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Leaky Gut Syndrome: Unraveling the Cause of Chronic Disease & Harnessing the Power to Heal Douglas A Wyatt, J.D.,Director Sovereign Health Initiative Foundation

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LEAKY GUT SYNDROME: UNRAVELING THE CAUSE OF CHRONIC DISEASE & HARNESSING THE POWER TO HEAL

Leaky gut syndrome, also referred to as leaky gut or intestinal permeability,

is arguably the most prolific killer in the United States. Leaky gut syndrome

is a condition that affects you and everyone you know, and it can take

decades off your life and cause untold misery. However, you probably

know it by another name, or names. It is called food allergies, arthritis,

asthma, autism, cancer, Crohn’s disease, dementia, depression, diabetes,

fibromyalgia, IBS, inflammatory heart disease, multiple sclerosis, psoriasis,

schizophrenia, scleroderma, ulcerative colitis, or any of the hundreds of

autoimmune diseases identified to date. More than two millennia ago,

Hippocrates said that “All disease begins in the gut.” If he was around today,

he’d need to revise that famous quote to, “All disease begins in a leaky gut.”

The chronic and systemic inflammation resulting from a leaky gut is now

believed to be responsible for nearly every type of allergy, autoimmune

disease, and chronic health condition. The growing problem of leaky gut

syndrome (LGS) has triggered a health crisis, the likes of which we may be

wholly unprepared to deal with. Many physicians now agree that nearly

everyone will die of an autoimmune condition. Moreover, there will be

untold physical and mental pain, disability, and suffering along the way.

Shorter lifespans and unfulfilled human potential doesn’t have to be our

fate, but we need to take action early and consistently to heal and protect

the gut.

Hippocrates said that “All disease begins in the gut.” If he was around today, he’d need to revise that famous quote to, “All disease begins in a leaky gut.”

Leaky Gut Syndrome: Unraveling the Cause of Chronic Disease & Harnessing the Power to HealDouglas A Wyatt, J.D.,

Director Sovereign Health Initiative Foundation

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LEAKY GUT SYNDROME: UNRAVELING THE CAUSE OF CHRONIC DISEASE & HARNESSING THE POWER TO HEAL

Statistics show that the incidence of LGS-related conditions is

exploding. For example, one in five adults has arthritis; one in

twelve adults has asthma; one in sixty-eight children has autism;

one in ten adults has type 2 diabetes; one in three-hundred

children has type 1 diabetes; and one in eight adults over sixty-

five has Alzheimer’s. Diseases that were once considered rare, are

now becoming increasingly prevalent, and many people have

more than one. As of 2012, nearly half of all American adults

(117 million) had one or more of ten different chronic health

conditions, and one of every four adults had two or more chronic

health conditions.1

As of 2012, nearly half of all American adults (117 million) had one or more of ten different chronic health conditions, and one of every four adults had two or more chronic health conditions.1

Leaky gut is perfectly normal in newborns. In fact, they have a

leaky gut for approximately the first seventy-two hours of life, and

it’s the foundation for health. This time frame allows for mothers’

colostrum to provide the immunoglobulins and antibodies which

initiate the immune system by passing freely from the gut into

the bloodstream. Subsequently, the epithelial growth factors in

colostrum seal up the natural holes and the continued supply

of growth factors in breast milk keep the holes from reopening.

Preventing intestinal permeability in infants is important so that

the milk proteins in breastmilk will not enter the bloodstream and

trigger an immune response. Additionally, mothers’ colostrum

and breastmilk contains a plethora of immune and growth factors

which assist in the healthy development and growth of the infant,

including beneficial bacteria which seed the gastrointestinal tract.

Intestinal permeability has a critical purpose in the first seventy-

two hours, but not beyond. During childhood or in adulthood, the

holes in the gut can re-open and cause intestinal permeability.

Essentially, without a consistent supply of immune and growth

factors in the diet, everyone will develop LGS. Currently, the most

critical and commonly utilized test for LGS is food sensitivity

testing. The reason being that food sensitivity or food allergy

are a symptom of LGS. When undigested food particles cross

the intestinal barrier and enter the bloodstream, the immune

system recognizes them as foreign and initiates an immune

response and creates antibodies against them. The antibodies

are initially effective against allergens, but over time, may begin

attacking healthy tissue within the body, which eventually leads

to autoimmunity.

Everyone has leaky gut. And I can prove it. My experience with

the more than 187,000 food sensitivity tests performed by Rocky

Mountain Analytical in the early 2000’s showed that only two

tests did not indicate LGS. Obviously, 187,000 positive food allergy

tests don’t lie. The data made it clear that for anyone experiencing

any type of food allergy, autoimmune disease, or chronic health

condition, there’s no need to perform food sensitivity testing.

Moreover, recommending food avoidance or elimination diets

may provide some symptom relief for patients, but it doesn’t do

anything to heal a leaky gut.

Since immune health is directly related to gut health,

understanding what causes intestinal permeability and how LGS

contributes to disease is critical to identifying a viable solution for

the millions of affected people. Ongoing intestinal permeability

is akin to sewer pipes that are chronically leaking their contents

into the body. The leaks may be few and far between at first,

but over time, become more prolific. As the immune system’s

inflammatory response to the sewage becomes chronic, there is

disruption in the normally beneficial immune response to foreign

material. Otherwise healthy cells, tissues, and organs are attacked

as the immune system malfunctions, and disease(s) develops. At

some point, the damage is so great that a patient’s symptoms

necessitate a doctor’s visit and/or a diagnosable condition can be

elicited.

Once practitioners understand that everyone has leaky gut

syndrome and that LGS is the cause of disease, the next question

to ask is what’s causing such disruption in the G.I. tract to bring

about intestinal permeability. Infection by gut-based pathogens is

the number one cause of G.I. disruption. The offending microbes

include Candida albicans, Rotavirus, Cryptosporidium, C. difficile,

E. coli, Salmonella, and Shigella, and although relatively few

people in the United States die from these pathogens, they can

cause a persistent, low-grade gut infection that eats away at

the gut lining. The misuse of antibiotics in both humans and in

animal husbandry has been a significant factor in changing the

balance of gut bacteria towards an unhealthy composition. The

emergence of superbugs was an unintended consequence, and it

remains to be seen whether it may be our undoing.

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LEAKY GUT SYNDROME: UNRAVELING THE CAUSE OF CHRONIC DISEASE & HARNESSING THE POWER TO HEAL

The number two cause of G.I. disruption is what we eat, often

man-made antagonists, that causes damage to the gut bacteria

and the gut lining itself. These include glyphosate and other

herbicide or pesticide-contaminated foods, GMOs, oral antibiotics,

antibiotics in foods, over-the-counter and prescription pain

medications, corticosteroids, refined carbohydrates and simple

sugars, alcohol, soda, caffeine, and other gut irritants. Many

of these are a consequence of our modern lifestyle and thus,

unavoidable to some degree.

Even if one treats his body like a temple -- lives a healthy lifestyle,

avoids the man-made antagonists as much as possible, and mom

breastfed him for at least two years, the holes in the gut can

still reopen. It is the lack of a consistent supply of immune and

growth factors in the diet that allows LGS to rear its ugly head.

From the earliest of times until the early part of the last century,

most people had a cow, goat, yak, or other ruminant animal that

provided the family with raw, fresh milk every day. The colostrum

and milk were the mainstay of the human diet, and the immune

and growth factors were plentiful. As people left the family farm

and moved to cities, diet composition changed greatly. The mass

production and widely available pasteurized, homogenized milk

and other dairy products guaranteed the disappearance of the

critical immune and growth factors. And with this disappearance

came the emergence of allergies, autoimmune diseases, and

other chronic health conditions.

The question then, is how do we get these critical immune and

growth factors back into the diet? The answers is really quite

simple, yet only recently rediscovered. And as everything that was

once old is now new again, bovine colostrum is the missing link

to optimal health. Ayurvedic doctors have used bovine colostrum

for thousands of years in India. Prior to the discovery of penicillin

and antibacterial sulfonamides, mainstream medical doctors

in the United States and around the globe utilized colostrum

as a natural antibiotic.2 In 1950, Dr. Albert Sabin used the

immunoglobulins in bovine colostrum to make his first oral polio

vaccine.3 In the words of my mentor, Dr. Robert Heinerman, Ph.D.,

“Colostrum is the most powerful healing substance in the world.

If it were not for colostrum, the human race wouldn’t even exist.”

Yet, the advent of antibiotics made Western doctors lose interest

in colostrum. My journey to rediscover colostrum was the result

of my wife’s health crisis and my mission to save her life. Personal

experience convinced me that raw fresh bovine colostrum dried

into a powder improved my wife’s gut and immune health, but

years of study and research were necessary to bring this “healing

miracle” to consumers in the United States and around the world.

“Colostrum is the most powerful healing substance in the world. If it were not for colostrum, the human race wouldn’t even exist.”

- Dr. Robert Heinerman, Ph.D.

Early research in piglets demonstrated that bovine colostrum

prevented G.I. damage caused by excess stomach acids and

healed existing damage.4 The colostrum-fed piglets had a twenty

percent increase in the surface area of the small intestine as

measured by villus height. Human clinical trials showed that

bovine colostrum was a novel and inexpensive approach for the

prevention and treatment of the injurious effects of NSAIDs on

the gut, with a possible role in the treatment of other ulcerative

bowel conditions.5 Subsequent studies showed a reduction in

the acute increase in intestinal permeability caused by NSAIDs.6

Although not widely utilized prior to the 2000’s, there was an

increasing interest in the possibility that whole colostrum or some

of its isolated components would be advantageous in treating

a wide range of intestinal conditions, including inflammatory

bowel disease and chemotherapy induced mucositis, in addition

to nonsteroidal anti-inflammatory drug–induced gut injury.7

Later, it was discovered that intestinal permeability could be

caused by heavy exercise, and colostrum was shown to be

effective in preventing heat stroke and enhancing athletic

performance.8

With the emergence of antibiotic-resistant bacterial strains and

deadly viral pathogens, interest in bovine colostrum began to

gain traction in the early 2000’s. Antibodies to at least nineteen

specific pathogens, including Escherichia coli, Cryptosporidium

parvum, Shigella flexneri, Salmonella species, Staphylococcus

species, and rotavirus, were identified in the colostrum of pasture-

fed cows.9 Anti-viral research showed colostrum supplementation,

both in healthy subjects and high-risk cardiovascular patients, was

at least three times more effective than vaccination to prevent

flu and is very cost-effective.10 Follow-up studies showed that

patients receiving either colostrum plus probiotics or colostrum

plus probiotics plus vaccination fared better than those receiving

vaccination alone or no treatment at all.11 They experienced fewer

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LEAKY GUT SYNDROME: UNRAVELING THE CAUSE OF CHRONIC DISEASE & HARNESSING THE POWER TO HEAL

incidences of flu and fewer flu days. Those receiving a vaccination

had twice as many episodes of flu than those receiving the

colostrum and probiotic supplement. Research in HIV/AIDS

suggested that proline-rich polypeptides in colostrum could

help enable a patient’s immune system to recover sufficiently to

fight HIV on its own. The apparent mechanism was stimulating

the production of new helper T-cells.12 Rotavirus infections are

common in HIV/AIDS patients in developing countries; colostrum

has shown to be effective in eliminating the virus, thereby

eliminating the massive diarrhea that may otherwise cause

dehydration and death.13, 14, 15, 16

Human clinical trials showed that bovine colostrum was a novel and inexpensive approach for the prevention and treatment of the injurious effects of NSAIDs on the gut, with a possible role in the treatment of other ulcerative bowel conditions.5

With bovine colostrum recently rediscovered and with access

to raw fresh colostrum extremely limited, practitioners and their

patients need to know how this vital liquid can be made into

a more widely-available supplement. They also must know if

supplements are as efficacious as raw fresh colostrum. Colostrum

can be dried into a powder, but that doesn’t necessarily mean

that it will exert a healing benefit. Two of the most critical

processing techniques for colostrum supplements are low heat

drying and an applied phospholipid coating (liposomal delivery).

If high heat is used, the growth factors are destroyed and only

a limited quantity of immunoglobulins remain intact. If the

colostrum particles are not coated with phospholipids, the harsh

stomach acids destroy the immune and growth factors. So, in

order to ensure a biologically active supplement, the finished

product must contain high levels of the active components which

are capable of reaching their target cells. Liposomal delivery also

allows verifiable results with lower dosages.

Over the past two decades, I have perfected the process of

liposomal delivery and developed a proprietary system for

protecting the delicate immune and growth factors. Thorough

examination of mammalian colostrum revealed that it is

surrounded by liposomes. An infant’s digestive tract is certainly

less harsh than that of an adult, so we knew that a liposomal

delivery system would be critical to the healing benefits of

colostrum supplements for more mature digestive tracts. With

the assistance of world renown colostrum researchers and

biochemists, I created Colostrum-LD™. It has been clinically

proven to heal and prevent leaky gut syndrome, and every

batch is tested and independently verified to contain the twenty

most important bioactive components before distribution to

consumers. Colostrum-LD™ is also SGS and GMP certified, Halal

and Kosher certified, and is produced in the only USDA- licensed

processing plant in the United States specifically designed to

process colostrum.

In conclusion, the Sovereign Health Initiative Foundation

advocates returning to life’s basics and taking control over

one’s health. It is critical that infants begin breastfeeding within

one hour of birth and breastfeed exclusively for the first two

years of life. Such action by new mothers is probably the best

health decision they will ever make for their children. Beyond

infancy, and especially in formula-fed infants, supplementing

with Colostrum-LD™ is recommended. Avoiding the man-made

antagonists that contribute to leaky gut syndrome is vital as well.

Committing oneself to a healthy lifestyle and supplementing

with bovine colostrum is arguably the best and perhaps only

means of surviving in a harsh environment that presently favors

quantity of life over quality of life. We may be living longer but not

necessarily better. Hippocrates also said, “Let food be thy medicine

and medicine be thy food.” Could he have been referring to

colostrum?

P.S. If you are wondering, as I suspect you may be, whose two

negative allergy tests belonged to… that would be my wife’s

and mine. We harnessed the power of colostrum to heal, and so

can you, your family, and every one of your patients. For more

information, visit ColostrumTherapy.com or MySovHealth.org.

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LEAKY GUT SYNDROME: UNRAVELING THE CAUSE OF CHRONIC DISEASE & HARNESSING THE POWER TO HEAL

Endnotes

1. Ward BW, Schiller JS, Goodman RA. Multiple Chronic Conditions

Among US Adults: A 2012 Update. Preventing Chronic Disease

2014;11:130389.

2. Rona Z. Clinical Applications: Bovine Colostrum As Immune

System Modulator. American Journal of Natural Medicine 1998

March;5(2):19-23.

3. Sabin AB. Antipoliomyelitic substance in milk of human beings

and certain cows. A.M.A. American Journal of Diseases of

Children 1950 Nov;80(5):866-7

4. Borissenko M. Malaysia Colostrum Piglet Clinical Trial. Unpublished

Research October 1998.

5. Playford RJ, Floyd DN, Macdonald CE, Calnan DP, Adenekan RO,

Johnson W, Goodlad RA, Marchbank T. Bovine colostrum is a

health food supplement which prevents NSAID induced gut

damage. Gut 1999;44:653-658.

6. Playford RJ, MacDonald CE, Calnan DP, Floyd DN, Podas T,

Johnson W, Wicks AC, Bashir O, Marchbank T. Co-administration

of the health food supplement, bovine colostrum, reduces the

acute non-steroidal anti-inflammatory drug-induced increase

in intestinal permeability. Clinical Science (London) 2001

Jun;100(6):627-33.

7. Playford RJ, Macdonald CE, Johnson W. Colostrum and

milk-derived peptide growth factors for the treatment of

gastrointestinal disorders. American Journal of Clinical Nutrition

2000;72:5-14.

8. Marchbank T, Davison G, Oakes JR, Ghatei MA, Patterson M, Moyer

MP, Playford RJ. The nutriceutical bovine colostrum truncates the

increase in gut permeability caused by heavy exercise in athletes.

Am J Physiol Gastrointest Liver Physiol. 2011;300:G477–G484.

9. McConnell MA, Buchan G, Borissenko MV, Brooks HJL. A

comparison of IgG and IgG1 activity in an early milk concentrate

from non-immunised cows and a milk from hyperimmunised

animals. Food Research International 2001;34(2–3):255–261..

10. Cesarone MR, Belcaro G, Di Renzo A, Dugall M, Cacchio M, Ruffini

I, Pellegrini L, Del Boccio G, Fano F, Ledda A, Bottari A, Ricci A,

Stuard S, Vinciguerra G. Prevention of influenza episodes with

colostrum compared with vaccination in healthy and high-

risk cardiovascular subjects: the epidemiologic study in San

Valentino. Clinical and Applied Thrombosis/Hemostasis 2007

Apr;13(2):130-6.

11. Belcaro G, Cesarone MR, Cornelli U, Pellegini L, Ledda A, Grossi

MG, Dugall M, Ruffini I, Fano F, Ricci A, Stuard S, Luzzi R, Grossi

MG, Hosoi M. Prevention of flu episodes with colostrum and

Bifivir compared with vaccination: an epidemiological, registry

study. Panminerva Medica 2010 Dec;52(4):269-75.

12. Keech A, Nwabuko U, Chikezie C, Wogu GUE. Peptide

immunotherapy: a new direction in HIV/AIDS treatment..

Unpublished Research. February 2008.

13. Rump JA, Arndt R, Arnold A, Bendick C, Dichtelmuller H, Franke

M, Helm EB, Jager H, Kampmann B, Kolb P, Kreuz W, Lissner

R, Meigek W, Ostendorf P, Peter HH, Plettenberg, Schedel I,

Stellbrink HW, Stephan W. Treatment of diarrhoea in human

immunodeficiency virus-infected patients with immunoglobulins

from bovine colostrum. Clinical Investigator 1992;70:588-594.

14. Floren CH, SONNY Chinenye S, Elfstrand L, Hahman C, Ihse

I. ColoPlus, a new product based on bovine colostrum,

alleviates HIV-associated diarrhea. Scandinavian Journal of

Gastroenterology 2006; 41:682-686.

15. Elfstrand L, Florén CH. Management of chronic diarrhea in HIV-

infected patients: current treatment options, challenges and

future directions. HIV/AIDS (Auckland, N.Z.) 2010;2:219-24.

16. Kaducu FO, Okia SA, Upenytho G, Elfstrand L, Florén CH.

Effect of bovine colostrum-based food supplement in the

treatment of HIV-associated diarrhea in Northern Uganda: a

randomized controlled trial. Indian Journal of Gastroenterology

2011;30(6):270–276..