Role of adding ovarian function suppression to tamoxifen in young women with hormone-sensitive breast cancer who remain premenopausal or resume menstruation after chemotherapy: the ASTRRA study

Presented By Woo Chul Noh at 2018 ASCO Annual Meeting

Background

Presented By Woo Chul Noh at 2018 ASCO Annual Meeting

Primary objective

Presented By Woo Chul Noh at 2018 ASCO Annual Meeting

Inclusion and exclusion criteria

Presented By Woo Chul Noh at 2018 ASCO Annual Meeting

Slide 5

Presented By Woo Chul Noh at 2018 ASCO Annual Meeting

Sample size and statistics (Initial design)

Presented By Woo Chul Noh at 2018 ASCO Annual Meeting

Trial progress

Presented By Woo Chul Noh at 2018 ASCO Annual Meeting

Trial progress (protocol amendments)

Presented By Woo Chul Noh at 2018 ASCO Annual Meeting

Trial progress

Presented By Woo Chul Noh at 2018 ASCO Annual Meeting

Patient Characteristics I

Presented By Woo Chul Noh at 2018 ASCO Annual Meeting

Patient Characteristics II

Presented By Woo Chul Noh at 2018 ASCO Annual Meeting

Frequency and Pattern of OF recovery <br />:defined as FSH<30mIU/mL or menstruation history (N=1,369)

Presented By Woo Chul Noh at 2018 ASCO Annual Meeting

Disease free survival (Primary Endpoint)

Presented By Woo Chul Noh at 2018 ASCO Annual Meeting

Disease free survival (Primary Endpoint)

Presented By Woo Chul Noh at 2018 ASCO Annual Meeting

Slide 15

Presented By Woo Chul Noh at 2018 ASCO Annual Meeting

Overall Survival (Secondary Endpoint)

Presented By Woo Chul Noh at 2018 ASCO Annual Meeting

Conclusion

Presented By Woo Chul Noh at 2018 ASCO Annual Meeting

Supplementary Results

Presented By Woo Chul Noh at 2018 ASCO Annual Meeting

Sites of distant metastasis

Presented By Woo Chul Noh at 2018 ASCO Annual Meeting

Sites of other primary cancer

Presented By Woo Chul Noh at 2018 ASCO Annual Meeting

Recurrence-free interval

Presented By Woo Chul Noh at 2018 ASCO Annual Meeting

Breast cancer-free interval

Presented By Woo Chul Noh at 2018 ASCO Annual Meeting

Disease free survival by randomized groups

Presented By Woo Chul Noh at 2018 ASCO Annual Meeting

Discussion: SOFT vs. ASTRRA

Presented By Woo Chul Noh at 2018 ASCO Annual Meeting

Acknowledgement

Presented By Woo Chul Noh at 2018 ASCO Annual Meeting

Acknowledgement

Presented By Woo Chul Noh at 2018 ASCO Annual Meeting

Special Thanks to

Presented By Woo Chul Noh at 2018 ASCO Annual Meeting