guidance of the undersigned.

    The data incorporated in this project is

    original and genuine.

    Dr. A. K. Bhardwaj

    MD, FIPSM, FIPHA

    Professor & Head

    Dept. of Community Medicine

    Indira Gandhi Medical College, Shimla, 171001

    Table of ContentsAcknowledgement

    5

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    Introduction

    .6

    Why our Study is

    Relevant?..............................................................................................................

    . 7

    Aims and

    Objectives

    ..9

    Material and

    Methods

    ..11

    Sampling

    Technique

    12

    Modified Jones

    Criteria

    .13

    Tools Used in

    Study

    .14

    Review of

    Literature15

    Epidemiology

    17

    Etiopathogenesis

    17

    Age

    Pattern

    18

    Previous

    Studies

    .19

    Observations

    .21

    Graphical Representations..

    .23

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    Summary

    .25

    Conclusion..

    .26

    Constrains.

    ..27

    Recommendations.

    .28

    ANNEXURE

    29

    Performa

    30

    Bibliography

    32

    ACKNOWLEDGEMENT

    We have the greatest privilege of expressing out

    heartiest thanks to Dr. (Mrs.) Anupam Parashar, Assoc. Professor and

    Dr. (Mrs.) Renu P.G. Student, Department of Community Medicine,

    Indira Gandhi Medical College, Shimla for their constant

    encouragement, invaluable guidance and constructive suggestions

    without which this work would have not been successfully completed.

    We are also highly obliged and extremely thankful to Dr.

    Ashok Kr. Bhardwaj, Prof. & Head Dept. of Community Medicine,

    Indira Gandhi Medical College, Shimla for providing us with the

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    opportunity to conduct such a study and understand the basics of an

    Epidemiological Study. We are also thankful for his expert guidance

    and vast and immense practical experience to make our project a

    success.

    We also extend our thanks to Dr. Anmol Gupta, Assoc.

    Professor Dept. of Community Med. IGMC for his invaluable

    guidance on project presentation via electronic media.We alsoexpress our heartfelt gratitude to all the faculty members of the Dept.

    of Community Medicine who helped us by all possible means.

    We would be failing in our duty if we dont thank all thestudents who became our subject of study without whom none of this

    would have been possible.

    Vaibhav Sharma (0458)

    Shimla Vikrant Sharma (0459)

    May, 2008. Vikrant Thakur (0460)

    Vineet Bhardwaj (0461)

    Virat Kuntalam (0463)Virender Chauhan (0464)

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    INTRODUCTION

    INTRODUCTION

    Rheumatic Heart Disease (RHD) is a noncommunicable but crippling disease, it is the cardiac

    manifestation of Rheumatic Fever, which is a febrile disease

    affecting connective tissue particularly in heart, joints,

    subcutaneous tissue in the form of sub cutaneous nodules and

    rarely does it affect the CNS. Initiated by infection of throat

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    by a Group A beta haemolytic streptococcus (GABHS), the

    heart lesions are the only one which can lead to chronic

    illness, disability and early death. Prognosis depends on

    seriousness of Carditis and frequency of recurrent attacks.

    Most of the time, it is preceded by an episode of sore throat.

    RHD is a world wide problem especially in

    population living in over crowded and low socioeconomic

    circumstances. It is especially prevalent in school children

    which happen to be the most vulnerable group. It can be

    called as profession hazard of school.

    Why our study is relevant?

    1. Crippling our Future generation

    2. Catches them young

    3. RHD Constitutes 20-25% of hospital admission due toCVD.

    4. Prevalence low but Significant Morbidity & Mortality.

    5. School going Children constitutes 20-25% of total

    population of India.

    6. Average age at the time of death due to RHD is 35 yrs.

    An epidemiological study of RHD in school going

    children in hilly area was done which gave the prevalence of

    2.98 per thousand with no significant difference between the

    age groups of 5-10 and 11-16 or in either sex.

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    With the advent of Penicillin and newer drugs,

    incidence and prevalence, mortality & morbidity associated

    with RHD has considerably reduced.

    Rheumatic Fever being an occupational disease of

    school children, it can effectively be screened.

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    AIMS

    &

    OBJECTIVES

    Aims and Objectives

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    1. To determine the prevalence of RHD among

    school children of Shimla.

    2. To study the relation of RHD with factors likeage and sex.

    3. To learn the basics of conducting an

    epidemiological study.

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    Material

    &

    Methods

    Materials and methods

    Geographical Area-

    Himachal Pradesh comprises of varied

    geographical terrains like plains, hills, valleys and mountains.

    The state has area of 55673 sq. km. and is divided into 12

    districts.

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    Shimla is capital of H.P. situated at an altitude

    of 2130 mts. With an area of 18 sq. km. town has temperature

    variation in winter (max. 18 degrees, min. -1 degrees) and

    summer (33 degrees max. and min. of 1degree)

    Sampling technique

    In the cross sectional study, a stratified

    random sample of 217 children was selected from one school

    in the age group of 5 to 15 years of age.

    Way of conducting survey

    Survey was conducted by the way of

    questionnaires. The questionnaire was structural already andthe questions in it were close ended questions which had their

    answers in only YES or NO.

    Criteria for study of RHD

    According to modified Jones criteria, the

    clinical features of rheumatic fever are divided into major and

    minor manifestations which lead to diagnosis of rheumatic

    fever.

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    For Diagnosis of Rheumatic Heart Disease

    Fig. Showing the Modified Jones Criteria for Diagnosis of RHD

    Tools of methods used in the study

    The school was visited with prior approval of

    the principal and purpose and nature of study were already

    discussed with her.

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    Children were randomly selected from classes and

    were examined after a detailed history was taken on the basis

    of pre-formed questionnaire.

    Then cardiovascular examination was done and

    murmurs were auscultated which was done in erect, left lateral

    and recumbent positions.

    There was only one case of murmurs with

    parasternal heave and was referred to Dept. of Cardiology

    IGMC Shimla.

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    REVIEW OF

    LITERATURE

    REVIEW OF LITERATURE

    Historically the disease was recognised by Hippocrates who

    categorically stated that:

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    child who has pain in legs is going to become short of

    breath.

    The name rheumatic was given by

    Haygarth in 1805 A.D. Its association to heart was established

    in 1800A.D. by Pit Cairn and Jenner.

    Before Second World War, relatively little

    was understood about epidemiology and pathogenesis of these

    infections and chains sequel. The lab studies of Rebecca

    Lancefield and those by Dr. Rammal Kamp and his colleaguesmade significant contribution to the understanding and control

    of RHD. Only studies on repository penicillin was another

    major achievement causing a significant decrease in incidence

    of RF/RHD. However, since mid 1980s with the resurgence of

    severe GABHS infections and their suppurative and non-

    suppurative sequel, the disease reoccupied its previous statusin epidemiologic and clinical studies.

    Currently success has been achieved not only

    in accurate diagnosis of GABHS in infection but also in

    secondary & primary prevention of RHD.

    EPIDEMIOLOGY

    Rheumatic fever or RHD presents a problem

    in all parts of world especially in developing countries. RF is

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    the most common cause of heart disease in the 5-30 yrs age

    group throughout the world. Rheumatic Heart Disease

    constitutes 30-35% of hospital admission due to Cardio-

    Vascular Diseases.

    ETIOPATHOGENESIS

    The disease is an example of molecular mimicry type ofautoimmunity. The complete pathogenesis of this disease is

    unknown. There are three main factors.

    1. Group A beta-haemolytic streptococcal infection of

    upper respiratory tract.

    2. Specific susceptibility of human host.

    3. Environmental factors like altitude, crowding

    &dampness.

    This disease is triggered by infection with

    group A beta haemolytic streptococci & the serotype that

    has attracted special emphasis is M- type 5 which is

    frequently associated with RF.

    ETIOPATHOGENESIS

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    Fig: Showing the Etiopathogenesis of RF

    AGE PATTERN

    RHD is common in children particularlyschool going children i.e. 5-15 yrs. With almost equal

    incidence among age groups 5-10 years and 11-16 years.

    PREVIOUS STUDIES IN INDIA

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    There have been many studies on this issue in

    India in past but few major ones are worth to mention here.

    As per the study conducted by Indian Council of Medical

    Research (ICMR), the prevalence of RHD was found to be

    2.1/1000 to 11/1000 in different regions of the country.

    Average prevalence was around 7/1000 with no male or

    female predilections.

    One of the largest studies conducted so far on

    this subject is the study conducted by Dept. of Cardiology,

    Christian Medical College (CMC), Vellore. The study

    sample consisted of more than 2 Lakh (n = 229,829) and in

    that study prevalence was found to be 0.68/1000. Thereason for such a low prevalence was that the final

    evaluation was done by the experts after echocardiography

    which omitted the possible false positive cases.

    PREVIOUS STUDIES HIMACHAL

    PRADESH

    Few studies have been done in hilly areas of

    North India and they have shown progressive decline in the

    prevalence of RHD. A study conducted in and around

    Shimla in 1994 showed the prevalence of 2.98/1000.

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    Earliest study in this region of country dates

    back to 1956 when prevalence was found to be 3.9/1000

    which happen to be the highest reported prevalence rate

    through out the country at that time.

    Another study was conducted in 1998 by

    Dept. of Community Medicine, IGMC, Shimla reported a

    prevalence rate of 3.627/1000.

    As per the ongoing study being conducted byDept. of Community Medicine, IGMC, Shimla so far only

    one case of RHD is reported in approximately 5000 student

    surveyed.

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    OBSERVATIO

    NS

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    OBSERVATIONS

    Out of 217 students studied there were 91 Girls and 126

    Boys. All were in the age Group of 5-11 years.

    Out of these, 23 (10.5%) reported to have cough at the

    time of study. 16 (7.4%) of them complained of having sore

    throat at that time or in the passed week.

    Shortness of Breath was reported by 14 students i.e.5.1%. 8 students said that they have some degree of chest pain

    off and on. This group comprised 3.7% of the total.

    7 students complained of occasional episodes of syncope

    i.e. approx 3% student have had syncope.

    Joint Pains were reported by 5 students (2.3%).

    Other complaints reported by students were Pain

    abdomen (2), giddiness etc. which were largely irrelevant to

    our study.

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    Fig. Showing findings in the form of Bars

    Most of the children reported with cough and

    sore throat that can be explained if we keep in mind thetime of study. The study was conducted in the month of

    Feb. when the weather here was freezing.

    Findings of cyanosis on physical examination

    can also be attributed to cold surroundings prevalent at the

    time of study.

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    Fig. Showing the observations in the form of Pie.

    Fig. Showing the findings on GPE

    In the above graph, the most frequent finding is shown by the complete

    cone while rest of the cones show the frequency of events relative to the

    most frequent finding.

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    SUMMARY

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    SUMMARY

    A stratified sample of 217 school children in

    the age group 5 years to 11 years was taken in a school in

    Shimla town. Since the main motive was to learn the basics

    involved in an epidemiological study and also there was a

    lot of constrains in the form of money, material and time.

    Therefore, such a small sample was chosen. Also it was the

    month of Feb. when most of the schools were closed.

    Percentages of absentees were 5 percent.

    In our study, no case was found to be positive

    for Rheumatic Heart Disease (RHD) on clinical grounds,

    though lot of positive findings were found related to

    cardiovascular system.

    CONCLUSION

    Clinical Examination as the method of

    identifying a case of Rheumatic Heart Disease is neither

    very specific nor it is sensitive. Parents were reluctant to

    get their child evaluated by the expert. There was no case of

    Rheumatic Heart Disease in our study. Pallor was positive

    in significant proportion (17%) of the subjects.

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    CONSTRAINTS

    Like any other epidemiological study, our

    study too was limited by constraints of money, material and

    time. Other than these the major limitations in our studies

    were:

    1. Inadequate sample size combined with a very low

    prevalence.

    2. Selection bias i.e. may be some of the students who were

    suffering from RHD might not have attended the school

    owing to their illness and thus were left out.

    3. Our limited knowledge in the concerned fields. We are

    students only.

    4. Compliance of children was also a limitation, but this

    was limited only to the younger age groups.5. Reliability of the history given.

    6. Clinical features of the disease are not very specific and

    there is wide range of overlap.

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    RECOMMMENDATIONS

    Based on our findings we make following

    recommendations in the benefit of health of school

    children:

    1. Teachers are recommended to remain ultra vigilant for

    the warning symptoms of the disease.

    2. Practical suggestions like opening certain windows for

    effective cross ventilation are advocated. But that is bit

    difficult to follow especially in the winters.

    3. We also suggest that at least one parents-teacher meeting

    should be held every quarterly to discuss the progress of

    their wards in the fields of studies and health as well.

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    ANNEXURE

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    PERFORMA

    Name: ____________________ Age: ____Sex: __

    School: __________________________________

    Address: ____________________

    _____________________

    HISTORY:

    H/o Recurrent Sore Throat Yes/No

    H/o Chest Pain Yes/No

    H/o Palpitation Yes/No

    If Yes, Is it aggravated by activities? Yes/No

    Is it even present at rest? Yes/No

    H/o Syncope (any postural association) Yes/No

    H/o Fever/Body aches/Chills/Rigors/Sweats Yes/No

    H/o fleeting joint pains Yes/No

    H/o abnormal movements of limbs Yes/No

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    H/o any penicillin prophylaxis for RHD Yes/No

    (If Yes then when and how long?)

    H/o Shortness of Breath Yes/No

    H/o PND/ Orthopnoea Yes/No

    H/o Cough Yes/No

    H/o Haemoptysis Yes/No

    H/o Discharge from Ear/Ear aches Yes/No

    Any Significant past History Yes/No

    GENERAL PHYSICAL EXAMINATION:

    Pallor: Yes/No

    Icterus: Yes/No

    Cyanosis: Yes/No

    Clubbing: Yes/No

    Lymphadenopathy Yes/No

    JVP: Raised/Not Raised

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    Detailed CVS Examination:

    Inspection:

    Chest Symmetry:

    Apex Beat:

    Thrill:

    Palpation:

    Palpable Thrill/Murmur:

    Parasternal Heave:

    Percussion:

    Cardiac Dullness:

    Auscultation:

    1st and 2nd heart sounds:

    Murmur:

    Any added Sounds:

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    BIBLIOGRAPHY

    1. Thakur JS, Negi PC, Ahluwalia SK, Vaidya NK. Epidemiological

    survey of RHD among school children in Shimla hills of Northern

    India: Prevalence and Risk Factors; Journal of Epidemiology &

    Community Health 1996 Feb; 50(1); 62-67.

    2. RF & RHD: Report of a WHO study Group. WHO Tech Rep Ser No.

    764, 1988.

    3. Jose VJ, Gomathi M. Declining Prevalence of Rheumatic Heart

    Disease in Rural School Children in India: 20012002;Indian Heart J2003; 55: 158160.

    4. Lalchandani A, Kumar HRP, Alam SM. Prevalence of rheumatic fever

    and rheumatic heart disease in rural and urban school children of

    district Kanpur [Abstract].Indian Heart J2000; 52: 672.

    5. K Rajesh, Controlling RHD in Developing Countries; Public Health

    Practice; 1995.

    6. Mahajan BK, 5th edition Methods in Biostatistics 1991. New Delhi:

    Jaypee Brothers, 87-101.

    7. Park K, 19th edition Parks Textbook of Preventive and Social

    Medicine 2007. Jabalpur: M/s Banarsidas Bhanot Publishers; 315-318,

    696-706.