Volume 1 Issue 2 April - June 2005

P R E S I D E N T ’ S M E S S A G ESince time immemorial Ayurvedicphysician himself was imposing selfregulation on maintaining the quality ofmedicines, as he had the knowledge ofidentification of the medicinal plants, thetherapeutic properties and thepreparation techniques. Commercialbenefits from the prepared medicinewere almost zero. The students in then

existing traditional guru-siwya parampara learnt the identification andcollection of herbs from their teacher in the forests where thesemedicines grew. Ayurveda has now been institutionalized and theeducation is more formal as compared to learning from individualguru.Ayurveda has always remained in high demand but the demand forAyurvedic medicines has shot up exponentially in recent years. Noindividual physician is either expected to or is capable of carryingout all the duties himself even if he so desires. Today cultivation ofherbs, trading of herbs, manufacturing and reaching the medicinesupto the consumer have all become independent commercial activitiesand hence the scenario is altogether different. As there is commerceinvolved into each of these aspects, the scope for adulteration hasincreased. Moreover Ayurveda and herbal medicines being nowglobally consumed, regulating authorities are more worried about thesafety of their populations. There are lot of efforts being made in thefield of Ayurvedic and herbal drug standardization. The standardizationprocess is not as easy as in case of chemicals in allopathic medicine.The traditional systems like Ayurveda have their own concepts and

methods of achieving standardized products. The marker compounds,which are used to standardize the herbal material today, are not thereal factors to decide the efficacy of the product. Markers are simplyused to identify a particular plant material. Presence of less or moreamount of marker compound does not ensure that the product is goingto be effective. In other words we hardly have any markers of decidingthe bioefficacy, which needs to be established. This too appears to bea difficult proposition as the action of the herb as a whole, may bedifferent than any of its bio-chemical components individually. Themetabolism of the herbal material in the body is also difficult to trace,as we cannot follow any material that is representing the whole plant.Ayurvedic medicine preparation involves several Ayurvedic procedureslike applying series of Putas (heated several times under high degreetemperature which could be as high as 900 Degree Centigrade). Thereis hardly any method to understand from the finished product as tohow many Putas have been applied on to achieve the final productand what are the chemical changes that have taken place as a result ofthese Putas. The industry is feeling very happy with the latest additionof Excipients into the Drug & Cosmetic Act of 1940. Government ofIndia needs to be congratulated on this move but simultaneously somestudies must be carried out to see if there are any interactions of theseexcipients with the herbal material. Shelf-life studies must also beconducted. Whatever raw material is procured and used in Industryshould have a logbook mentioning the place of collection, time ofcollection and its full movement from the cultivator to the user.Hence this is a real challenge right now for the Academicians, for theResearchers and for the Industry to get on to this job of standardizationand let the world know that Ayurveda is safe and effective too.

(Honored with Padamshree) Vaidya Devender Triguna

Editor in chief : Prof. (Dr.) K. R. Kohli, Director, Dabur Research Foundation, 22, Site IV, Sahibabad, GhaziabadCo-Editors: Mr. Pradeep Multani, Dr. Preeti Kachroo Bhagat

MESSAGE

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AAAAAYURVEDA DEGREE COURSES ATMIDDLESEX UNIVERSITY UK BYSEPTEMBER 2005APA –Press release June 6, 2005

Middlesex University has announced, that it will be runninga full range of Ayurvedic degree courses starting inSeptember 2005. Dr Mauroof Athique, Director of theCollege of Ayurveda, was delighted that his two-year projectto get the first UK-based BSc and MSc programmes inAyurvedic Medicine underway has succeeded.

Middlesex University has a great reputation for being thefirst UK University to offer BSc courses in Herbal Medicineand Chinese Medicine and now the first to offer a BSc inAyurvedic Medicine.

WHO ACCEPTS REPORT ON TRADITIONALMEDICINEThe Times of India June 16, 2005

World health organization (WHO) evinced keen interest intraditional medicine (TM), and formulated a study groupunder a Pune-based researcher to examine whether moreeffective use can be made of in providing affordabletreatment.

Eight months thereafter, the WHO-appointed commissionon intellectual property rights, innovation and public health

TOP NEWS STORIES

AMAM HAS A NEW VICE PRESIDENT

Mr. Nitin Ghadiyar, is a very dynamicpersonality, pro-active in Ayurvedichealthcare business. He has been takeninto managing committee of AMAM asVice President. Mr. Nitin Ghadiyar is theExecutive Director of ConsumerHealthcare Business of one of India’sleading FMCG companies, Dabur India

Limited. Mr. Ghadiyar is lending his expertise of vastexperience in the FMCG and Pharmaceutical industry, bygiving impetus to the growth of the OTC sector , one of theleading growth drivers. With an experience of over 25 years,Mr. Ghadiyar has held several senior management positions,including those of Group Director, Parke Davis; ManagingDirector Reckitt-Piramal; and President and ExecutiveDirector Johnson & Johnson in his earlier assignments. Inhis last assignment he was the President and CEO ofMorepen Laboratories.

A Masters in Management from Jamnalal Bajaj Institute,Mr. Ghadiyar is widely regarded as an expert in the IndianFMCG, Pharmaceutical and Health Care business and hasan experience of building more than 20 national brandsincluding Halls, Chiclets, Listerine, Benedryl, Gelusil,Saridon, Lacto Calamine and the Erythropoietin megabrand- Eprex- in his earlier stints with various companies.

DEPT. OF AYUSH, GETS A NEWJT. SECRETARY

Mr. Shiv Basant is an officer of IndianAdministrative Service (IAS), 1976batch of Jharkhand cadre. Aftergraduating in Biology, Chemistry andLaw, he joined the IndianAdministrative Service. During thecourse of his service, spanning 28

years, he has held assignments including DeputyCommissioner and Divisional Commissioner in the Stateof Bihar. He was Managing Director of the Bihar State Co-operative Dairy Federation, which was turned around duringhis period and is now one of the few profit making StateCo-operative Dairy Federations of the country. Shri ShivBasant has worked earlier in the Ministry of Home Affairs,Government of India in various capacities includinginternational cooperation in the field of combating crimeand terrorism. Before joining in the Department of AYUSHhe was Principal Secretary, Department of Agriculture andForest & Environment in the Government of Jharkhand.

AMAM congratulates Sh. Shiv Basant on joining as Jt.Secretary, in the Department of AYUSH, Ministry of Healthand Family Welfare, Govt. of India.

Industry Perspective

(Cipih) has not only accepted the report and its variousrecommendations, but has also outlined the need toframework an international strategy regarding use of TMfor new drug discovery.

Director of the University of Pune’s interdisciplinary schoolof health sciences, Bhushan Patwardhan, told TNN that ata recently held open forum of the commission at Geneva,there was a consensus that “TM should be respected,protected and explored optimally using science andtechnology to develop affordable and validated treatments,especially for developing countries, and the poor andundeserved community.”

PATENTS ACT DRAFT NORMS FINALISEDBusiness Standard, June 23, 2005

The government has formulated the draft guidelines forthe newly amended Patents Act, 2005. As per the guidelines,non-inventions, inventions relating to atomic energy, orthose contrary to public order or causing serious prejudiceto human beings, animals, health or environment will notbe patentable.

“Any process for medicinal, surgical, curative, diagnosticand therapeutic treatment of human beings or animals tocure them is not patentable under the Indian Patents Act.Patents, however, can be obtained for surgical, therapeuticor diagnostic instruments,” according to the draft guidelines

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which have been put on the official website for publiccomments. The draft guidelines relate to the practice andprocedure to be followed in examination of patentsapplications in India.

LAW SOON TO REIN IN AAAAAYURVEDACENTRESThe Hindu Jun 15, 2005

The Health and Tourism departments have readiedAyurveda Bill, a draft legislation to classify Ayurveda andrejuvenation centres into A, B and C categories, to ensurethat they provided quality service. Another aim is to preventunscrupulous activities in the garb of Ayurveda. Thelegislation, which is supported by the Tourism Department,will in all likelihood be passed in the next session of theAssembly, said sources in the department.

TRADITIONAL MEDICINE ‘IMPORTANT FORNEGLECTED DISEASES’Scidev.net June 3, 2005

Research into traditional medicine is vital for tacklingdiseases that affect the world’s poor, according tointellectual property and health specialists who met inGeneva, Switzerland. The closed discussion of stakeholdersfrom academia, industry and non-governmentalorganizations took place at a meeting organized by theWorld Health Organization (WHO) Commission onIntellectual Property Rights, Innovation and Public Healthon 30-31 May. An open forum was held on 1 June.

EU TO PROTECT INDIA’S TRADITIONALKNOWLEDGEThe Economic Times May 16, 2005

The European Patent Office (EPO) has, in principle, agreedto make a conscious effort to block anyone from stealingpatents on India’s traditional knowledge in medicine. Thiswill ensure that instances like the patenting of turmeric’smedicinal property in the US, does not occur in the 30-member superstate. India had, earlier, spent $ 6 million tobust the US patent on turmeric.

A non-disclosure agreement between the union science andtechnology ministry and the EPO is expected soon, whichwill give EPO access to a digital database of at least1,36,000 traditional Indian medicines. EPO will protect thishighly valuable information and refer it routinely whilereviewing patent applications where the innovation is ofbotanical origin. The National Institute of ScienceCommunication and Information Resources (NISCIR)under the science and technology ministry is developingthe nearly one-crore page digital database of Ayurveda,Siddha and Unani medicines.

AAAAAYURVEDA DRUGS TO BE RE-INTRODUCED IN INDIAN PHARMACOPOEIAPharma Biz May 17, 2005

The plant-based medicines that had been withdrawn fromIndian Pharmacopoeia (IP) and subsequently incorporated

in Ayurvedic Pharmacopoeia may soon find its way placein IP. The new edition of IP planned for 2006 will have atleast 10 such herbal medicines, it is learnt. The return ofherbal drug monographs could thus be among the first jobstaken up by the newly formed Indian PharmacopoeiaCommission.

PHARMACOPOEIAL LABORATORY TO BECENTRAL DRUGS LAB FOR AAAAAYURVEDA,UNAAAAANI, SIDDHAAAAAPharma Biz July 4, 2005

The Central Government has decided to notify“Pharmacopoeial Laboratory for Indian Medicines” inGhaziabad as the Central Drugs Laboratory for the purposeof testing or analysis of Ayurveda, Siddha and Unani (ASU)drugs. The government is also to fix the fees for each typeof testing / analysis that would be carried out there. It willfunction as the training center for quality control andstandardization of ASU drugs.

AAAAAYURVEDA ABROAD

AAAAAYURVEDA THE LATEST DARLING OFHOLISTIC HEALINGChicago Tribune

Former Miami Dolphins football star Ricky Williams hasbecome a vocal champion for Ayurveda, a 5,000-year-oldsystem of body-mind balancing from India. The formerHeisman Trophy winner credits Ayurvedic principles forhelping him regain physical and spiritual strength after along period of feeling stress and imbalance.

DRUG CO’S PLAN ONE STOP WEBSITE FORTRIAL DATAHindustan Times May 17, 2005

The pharmaceutical industry plans to launch a globalwebsite in September, pooling information on ongoing andcompleted clinical trials, as it steps up a campaign toreassure patients about medicine safety. The Geneva baseInternational Federation of Pharmaceutical Manufacturersand Associations said that IBM would develop the Internetsearch portal, which will tap into information held inindustry trial registries and databases. Drug companyexecutives are generally keen to take part in the scheme.

MADONNA TURNS TO AAAAAYURVEDA FORTHIRD CHILDHindustan Times May 17, 2005.

The pop queen Madonna, now 46, is reported to have startedAyurvedic treatment. Madonna is using old Indian fertilityremedies to try for a third child at the age of 46. Accordingto ‘The Mirror’, she hopes a stash of Ayurvedic medicineswill help her conceive. Her husband Guy Ritchie has alsohad the pills to boost the couple’s chances of having a baby.

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EU Directives come into force from30th Oct 2005The demand of complementary/ traditional medicines isincreasing worldwide. As more and more people seek solacein herbal medicines, concerns about quality, safety andefficacy too are proportionately increasing. To regularizethe usage of herbal medicines and to safeguard the interestof consumers and other stakeholders, regulators andgovernment bodies are modifying present sets of rules/ act.All the countries across the globe are in the process ofregulating the Herbal/Complimentary Alternate Medicines(CAM). Ayurved and Unani medicines are understood tobe a part of CAM.

European Union (EU) is having 20 member countries, andis governed by independent parliament. European Unionand the government of UK introduced ‘Traditional HerbalMedicinal Products Directive’ (THMPD). These new EUDirective on Traditional Herbal Medicinal Products (agreedin April 2004) will come into force on 30th October 2005.For the products already present in the market on 30 April2004, there will be a transitional period of seven years,giving them protection until 2011.

Some medical herbalists believe that these Directives willhave a beneficial effect overall, both for practitioners andconsumers. It is worthwhile examining these directivesclosely as has been done below:-

Implications of EC Directives on Legalityof Herbal Medicines• It provides a secure legal basis for herbal medicinal

products and the practice of herbal medicine.�

• It is likely to have a beneficial impact on the quality ofover the counter herbal medicines in UK.

• The MHRA (UK Medicines and Healthcare ProductsRegulatory Agency) has declared their intention toimplement the Directive in a sensitive manner and theymay allow the practice of systems such as TraditionalChinese Medicine and Ayurveda. However, theconsultation process is yet to be completed.

Implications of the above leads to some consequences,which could be less desirable and may restrict consumerchoice. These include:-

a. Implications due to Licensing requirements

• At present many herbal products sold in the UK areexempt from licensing. The new regulations mean thatmanufacturers will have to apply for a license for everyproduct, and each must comply with the officialpublished standards.

• The cost to a manufacturer of licensing an individualherbal product is prohibitively expensive.

• �This means that many popular herbal products, such asgarlic and ginseng, may still be commercially viable,but others may disappear from sale because it is not

worth the expense of getting them certified andregistered.

• Herbal products, without licenses, must currently be soldas ‘food products’. These are not subject to the samequality control or restrictions as ‘medicinal products’and there have been instances in the past of misleadingor erroneous labeling. However Health Claims have tobe justified with the new set of rules.

b. The 30-year rule

• The Directive also demands that a traditional herbalmedicinal product must be shown to have been in usefor 30 years in the EU (or at least 15 years in the EUand 15 years elsewhere) for it to be licensed andobtainable over the counter.

• It could also mean that some traditional herbal medicinesthat are in common use for more than 30 years as on30th April 2004, but have since fallen into disuse, maynot be licensed.

• The most important negative aspect of the rule that itdoes not recognize traditional medicines of East suchas Ayurveda and Traditional Chinese Medicines that arein practice in the respective countries (but not in Europe)since ages.

c. Concern related to imported goods from US• Imported US herbal products are subject to almost no

quality control, and some combinations of herbalmedicines are with vitamins and minerals. Some medicalherbalists hope that US companies will reformulate theirproducts to comply with the new EU regulations withinthe 5-7 year implementation period.

d. Restricted herbs• The supply of some herbs - such as lobelia, belladonna

and Ephedra species are currently restricted to registeredherbal practitioners only. There are more herbs, such aswormwood, pokeroot and mistletoe, which are likely tobe included in to this category. This might reduce choicebut could protect the consumer from buying herbs withpotentially harmful properties over the counter. This rulewill entail a lot of caution related to banned herbs in theproducts which we manufacture in India and are targetedfor EU.

• The Directive could also mean that due to licensingrequirements, there will be fewer herbs available topractitioners as well.

Ayurveda is one of the already-in-use medicine systems inthe UK that is going to be grossly affected. Although theDirective is targeting the traditional herbal products, anumber of Ayurvedic products will be restricted in theEuropean market as Ayurveda is often confused with herbalmedicines. So, it is required to be clarified to the Authorityhere that the Ayurveda is a centuries old and time testedmedicinal system to get the same exemption from the ambitof the Directive. Otherwise, it would ultimately result indenying the fundamental rights of Ayurveda users in the

FUTURE OF AAAAAYURVEDA IN EUROPE

Industry Perspective

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region to opt for their choice of medication.

There is a need to provide evidence of product safety forregistration based on a geographical region, where it wasobtained. The Govt. of India is already working withEuropean Union to place Ayurveda as an independent, well-documented system of medicine. Success in such effortsfor the time being appears to be at a distance.

MLX299 includes the proposals for the reform of regulationof unlicensed herbal remedies in the United Kingdom madeup to meet the needs of individual patients.

For further details please refer to EU Directive 2004/24/EC, which is available on, website: http://www.mca.gov.uk

References:

1. http://europa.eu.int:

a. Directive 2004/24/EC of the European Parliament andof the Council of 31 March 2004 amending, as regardstraditional herbal medicinal products, Directive 2001/83/EC on the Community code relating to medicinalproducts for human use.

2. http://www.mca.gov.uk

a. Guidance note: provisions of the Directive onTraditional Herbal Medicinal Products that woulddetermine dates of introduction

Briefing note: sources of evidence of traditional use underthe Directive on Traditional Herbal Medicinal Products.

• The scope for export of Ayurvedic drugs from India willincrease.

Other Benefits of GMP• GMP implementation, maintains the uniform quality

control nation wide.

• GMP insists that the methods developed by themanufacturers for quality testing as well as thosementioned in the ancient authoritative books have to bemaintained to ensure the quality of the products.

• GMP insists on modern and scientific outlook, but it isequally particular about upkeeping the hierarchy ofAyurveda.

• GMP conditions are not merely a method of controlbut rather more relevant as the guardian of this branchof indigenous medicine.

Note:- For maintaining quality and therapeutic efficacy ofraw materials to finished products, it is absolutely necessaryto follow GMP or Good Manufacturing Practices. As perGMP the contact parts of the machinery involved inmanufacturing has to be of stainless steel. However, underIMCC Act, 1940 registered Vaidyas, Siddhas and Hakimswho prepare medicines on their own to dispense to theirpatients and not selling such drugs in the market areexempted from the purview of G.M.P.

GMP Certification is the only way to progress

Mr. Pradeep Multani, is the GeneralSecretary of AMAM. With a rich experienceof 25 years in the field of—AyurvedicMedicines, is lending his expertise in thepromotion of Ayurveda.

He is the chairman and MD of 67 years old multi-croreAyurvedic company, Multani Pharmaceuticals Ltd. for 18long years. He has been actively associated with numberof executive committees. He is an executive member ofThe Hinduites, Delhi Factory Owners Federation, NewDelhi Traders Association and All India Small ScalePharmaceutical Manufacturers Association.

He is also member of FICCI Pharmaceutical Committee,Okhla Industrial Association, Regional Advisory committee& Public Grievance Committee of Central Excise, StandingFinance Committee, Medicinal Plant Board, Rotatory Cluband DOXA- Delhi Old Xaverian’s Association.

AMAM is proud to have Mr. Multani as the GeneralSecretary.

ABOUT OUR GENERAL SECRETARY

Quote: “If you would thoroughly know anything,teach it to others.” - Tryon Edwards

In the manufacturing process of Ayurvedic medicines, thereexists different practices in different parts of the country.So, in Ayurvedic Drugs and formulations it is absolutelynecessary to follow certain specific recommended practicesfor overall control in manufacturing units (i.e. GoodManufacturing Practices). This is to ensure that theconsumer receives the medicines of guaranteed purity,strength, quality, therapeutic efficacy, potency and safety.The manufacture, sale and distribution of Ayurvedicmedicines are under the statutory control of the Drugs &Cosmetics Act 1940 and Rules framed there under.

Why GMP is prescribed to Industry?• To ensure.. Raw materials used in the manufacture of

drugs are authentic, of prescribed quality and are freefrom contamination.

• The manufacturing process is, as has been prescribedto maintain the standards.

• The manufactured drug, which is released for sale isof acceptable quality.

Major advantages of GMP to AAAAAyurvedic Industry• By following the GMP guidelines, every manufacturer

can ensure medicines of highest quality to the peoplethat will repose the faith of consumers in AyurvedicMedicines.

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The Gazette of India (Extraordinary)Part II-Section 3- Sub-section (i)Published by Authority

New Delhi ,Thursday, May 12, 2005/Vaisakha 22, 1927

List of Permitted Excipients (169)

Permitted Excipients, i.e. additives, preservatives, anti-oxidants, coloring agents, flavoring agents, alternate sweetenersspecified in column (2) of the Table below are permitted in Ayurveda or Siddha or Unani drugs as per reference standard orgrade under the prevention of Food Adulteration Act (PFA), Indian Pharmacopoeia (IP), British Pharmacopoeia (BP),United States National Formulary (USNF) and others as mentioned in column (3) of the Table, namely;A. Additives*

1 Gum Acacia PFA2 Activated Charcoal IP3 Agar PFA4 Alginic Acid & its salts PFA5 Arachis Oil PFA6 Beeswax IP7 Bentonite IP8 Calcium Carbonate PFA9 Calcium Phosphate Dibasic IP10 Calcium Phosphate Tribasic IP11 Carbomer IP12 Carnauba Wax IP13 Cellulose & its derivatives IP14 Cetocetyl alcohol IP15 Citric acid & its salts PFA16 Colloidal Silicon Dioxide IP17 Carmellose Sodium IP18 Dextrin & its derivatives PFA/IP19 Dextrose PFA20 Emulsifying Anionic Wax IP21 Gelatin IP22 Glucose PFA23 Glycerin IP24 Guar Gum PFA25 Hard Paraffin IP26 Hydrogenated Vegetable Oil PFA27 Icing sugar PFA28 Invert Sugar Syrup BP29 Isopropyl myristate IP30 Isopropyl palmitate BP31 Kokam Butter PFA32 Lactose IP33 Lecithin/Soya Lecithin USNF34 Light Magnesium Carbonate IP35 Light Mineral Oil IP36 Liquid Glucose PFA37 Liquid Paraffin IP38 Magnesium aluminium silicate BP39 Magnesium Carbonate IP

40 Magnesium Oxide IP41 Malic Acid PFA42 Malt Extract IP43 Maltodextrin USNF44 Mannitol IP45 Methcrylic acid ethylacrylate USNF46 Microcrystalline Wax IP47 Pectic Enzyme In-house

specification48 Pectin PFA49 Poloxamer USNF50 Polyethylene Glycol IP51 Polymethacrylate USNF52 Polysorbates IP53 Polyvinyl alcohol IP54 Polyvinyl pyrollidone IP55 Polyvinyl acetate phthalate IP56 Potassium Bicarbonate IP57 Povidone & its derivatives IP58 Propylene Glycol IP59 Shellac IP60 Skimmed Milk Powder PFA61 Sodium Bicarbonate IP62 Sodium Chloride PFA63 Sodium Edetate PFA64 Sodium Hydroxide IP65 Sodium Lauryl Sulphate IP66 Sodium Silicate IP67 Sodium Starch Glycollate IP68 Sodium Stearyl Fumarate IP69 Soft Paraffin IP70 Sorbitan Esters BP71 Sorbitol IP72 Starch & its derivatives IP73 Stearic Acid & its salts IP74 Sucrose IP75 Talc IP76 Tartaric Acid & its salts PFA77 Titanium Dioxide IP

78 Tragacanth Gum IP79 Wax non-ionic emulsifying IP80 Wax microfine IP81 White petroleum jelly IP82 Xanthum Gum USNF83 Xylitol USNF84 Yeast PFA85 Yellow petroleum wax IP86 Yellow petroleum jelly IP87 Zinc oxide IP

B. Preservatives*:1 Acetic acid PFA2 Benzalkonium chloride IP3 Benzethonium chloride IP4 Benzoic acid & its salts PFA5 Bronopol BP6 Butyl paraben BP7 Cetrimide IP8 Ethyl paraben BP9 Imid urea In-house specifications10 Propyl paraben & its salts PFA11 Methyl paraben & its salts PFA12 Phenyl mercuric nitrate IP13 Propionic acid & its salts PFA14 Sorbic acid & its salts PFA

C. Antioxidants*:1 Ascorbic acid & its

salts & esters PFA2 Butylated hydroxyl anisole PFA3 Butylated hydroxyl toluene PFA4 Gallic acid esters PFA5 Potassium metabisulphite PFA6 Sodium metabisulphite PFA

S. Permitted ReferenceNo. Excipients Standard

Grade

S. Permitted ReferenceNo. Excipients Standard

Grade

S. Permitted ReferenceNo. Excipients Standard

Grade

Quote: “The truth of the matter is that you always know the right thing to do. The hard part is doing it.”- Gen. H. Norman Schwarzkoff

Industry Perspective

* Excipients and their salts contribute towards the list of permitted grade of excipients for eg; Alginic acid and its salts likesodium alginate etc.

Note:- 1. Preservatives, alternative sweeteners and coloring agents shall be mentioned on the label for information of the user.

2. Additives used in various processes and to formulate dosage form shall be mentioned clearly with quantity in the flow sheetand the record shall be maintained by the manufacturing unit.

3. Manufacturers shall be responsible to ensure rationality, safety and quantity of various additives used in the formulation.This will be as per IP/BP/USP/PFA/or other “Standard Reference Book”

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*Director - Ayurveda Research, Dabur Research Foundation, Ex-Consultant WHO, Ex-Dean, R.A.Podar Medical(Ayu) college, Mumbai

Ayurvedic knowledge & practice in Diabetes MellitusProf(Dr.) K. R. Kohli M.D(Ay), Ph.D*

“Anger is the wind which blows out the lamp of the mind.” - Robert G. Ingersoll“Laughter is the shortest distance between two people.” - Victor BorgeQUOTE

Disease of the Quarter

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Major Principle of management suggests two groups ofpatients, viz,:

1) In obese prameha patients with adequate body strengthhaving intense increase of dowas, purification of thebody is advocated depending on the dowa predominanceviz. Kaphaja are advised to have emetics, Pittajapurgatives

2) Slender and weak patients are advised to have‘Brmha6a’ i.e. medications and diet which increasedhatus in the body. Palliative medications dependingon the symptoms and predominance of dowas areadvocated and in case of weak patients Caraka hasadvised “Santarpa6a cikitsa”.

SSSSSamana (Palliative Therapeutic Measures):

The herbal drugs used in the management of Pramehaare bitter, astringent and pungent in taste, as one has tocheck the extra fluidity of dhatus and, give them goodstrength and compactness.

The most commonly used classical drugs may not havea very good research backing but these are in use since along time and hence are tabulated below: -

• Swarasa : Guduci, Amlaki (B.R.)

• Cuuuuur66666a : Ankolyadi Yoga, Kataka Bijayoga(Nighantu Ratnakar), Sphatika Cur6a(B.R.)

• Kwaaaaatha : Palasa puwpa kwatha, Phalatrika kwatha.Vidangadi Kwatha, Nyagrodhadi Kawaya.

• AAAAAsava : Lodhrasava, Dantyasava (C.S., Ci.)

• Sneha : Trika6takadi taila, Simhamr ta ghr ta,Haridradi taila, Dadimadhya ghrta.

• Vatiiiii : Candrakalavati , Candraprabhavati ,Sukramatrka Vati.

• Bhasmas : Mandur bhasma, Loha bhasma, Nagbhasma, Vanga bhasma, Swar6a makwikabhasma.

• Rasaaaaayana: Pancaloha Rasayana Vasanta kusumakaraRasa, Vangeswar Rasa, Mehari Rasa,Trivanga Bhasma

Vasanta Kusumaaaaakar Rasa of Dabur has been very wellresearched for its efficacy in diabetes as well as indiabetic retinopathy and diabetic neuropathy

Role of Activity and Exercise:

Rigorous physical activity is advocated for Pramehapatients. But while advising these activities, individualshave been categorized according to their social status asper Caturvar6ya Vyavastha.

Individual Drugs that have been screened extensively.

1. Eugenia jambolana : Jamun bija cur6a

2. Gymnema sylvestre: Gudmar patra cur6a

3. Pterocarpus marsupium: Vijaysara kawtha cur6a

3. Ficus bengalensis: Nyagrodha twaka cur6a

4. Shilajattu: Salsaradiga6a Bhavita

5. Cinnamomum tamala: Tejpatra

6. Fenugreek seeds : Methika cur6a

7. Momordica chirantia : Karvellaka

What stages one should expectAAAAAyurvedic Medicines to be effective?

1. Newly diagnosed mild to moderate diabeticmellitus.

2. Non- Insulin Dependant Diabetes Mellitus.3. Post prandial Blood sugar below 450 Mgm%.4. Obese Diabetics.5. Uncomplicated Diabetes mellitus.6. Those in whom there is a secondary failure: in

such cases Ayurvedic drugs can be combined totheir regular oral hypoglycaemic agents andinsulin.

Complications need to beassessed by modernmeans, although somegood remedies inAAAAAyurveda are available forearly nephropathies,neuropathies andretinopathies too.

The company hasdiscontinued all physicalfitness programs sinceeveryone gets enoughexercise by:-jumping to conclusions,flying off the handle,beating around the bush,running down the boss,going around in circles,dragging their feet,dodging responsibility,passing the buck,climbing the ladder,wading throughpaperwork,pulling strings,shooting the breeze,throwing their weightaround,stretching the truth,bending the rules,pushing their luck,shuffling papers,and playing hide and seek.

Man goes to lawyer for help.Man: What is your least expensive fee?Lawyer: Rs.750 for three questions.Man: That’s pretty expensive isn’t it?Lawyer: Yes. So what’s your third question?

A pipe burst in a doctor’s house. He called a plumber. The plumber arrived,unpacked his tools, did mysterious plumber-type things for a while, andhanded the doctor a bill for Rs. 500.The doctor exclaimed, “This is ridiculous! I don’t even make that muchas a doctor!.”The plumber quietly answered, “Neither did I when I was a doctor.”

FUNLINE

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Gudddddmaaaaara (GYMNEMA SYLVESTRE R. BR.)A Herb with potential Anti-Diabetic Properties

Biological Source: Gymnemasylvestre (Retz.) R. Br. ex. Schult.Family: ASCLEPIDACEAE.

Geographical Source: A climbingplant commonly found in central andsouthern India; Western Ghats andin the Goa territory.

Vernacular Names:Sanskrit: Madhunasini, MewawrngiHindi: Gudmara, MedhasingiBengali: MedhasingiGujarati: KavaliTelgu: PodapatriTamil: Shirukurunja

Morphological Characteristics: G. sylvestre is a large,more or less pubescent woody climber. The leaves areopposite, elliptic or ovate; the flowers are small, yellowand in umbellate cymes; the follicles are terete, lanceolateand up to 3 inches in length. The lamina is ovate, elliptic,or ovate- lanceolate with both surface pubescent hair.

Properties in AAAAAyurveda:Parts Used: Leaves Ayurvedic description:Rasa: Tikta, Kawaya,KatuGuna: Laghu, RukwaVirya: Uw6aVipaka: KatuKarma: Kapha-Vata hara, Dipana

(appetite improving), Sramsana (laxative)AAAAAyurvedic Indications:Madhumeha (diabetes), Kuwtha (skin diseases), Krmiroga, Vra6a (wounds),Kasa-Swasa (respiratory disoders) etc.

Principal Constituents: Dried leaves contain two resins;larger part is insoluble in alcohol while smaller portion issoluble in alcohol. There are also bitter neutral principle,albuminous and coloring matter, calcium oxalate,pararobin, glucose, carbohydrates, gymnemic acid,cellulose, and quercitol. Many chemical constituents areisolated and characterized from the plant. Gymnemic acidsare reported to be the main class of chemical constituentsGymnema sylvestre. Gymnemic acids I-IV were thecomponents considered to be of prime importance, firstreported from the leaves of the plant followed by gymnemicacids V and VI20,25 Besides six known gymnemic acids,four feco-triterpenoid saponins, gymnemasins A, B, C, andD, isolated from the leaves of G. sylvestre. The aglycone,gynemanol is also characterized 24

Medicinal properties and uses: It is used to treat glycosuriaand other urinary disorders. Because of its property ofabolishing the taste of sugar, it has been given the name ofgudmara (Sugar destroying). It also neutralizes the excessof sugar present in the body in diabetes mellitus. Root is

referred to be a remedy for snakebite; its powder is dustedupon the wound or made into a paste with water andapplied, whereas its decoction is given internally. Adecoction of the leaves is given in fever and cough. Leavestriturated and mixed with castor oil are applied to swollenglands. 26

Pharmacological / Clinical Studies:

Anti diabetic activityPharmacological StudiesOral administration of aqueous extract of leaves (200 mg/kg) produced reduction in blood sugar levels in normaland alloxan-induced diabetic male rabbits and albino rats.1

In another study, oral administration of G sylvestre leafextract, increased circulating insulin levels in the alloxandiabetic rabbits2 and reduced blood sugar levels3.Oral administration of aqueous suspension of dried leavesof G. sylvestre leaves (0.2 g/2 ml) exhibited hypoglycaemicactivity in moderately diabetic animals. 4 Dried leaf powderof G. sylvestre regulated the blood sugar levels in alloxandiabetic rabbits. It is presumed that pathological changesinitiated in the liver during the hypoglycemic phase werereversed by G. sylvestre. 5

Gymnemic acids, active constituents isolated fromGymnema sylvestre, are having prominent influence onblood sugar level. Given orally even at small concentrations(0.2g/kg), they produced a reduction in the elevate levelsof blood sugar induced by sucrose.7 Systemic fractionationof the leaf extract (CE) guided by biological assay againststreptozotocin-induced diabetic rats, had led to the isolationof the water soluble active principle (GS), which has lowacute toxicity while chronic toxicity study does not showany abnormality. Experimental studies reveal significanthypoglycaemic effect in alloxan-induced diabetic rats isalso. 8 In another study of two water soluble extracts GS3and GS4, rise in serum insulin to levels closer to normalfasting levels were observed. This herbal therapy appearsto bring about glucose homoeostasis through increasedserum insulin levels provided by repair / regeneration ofthe endocrine pancreas. 9 Oral administration of watersoluble fraction of alcoholic extract of leaves led to markedlowering of blood glucose level in normal, glucose-fedhyperglycemic insulin-treated and steptozotocin-induceddiabetic rats. 11

Clinical StudiesClinical studies with oral therapy of GS recordedsatisfactory control in 70% NIDDM patients (withcontrolled calorie intake) without showing side-effects orhypoglycemic shock. 8

Fasting blood sugar lowering effects in normal and diabeticindividuals. However, the reduction in the post-prandialblood sugar level was found to be significant only in thediabetics. 6

GS4, an extract from leaves of G. sylvestre was administered

(400 mg/kg) for 18-20 months as a supplement to theconventional oral drugs. A significant reduction in blood

Herb of the Quater

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glucose, glycosylated Hb and glycosylated plasma proteins,and conventional drug dosage could be decreased. 10 Theplant has found to possess hypoglycemic activityapproximately to that of tolbutamide. 12

Leaf extract showed hypoglycemic activity in humans (33-70 yrs); no toxic effect was observed on liver, kidney andhaemopoetic system.13 G. sylvestre was found to be usefulin the management of diabetes in pregnant women andnursing mothers. 14

Hypochloesterolemic Activity:Leaf extract (25-100 mg/kg) when orally administered toexperimentally induced hyperlipidaemic rats for 2 weeks,reduced the elevated serum triglycerides (TG), totalcholesterol (TC), very low density lipoprotein (VLDL) andlow density cholesterol (LDL) in a dose-dependent manner.The decreased serum high-density cholesterol (HDL) andantiatherogenic index (AAI) in hyperlipidaemia were alsoreversed towards normalization. The ability of this extract(at 100 mg/kg) to lower TG and TC in serum and its anti-atherogenic potential were almost similar to that of astandard lipid lowering agent clofibrate. 15

Anti-Obesity Properties:A polyherbal preparation containing aqueous extracts ofG. sylvestre and other herbs, exhibited antiobesity effecton dietary animal models27. Food containing high amountsof oils and fats is prepared with gymnemic acids helps inthe inhibition of fat and oil hydrolyzates from the digestivetract thereby preventing obesity. 16 Health food containingGymnema sylvestre in combination with Commiphoramukul, guar gum and Allium sativum is reported to be usefulto overcome obesity. 17

Dental Care:Gymnemic acids inhibited glucan formation bystreptococcus mutans in vivo and also markedly inhibitedthe activity of glucosyltransferase from bacterial coat ofS.mutans. Gymnemic acids are useful for prevention ofthe formation of dental plaque and caries. 18

Sweetness Inhibition Activity:G. sylvestre when chewed was found to cause hypgensiai.e., loss of taste. Active ingredients affecting the sense oftaste have been discussed19. G. sylvestre is found to inhibitthe sweet taste sensation20-22

Anti-snake venom Activity:G. sylvestre is reported as an useful herb with anti-snakevenom activity. 23

References:1. Panwar H.S. & Joshi H.C.; Hypoglyceamic Activity of G. sylvestre.

Orissa Vet. J., (1978): 12 (4), p. 147-150.

2. Shanmugasundaram K.R.;( 1981): The Insulinotropic Activity Of G.Sylvestre – An Indian Medicinal Herb Used In Controlling DiabetesMellitus. Pharmacol. Res. Commun., 13 (5), p. 475-486.

3. Java A.H. et al; ( 1978): Studies On The Anti-Diabetic Effects Of G.sylvestre Extract. Pak. J. Res., 30, p. 65-68..

4. Srivastava Y. et al; (1981):Experimental Evaluation Of HypoglycemicEffect Of G. Sylvestre In Alloxan Diabetic Charles Foster Rats. J.Diabetic Assn. India, 21, (4), p. 139-142.

5. Shanmugasundaram K.R. et al; ( 1983): Enzyme Changes AndGlucose Utilization In Diabetic Rabbits : The Effects Of G. sylvestre.J. Ethnopharmacol., 7 (2), p. 205-234. Dhawan, 1986

6. Yoshioka, S, Takeuchi, T. Imoto T, Hiji. Y. (1985): Igaku No

Ayumi,135,241

7. Chakroborty T.; (1992): Hypoglycemic Drug From G. sylvestre InDiabetes. Int. Seminar – Trad. Med., Calcutta. 7th-9th Nov. p.80

8. Shanbugasundaram E.R.B. et al; (1990): Possible Refeneration OfThe Islets Of Langerhans In Streptozotocin-Diabetic Rats Given G.sylvestre Leaf Extracts. J. of Ethnopharmacol., 30 (3), p. 265-279.

9. Chattopadhyaya R.R. et al; (1993): Hypoglycemic AndAntihyperglycemic Effect Of G. sylvestre Leaf Extract In Rats.Fitoterapia, 64 (5), p. 450-454.

10. Khare A.K. et al; (1983): Hypoglycaemic Activity Of An IndigenousDrug (G. sylvestre) In Normal And Diabetic Persons. Ind. J. Phsiol.& Pharmacol., 27 (3), p. 257-258.

11. Baskaran K. et al; (1990): Anti-diabetic effect of a leaf extract fromG. sylvestre in N.I.D.D.M. patients. J. of Ethnopharmacol., 30 (3), p.295-305.

12. Liberti L.; (1993): Gymnema – A Monograph. Lawrence Review ofNatural Products, August. pp. 1-1

13. Arogya (1988): 14,p. 62

14. Bomborde A; (1994): Diabetes In Pregnant Women And NursingMothers. Sachitra Ayurved. 47 (2), p. 108-111

15. Bishayee A. et al; (1992): Hypolipidaemic And Anti-AtheroscleroticEffects Of G. Sylvestre Leaf Extract In Rats Fed In A High Fat Diet.Int. Seminar – Trad. Med., Calcutta. 7th-9th Nov. p.1

16. Hichi, Y; Jpn ko Kai.(1994):Tokkyo Koho 8, Application, Jp,94-191291

17. Ito.N.,Jpn Kokai. (1996): Tokkyo Koho ,318. Rastogi et al.,(1991-93): Compendium Of Indian Medicinal Plants.

CSIR Publications : New Delhi.. Vol I (p.128), II (p.355), III (p.325)& IV (p.357-358).

19. Janujua K.M & Ali S.; (1986): Human Health And Minor Minerals.Part-Ii. Studies Of The Chewing Effect Of G. sylvestre (Gurmar buti).Pak. J. Sci. & Ind. Res., 29 (6), p. 422-423.

20. Liu H.M. et al; (1992): Isolation And Structure Elucidation OfGymnemic Acids, Anti-Sweet Principles of G. Sylvestre. Chemical &Pharmacol. Bull., (1992): 40 (6), p. 1366-1375.

21. Suttisri R., Lee I.S. & Kinghorn A.D.; (1995): Plant-DerivedTriterpenoid Sweetness Inhibitors. J. of Ethnopharmacol., 47 (1), p.9-26.

22. Yoshikawa K. et al; (1992): Bammarane Saponins From G. Sylvestre.Phytochemistry, 31 (1), p. 237-241.

23. Selvanayangam Z.E. et al;( 1994): Plants With Anti-Snake VenomActivity – A Review On Pharmacological And Clinical Studies.Fitoterapia, 65 (2), p. 92-111.

24. Sahu N.P. et al; Triterpenoid Saponins From G. Sylvestre.Phytochemistry(1996): 41 (4), p. 1181-1185.

25. Yoshikawa M, Murakami T, Matsuda H. (1997):Medicinal foodstuffs.X. Structures of new triterpene glycosides, gymnemosides-c, -d, -e,and -f, from the leaves of Gymnema sylvestre R. Br.: influence ofgymnema glycosides on glucose uptake in rat small intestinalfragments. Chem Pharm Bull (Tokyo). 45(12, p.2034-8.

26. Kapoor L.D., (1982): Gymnema sylvestre, CRC Handbook ofAyurvedic Medicinal Plants, p.200-01

AMAZING FACTS☺ A red blood cell can circumnavigate your body in under 20 seconds.

☺ There are more living organisms on the skin of a single human beingthan there are human beings on the surface of the earth.

☺ There are 2.5 trillion (give or take) of red blood cells in your bodyat any moment. To maintain this number, about two and a half millionnew ones need to be produced every second by your bone marrow.

☺ Nerve Impulses travel at over 400 km/hr (25 mi/hr).

☺ In 24 hours, the blood in the body travels a total of 12,000 miles.

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“Clinical Study of the Effect of DaaaaarvyaaaaadiYoga in Prameha.”Dr. Shrinivas M. Datar, Dept. of Kaaaaayacikitsaaaaa, R. A. PodarMedical College, Mumbai (2000)

Abstract: Diabetes has taken shape of pandemic. With highincidence rate in classes as well as masses, the day is notfar when India will become world capital for Diabetes. Highincidence of primary and secondary failure of OHAs andinsulin resistance shows limitations of modernmanagement. In such scenario Ayurvedic drugs have shownsome good results in treating diabetes and its complications.Diabetes mellitus can be very well correlated with Pramehamentioned in Ayurveda. For present study the author hasselected newly diagnosed patients of diabetes and treatedthem with a classical herbal combination called DarvyadiYoga. It contains –Daaaaaruuuuuharidraaaaa : Berberis aristata –antidiabetic(Pramehaghna), Kaphaghna.Deodaaaaaru: Cedrus deodar –Kapha Vataghna, Lekhan.AAAAAamlakiiiii: Emblica officinalis–anti diabetic (Pramehaghna), Tridowaghna.Bibhiiiiitaka: Terminalia bellerica ––Kaphaghna, Rukwa.Haritakiiiii: Terminalia chebula – anti diabetic, Sthaulyahara, Kaphavataghna.Mustaaaaa: Cyprus rotundus ––Kaphaghna, Pacana.

The study showed marked reduction in blood sugar. It alsorelieved patients from symptoms of diabetes such aspolydypsia, polyuria, and polyphagia. The drug was foundmore effective in newly diagnosed diabetics or patientsdiagnosed within one year of type II diabetes (NIDDM).

Knowledge flow- Academia to IndustryA Review of University Dissertations/Thesis on Diabetes

“A Clinical Evaluation of the Role ofVasant Kusumaaaaakara Rasa in theManagement of Diabetic Retinopathy.”Dr. Prasad S. Vaidya, Prof. K. R. Kohli, Dept. of Kaaaaayacikitsaaaaa,R. A. Podar Medical College, Mumbai (2003)

Abstract: Diabetes Mellitus along with its complicationsremains a challenge in present day practice. The factsremains proved that a diabetic patient lands in tocomplications in spite of good blood sugar control. Withproved limitations of modern sciences in the managementof the disease and its complications, diversity of Ayurvedaremains only ray of hope. In the present study 40 patientsin various stages of Diabetic retinopathy were included andtreated with a classical herbo-mineral preparation namedVasanta Kusumakara Rasa. This placebo controlledcomparative study was done under the guidance of modernophthalmologists and Ayurvedic physicians. Theobservations were good enough to prove that with VasantaKusumakara Rasa, there is a fair chance that the patientwill improve. The observations showed marked reversal tomoderate reversal in almost 40% patients of Diabeticretinopathy. No patient in the placebo group showed anyimprovement. With the available management this chanceof recovery should be considered as landmark improvement.These results are evidenced by Fundus photograph of eachpatient.

“Evaluation of Mañjiwtwtwtwtwthadi Ghanavatiiiii in Prameha Upadrava with Special Reference toDiabetic Neuropathy”Dr. Narendra Munde, Dept. of Kaaaaayachikitsaaaaa, R. A. Podar Medical College, Mumbai (2004)

Abstract: Diabetic Neuropathy is the most common and troublesome complication of Diabetes. Though it occurs morecommonly in type II diabetes mellitus (NIDDM), its incidence is very high with 60 – 70% of diabetics have some form ofneuropathy in the progression of the disease. In the present study the author has selected a classical herbal combinationcalled Mañjiwwwwwhthadi Ghanavati for trial. It contains –Mañjiwwwwwttttthaaaaa: Rubia cordifolia - Nervine tonic and rejuvenator. Vacaaaaa: Acorus calamus - Nervine tonic and rejuvenatorGuddddduci: Tinospora cordifolia - Nervine tonic and rejuvenator Triphalaaaaa: Nervine tonic and rejuvenator. Antidiabetic.Kutkiiiii: Picrorrhiza kurroa - Beneficial in relieving burning sensation. Daaaaaruharidraaaaa: Berberis aristata - Useful in nervous debility.Nimba: Azadirachta indica - Reduces burning sensation.

The drug shows excellent improvement in almost all symptoms of neuropathy including tingling, burning sensation andweakness. The results are evidenced by EMG and NCV studies of each patient before and after the trial under guidance ofmodern neurologists.

ANCIENT WISDOMANCIENT WISDOM

Definition of Health and DiseaseAn equilibrium of all the three dowas, all seven dhatus and malas(excretory functions) is termed as the state of Health that leadsto happiness of body, sensory organs, mind and soul. In contrastto this, a disequilibrium of Dowas, Dhatus and Malas leads todisease and painful experiences at all levels.

[Caraka Samhita, Sutra Sthana, Chapter 9, Sloka –3]

Cause of DisordersPerverted , disuse and excessive use of time, intelligence andsense objects is the threefold cause of both psychic and somaticdisorders.

[Caraka Samhita, Sutra Sthana, Chapter 1, Sloka –53]

Industry Perspective

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UPCOMING EVENTS

July 2005NNFA 2005

68th Annual Natural Products Convention andTrade Show (15-17th July, 2005)The National Nutritional Foods Association, represents theinterests of manufacturers and retailers of a wide variety ofnatural products including organic and health foods, herbsand other dietary supplements. The objective of Annualconvention is for mutual interaction and natural productsinformation dissemination.Contact : Amy LounsburySho Sands Expo and Convention CenterLas Vegas, N, Phone: (800) 966-6632, x237,Fax: (949) 622-6266, E-mail : conventions@nnfa.orgWebsite : www.nnfa.org

August 2005INHEX 2005 [Catalyzing the globalization ofIntegrated Healthcare Systems] (19 – 21st August, 2005)

The International Integrated Healthcare Expo and Seminaris being jointly organized with VHERDS (an NGO) betweenin Edison, NJ, USA. It will be showcasing the advantagesof integrating the complimentary & alternative medicinewith existing healthcare systems to provide an integratedhealthcare approach. Providing a global platform forworldwide practitioners, buyers and sellers to meet,exchange information and explore new opportunities infields of alternate and complementary systems of medicine.The New Jersey Convention And Exposition Center NewJersey, USAContact: Ms. Nazeeba ZarinDeputy manager- Events & Expos, IndiaTel:-91 (080) 25547434, Fax:- 91(80) 25542258,E mail: pdaexpo@vsnl.com,Website:www.pdatradefairs.com; http://www.inhex.com/default.htm

Women’s Health and Asian Traditional Medicine(WHAT Medicine), (23-25th August 2005)The first international conference on Women’s Health &Asian traditional Medicine (WHAT Medicine), with thetheme of Promoting Complete Healthcare for Women, willfocus on Asian healthcare traditions for women’s health andwell being. WHAT Medicine will begin a process ofensuring that the best of Asian Healthcare traditions arepreserved, evaluated and promoted in women’s healthcare.Kuala Lumpur Convention Center (KLCC), MalaysiaContact : E-mail : enquiry@whatmedicine.org

11th International Holistic Health Conference:(12-15th August 2005 )International conference uniting the art and science ofholistic health.Integrating the Art & ScienceNovotel Twin Waters Resort, Sunshine Coast, QLD,Australia,Contact : Email :aima@bigpond.com

Website: www.aima.net.au

September 200533rd Annual Conference of Research Society for theStudy of Diabetes in India (RSSDI) (23rd – 24th September2005)Annual conference of Diabetes, will be held in Bangalore,the city of gardens, lakes, opportunities, empowerment andchampions. It has recently been in the national andinternational media for Information Technology &Healthcare facilities.Contact : Phone: +91-080-57726555, Fax: 51307737

Email: krnsetty@touchtelindia.netWeb: www.rssdi2005.com

November 2005International Workshop On Adverse Drug ReactionMonitoring& Fifth Annual Conference of Society ofPharmacovigilance (11th - 13th November, 2005)Objective of the workshop organized by the Society ofPharmacovigilance is to foster the concepts of rational useof drugs, adverse drug reaction monitoring and pharmaco-economics. Annual conference will highlight the core issueson pharmacovigilance.Contact :

Department Of Pharmacology,L. M. College Of Pharmacy, P.O.Box 4011,Navrangpura, Ahmedabad-380 009, India.Contact : Dr. D. D. Santani & Dr. R. K. GoyalE-mail :sopi5@rediffmail.com

2nd International AAAAAyurveda Congress (11th –13th

November 2005)International Congress of Ayurveda is dedicated topropagate Ayurveda and has been making concerted effortsby way of National & International Ayurveda Congressesand thus achieve a Confluence of the Minds of the Expertsin the field, collate their wisdom and spread it among thepractitioners and thus enable Ayurveda to achieve popularityamong the populace.Contact :

The Conference Co-Ordinator2nd International Ayurveda Congress – 2005,No: 70, J-Block, 15 th Main Road,Anna Nagar East, Chennai – 600 102.Tamil Nadu, India.Phone : 91-44-26163779Email : ayurveda@cholayil.com

AMAZINGFACTS

☺ Our lungs inhale over two million liters of air every day.

☺ The amount of carbon in the human body is enough to fillabout 9,000 ‘lead’ pencils.

☺ One square inch of human skin contains 625 sweat glands.

☺ In the average lifetime, we spend five years eating and weconsume food amounting to 7,000 times of our own weightin food.

☺ A sneeze generates a wind of 166 km/hr (100 mi/hr), and acough moves out at 100 km/hr (60 mi/hr).

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AMAM Office Bearers1. Padmabhushan Vaidya

Brahaspati Dev Triguna Patron2. Mr. A.C.Burman Patron3. Mr. Pradip Burman Patron4. Mr. Suresh Sharma Patron5. Vaidya Devender Triguna President6. Mr. Pradeep Multani General Secretary7. Mr. Nitin Ghadiyar Vice President8. Mr. Asad Mueed Vice President9. Mr. Ravi Prasad Vice President10. Mr. Anurag Sharma Vice President11. . Dr. K.R.Kohli Joint Secretary12. Mr. Manoj Pahwa Joint Secretary13. Mr. Ajay Sharma Joint Secretary14. Mr. Arun Chauhan Joint Secretary15. Mr. Tejinder Singh Treasurer16. Mr. Jagdish Prasad Executive Secretary17. Dr. A.V.Anoop Executive Members18. Mr. Vijay Grover Executive Members19. Dr. D. Ramanathan Executive Members20. Dr. Durga Prasad Executive Members21. Dr. Amit Agarwal Executive Members22. Dr. N.B.Brindavanam Executive Members23. Mr. Pramod Sharma Executive Members

Members of AMAM Family1 Dr. M K Bhardwaj, Surya Herbals2 Ms. Vindu Goenka, HERBVEDA3 Mr. Nimish Kumar Shroff, Charak Pharma Pvt. Ltd.4 M/S SBL Pvt. Ltd.5 Mr. Milan.V. Mehta, M/S RYM Exports6 Vinod Haritwal7 Mr. Charanjit Mohan, Dabur India Limited8 M/S Himachal Ayur-Health (P) Ltd.9 Mr. Yogesh Kharb; M/S Devicas Herbal Products Pvt. Ltd.10 Mr. Manoj Pahwa, Sanat Laboratories11 Dr. Kuldip Raj Kohli, DRF12 Mr. R K Maheshwari, Jamuna Pharmaceuticals13 Pharma Lab Packging Systems Pvt. Ltd.14 Mr. Ajay Sharma, Shree Baidyanath Ayurved Bhawan

Ltd.(Delhi)15 Mr. Arun Chauhan, BACFO Pharmaceuticals India Ltd.16 Mr. Pradeep Multani, Multani Pharmaceuticals Ltd.17 Dr. Jagdish Prasad Singh, Shri Dhanwantri Ayurvedic

Pharmacy18 Mr. Anurag Sharma,Shree Baidyanath Ayurved Bhawan

Ltd.(Jhansi)19 Mr. Vijay Grover, Kamal Pharmacy20 Mr. Tejinder Singh, DIL21 Dr. A V Anoop, Cholayil Pharmaceuticals Pvt. Ltd.22 Mr. Asad Mueed, Hamdard (Wakf) Laboratories23 Mr. M.J. Saxena, Ayurvet24 Dr. Durga Prasad, DIL25 Mr. Ravi Prasad, The Himalaya Drug Co.26 Mr. Pramod Sharma, Shree Baidyanath Ayurved, Patna27 Dr. N M Brindavanam, DIL28 Mr. Dilip Bhujbal, DIL29 Dr. Amit Agarwal, Natural Remedies Pvt. Ltd.30 Mr. N Gurumurty, Fortune Biotech Ltd31 M/S La-medicca (India) Private Limited32 Mr. V K Jain, Anusha India Pvt. Ltd.33 Dr. D Ramanathan, Sitaram Ayurveda Pharmacy Ltd34 Mr. Dilvinder Singh Narang35 Mr. Rohit Vohra36 M/S Guruji Ayurvedic Pharmaceutical Pvt. Ltd.37 Mr. John Wilking Einsein, St. John’s Pharmacy College38 Mr. K.V. Shah,Vasu Pharmaceuticals Pvt Ltd 39 Dr. M. Madhukar Reddy 40 Rakesh Ralhan41 Mr. K. Raghunathan42 Mr. Vikrant Dattajirao Amre43 Mr. Mahaveer Singh44 Mr. Maulesh D. Ukani45 Soundhar, Herbal Industrial Estate Mysore46 Dr. M.Madhukar Reddy47 Pravek Kalp Herbal Products Pvt. Ltd.48 E.T.Nilakandhan Moss, Vaidaratnam Oushadhasala49 Prof. Mohd. Khaleel50 Abhit K. Sud, Mayar India Ltd.

INFOLINEAAAAAyurvedic Pharmacopoeia of India

Ayurvedic Pharmacopoeia Committee (APC) of India was constituted in 1963 to prepare monographs of single & compounddrugs. Pharmacopoeial standards of 326 single plant drugs have been evolved by the scientists working in PharmacopoeialLaboratory of Indian Medicine (PLIM). These are duly approved by the Ayurveda Pharmacopoeia Committee and Govt. ofIndia. Four volumes of Ayurvedic Pharmacopoeia have been published by Govt. of India. The work on remaining singledrugs of plant, animal, mineral/ metal and marine origin and multi-ingredients formulations is being carried out in 30laboratories of different institutions. Till date 326 monographs have been released in the form of API (AyurvedicPharmacopoeia of India) covered in 4 volumes (Part –I, Volume -I (80), Part –I, Volume -II (78), Part––I, Volume -III (100),Part –I, Volume –IV (68)). 32 Laboratories/Institutions are engaged in developing Pharmacopoeial standards of Ayurvedic,Unani and Siddha drugs under central scheme of APC. The work is scrutinized by Ayurvedic, Siddha, Unani PharmacopoeiaCommittees.

AMAM FAMILY

A man speaks frantically into the phone, “My wife is pregnant,and her contractions are only two minutes apart!”

“Is this her first child?” the doctor queries.

“No, you idiot!” the man shouts. “This is her husband!”

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� We, would also like to congratulate you and all thoseassociated in its publication, which surely will provide usefuland important information on Ayurvedic Medicines…Thanking you again for bringing out this fabulouspublication.Ms Anchalee Chamchuklin, � Information Managementand Dissemination (IMD)�WHO, New Delhi

� Please accept our best wishes on your efforts to bring out anewsletter to keep everyone posted on the current events ofayurveda, herbal trade and research activities.Michel Saint, UNICEF Representative

� Ayurveda heritage is excellent and infomative and it will befurther finetuned to shape and make Ayurvedic people byupdating their knowledge and skills to meet the demands oftoday and face the challenges of day today ..Dr. M.A.Virinchi Saroni, sridattasai nilayam

� It was a pleasing surprise to see a quality Ayurved magazineby our association. Congratulations, especially to theEditorial team!Milan Mehta- RYM EXPORTS

� It has come out very well in terms of content and layout.V. Krishnan, GM-HR, Dabur India Limited

� AMAM looks quite impressive green and fresh! All the Best!Dr. Arun Bhatt - Clininvent.

� …Please allow us to congratulate on the splendid work beingdone in this field by your team….Chaitanya’s Agro Herbals

� …I wish you all the best for your efforts for growth ofAyurveda…Rakesh Chawla- Gunjan Traders

� ..We read the AYURVEDA HERITAGE and observed a lotof things about the herbals…Ramasamy Murugesan-Secretary, Eco Foundation

� Congratulations to you for this excellent initiative. …Ajay Sharma, President, Shree Baidyanath

� I would certainly like to say that the newsletter is not onlyvery informative but also the presentation is praiseworthy…Nimish Shroff- Charak Pharma Pvt. Ltd.

� I thank you very much in bringing out an informative journalwith elegant getup and array of information. Indeed, itreflects the efforts, the organization is making and definitelyit will serve the cause of Ayurveda in a glorious manner.Dr. S. Farooq

� I have just gone through the first issue of AMAM Journaland I really appreciate the contents of the journal.Dr. Deepak�Acharya, Natural Products�Laboratory,Gujarat University�Area

� It is a good start. Please accept our Congratulations.Dr. J.P.Singh- Shri Dhanwantry Ayurvedic Pharmacy

Prof. K. R. Kohli, Director- Dabur Research Foundationvisits Russia for preaching AAAAAyurveda

Recently Prof. Dr. K.R. Kohli made a visit to Russia fromJune 9-14, 2005 on the request of the organizers of theWorkshop for the Doctors of Ministry of Health in Russia.The workshop was jointly organized by the Ministry of Healthand Social Development of Russian Federation, RussianAcademy of Postgraduate Education and Light of the MorningStar, a Humanitarian Charitable Organization. Seminars wereheld for University Teachers of Medical stream on“Fundamental principles of Traditional Medical System-Ayurveda”. On the first day, the representatives of Ministryof Health and Social Development of Russian Federation,WHO, amd members from Indian Embassy were present onthe occasion.

Dr. Kohli also assessed the position of Ayurveda in Russiaand also made visits to many pharmacy shops to see thepositioning of herbals/Ayurvedic products in Russia. The understanding was that there is a lot of curiosity among thedoctors about Ayurveda. Common people appeared to be still unaware of such a stream. A few of the interested peopleknew about Chyawanprash, Ashwagandha and a few were even aware of the Prakrti/Body constitution as per Ayurveda.There was hardly any presence of Ayurvedic products on the shelves. Some European and Russian herbs could be seen inSuper stores as well as in pharmacies. There are 3-4 Pancakarma centers in and around Moscow which are doing a goodbusiness and are run by Ayurvedic doctors, who organize the medications and oils from India on their own.

FEEDBACK - on Inaugural Issue(Jan.-Mar. 2005)

Quote: “I am a great believer in luck, and I find theharder I work the more I have of it.”

- Stephen Leacock

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Published by:Association of Manufacturers of Ayurvedic MedicineRegd. Office: 22 Site –IV, Sahibabad, Ghaziabad (UP)Correspondence Address: H-36, Connaught Place, New Delhi-110001, Tel: 011-23350062,Fax: 011-23350063, E-mail : krkohli@rediffmail.com; multaniayurveda@hotmail.com