presentation - miniaturised diagnostics for health - zulf ali
TRANSCRIPT
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8/7/2019 Presentation - Miniaturised Diagnostics for Health - Zulf Ali
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Miniaturised Diagnostics for Health
Zulfiqur Ali, ([email protected])
School of Science and Technology
University of Teesside
Microdiagnostics, EKTN, NetPark, 1stJune 2009
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Miniaturised diagnostics for health
Increasing costs of healthcare
Demographics
Chronic diseases (heart disease, stroke,
cancer, diabetes, lung cancer) are leading
causes of mortality and increasing in
prevalence
Prevention and early detection of disease
Care at the point of need
More efficient approach for development
of drug therapies
Need for complex chemical and biologicaloperations at low cost in automated
manner to allow operation by non-
specialist staff
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Microfluidics
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Storage, dosing, moving and mixing smallvolumes (mL pL) of liquids in channelstypically 10-100Qm wide
Design and construction
Fabrication protocol
Fluidic control (pressure, electrokinetic,centrifugal, acoustic)
Detection (optical, electrochemical,acoustic)
Packaging, macro world interface (fluidic,mechanical, optical, electrical)
Materials - glass, silicon, polymer, hybrid
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DVT-IMP: aid diagnosis of deep vein
thrombosis DVT is the leading cause of unexpected death in
most developed nations
results from the formation of blood clots in deepveins, usually in the leg.
Diagnosis is problematic.
Requires blood test and clinical assessmentfollowed by medical imaging if required.
Current blood tests can only eliminate DVT.
Specificity of current tests results in false negativeresults, putting patients at risk.
http://www.diagnosingdvt.com
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DVT-IMP
Measure D-dimer concentration
in whole blood
Immunoassay using high
affinity antigen-antibody
binding
Impedance based detection
Microfluidics for sample
processing
Quantitative, accurate and
reproducible
Simple and easy to use Potential use in primary care
and clinics
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A
b -
.4 mg/ml
Ag -
pg/ml
Ag - 5
pg/ml
Ag - 4,5 ng/ml
Ag - 5
ng/ml
Ag - 4,5 g/ml
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I
(Z)(;
2)
Re (Z) (;
2)
Nyquist Plots for varying model [ g]
Dynamic range: 100pg/ml 100ng/ml, Opt. temp. 20
C
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Transducer layer
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Diagnostic Cartridge
Micr idic body
dhesive foil
Electrode layer
Microfluidic body
dhesive foil
Electrode layer
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Roll-to-roll process
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