PREGLED 2013.

Zagreb, 2014.

ISBN 978-953-6998-57-9

9 7 8 9 5 3 6 9 9 8 5 7 9

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EG

LED

2013. Stručni i znanstveni rad

ovi

Stručni i znanstveni radovi

PREGLED2013.

StručniiznanstveniradoviNastavni zavodzajavnozdravstvo

„Dr.AndrijaŠtampar“

REVIEW2013

ProfessionalandscientificarticlesAndrijaŠtampar

TeachingInstituteofPublicHealth

Zagreb,2014.

IzdavačSlužbazaznanostinastavu

Nastavnogzavodazajavnozdravstvo„Dr.AndrijaŠtampar“

Uredništvo:JosipČulig

MarcelLeppéeIvanaPrgaJankač

Grafičkapripremaitisak:

ISBN:978-953-6998-57-9

Naklada200primjeraka

Zagreb,2014.

MojUredd.o.o.

Predgovor

Temeljem istraživačkog rada u znanstvenom području biomedicina i zdravstvo,znanstvenompoljujavnozdravstvoizdravstvenazaštita,utadašnjemZavoduzajavnozdravstvo Grada Zagreba, osnovana je Znanstvena jedinica, koja je 2001. godineregistrirana u Ministarstvu znanosti, obrazovanja i sporta (MZOS), kao Znanstvenajedinica ZZJZGZ s istraživačkim djelokrugom u znanstvenom području biomedicina izdravstvoteznanstvenompoljujavnozdravstvoizdravstvenazaštita.ZnanstvenapostignućadjelatnikaZavodaseredovitopublicirajuudomaćimiinozemnimčasopisima i knjigama. Znanstvenici i sveučilišni nastavnici zaposleni u ZavoduevidentiranisuuUpisnikuznanstvenikapriMinistarstvuznanosti,obrazovanjaisportaRepublike Hrvatske. Znanstveno istražuju u različitim područjima (javno zdravstvo izdravstvena zaštita, temeljna i kliničkamedicina, farmacija,prehrambena tehnologija,kemija,biologijaidrugo).ZahvaljujućiintenzivnimznanstvenimpostignućimaZavodjepostaosuradnaustanovamedicinskih fakulteta u Zagrebu, Osijeku i Rijeci, farmaceutskog fakulteta u Zagrebu,Zdravstvenog veleučilišta te drugih učilišta i znanstvenih instituta, zbog čega jepromijenioimeuNastavnizavod.UPregledustručnihiznanstvenihradovakojegredovitotiskamo,najednomsumjestuprikupljeneosnovneinformacijeopublikacijamaznanstvenikazaposlenihuNastavnomzavoduza javnozdravstvo„Dr.AndrijaŠtampar“.Znanstvenom,nastavnomistručnomraduseposvećujeznačajannaporuzizvršavanjeosnovnezdravstvenedjelatnostiZavoda.U2013.godinitojerezultiralouspješnimzavršetkomrazličitihznanstvenihprojekataštoseočitujeučak17radovaobjavljenihucijelosti(inextenso)učasopisimakojisecitirajuuCurrentContents(CC)bazipodataka,aukojimasudjelatniciZavodaimaliautorskuilikoautorskuulogu.Jošje6radovaobjavljenihudrugimindeksiranimčasopisima(PubMed,Medline)ucijelosti(inextenso)te10sažetakaradovaobjavljenihiprikazanihnaraznimmeđunarodnimkongresima,simpozijimaitiskanihurazličitimpublikacijama.Znanstvena djelatnost Nastavnog zavoda za javno zdravstvo „Dr. Andrija Štampar“ jeuspješno umrežena u međunarodne projekte, što je pretpostavka daljnjeg razvoja inapretka,unatočsloženimfinancijskimuvjetimazaovukomponentusvakodnevnograda.Bezznanstvenognapredovanjanemaukupnograzvojapajeznanostvažandiostrategijenašeustanove,aovamalapublikacijadokazjedaitekakoimasmislapoticatizaposlenikenadodatnenapore.

ZvonimirŠostar,dr.med.,ravnatelj

3

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SADRŽAJ

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1) RADOVIOBJAVLJENIUCURRENTCONTENTS-U(CC)U CIJELOSTI(INEXTENSO)

Broj1.DETERMINATIONOFCYANURICACIDINWHEYPOWDERUSINGHILIC-MS/MSIvešićM,BabićS,KrivohlavekA,ŠmitZ.

Broj2.ORGANOCHLORINEPESTICIDESINMURAENAHELENAL.1758FROMTHEEASTERNADRIATICSEA.DikicD,Mojsovic-CuicA,JurakG,LasicD,SkaramucaD,Matic-SkokoD,TutmanP,BosnirJ,FranjevicD,FranicZ,FuchsR,SkaramucaB.

Broj3.EFFECTSOFTEMPERATURE,LENGTHOFSTORAGEANDTECHNOLOGICALPROCESSESONTHEFORMATIONOFN-NITROSAMINESINLIVERPÂTÉJurak G Bo nir J Puntari D Pavlini Prokurica I mit Z Medi H Puntari I , š , ć , ć- ,Š , ć , ć ,Puntari E.ć

Broj4.NATURALOCCURRENCEOFAFLATOXINB1,OCHRATOXINAANDCITRINININCROATIANFERMENTEDMEATPRODUCTSMarkovK,PleadinJ,BevardiM,VahčićN,Sokolić-MihalakD,FreceJ.

Broj5.EFFECTSOFMAGNESIUM,CHROMIUM,IRONANDZINCFROMFOODSUPPLEMENTSONSELECTEDAQUATICORGANISMSBosnirJ,PuntaricD,CvetkovicZ,PollakL,BarusicL,KlaricI,MiskulinM,PuntaricI,PuntaricE,MilosevicM.

Broj6.HEAVYMETALSANDMETALLOIDCONTENTINVEGETABLESANDSOILCOLLECTEDFROMTHEGARDENSOFZAGREB,CROATIAPuntaricD,VidosavljevićD,GvozdićV,PuntarićE,PuntarićI,MayerD,BošnirJ,LasićD,JergovićM,KlarićI,VidosavljevićM,KrivdićI.

Broj7.FIGHTINGRABIESINEASTERNEUROPE,THEMIDDLEEASTANDCENTRALASIA-EXPERTSCALLFORAREGIONALINITIATIVEFORRABIESELIMINATIONAikimbayevA,BriggsD,ColtanG,DodetB,FarahtajF,ImnadzeP,KorejwoJ,MoiseievaA,TordoN,UsluerG,VodopijaR,VranješN.

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Broj8.MAMMOGRAPHICDENSITYANDESTIMATIONOFBREASTCANCERRISKININTERMEDIATERISKPOPULATIONTešićV,KolarićB,ZnaorA,KusacicKunaS,BrkljačićB.

Broj9.RISKFACTORSFORPULMONARYTUBERCULOSISINCROATIA:AMATCHEDCASE-CONTROLSTUDYJurcev-SavicevicA,MulicR,BanB,KozulK,Bacun-IvcekL,ValicJ,Popijac-CesarG,Marinovic-DunatovS,GotovacM,SimunovicA.

Broj10.HEALTHSYSTEMDELAYINPULMONARYTUBERCULOSISTREATMENTINACOUNTRYWITHANINTERMEDIATEBURDENOFTUBERCULOSIS:ACROSS-SECTIONALSTUDYJurcev-SavicevicA,MulicR,KozulK,BanB,ValicJ,Bacun-IvcekLj,GudeljI,Popijac-CesarG,Marinovic-DunatovS,SimunovicAetal.

Broj11.ASIXDECADESLONGFOLLOW-UPONBODYSIZEINADOLESCENTSFROMZAGREB,CROATIA(1951-2010)Zajc-PetranovićM,TomasZ,Smolej-NarancicN,Skaric-JuricT,VecekA,MilicicJ.

Broj12.INEQUALITIESINCROATIANPUPILS'RISKBEHAVIORSASSOCIATEDTOSOCIOECONOMICENVIRONMENTATSCHOOLANDAREALEVEL:AMULTILEVELAPPROACHPavic-SimetinI,KernJ,KuzmanM,PfoertnerTK.

Broj13.ESTIMATINGGLOBALANDREGIONALMORBIDITYFROMACUTEBACTERIALMENINGITISINCHILDREN:ASSESSMENTOFTHEEVIDENCELuksicI,MulicR,FalconerR,OrbanM,SidhuS,RudanI.

Broj14.EFFECTIVENESSOFSEASONALINFLUENZAVACCINESINCHILDREN-ASYSTEMATICREVIEWANDMETA-ANALYSISLukšićI,ClayS,FalconerR,PulanicD,RudanI,CampbellH,NairH.

Broj15.VIRALETIOLOGYOFHOSPITALIZEDACUTELOWERRESPIRATORYINFECTIONSINCHILDRENUNDER5YEARSOFAGE-ASYSTEMATICREVIEWANDMETA-ANALYSISLukšićI,KearnsPK,ScottF,RudanI,CampbellH,NairH.

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Broj16.PATIENTSELF-REPORTEDADHERENCEFORTHEMOSTCOMMONCHRONICMEDICATIONTHERAPYBoskovicJ,LeppéeM,CuligJ,EricM.

Broj17.SOILCONTAMINATIONASAPOSSIBLELONG-TERMCONSEQUENCEOFWARINCROATIAVidosavljevicD,PuntaricD,GvozdicV,JergovicM,MiskulinM,PuntaricI,PuntaricE,SijanovicS.

2) RADOVIOBJAVLJENIUCURRENTCONTENTS-U(CC)U OBLIKUSAŽETKA

Broj1.ADHERENCETOMEDICATIONINTHEMOSTCOMMONCHRONICDISEASESLeppéeM,CuligJ,MandicK,SkesM,Maric-BajsM.

Broj2.CONSUMPTIONOFANTIDEPRESSANTSINCROATIA:TRENDSINTHERATEOFHOSPITALIZATIONFORDEPRESSIONANDSUICIDE(2001-2010)Polic-VizintinM,StimacD,TripkovicI.

3) RADOVIOBJAVLJENIUDRUGIMINDEKSIRANIM ČASOPISIMAUCIJELOSTI(INEXTENSO)

Broj1.DETERMINATIONOFBOTANICORIGINOFTHECROATIANBLACKLOCUSTHONEY(ISTRIAREGION)USINGMELISSOPALYNOLOGICALANALYSISUršulin-TrstenjakN,HrgaI,StjepanovićB,DragojlovićD,LevanićD.

Broj2.UDIOMIKROELEMENATAUPOČETNOJIPRIJELAZNOJHRANIZADOJENČADTEHRANINABAZIŽITARICABošnirJ,FilipovićVrhovacI,RaczA,AntolićS,PuntarićD.

Broj3.ANTIFUGALNAIANTIPATULINSKAAKTIVNOSTGLUCONOBACTEROXIDANSIZOLIRANESPOVRŠINEJABUKEBevardiM,FreceJ,MesarekD,BošnirJ,MrvčičJ,DelašF,MarkovK.

Broj4.EPIDEMIOLOGYANDETIOLOGYOFCHILDHOODPNEUMONIAIN2010:ESTIMATESOFINCIDENCE,SEVEREMORBIDITY,MORTALITY,UNDERLYINGRISKFACTORSANDCAUSATIVEPATHOGENSFOR192COUNTRIESRudanI,O'BrienKL,NairH,LiuL,TheodoratouE,QaziS,LukšićI,FischerWalkerCL,BlackRE,CampbellH;ChildHealthEpidemiologyReferenceGroup(CHERG).

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Broj5.GERONTOLOGYPUBLICHEALTHMANAGEMENTINCROATIATomek-RoksandićS,TomasovićMrčelaN,SmolejNarančićN,ŠostarZ,LukićM,DurakovićZ,LjubičićM.

Broj6.PROGRAMOFPRIMARY,SECONDARYANDTERTIARYPREVENTIONFORTHEELDERLYTomek-RoksandićS,TomasovićMrčelaN,SmolejNarančićN,ŠostarZ,LukićM,DurakovićZ,LjubičićM,VučevacV.

4) OSTALIRADOVI

4.1)INOZEMNI

Broj1.VALIDATIONOFAMETHODFORDETERMINATIONOFPHTHALATESINCOMMONUSEOBJECTS(TOYSANDCHILDCAREARTICLES)BYGASCHROMA-TOGRAPHYMASSSPECTROMETRY(GCMS)MandićAndačićI,RanogajecA,SmitZ.

Broj2.COMPARASIONOFFINEPARTICULATECONCENTRATIONSINURBANAREATRAFFICEXPOSEDAREAANDLANDFILLINTHEZAGREBCITY.MajićI,KrivohlavekA,ŠikićS,ŠostarZ.

Broj3.OXIDATIVESTRESSRESPONSEINTOBACCOEXPERIMENTALLYEXPOSEDTOCADMIUMANDZINCCvjetkoP,ŠikićS,Peharec-ŠtefanićP,TolićS,PavlicaM,BalenB.

Broj4.REGIONALDIFFERENCIESINDRINKINGHABITSAMONGCROATIANADOLESCENTSKuzmanM,Pavic-SimetinI,MarkelicM,Pejnovic-FranelicI.

Broj5.QUALITYLIFEIMPROVEMENTOFPEOPLEWITHINTELLEC-TUALDISABILITIESTHROUGHOUTARTTHERAPYANDMOVEMENTREHABILITATIONTHERAPYPROGRAMSŠ , č , č .kes M Lukave ki V Kli ek M

Broj6.THERELIABILITYOFADHERENCETOMEDICATIONSELF-REPORTINGSCALESCuligJ,LeppéeM,CuligB.

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Broj7.IMPACTOFP ' ATIENTS ADHERENCE TO MEDICATION ANDPHARMACOECONOMIC ANALYSISCuligJ,LeppéeM,CuligB.

Broj8.SELF-REPORTEDADHERENCEFORTHECHRONICMEDICATIONTHERAPYLeppéeM,CuligJ,Maric-BajsM.

4.2)DOMAĆI

Broj1.MELISOPALINOLOŠKEKARAKTERISTIKENAJVAŽNIJIHVRSTAMEDAUREPUBLICIHRVATSKOJHrgaI,StjepanovićB.

Broj2.ODREĐIVANJEBOTANIČKOGIGEOGRAFSKOGPODRIJETLAKONTINENTALNIHMEDOVAHRVATSKEHudinaT,MitićB,HrgaI,B.Stjepanović,D.Lasić,I.Nemet,S.Rončević.

Broj3.USPOREDBA KONCENTRACIJA SO U GRADSKOJ ZONI I ODLAGALI TU 2 Š OTPADAGRADAZAGREBAMajićI,KrivohlavekA,ŠikićS.

Broj4.ODREĐIVANJEADSORBILNIHORGANSKIVEZANIHHALOGENA(AOX)UVODIJukićM,SimonM,LazićV,KrivohlavekA,ŠikićS,OžićS.

Broj5.DESETGODINAAKREDITACIJEZAVODAZAJAVNOZDRAVSTVO„DR.ANDRIJAŠTAMPAR“;NormaHRNENISO/IEC17025:2007KrivohlavekA,Devčić-JerasA,ŠikićS.

Broj6.INSTITUCIONALNOPRAĆENJEUPORABEANTIBIOTIKAUPČELINJIMPROIZVODIMAKrivohlavekA.

Broj7.VAŽNOSTPRAĆENJACITRININAUŽITARICAMANAPODRUČJUREPUBLIKEHRVATSKE.BevardiM,OžićS,BošnirJ,BudečM.

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Broj8.OTPUŠTANJEFTALATAIZAMBALAŽEURAZNEVRSTEPIĆAGalićA,BarušićL,MandićI,JurkovićZ, ž D.Stra anac

Broj9.PRIKAZREZULTATAMONITORINGAISLUŽBENIHKONTROLAHRANENAPRISUTNOSTANALIZIRANIHMIKOTOKSINALasićD,BudečM,IvešićM,RanogajecA,BlagojevićK,KnezićK.

Broj10.KONTROLE MIKOTOKSINA U HRANI I HRANI ZA ŽIVOTINJE S NAGLASKOM NA UZORKOVANJEBošnirJ,PrskaloI,PavlekŽ,NovakA.

Broj11.ODREĐIVANJEBIOGENOGAMINA,HISTAMINA,UUZORCIMAKONZERVIRANERIBETEKUĆINSKOMKROMATOGRAFIJOMVISOKEDJELOTVORNOSTIBevardiM,BošnirJ,HorvatG,SerdarS,BrkićD.

Broj12.MIKROBIOLOŠKEIMIKOTOKSIKOLOŠKEOPASNOSTIZAZDRAVSTVENUISPRAVNOSTIKARAKTERIZACIJADOMAĆIHKOBASICAODMESADIVLJAČIMarkovK,PleadinJ,HorvatM,BevardiM,BošnirJ,Sokolić-MihalakD,DelašF,FreceJ.

Broj13.UGRIZI I UBODI KUKACA PAU NJAKA ZA TITA I OBRANA ( Č ), Š VodopijaI,VodopijaR,KrajcarD.

Broj14.MOGUĆATROVANJAANTIKOAGULANTIMATIJEKOMSUSTAVNEDERATIZACIJE–NEUOBIČAJENIKONTAKTISGLODAVCIMAVodopijaR.

Broj15.HUMANAANTIRABIČNAZAŠTITANAPODRUČJUKOPRIVNIČKO-KRIŽEVAČKEŽUPANIJEURAZDOBLJUOD2009.DO2011.GODINEPinterD,VodopijaR.

Broj16.INFEKCIJEUPUTNIKA:EPIDEMIOLOGIJA,KLINIČKASLIKA,DIJAGNOSTIKA,TERAPIJAIPREVENCIJAKosanovićML.

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Broj17.NADZORIPRAĆENJETIGRASTOGKOMARCA(AEDESALBOPICTUS)NANAJČEŠĆIMMJESTIMAUNOSAUKONTINENTALNOJHRVATSKOJKlobučarA,BenićN,KrajcarD,VrućinaI,VignjevićG,MerdićE.

Broj18.SUVREMENAPRIMJENAINFORMACIJSKO-KOMUNIKACIJSKETEHNOLOGIJE-GLODAVCIIKOMARCIUDIGITALNOMSVIJETUPuhaloD,KlobučarA,BenićN.

Broj19.EPIDEMIOLOGIJAGROZNICEZAPADNOGNILABenićN.

Broj20.KONTROVERZE I INJENICE O PRIMARNOJ PREVENCIJI SPOLNO PRENOSIVIH Č INFEKCIJAKuzman M.

Broj21.KAKO UNAPRIJEDITI ZA TITU REPRODUKTIVNOG ZDRAVLJA MLADIH Š ?KuzmanM.

Broj22.DIJAGNOSTIKA I PREVALENCIJA HPV INFEKCIJE U ENA ZAGREBA KE REGIJE Ž Č MarijanT.

Broj23.ZNAČENJESTALNEEDUKACIJEOOSNOVAMAIZGERONTOLOGIJEIGERIJATRIJEZARAZVOJHRVATSKOGGOSPODARSTVATomek-RoksandićS,TomasovićMrčelaN,SmolejNarančićN,DurakovićZ,LjubičićM,ŠostarZ,FortunaV,LukićM,PerkoG,ŠimunecD,HlatkiMatijevićS,JurišićS.

Broj24.ISKUSTVAISTAVOVIOKOCKANJUIKLAĐENJUPACIJENATAIKLIJENATASLUŽBEZAMENTALNOZDRAVLJEIPREVENCIJUOVISNOSTIZAVODAZAJAVNOZDRAVSTVO„DRANDRIJAŠTAMPAR”ŠalamonS,SabljićL,BekićM.

Broj25.PROFESIONALNIDJELOKRUGRADASOCIJALNOGRADNIKAUZDRAVSTVUINEPROFITNOMSEKTORURadicA,Devcic-MajericK,KovacevicN.

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Broj26.„PLESNARUBU“-VIŠEGODIŠNJEIZVANBOLNIČKOLIJEČENJEHEROINSKOGOVISNIKASKOMORBIDNIMPOREMEĆAJIMAGracinB,ĆavarZ,RomacD,BorovečkiŠimurinaA.

Broj27.KARAKTERISTIKEŽENA-OVISNICAOPSIHOAKTIVNIMSREDSTVIMABorovečkiŠimurinaA,Cahunek-ŽunecM,RomacD,GracinB,ĆavarZ.

Broj28.POSTAVLJANJEUPITAOPREZENTACIJSKOMEMEDIJUUCSS-KODURESPONZIVNEWEB-STRANICEPeterK.

Broj29.HRVATSKIZDRAVSTVENITURIZAMZASTRANEIDOMAĆESTARIJETURISTETomek-RoksandićS,Tomasović-MrčelaN,Smolej-NarančićN,LjubičićM,SmoljanovićM,StrnadM,DrakulićV,PredavecS,LukićM,MravakS,PerkoG,LeppéeM,BaklaićŽ,FortunaV,ŠostarZ,VlašićV.

Broj30.PATIENTS'ADHERENCETOMEDICATIONRATEANDPHARMACOECONOMICANALYSISCuligJ,LeppéeM,SkaronN,MalovicM,BilusicM.

Broj31.THEMOSTCOMMONCHRONICDISEASESANDADHERENCETODRUGSCuligJ,LeppéeM,BoskovicJ,MalovicM.

Broj32.ESTIMATESOFRELIABILITYADHERENCESELF-REPORTINGSCALESBYTHECOEFFICIENTOFINTERNALCONSISTENCYRELIABILITY(CRONBACH'S )αLeppéeM,Vracan-MravakS,MalovicM,CuligB.

Broj33.USPOREDBAOPĆEUSTRAJNOSTIPREMATERAPIJISUSTRAJNOŠĆUKODOBOLJELIHODARTERIJSKEHIPERTENZIJELeppéeM,CuligJ,Marić-BajsM,CuligB.

5) NAPREDOVANJA

6) DOKTORIZNANOSTI,MAGISTRIZNANOSTIISTRUČNIMAGISTRI

7) INDEKSAUTORA

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UVOD

Stručniiznanstveniradovipodijeljenisuučetirikategorije,sukladnokriterijimakojehrvatskasveučilištaprimjenjujuprilikomprocesanapredovanjaznanstvenikauvišiznanstvenistupanj:

1) RADOVIOBJAVLJENIUCURRENTCONTENTS(CC)ČASOPISIMAUCIJELOSTI (INEXTENSO) 2) RADOVI OBJAVLJENI U CURRENT CONTENTS (CC) ČASOPISIMA U OBLIKU SAŽETKA 3) RADOVIOBJAVLJENIUDRUGIMINDEKSIRANIMČASOPISIMA(PUBMED, MEDLINEIOSTALI)UCIJELOSTI(INEXTENSO) 4) OSTALIRADOVI

CurrentContents(ThomsonReuters)najpopularnijajebazapodataka,ahrvatskimjeznanstvenicimadostupnaprekoOvidsučelja.Razlozipopularnostisurelativnovisokikriterijodabiračasopisa,pokrivenostsvihpodručjaznanosti,učestalostažuriranja,citiranje autorskog sažetka, adrese autora, nazivi i adrese izdavača, mogućnostpregledasadržajapojedinogbrojačasopisatedodatneključneriječikojeunapređujupretraživanje.PremanavodimauređivačaCurrentContents citiraju se svi radovi izuključenihčasopisa,odkoricadokorica,tj.neradisenikakavodabir,kaokodnekihdrugihbaza.CCbazapodatakasastojiseod:

1. sadržajabrojevačasopisa 2. bibliografskihzapisaradovaiz9,500vodećihsvjetskihčasopisaizsvih područjaznanosti,višetisućaknjigaizbornihskupova.

PrekosvojihsedamsekcijaCurrentContentspokrivasvapodručjaznanosti:

1. Agriculture,BiologyandEnvironmentalSciences(AGRI)–citiravišeod 1040vodećihsvjetskihčasopisaizdisciplinakaoštosuagronomija, biotehnologija,botanika,ekologija,entomologija,hidrologija,nutricionizami veterinarskamedicina. 2. ClinicalMedicine(CLIN)–citiravišeod1120vodećihsvjetskihčasopisaiz kliničkemedicine,uključujućipodručjakaoštosuanatomija,anesteziologija, kirurgija,kliničkapsihijatrija,kliničkafarmakologija,nuklearnamedicina, onkologija,pedijatrijaiinternamedicina. 3. Engineering,TechnologyandAppliedSciences(TECH)–citiravišeod1120 vodećihsvjetskihčasopisaizinženjerstva,tehnologijaiprimijenjenihznanosti, uključujućiaeronautiku,automatizaciju,elektrotehniku,energetiku,optiku, računalneznanostiitehnologijuitelekomunikacije. 4. LifeSciences(LIFE)–citiravišeod1370vodećihsvjetskihčasopisaizbio-

znanosti,uključujućipodručjakaoštosubiokemija,biofizika,farmakologija, fiziologijaitoksikologija. 5. Physical,ChemicalandEarthSciences(PHYS)–citiravišeod1050vodećih svjetskihčasopisaizprirodnihznanostiuključujućipodručjakaoštosu astronomija,fizika,kemija,matematika,meteorologija,paleontologija, statistikaivjerojatnost. 6. SocialandBehavioralSciences(BEHA)–citiravišeod1620vodećih svjetskihčasopisaizdruštvenihznanostiuključujućipodručjakaoštosu antropologija,ekonomija,informacijskeznanosti,knjižničarstvo, komunikacije,lingvistika,međunarodniodnosi,obrazovanje,planiranjei razvoj,političkeznanosti,poslovanje,povijest,pravo,socijalnamedicina, sociologija,upravljanjetezemljopis. 7. ArtsandHumanities(ARTS)–pokrivaoko1120vodećihsvjetskihčasopisaiz humanističkihznanosti,uključujućipodručjakaoštosuarhitektura,izvedbena umjetnost,filozofija,lingvistika,književnost,povijest,religijaiteologijate vizualnaumjetnost.

KnjižnicaNastavnogzavodaza javnozdravstvo „Dr.AndrijaŠtampar“ senalazinadrugomkatuUpravnezgradeZavodaiotvorenajezaposlenicimaisuradnicimasvakogradnogdana.UKnjižnicijemogućekoristitiznanstveno-stručnuliteraturu.Ukupnojena raspolaganju 19 časopisa u tiskanom obliku (vidi priloženu tablicu), a prekoCARNETajeomogućenpristuprazličitimbazamapodataka,npr.PubMed.

PubMedjeslobodnodostupnabazapodatakaizprirodnihznanostiibiomedicine,kojasadrži citate, apstrakte i za određenbroj članaka cijeli tekst.AmeričkaNacionalnabibliotekazamedicinu(NLM)podpokroviteljstvomNacionalnoginstitutazazdravlje(NIH)održavaPubMedkaodioEntrezsustavazapretraguinformacija.

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Pregled2013.

TablicaPopisčasopisadostupnihuKnjižniciNastavnogzavodazajavnozdravstvo„Dr.AndrijaŠtampar“

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ClinicalMicrobiologyandInfection

ClinicalInfectiousDiseases

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InternationalJournalofEpidemiology

FoodMicrobiology

PharmacoEconomics

Liječničkenovine

Farmaceutskiglasnik

ActaPharmaceutica

NeurologiaCroatica

PaediatriaCroatica

GynaecologiaetPerinatologia

Hrvatskimeteorološkičasopis

Librioncologici

Pharmaca

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Pregled2013.

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Pregled2013.

1)RADOVIOBJAVLJENIUCURRENTCONTENTS(CC)UCIJELOSTI(INEXTENSO)

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Pregled2013.

18

Pregled2013.

Broj1.

Anal.Methods,2013,5,5188–94.

DETERMINATIONOFCYANURICACIDINWHEYPOWDERUSINGHILIC-MS/MS

1 2 1 1IvešićM ,BabićS ,KrivohlavekA ,ŠmitZ .1AndrijaStamparInstituteofPublicHealth2FacultyofChemicalEngineeringandTechnology,Zagreb,Croatiamartina.ivesic@stampar.hr

Ahydrophilicliquidchromatography-tandemmassspectrometrymethodwasdevelopedfordeterminationofcyanuricacidinwheypowdersamplesinthemassfractionrange

-1from1.00to100.0mgkg .Thecyanuricacidwasextractedfromwheypowderwithanacetonitrile: water (60:40, v/v) extraction solution. Separation was performed on aXBridgeAmidecolumn3.5µmusingacetonitrile:water(90:10,v/v)asthemobilephaseat

-1a flow rate of 0.2 mL min . Detection was achieved by triple quadrupole massspectrometryusingheatedelectrosprayionizationinterface.TheanalysiswasperformedinthenegativeionizationmodeusingtheSRMtransitionscombinationsofm/z128→42andm/z128→85forquantitativeandqualitativedetectionofcyanuricacid,respectively

13 15andm/z134→44andm/z134→89forisotope-labelledcyanuricacid( C , N –CYA)3 3detection,usedtocorrectformatrixeffects.Thedevelopedandoptimizedmethodwasvalidatedbydetermingfollowingvalidationparameters:selectivity,linearity,precision,accuracy,recovery,limitsofdetectionandquantificationandstabilityofcyanuricacidinwheypowderextract.Therecoveriesofcyanuricacidfromwheypowderspikedat1.00,

-12.50, 7.00, 50.0 and 100.0 mg kg were within the range of 96.7-107.2%, intra-dayprecisionwas≤6.45%,inter-dayprecisionwas≤9.13%andaccuracywasbelow10%.Matrixeffectsinvestigatedwiththreedifferentmatriceswerelessthan15%.Thelimitof

-1 -1detectionandquantificationwas0.30mgkg and1.00mgkg respectively.Thesuitabilityofthedevelopedmethodforuseinroutinedeterminationwasconfirmedthroughanalysisofwheypowdersamplesfromdairyindustryandsupermarkets.

19

Pregled2013.

Broj2.

JournalofAppliedIchthyol2013;:1–6

ORGANOCHLORINEPESTICIDESINMURAENAHELENAL.1758FROMTHEEASTERNADRIATICSEA.

1 2 3 3 1 4DikicD ,Mojsovic-CuicA ,JurakG ,LasicD ,SkaramucaD ,Matic-SkokoD ,

4 3 1 5 5 5,6TutmanP ,BosnirJ ,FranjevicD ,FranicZ ,FuchsR ,SkaramucaB .1FacultyofScience,DepartmentofAnimalPhysiology,UniversityofZagreb,Zagreb,Croatia2UniversityofAppliedHealthStudies,Zagreb,Croatia3AndrijaStamparInstituteofPublicHealth4InstituteofOceanographyandFisheries,Split,Croatia5InstituteofMedicalResearch,Zagreb,Croatia6DepartmentofAquaculture,UniversityofDubrovnik,Dubrovnik,Croatiagordana.jurak@stampar.hr

ThisworkexaminesthebioaccumulatedorganochlorinecompoundsinMuraenahelenatodrawattentiontothisspeciesasapotentialbioindicatororganism.ThemorayswerecaughtintheEastAdriaticSea,ElaphiteIslands,nearDubrovnik,Croatia(lat:42°45′38.8″;long:17°45′53.6″)atthesamelocationinsummer(August,2009)andwinter(January,2010),atdepthsfrom5to10m.Ninefishwerecaughtbylonglinehookspereachfieldtrip(totalinsummerandwinter,N=18).Nosinglefishwasfreeoforganochlorines(OC),butnotallpesticideswerepresentineveryfish.Theconcentrationlevelwas:Endrin>ppDDE> Heptachlor epoxide > Heptachlor > Aldrine > Lindane > bHCH > dHCH > Endrinaldehyde). Endrin was the only pesticide approaching the maximum concentrations

-1proposedbytheEuropeanUnionandCroatia(summermax.concentration=14.75lgkg ;-1 -1

wintermax.concentration=8.35lgkg ).Allotherpesticidesrangedfrom0.1to0.7lgkg .Heptachlor was absent in winter and d-HCH and Endrin aldehyde in summer, whileLindaneandpp-DDEhadhigher(P≤0.05)concentrationsinsummer.Otherresidueshadsimilarseasonalconcentrationlevels.Thep-DDTwassimilarasinotherbiotafromtheAdriatic or Mediterranean. HCH concentrations corresponded to those found inorganisms from the Italian area of the Adriatic. The endocrine and reproductivedisruptingpotentialofthedetectedOCsarebasesforfuturestudies.Resultsshowthatmoraysareagoodbioindicatormodel,withslightinterspeciesandseasonalvariabilityinOCbioaccumulationasaconsequenceofdiversefoodconsumption.

20

Pregled2013.

Broj3.

ActaAlimentaria2013;42:481–94

EFFECTSOFTEMPERATURE,LENGTHOFSTORAGEANDTECHNOLOGICALPROCESSESONTHEFORMATION

OFN-NITROSAMINESINLIVERPÂTÉ

Jurak G Bo nir J Puntari D Pavlini Prokurica I mit Z Medi H Puntari I , š , ć , ć- ,Š , ć , ć ,Puntari Eć .AndrijaStamparInstituteofPublicHealthgordana.jurak@stampar.hr

TheaimofthestudywastodeterminethepossiblepresenceofN-nitrosaminesinliverpâtésavailableontheCroatianmarketandtocomparethemwithaliverpâtéfromEUmarket.Inaddition,theeffectsoftemperature,andlengthofstorageonN-nitrosamineconcentrationswere assessed. A total of 630 sampleswere randomly chosen. Thirtysamplesofeachwereanalyzedimmediatelyuponsampling,whereasanother30sampleswerestoredfor5and10daysat4ºC,22ºCand37ºC,respectively.Inthesamplesstoredat4ºC,themeantotalN-nitrosaminelevelwas1.3-6.8 g/kgonday5and1.0-5.0 g/kgonμ μday10.Inthesamplesstoredat22ºC,themeantotalN-nitrosaminelevelwas3.6-9.3μ μ μg/kg(day0),11.9-24.5 g/kgonday5,and22.7-32.3 g/kgonday10.Inthesamplesstoredat37ºC,themeantotalN-nitrosaminelevelwas104.9-231.1 g/kg(day5)andμ801.3-1329.0 g/kg (day 10). Temperature and length of storage were found to beμassociatedwiththeformationofN-nitrosaminesinmeatproducts,butcarciongenicdiEtinparticular,accidentlyornot,wasnotpresentatallintheproductsoriginatingfromEU.

Keywords:N-nitrosamines,diet,meatproducts,liverpâté,temperature,storage

21

Pregled2013.

Broj4.

FoodControl34,312-7

NATURALOCCURRENCEOFAFLATOXINB1,OCHRATOXINAANDCITRINININCROATIAN

FERMENTEDMEATPRODUCTS2 2 1 2 2 2

MarkovK ,PleadinJ ,BevardiM ,VahčićN ,Sokolić-MihalakD ,FreceJ .1AndrijaStamparInstituteofPublicHealth2Prehrambeno-biotehnološkifakultet,Zagreb,Hrvatskakmarko@pbf.hr

Whendomesticanimalsareexposedtomycotoxins,significantamountsofthelattershallbecarriedoverintoanimalproductssuchasmilk,eggsandmeat.ThisstudywascarriedoutinordertodeterminethepossiblepresenceofaflatoxinB1(AFB1),ochratoxinA(OTA)andcitrinin(CIT)ingamesausages(nĽ15),semi-drysausages(nĽ25)andfermenteddry-meatproducts(nĽ50),randomlytakenfromindividualproducersandtheCroatianmarket.AFB1andOTAwerequantifiedusingELISA,whileCITwasquantifiedusingHPLC-fluorescencedetector.Outof90samples, thefungimostfrequently isolatedfromdry-curedmeatproductswereofPenicilliumspecies,whileAspergilluswasisolatedfromonlyonesample.Asmuchas68.88%ofthesampleswerepositiveformycotoxins.Finally,theanalysisofdifferenttypesofmeatproductsresultedinOTAidentificationin64.44%,CITidentificationin4.44%andAFB1identificationin10%ofthesamples.ThemaximumOTAconcentrationsestablishedinthecommercialsausagesamplesequalledto7.83mg/kg,whilethatofAFB1amountedto3.0mg/kg.Generally,althoughOTAwasdetectedinallthree types of products in different percentage shares, mutual differences were notstatisticallysignificant(P>0.05).

22

Pregled2013.

Broj5.

CollAntropol2103;37(3):965-71

EFFECTSOFMAGNESIUM,CHROMIUM,IRONANDZINCFROMFOODSUPPLEMENTSONSELECTEDAQUATIC

ORGANISMS

BosnirJ,PuntaricD,CvetkovicZ,PollakL,BarusicL,KlaricI,MiskulinM,PuntaricI,PuntaricE,MilosevicM.AndrijaStamparInstituteofPublicHealthjasna.bosnir@stampar.hr

Theaimofthisstudywastodeterminetheeffectofuncontrolledenvironmentaldisposaloffoodsupplementscontainingmagnesium(Mg),chromium(Cr),iron(Fe)andzinc(Zn)onselectedaquaticorganismsincludingfreshwateralgaeScenedesmussubspicatusandRaphidocelissubcapitata,waterfleaDaphniamagnaandduckweedLemnaminor.Thirtydifferent foodsupplements containingMg,Cr,FeandZnwereanalyzed.Resultswereexpressedaseffectiveconcentration50(EC ), i.e.growth inhibitingMg,Cr,FeandZn50(mg/L) concentration immobilizing 50%of treated organisms. Particularmetal EC50differedsignificantly(p

Broj6.

CollAntropol2013;37(3):957-64

HEAVYMETALSANDMETALLOIDCONTENTINVEGETABLESANDSOILCOLLECTEDFROMTHE

GARDENSOFZAGREB,CROATIA1 1,2 3 4 5 6

PuntarićD ,VidosavljevićD ,GvozdićV ,PuntarićE ,PuntarićI ,MayerD ,7 8 7 8 9 10BošnirJ ,LasićD ,JergovićM ,KlarićI ,VidosavljevićM ,KrivdićI .

1„JosipJurajStrossmayer“UniversityOsijek,SchoolofMedicine,DepartmentofPublicHealth,Osijek,Croatia2VukovarGeneralHospital,Vukovar,Croatia3„JosipJurajStrossmayer“UniversityOsijek,DepartmentofChemistry,Osijek,Croatia4UniversityofZagreb,FacultyofScience,BiologyDepartment,EnvironmentalSciencesDirection,Zagreb,Croatia5ZagrebCountyInstituteforEmergencyMedicine,Zagreb,Croatia6CroatianNationalInstituteofPublicHealth,Zagreb,Croatia7ZagrebPublicHealthInstitute,DepartmentodHealthEcology,Zagreb,Croatia8„JosipJurajStrossmayer“UniversityOsijek,FacultyofAgriculture,Osijek,Croatia9VinkovciGeneralHospital,DepartmentforInternalMedicine,Vinkovci,Croatia10SINACOLtd.,Zagreb,Croatiajasna.bosnir@stampar.hr

Aimof this studywas todetermineconcentrationofPb,Cd,AsandHg ingreen leafyvegetablesandsoil in theurbanareaofZagreb,Croatiaandtodetermine if there isaconnectionbetweenthecontaminationofsoilandvegetables.Greenleafyvegetablesandsoil samples were taken from the gardens located in the outskirts of the city.ConcentrationsofPb,Cd,AsandHgweredeterminedbyatomicabsorptionspectrometry;showingthataverageconcentrationsofmetalsandmetalloidsinvegetablesandinsoil,regardlessofthelocationofsamplingwerebelowthemaximumallowedconcentration(MAC).Theanalysisdeterminedthatmetalconcentrationsinonlyninevegetablesamples(9%) were above maximum allowed values prescribed by national and Europeanlegislation(threewithhigherconcentrationsofPb,onewithahigherconcentrationofCdandfivewithhigherconcentrationsofHg).Concentrationsofcontaminantspresentintheanalysedsamples,ingeneral,arelowerthantheonespublishedinsimilarstudies.Thefinal distribution and concentration of contaminants in vegetables of Zagreb, besidesindustryandtraffic,isaffectedbythedominantwinddirection.Keywords:atomicabsorptionspectroscopy,metals,metalloids,soil,vegetables,Zagreb

24

Pregled2013.

25

Pregled2013.

Broj7.

ZoonosesPublicHealth.2013Jun19.doi:10.1111/zph.12060.[Epubaheadofprint]

FIGHTINGRABIESINEASTERNEUROPE,THEMIDDLEEASTANDCENTRALASIA-EXPERTSCALLFORAREGIONALINITIATIVEFORRABIESELIMINATION

AikimbayevA,BriggsD,ColtanG,DodetB,FarahtajF,ImnadzeP,KorejwoJ,MoiseievaA,TordoN,UsluerG,VodopijaR,VranješN.AndrijaStamparInstituteofPublicHealthradovan.vodopija@stampar.hr

RabiesexpertsfromeightMiddleEastandEasternEuropeancountries(Croatia,Georgia,Iran,Kazakhstan,Romania,Serbia,TurkeyandUkraine)metinParisonJune5-8,2012.These experts constitute an informal network of 'local champions' dedicated to theeliminationofhumanrabies.During the three day meeting, these champions met with experts from the PasteurInstituteandtheGlobalAllianceforRabiesControl(GARC)todiscusstherabiessituationintheirrespectivecountriesandidentifiedstrategiestopreventandcontrolthediseaseintheirregionalcontext.SuccessstoriesinCroatiaandSerbiaprovethateliminationofhumanrabiesisachievableintheMEEREBregion.Itrequirespoliticalwillingnessandcooperationofallstakeholders,includingMinistriesofHealthandofAgriculture;adequatemanagementofanimalbitesthroughPEPusingappropriaterabiesimmunobiologicals;pre-exposureprophylaxisforpopulationsathighriskofrabiesexposure;animalvaccination;andhumanecontrolofstraydogpopulations.MEEREBmemberscallforaregionalinitiativeforrabieseliminationinEasternEuropeandMiddleEast.Theyareconfidentthattheeliminationofhumanrabiesofcanineorigincan be achieved in the region through intersectorial cooperation and a One Healthapproach,andthatcampaignsforrabieseliminationwillhavesignificantbenefitforpublichealth,includingstrengtheningthestructureforcontrolofotherzoonoses.

26

Pregled2013.

Broj8.

TheBreastJournal2013;19:71-8.

MAMMOGRAPHICDENSITYANDESTIMATIONOFBREASTCANCERRISKININTERMEDIATERISK

POPULATION1 2,3 4 5 6

TešićV ,KolarićB ,ZnaorA ,KusacicKunaS ,BrkljačićB .1AndrijaStamparInstituteofPublicHealth2SchoolofMedicine,UniversityofRijeka,Rijeka,Croatia3ZagrebCountyInstituteofPublicHealth,Zagreb,Croatia4CroatianInstituteofPublicHealth,Zagreb,Croatia5ClinicalHospitalCentre,Zagreb,Croatia6UniversityHospital„Dubrava“,MedicalSchool,UniversityofZagreb,Zagreb,Croatiavanja.tesic@stampar.hr

Itisnotcleartowhatextentmammographicdensityrepresentsariskfactorforbreastcanceramongwomenwithmoderateriskfordisease.Weconductedapopulation-basedstudytoestimatetheindependenteffectofbreastdensityonbreastcancerriskandtoevaluate the potential of breast density as a marker of risk in an intermediate riskpopulation.FromNovember2006toApril2009,datathatincludedAmericanCollegeofRadiologyBreastImagingReportingandDataSystem(BI-RADS)breastdensitycategoriesand risk information were collected on 52,752 women aged 50-69 years withoutpreviously diagnosed breast cancer who underwent screening mammographyexamination. A total of 257 screen-detected breast cancers were identified. Logisticregressionwasusedtoassesstheeffectofbreastdensityonbreastcarcinomariskandtocontrolforotherriskfactors.Theriskincreasedwithdensityandtheoddsratioforbreastcanceramongwomenwithdensebreast(heterogeneouslyandextremelydensebreast),was1.9(95%confidenceinterval,1.3-2.8)comparedwithwomenwithalmostentirelyfatbreasts,afteradjustmentforage,bodymassindex,ageatmenarche,ageatmenopause,ageatfirstchildbirth,numberoflivebirths,useoforalcontraceptive,familyhistoryofbreastcancer,priorbreastprocedures,andhormonereplacementtherapyusethatwereallsignificantlyrelatedtobreastdensity(p<0.001).Inmultivariatemodel,breastcancerrisk increasedwithage,bodymass index, familyhistoryofbreastcancer,priorbreastprocedureandbreastdensityanddecreasedwithnumberoflivebirths.Ourfindingthatmammographic density is an independent risk factor for breast cancer indicates theimportanceofbreastdensitymeasurements forbreastcancerriskassessmentalso inmoderateriskpopulations.

27

Pregled2013.

Broj9.

BMCPublicHealth.2013Oct21;13(1):991.doi:10.1186/1471-2458-13-991.

RISKFACTORSFORPULMONARYTUBERCULOSISINCROATIA:AMATCHEDCASE-CONTROLSTUDY

1 2 3 4 3 5Jurcev-SavicevicA ,MulicR ,BanB ,KozulK ,Bacun-IvcekL ,ValicJ ,

6 7 1 8Popijac-CesarG ,Marinovic-DunatovS ,GotovacM ,SimunovicA .1TeachingPublicHealthInstituteofSplitandDalmatiaCounty,Split,Croatia2SchoolofMedicine,UniversityofSplit,Split,Croatia3AndrijaStamparInstituteofPublicHealth,Zagreb,Croatia4PublicHealthInstituteofOsječko-BaranjskaCounty,Osijek,Croatia5PublicHealthInstituteofIstarskaCounty,Pula,Croatia6PublicHealthInstituteofKrapinsko-ZagorskaCounty,Zlatar,Croatia7PublicHealthInstituteofZadarskaCounty,Zadar,Croatia8CroatianNationalInstituteofPublicHealth,Zagreb,Croatiabozica.ban@stampar.hr

Background

Mycobacteriumtuberculosis isanecessary,butnotsufficient,causeof tuberculosis.Anumberofstudieshaveaddressedtheissueofriskfactorsfortuberculosisdevelopment.Croatia is a European countrywith an incidence rate of 14/100000which is slowlydecreasing.Theaimofthisstudyistoevaluatethepotentialdemographic,socioeconomic,behaviouralandbiologicalriskfactorsfortuberculosisinCroatiaincomparisontootherhigh-income,low-incidenceEuropeancountries.

Methods

Atotalof300tuberculosispatientswerematchedforage,sexandcountyofresidenceto300 controls randomly selected from general practitioners' registers. They wereinterviewedandtheirmedicalrecordswereevaluatedforvariablesbroadlydescribedaspotentialriskfactors.

Results

Inmultiplelogisticregression,thefollowingfactorsweresignificant:parentsborninaparticularneighbouringcounty(BosniaandHerzegovina)(OR = 3.90,95%CI2.01-7.58),thelowestlevelofeducation(OR = 3.44,95%CI1.39-8.50),poorhouseholdequipment(OR = 4.72,95%CI1.51-14.76),unemployment(OR = 2.69,95%CI1.18-6.16),contactwithtuberculosis(OR = 2.19,95%CI1.27-3.77),former(OR = 2.27,95%CI1.19-4.33)andcurrentsmokinghabits(OR = 2.35,95%CI1.27-4.36),diabetes(OR = 2.38,95%CI1.05-5.38), amalignant disease (OR = 5.79, 95% CI 1.49-22.42), being underweight in thepreviousyear(OR = 13.57,95%CI1.21-152.38).

Conclusion

In our study, the identified risk groups for tuberculosis reflect a complex interaction

28

Pregled2013.

between socioeconomic conditions, lifestyle and non-communicable diseases.Interventions focused on poverty will undoubtedly be useful, but not sufficient.Tuberculosiscontrolwouldbenefitfromacombinationofbroadpublichealthactivitiesaimedatthepreventionandcontrolofriskylifestylesandnon-communicablediseases,interventionsoutsidethehealthsector,andeffortstoconstantlyimprovetheCroatiannationaltuberculosisprogramme.

29

Pregled2013.

Broj10.

HEALTHSYSTEMDELAYINPULMONARYTUBERCULOSISTREATMENTINACOUNTRY

WITHANINTERMEDIATEBURDENOFTUBERCULOSIS:ACROSS-SECTIONALSTUDY

1 2 3 4 5 4 6Jurcev-SavicevicA ,MulicR ,KozulK ,BanB ,ValicJ ,Bacun-IvcekLj ,GudeljI ,

7 8 9Popijac-CesarG ,Marinovic-DunatovS ,SimunovicA etal.1TeachingPublicHealthInstituteofSplitandDalmatiaCounty,Split,Croatia2SchoolofMedicine,UniversityofSplit,Split,Croatia3PublicHealthInstituteofOsječko-BaranjskaCounty,Osijek,Croatia4AndrijaStamparInstituteofPublicHealth,Zagreb,Croatia5PublicHealthInstituteofIstarskaCounty,Pula,Croatia6DepartmentofpulmonaryDiseases,SplitUniversityHospital,Split,Croatia7PublicHealthInstituteofKrapinsko-ZagorskaCounty,Zlatar,Croatia8PublicHealthInstituteofZadarskaCounty,Zadar,Croatia9CroatianNationalInstituteofPublicHealth,Zagreb,Croatiabozica.ban@stampar.hr

Background

Delayeddiagnosisandtreatmentoftuberculosisincreaseboththeseverityofthediseaseandthedurationofinfectivity.Anumberofstudieshaveaddressedtheissueofhealthsystemdelaysinthetreatmentoftuberculosis,butmostlyincountrieswithahighorlowincidenceofthedisease.Ourunderstandingofdelayisquitelimitedinsettingswithanintermediateburdenoftuberculosis.WeexplorethedurationandfactorsassociatedwithdelaysintheCroatianhealthsystemwhichhasfreehealthcareandasufficientnetworkofhealthservicesprovidingtuberculosisdiagnosisandcare.

Methods

Atotalof241consecutiveadultswithculture-confirmedpulmonarytuberculosiswereinterviewedinsevenrandomlyselectedCroatiancountiesandtheirmedicalrecordswereevaluated. A health system delay was defined as the number of days from the firstconsultationwithaphysiciantotheinitiationofanti-tuberculosistreatment.Alongdelaywas defined as a period exceeding the median delay, while an extreme delay wasconsideredtobeabovethe75thpercentiledelay.

Results

Themedianhealthsystemdelaywas15dayswhilethe75thpercentilewas42days(the5thand95thpercentilebeing1and105daysrespectively).Almost30%oftuberculosispatientsremainedundiagnosedformorethan30daysaftertheinitialhealthcarevisit.Female patients (p = 0.005), patients with a negative sputum smear (p = 0.002) and       patients having symptoms other than the usual ones (0.027) were found to be insignificantcorrelationwithalongdelay.Inamultivariatemodel,alongdelayremainedassociatedwiththesamevariables(p = 0.008,p = 0.003,andp = 0.037,respectively).           

30

Pregled2013.

Asignificantassociationwasdemonstratedbetweenboththefemalegender(p = 0.042)   andanegativesputumsmear(p < 0.001)andextremedelay,whileonlyanegativesputum   smear(p < 0.001)remainedsignificantinthemultivariateanalysis.   

Conclusions

Our findings suggest that some groups of tuberculosis patients experienced a healthsystemdelay.Insuchasettingwheretuberculosisincidenceisdecreasing,whichleadstoalack of physician experience and expertise, training in tuberculosis is required. Suchmeasuremaybeusefulinreducingthenumberofmissedopportunitiesfortuberculosisdiagnosis.

31

Pregled2013.

Broj11.

ASIXDECADESLONGFOLLOW-UPONBODYSIZEINADOLESCENTSFROMZAGREB,CROATIA(1951-2010)

EconomicsandHumanBiology2013;xxx:xxx.Articleinpress

1 1 1 1 2Zajc-PetranovićM ,TomasZ ,Smolej-NarancicN ,Skaric-JuricT ,VecekA ,

1MilicicJ .1InstituteforAnthropologicalResearch,Zagreb,Croatia2AndrijaStamparInstituteofPublicHealthandrea.vecek@stampar.hr

Moststudiesanalysingtheinfluenceofsocioeconomicdeterirationonbodysizefocusontheimpactoffoodshortagesanddiseasesongrowthinearlychildhood.Toevaluatehowsocioeconomicconditionsinfluencethegrowthduringtheadolescence,wetrackedthebody sizeof15-19year-olds the last sixtyyears covering the socijalistperiod (1951-1990), thewar (1991-1995) and the transition to capitalistic economy. This study ofZagreb, Croatia, adolescent population provides information on the secular trend inheight,weightandBodyMassIndeks(BMI)andexaminestheirrelationwithRealGrossDomesticProduct.From1951to2010thegirlsᶦheightapproximatelyincreasedby6.2cmandweightby6,8kgwhiletheboysᶦheightincreasedby12.2cmandweightby17,3kg.Prior to 1991 mean BMI in girls was higher than in boys, but from 1991 on, theinterrelationbetweenthesexeshasbeenopposite,possiblymirroringtheculturaltrendsthatstartedinmid-1970sandreflectinghighersensitivityofboystothesocioeconomicchanges.Inconclusion,theseculartrendinbodysizeovertheinvestigatedperiodreflectsthe positive economic trends interrupted by the war. The recent increase in BMIcorrespondstothecountryᶦseconomicrecoveryandindicatesthe„nutritiontransition̋.

32

Pregled2013.

Broj12.

SocialScience&Medicine2013;98:154-61.

INEQUALITIESINCROATIANPUPILS'RISKBEHAVIORSASSOCIATEDTOSOCIOECONOMICENVIRONMENT

ATSCHOOLANDAREALEVEL:AMULTILEVELAPPROACH

1 2 1 3Pavic-SimetinI ,KernJ ,KuzmanM ,PfoertnerTK .1YouthHealthCareandDrugAddictionPreventionDepartment,CroatianNationalInstituteofPublicHealth,Zagreb,Croatia2DepartmentofMedicalStatistics,EpidemiologyandMedicalInformatics,UniversityofZagreb,SchoolofMedicine,AndrijaStamparSchoolofPublicHealth,Zagreb,Croatia3InstituteofMedicalSociology,MedicalFaculty,Martin-LutherUniversityofHalle-Wittenberg,Halle,Saale,Germanyiva.pavic-simetin@hzjz.hr

Thesocioeconomicinequalityinpupils'riskbehaviorshasbeenthetopicofmanystudieswithquitecontradictoryfindings.Furthermore,theroleofsocioeconomicenvironmenthasbeenanalyzedmuchlessoftenthantheroleofindividualsocioeconomicstatus(SES).This study examined the association between school/area-level socioeconomicenvironmentandCroatianpupils' riskbehaviors (tobaccouse,drunkenness, cannabisuse, early sexual initiation and fighting). Data from the WHO-Collaborative 'HealthBehaviorinSchool-agedChildren'studyconductedinCroatiain2006(1601secondaryschools' pupils, aged 15) and census data were used. Multilevel logistic regressionanalyses,adjustedbygender,wereperformed.TheindividuallevelofSESexplainedthemajorityofdifferencesinallriskbehaviorsamongadolescents.Differencesintobaccouse,earlysexualinitiationandfightingweremorecloselyattributedtoschoollevelthanarealevel,whichwasmorecloselyassociatedwithdifferencesinadolescentdrunkennessandcannabis use. At the individual level, high individual SESwas associatedwith higherprobability for tobacco use and drunkenness compared to low individual SES.Furthermore, school heterogeneity (compared to school homogeneity) and mediumschool-level SES (compared to low school-level SES) were associated with higherprobability for cannabis use. Compared to themost advanced schools (gymnasiums),attendingtheleastadvancedschools(industrialandcraftsschools)wasassociatedwithhigherprobabilityforfighting.Comparedtolowarea-levelSES,mediumarea-levelSESwasassociatedwithhigherprobabilityforcannabisuseandfighting.Conclusively,itwasfoundthatlowSESatindividual,schoolandarealevels,schoolhomogeneityandadvancedschoolattendanceplayaprotectiveroleagainstriskbehaviours.Toreduceinequalitiesinpupils'riskbehaviors,thereisaneedforcommunityandschool-basedprogramsthattake

intoconsiderationnotonlyindividualSESbutalsoschool-andarea-levelsocioeconomiccircumstances.

Keywords: socioeconomic environment; Croatia; school; tobacco use; drunkenness;sannabisuse;earlysexualinitiation;fighting

33

Pregled2013.

Broj13.

CroatMedJ.2013Dec28;54(6):510-8.

ESTIMATINGGLOBALANDREGIONALMORBIDITYFROMACUTEBACTERIALMENINGITISINCHILDREN:

ASSESSMENTOFTHEEVIDENCE1 2 3 1 3 3

LuksicI ,MulicR ,FalconerR ,OrbanM ,SidhuS ,RudanI .1AndrijaStamparInstituteofPublicHealth2DepartmentofPublicHealth,UniversityofSplit,MedicalSchool,Croatia3CentreforPopulationHealthSciences,UniversityofEdinburgh,MedicalSchool,Edinburgh,Scotland,UKivana.luksic@stampar.hr

AimToestimateglobalmorbidityfromacutebacterialmeningitisinchildren.MethodsWeconductedasystematicreviewofthePubMedandScopusdatabasestoidentifybothcommunity-basedandhospitalregistry-basedstudiesthatcouldbeusefulinestimationof the global morbidity from bacterial meningitis in children. We were primarilyinterestedintheavailabilityandqualityoftheinformationonincidenceratesandcase-fatalityrates.Weassessedtheimpactoftheyearofstudy,studydesign,studysetting,thedurationofstudy,andsamplesizeonreportedincidencevalues,andalsoanyassociationbetween incidence and case-fatality rate.We also categorized the studies by6WorldHealthOrganizationregionsandanalyzedtheplausibilityofestimatesderivedfromthecurrentevidenceusingmedianandinter-quartilerangeoftheavailablereportsineachregion.ResultsWefound71studiesthatmettheinclusioncriteria.Theonlytwosignificantassociationsbetween the reported incidence and studied covariateswere thenegative correlationbetween the incidence and sample size (P

Broj14.

CroatMedJ.2013;54:135-45.

EFFECTIVENESSOFSEASONALINFLUENZAVACCINESINCHILDREN-ASYSTEMATICREVIEW

ANDMETA-ANALYSIS1 2 2 3,4 2 2 2,5

LukšićI ,ClayS ,FalconerR ,PulanicD ,RudanI ,CampbellH ,NairH .1AndrijaStamparInstituteofPublicHealth2CentreforPopulationHealthSciences,UniversityofEdinburgh,MedicalSchool,Edinburgh,Scotland,UK3ClinicalHospitalCentreZagreb,Zagreb,Croatia4J.J.StrossmayerUniversityofOsijek,MedicalSchool,Osijek,Croatia5PublicHealthFoundationofIndia,NewDelhi,Indiaivana.luksic@stampar.hr

Aim

Toassesstheefficacyandeffectivenessofseasonalinfluenzavaccinesinhealthychildrenuptotheageof18years.

Methods

MedLine,EMBASE,CENTRAL,CINAHL,WHOLIS,LILACS,andGlobalHealthweresearchedforrandomizedcontrolledtrialsandcohortandcase-controlstudies investigatingtheefficacyoreffectivenessofinfluenzavaccinesinhealthychildrenuptotheageof18years.Thestudieswereassessedfortheirqualityanddataontheoutcomesofinfluenza-likeillness,laboratory-confirmedinfluenza,andhospitalizationswereextracted.Sevenmeta-analyseswereperformedfordifferentvaccinesanddifferentstudyoutcomes.

Results

Vaccine efficacy for live vaccines, using random effectsmodel,was as follows: (i) forsimilar antigen, using per-protocol analysis: 83.4% (78.3%-88.8%); (ii) for similarantigen,usingintentiontotreatanalysis:82.5(76.7%-88.6%);(iii)foranyantigen,usingperprotocolanalysis:76.4%(68.7%-85.0%);(iv)foranyantigen,usingintentiontotreatanalysis: 76.7% (68.8%-85.6%). Vaccine efficacy for inactivated vaccines, for similarantigen,usingrandomeffectsmodel,was67.3%(58.2%-77.9%).Vaccineeffectivenessagainst influenza-like illnessfor livevaccines,usingrandomeffectsmodel,was31.4%(24.8%-39.6%)andusingfixed-effectmodel44.3%(42.6%-45.9%).Vaccineeffectivenessagainstinfluenza-likeillnessforinactivatedvaccines,usingrandomeffectsmodel,was32.5%(20.0%-52.9%)andusingfixed-effectmodel42.6%(38.3%-47.5%).

Conclusions

Influenza vaccines showed high efficacy in children, particularly live vaccines.Effectivenesswaslowerandthedataonhospitalizationswereverylimited.

35

Pregled2013.

Broj15.

CroatMedJ.2013Apr;54(2):122-34.

VIRALETIOLOGYOFHOSPITALIZEDACUTELOWERRESPIRATORYINFECTIONSINCHILDRENUNDER5

YEARSOFAGE-ASYSTEMATICREVIEWANDMETA-ANALYSIS

1 2 2 2 2 2,3LukšićI ,KearnsPK ,ScottF ,RudanI ,CampbellH ,NairH .1AndrijaStamparInstituteofPublicHealth2CentreforPopulationHealthSciences,UniversityofEdinburgh,MedicalSchool,Edinburgh,Scotland,UK3PublicHealthFoundationofIndia,NewDelhi,Indiaivana.luksic@stampar.hr

Aim

Toestimatetheproportionalcontributionofinfluenzaviruses(IV),parainfluenzaviruses(PIV),adenoviruses(AV),andcoronaviruses(CV)totheburdenofsevereacute lowerrespiratoryinfections(ALRI).

Methods

The review of the literature followed PRISMA guidelines. We included studies ofhospitalizedchildrenaged0-4yearswithconfirmedALRIpublishedbetween1995and2011. A total of 51 studies were included in the final review, comprising 56091hospitalizedALRIepisodes.

Results

IVwasdetectedin3.0%(2.2%-4.0%)ofallhospitalizedALRIcases,PIVin2.7%(1.9%-3.7%),andAVin5.8%(3.4%-9.1%).CVaretechnicallydifficulttoculture,andtheyweredetectedin4.8%ofallhospitalizedALRIpatientsinonestudy.Whenrespiratorysyncytialvirus(RSV)andlesscommonviruseswereincluded,atleastoneviruswasdetectedin50.4%(40.0%-60.7%)ofallhospitalizedsevereALRIepisodes.Moreover,21.9%(17.7%-26.4%)oftheseviralALRIweremixed,includingmorethanoneviralpathogen.AmongallsevereALRIwithconfirmedviraletiology,IVaccountedfor7.0%(5.5%-8.7%),PIVfor5.8% (4.1%-7.7%), andAV for 8.8% (5.3%-13.0%). CVwas found in 10.6%of virus-positivepneumoniapatientsinonestudy.

Conclusions

Thisarticleprovidesthemostcomprehensiveanalysisofthecontributionoffourviralcauses to severe ALRI to date. Our results can be used in further cost-effectivenessanalysesofvaccinedevelopmentandimplementationforanumberofrespiratoryviruses.

36

Pregled2013.

Broj16.

ScandJPublicHealth2013;41(4):333–335.doi:10.1177/1403494812471447

PATIENTSELF-REPORTEDADHERENCEFORTHEMOSTCOMMONCHRONICMEDICATIONTHERAPY1 2 2,3 4

BoskovicJ ,LeppéeM ,CuligJ ,EricM .1SchoolofPharmacyandBiochemistry,UniversityofZagreb,Zagreb,Croatia2AndrijaStamparInstituteofPublicHealth,Zagreb,Croatia3SchoolofMedicine,JosipJurajStrossmayerUniversity,Osijek,Croatia4SchoolofMedicine,UniversityofNoviSad,NoviSad,Serbiajelboskovic@gmail.com

Aims

To determine adherence to chronic disease medication measured by self-reportedquestionnaire.

Methods

Thesurveywasconductedat106Zagrebpharmacies,andthequestionnairewasfilledoutbythestudysubjects.

Results

A total 1.357 diagnoseswere reported by survey respondents (i.e., an average of 2.1diagnosesperrespondent).Themostcommondiagnoseswerediseasesofthecirculatorysystem(n=500;36.8%).Thegreatmajorityofstudysubjectsreportedforgetfulness(“Ijustforgot”)asthemainreasonforskippingdrugdoses.

Conclusions

Amongthemanyreasonspeoplegivefornotadheringtodrugtreatment,forgetfulnesswasthemostcommon.Commonbarrierstoadherenceareunderthepatient'scontrol,sothatattentiontothemisanecessaryandimportantstepinimprovingadherence.Theexistenceofmorethanonecauseofriskconsiderablyincreasesthenonadherenceriskofapatient.

Keywords:adherence;chronictherapy;self-report;Zagreb.

37

Pregled2013.

Broj17.

ActaAgriculturaeScandinavicaSectionB-SoilandPlantScience,2013http://dx.doi.org/10.1080/09064710.2013.777093

SOILCONTAMINATIONASAPOSSIBLELONG-TERMCONSEQUENCEOFWARINCROATIA1,2 2 3 4 2,5 6

VidosavljevicD ,PuntaricD ,GvozdicV ,JergovicM ,MiskulinM ,PuntaricI ,7 2

PuntaricE ,SijanovicS .1VukovarGeneralHospital,Vukovar,Croatia2DepartmentofPublicHealth,SchoolofMedicine,JosipJurajStrossmayerUniversityofOsijek,Osijek,Croatia3DepartmentofChemistry,JosipJurajStrossmayerUniversityofOsijek,Osijek,Croatia4DepartmentofHealthEcology,ZagrebPublicHealthInstitute,Zagreb,Croatia5DepartmentofHealthEcology,PublicHealthInstituteofOsijek-BaranjaCounty,Osijek,Croatia6SchoolofMedicine,UniversityofZagreb,Zagreb,Croatia7DepartmentofBiology,EnvironmentalSciencesDirection,FacultyofScience,ZagrebUniversity,Zagreb,Croatiadinko.puntaric@stampar.hr

WarinCroatiaresultedinasignificantreleaseofcontaminantsintotheenvironmentasaresultoftheuseofcombatassets,mainlyconventional,mostlyaimedatciviliantargets.TheaimofthestudywastoinvestigatetheconcentrationofmetalsandmetalloidsinthesoilsofeasternCroatia.Comparedwithsoilsamplesfromareasexposedtolowintensitycombat activity soil samples from areas exposed to heavy fighting had higherconcentrationsofAs,HgandPbthanallowedbynationallegislationforecologicfarmingas well as even higher concentrations of Hg than the maximum allowed values foragricultureingeneral.DescriptivestatisticsshowsthatmeanvaluesofCu,Zn,Ni,Pb,PandBaareallhigherinsamplescollectedattheareasofhighcombatactivitycomparedwiththeonescollectedfromthelowcombatactivityareas.Sbconcentrationwaselevatedinonelocation,whichcanalsobecorrelatedwithpopulationexposure.Theresultsoftheprincipalcomponentanalysissuggestpossiblecorrelationbetweenthewaractivityandthedegreeofcontaminationbythemetalsfoundinammunition.

Keywords:ammunition,environment,metals,metalloids,traceelements.

38

Pregled2013.

2)RADOVIOBJAVLJENIUCURRENTCONTENTS-U(CC)UOBLIKUSAŽETKA

39

Pregled2013.

40

Pregled2013.

Broj1.

EurJPubHealth2013;AbstractBook

ADHERENCETOMEDICATIONINTHEMOSTCOMMONCHRONICDISEASES

1 1,2 3 1 1LeppéeM ,CuligJ ,MandicK ,SkesM ,Maric-BajsM .1AndrijaStamparInstituteofPublicHealth,Zagreb,Croatia2SchoolofMedicine,JosipJurajStrossmayerUniversity,Osijek,Croatia3UniversityHospitalCenter,Zagreb,Croatiamarcel.leppee@stampar.hr

Background

Priorresearchhasshownthatadherencetomedicationislow,whichisasignificantpublichealthproblem.

Aims

Theaimwastodetermineeventuallydifferencetomedicationadherencebetweenthemostchronicdiseases.

Methods

Weconductedacross-sectionalsurveyusinga33-itemself-administeredquestionnairethat includedaconveniencesampleof635 individualswhowerecollectingorbuyingdrugs for thetreatmentofchronicdiseases.Thesurveywasconductedat106Zagrebpharmaciesandthequestionnairewasfilledoutbythestudysubjectswithinstructionsandhelpprovidedbythepharmacist,whoadministeredthequestionnaire.Studysubjectsweredividedintotwogroups,withadherentdefinedasa“yes”responsetothestatementthatthey“neverfailtotaketheirmedicationontime.”

Results

Thesurveyquestionnairelistedthe16mostcommonreasonsfornon-adherenceandthestudysubjectshadtoanswerthequestionforeachofthesereasonsreportingitasthepossible cause of his non-adherence. In our study population (n=635), non-adherentsubjectsprevailedoveradherentsubjects(n=370;58.3%vs.n=265;41.7%).Atotal1357diagnoseswere reportedbysurveyrespondents (i.e., anaverageof2.1diagnosesperrespondent). The most common diagnoses were diseases of the circulatory system(n=500;36.8%)andendocrine,nutritionalandmetabolicdiseases(n=285;21.0%).Eachpatientwasclassifiedintooneprimarychronicdiagnosis.Therewasnodifferenceintheproportionofself-reportedadherenceacrossthedistributionofnineprimarydiagnoses.Thegreatmajorityofstudysubjectsreportedforgetfulness(“Ijustforgot”)asthemainreasonforskippingdrugdoses,followedbybeingawayfromhomeandshortageofthedrug(havingconsumeditall).Onlyinpatientswithdepressivedisorderthereasonsweresomewhatdifferent.

Conclusions

Researchonadherencehastypicallyfocusedonthebarrierspatientsfaceintakingtheirmedications. Common barriers to adherence are under the patient's control(forgetfulness was the most common, so that attention to them is a necessary andimportantstepinimprovingadherence).Theexistenceofmorethanonecauseofriskconsiderablyincreasesthenon-adherenceriskofapatient.

41

Pregled2013.

Broj2.

EurJPubHealth2013;(Suppl).6thEuropeanPublicHealthConference,EUPHA,Brussels,Belgium,13-16November2013.

CONSUMPTIONOFANTIDEPRESSANTSINCROATIA:TRENDSINTHERATEOFHOSPITALIZATIONFOR

DEPRESSIONANDSUICIDE(2001-2010)1 1 2Polic-VizintinM ,StimacD ,TripkovicI .

1AndrijaStamparInstituteofPublicHealth2PublicHealthInstituteofSplit-DalmatiaCounty,Split,Croatiamarina.polic-vizintin@stampar.hr

Aims

To assess the effect of antidepressant consumption on the rate of hospitalization fordepressionandsuicide.

Methods

Theepidemiologicalmethodofdescriptiveandanalyticalobservationwasusedin10-yearstudy.Hospitalizationdatawerecollectedforeverypatient hospitalizedfordepression.Suicidedatawereobtainedfrommortalitystatistics.DataondrugutilizationfromZagrebMunicipalPharmacywereusedtocalculatethenumberofdefineddailydoses(DDD)andDDDper1000inhabitantsperday(DDD/TID)usingtheWHOAnatomical-Therapeutic-Chemicalmethodology.OnDDD/TIDcalculation,datafromthe2001censuswereused,accordingtowhichthepopulationofZagrebwas770058.

Results

From 2001 to 2010, the rate of hospitalization for depression was reduced from17.3/10,000to15.4/10,000.Themeanlengthofhospitalstaywasreducedfrom34.9to31.2days.Therateofsuicidedecreasedfrom19.9/100,000to14/100,00.From2001to2010,consumptionofantidepressantsincreasedby89,8%(from10.8to20.5DDD/TID)inoutpatienthealthcare.ThehighestrisewasrecordedintheoutpatientconsumptionofSSRI by 106% (from 6.9 to 14.2 DDD/TID). Outpatient consumption of nonselectiveinhibitorsofmonoaminereuptakedecreasedby46%(from3.9to2.1DDD/TID).Theanxiolytic/antidepressantratiodecreasedfrom6,45to2.55.

Conclusions

Therateofhospitalizationfordepressiondecreased,themeanlengthofhospitalstaywasreduced,therateofsuicidedecreased,whileconsumptionofantidepressants,especiallySSRI increased. The anxiolytic/antidepressant ratio as quality indicator decreasedsignificantly.Thesetrendsreflectanimprovedpsychiatricmanagementthroughintensiveprograms,outpatientfollow-up,andtreatmentwithspecificantidepressants.Respectiveeducationoffamilyphysiciansinclinicalpsychopharmacologyisofutmostimportanceforearlyrecognitionandtreatmentofmildandmoderatedepressivedisorders.

42

Pregled2013.

3)RADOVIOBJAVLJENIUDRUGIMINDEKSIRANIMČASOPISIMAUCIJELOSTI(INEXTENSO)

43

Pregled2013.

44

Pregled2013.

45

Pregled2013.

Broj1.

JournalofHygienicEngineeringandDesign,inpress

DETERMINATIONOFBOTANICORIGINOFTHECROATIANBLACKLOCUSTHONEY(ISTRIAREGION)

USINGMELISSOPALYNOLOGICALANALYSIS1 2 2 3 1

Uršulin-TrstenjakN ,HrgaI ,StjepanovićB ,DragojlovićD ,LevanićD .1PolytechnicofVaraždin,Varaždin,Croatia2AndrijaStamparInstituteofPublicHealth3MeteorologicalandHydrologicalInstituteofCroatia,Zagreb,Croatianatalija.ursulin-trstenjak@velv.hr

InCroatia,thelargesthoneyproductionisrelatedtotheproductionofblacklocusthoney.For the purpose of proving botanical and geographical origin of honeymelissopalynologicalanalysisisused-itincludesquantitativeanalysisofpolleninhoney,i.e.thedeterminationoftherelativecontentofpolleninhoney.Theaimofthispaperistopresenttheresultsofmelissopalynologicalanalysisoffortysamplesofblacklocusthoneycollected by the Istria region beekeepers during two seasons. The analyses of honeysamplesconfirmedthebotanicaloriginofhoneydefinedbythemanufacturer.AllofthecollectedsamplesconformtothecriteriaofunifloralityaccordingtotherequirementsoftheCroatianregulations,whichprescribetheminimumof20%ofthepollengrainsofaplantRobiniapseudacacia.Conductingpollenanalysisonsamplesofblacklocusthoneyovertwoseasonshasledtoidentifyingpollengrainsof36plantspecies.ThemostcommononesarepollengrainsofgenusRobinia pseudacacia (family Fabaceae), rose family (Rosaceae), cabbage family(Brassicaceae)andbeanfamily(Fabaceae).

Keywords:Blacklocusthoney,Botanicoriginofhoney,Melissopalynologicalanalysi

46

Pregled2013.

Broj2.

MedJad2013;43(1-2):23-31

UDIOMIKROELEMENATAUPOČETNOJIPRIJELAZNOJHRANIZADOJENČADTE

HRANINABAZIŽITARICA1 1 2 2 1

BošnirJ ,FilipovićVrhovacI ,RaczA ,AntolićS ,PuntarićD .1Zavodzajavnozdravstvo„Dr.AndrijaŠtampar“2Zdravstvenoveleučilište,Zagrebjasna.bosnir@stampar.hr

Usprkospreporuci o dojenju kao optimalnomoblikuprehrane za dojenčaddo šestogmjesecaživota,višeod75%djeceuHrvatskojbivahranjenoizamjenskimindustrijskimproizvodima.CiljradajeispitatiudiomikroelemenataupočetnojiprijelaznojhranizadojenčadihraninabazižitaricadostupnimanatržištuHrvatske,usporeditiprikladnostproizvoda sobziromnapreporučenidnevniunos te sunosompriprehrani isključivomajčinim mlijekom. Drugi cilj rada je ispitati utjecaj različitih temperatura vode zarehidraciju pripravaka na mikroelementarni sastav. Za kvantifikaciju je korištenamultielementarna tehnikamasene spektrometrije s induktivno spregnutomplazmom.Količine željeza,mangana i selena znatno variraju, dok je udio bakra i cinka priličnoujednačen.Prijelaznoadaptiranomlijekosadržistatističkiznačajnovećekoličineželjezaod početnog adaptiranog mlijeka, dok prosječni dnevni unos adaptiranoga mlijeka ijednoga obroka hrane na bazi žitarica, osigurava 75%potreba dojenčadi za željezomtijekomdrugihšestmjeseciživota.Dnevniunoscinkapremašujeprihvatljivigornjidnevniunos,dokjednevniunosmanganakoddojenčadistarostitrimjesecaza40putavećiodadekvatnoga.Trećinaproizvodaneosiguravanitipolovinupreporučenogdnevnogunosaselena za dojenčad do 6 mjeseci. Statistički nije potvrđen utjecaj temperature nasmanjenjekoličinemikroelementa.

Ključneriječi:hranazadojenčad,mikroelementi,dnevniunos,ICP-MS

47

Pregled2013.

Broj3.

Arhivzahigijenuradaitoksikologiju,2013;64(2):93-8

ANTIFUGALNAIANTIPATULINSKAAKTIVNOSTGLUCONOBACTEROXIDANSIZOLIRANE

SPOVRŠINEJABUKE1 2 2 2 2 2 2

BevardiM ,FreceJ ,MesarekD ,BošnirJ ,MrvčičJ ,DelašF ,MarkovK .1Zavodzajavnozdravstvo„Dr.AndrijaŠtampar“2Prehrambeno-biotehnološkifakultet,Zagreb,Hrvatskamartina.bevardi@stampar.hr

Tretiranjevoća fungicidimanakonberbe,uobičajeni jenačinsuzbijanjaplaveplijesni.Međutim, propadanje voća može se spriječiti i upotrebom antagonističkihmikroorganizama,kaoštojebakterijaGluconobacteroxydans.SvrhaovogaradabilajeizoliratiprirodnumikrobnupopulacijuspovršinejabukaiistražitimogućeinhibitornodjelovanjeGluconobacteroxydans1Jnaplavuplijesan,Penicilliumexpansum,najvažnijeguzročnika kvarenja jabuka u skladištu. Najveća antifungalna aktivnost bakterijeprimijećenajeizmeđu3.i9.dana,kadanijezabilježenporastkolonija,anakon12.danapromjerkolonijeplijesnibiojemanjiza42,3%.IakoistraživanabakterijaGluconobacteroxydans1Jnijeupotpunostiinhibiralarastplijesniujabučnomsokupokazalajevisokurazinuučinkovitosti(od86%do95%).Gluconobacteroxydans1Jdjelomičnoinhibirarastplijesniiupotpunostibiosintezupatulina,ovisnoovremenuiuvjetimauzgoja.

Ključne riječi: antagonistički mikroorganizmi, nakupljanje toksina, Penicilliumexpansum,rastplijesni

48

Pregled2013.

Broj4.

JGlobHealth.2013;3:10401.doi:10.7189/jogh.03.010401.

EPIDEMIOLOGYANDETIOLOGYOFCHILDHOODPNEUMONIAIN2010:ESTIMATESOFINCIDENCE,SEVEREMORBIDITY,MORTALITY,UNDERLYINGRISKFACTORSANDCAUSATIVEPATHOGENS

FOR192COUNTRIES1 2 1 2 1 3 4RudanI ,O'BrienKL ,NairH ,LiuL ,TheodoratouE ,QaziS ,LukšićI ,

2 2 1FischerWalkerCL ,BlackRE ,CampbellH ;ChildHealthEpidemiologyReferenceGroup(CHERG).1CentreforPopulationHealthSciencesandGlobalHealthAcademy,UniversityofEdinburghMedicalSchool,Edinburgh,UK2DepartmentofInternationalHealth,JohnsHopkinsBloombergSchoolofPublicHealth,Baltimore,MD,USA3DepartmentofMaternal,Newborn,ChildandAdolescentHealth,WorldHealthOrganization,Geneva,Switzerland4AndrijaStamparInstituteofPublicHealthivana.luksic@stampar.hr

Background

TherecentseriesofreviewsconductedwithintheGlobalActionPlanforPneumoniaandDiarrhoea(GAPPD)addressedepidemiologyofthetwodeadlydiseasesattheglobalandregionallevel;italsoestimatedtheeffectivenessofinterventions,barrierstoachievinghighcoverageand themain implications forhealthpolicy.Theaimof thispaper is toprovidetheestimatesofchildhoodpneumoniaat thecountry level.Thisshouldallownationalpolicy-makersandstakeholderstoimplementproposedpoliciesintheWorldHealthOrganization(WHO)andUNICEFmembercountries.

Methods

Weconductedaseriesofsystematicreviewstoupdatepreviousestimatesoftheglobal,regional and national burden of childhood pneumonia incidence, severe morbidity,mortality, risk factors and specific contributions of the most common pathogens:streptococcus pneumoniae (sp), haemophilus influenzae type b (hib), respiratorysyncytialvirus(RSV)andinfluenzavirus(flu).Wedistributedtheglobalandregional-level estimates of the number of cases, severe cases and deaths from childhoodpneumonia in 2010-2011 by specific countries using an epidemiological model. Themodelwasbasedontheprevalenceofthefivemainriskfactorsforchildhoodpneumoniawithincountries(malnutrition,lowbirthweight,non-exclusivebreastfeedinginthefirstfourmonths, solid fueluseandcrowding)andriskeffect sizesestimatedusingmeta-analysis.

49

Pregled2013.

Findings

Theincidenceofcommunity-acquiredchildhoodpneumoniainlow-andmiddle-incomecountries (LMIC) in the year2010, usingWorldHealthOrganization's definition,wasabout 0.22 (interquartile range (IQR) 0.11-0.51) episodes per child-year (e/cy),with11.5%(IQR8.0-33.0%)ofcasesprogressingtosevereepisodes.This isareductionofnearly25%overthepastdecade,whichisconsistentwithobservedreductionsintheprevalenceof risk factors forpneumonia throughoutLMIC.At the levelofpneumoniaincidence, RSV is themost common pathogen, present in about 29% of all episodes,followed by influenza (17%). The contribution of different pathogens varies bypneumoniaseveritystrata,withviraletiologiesbecomingrelativelylessimportantandmostdeaths in2010causedby themainbacterialagents -SP (33%)andHib (16%),accountingforvaccineuseagainstthesetwopathogens.

Conclusions

Incomparisonto2000,theprimaryepidemiologicalevidencecontributingtothemodelsof childhood pneumonia burden has improved only slightly; all estimates have wideuncertaintybounds.Still,thereisevidenceofadecreasingtrendforallmeasuresoftheburden over the period 2000-2010. The estimates of pneumonia incidence, severemorbidity,mortalityandetiology,althougheachderivedfromdifferentandindependentdata,areinternallyconsistent-lendingcredibilitytothenewsetofestimates.Pneumoniacontinues tobe the leadingcauseofbothmorbidityandmortality foryoungchildrenbeyondtheneonatalperiodandrequiresongoingstrategiesandprogresstoreducetheburdenfurther.

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Broj5.

Periodicumbiologorum2013;115:469-74

GERONTOLOGYPUBLICHEALTHMANAGEMENTINCROATIA

1 1 2 1Tomek-RoksandićS ,TomasovićMrčelaN ,SmolejNarančićN ,ŠostarZ ,

1 2 3LukićM ,DurakovićZ ,LjubičićM .1AndrijaStamparInstituteofPublicHealth2InstituteforAnthropologicalResearch,Zagreb,Croatia,3CroatianInstituteofPublicHealth,Zagreb,Croatia.spomenka.tomek-roksandić@stampar.hr

The gerontologic-public health service provided at primary health care level by theCenters of Gerontology of the Public Health Institutes (PHI) in particular Croatiancounties,CityofZagrebandRepublicofCroatiaisbasedontheestablishedgerontologic-public health parameters of health care needs and functional ability of the elderly ininstitutional and non-institutional health care. Appropriate preventive gerontologicprogramofprimarypreventionfortheelderlyhasalsobeenperformedbyGerontologyCentersinlocalcommunity,providingimmediategerontologicnon-institutionalcarefortheelderly.Acomprehensiveapproachinhealthcareoftheelderly,withfamilymedicineplayingtheleadingrole,isensuredbyduecoordinationatthelevelofprimaryhealthcarefor the elderly as part of the gerontologic-public health service with a catchmentpopulationof30,000peopleolderthan65.Thepublichealthrelevanceofhealthmanagementfortheelderlyatthesethreelevels(superior,intermediaryandbasichealthmanagement)isbasedontheprimaryhealthcarefortheelderly.Thestrategicgoalsisbasedonthemonitoring,studying,evaluationandreporting,withcoordinationandsupervisionoftheimplementationofhealthcareneedsoftheelderlythroughmonitoringofhealthcareneeds.

Keywords:healthmanagementfortheelderly,CentersofGerontologyofthePublicHealthInstitutes, Gerontology Centers, gerontologic-public health team, the measures ofgerontologic-publichealthcare.

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Pregled2013.

Broj6.

Periodicumbiologorum2013;115:475-81

PROGRAMOFPRIMARY,SECONDARYANDTERTIARYPREVENTIONFORTHEELDERLY

1 1 2 1Tomek-RoksandićS ,Tomasović-MrčelaN ,Smolej-NarančićN ,ŠostarZ ,1 2 3

LukićM ,DurakovićZ ,LjubičićM ,VučevacV.1AndrijaStamparInstituteofPublicHealth2InstituteforAnthropologicalResearch,Zagreb,Croatia,3CroatianInstituteofPublicHealth,Zagreb,Croatia.spomenka.tomek-roksandić@stampar.hr

The aging process is very individual and normal physiological phenomenon. Thisindicates that the elderly are a heterogeneous group that requires individualgerontological approach.Thebasis for the implementationof theprogramof healthyagingrepresenttheirowndecisionsaboutpositivehealthbehaviors,thataremadeatayoungerageandinteractwithaneffectivehealthprogramsofpreventivehealthmeasuresfortheelderly.Aspartofevaluationoftheimplementationofthepreventiveprogramfortheelderlyisimportanttodefinenegativehealthbehaviouroftheelderlyanddeterminetheriskfactorsofpathologicalageing.Primarypreventionfortheelderlyensuresnotonlypreventionofdeathinearlyoldagebutalsopreservationoffunctionalabilityindeepoldagethroughhealthpromotioninoldage.Theimplementationofsecondarypreventioninhealthcareoftheelderlypeopleresultsintimelydiagnosisofdiseasewhichcanstopitsfurtherdevelopmentandhelpinitstreatment,nursingcareandrehabilitation.Tertiarypreventionincludesdifferenthealthproceduresthatpreventphysicalandmentaldeclineinadiseasedoldindividualanddevelopstheremainingfunctionalcapacity.TheProgramofHealthcareMeasuresofPrevention for theElderly isprimarilycarriedout throughactiveprimaryhealthcareinstitutionswithinlocal,regionalandnationalgerontologicalcentresoftheInstituteofPublicHealth.Implementationofpreventiveprogramsfortheelderly can avert thedevelopment of a number of preventable diseases; for instance,diabetesmellitus, obesity, hypertension, cerebrovascular and cardiovascular diseases,cancer of the breast, ovaries, prostate, lungs, osteoporosis/fractures, incontinence,mentaldisorders,respiratorydiseases.InCroatia,theprogrampromotesahealthyactiveaging,consistingofthe"Guideforactivehealthyaging“.

Keywords:active,healthyaging,gerontology,familymedicine,positivehealthbehaviour,Programofhealthpromotionfortheelderly,primaryprevention,secondaryprevention,tertiaryprevention,negativehealthbehaviour,Programofbasicpreventivehealthcaremeasuresforelderly.

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Pregled2013.

4)OSTALIRADOVI

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4.1)INOZEMNI

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Pregled2013.

Broj1.

6thBlackSeaBasinconferenceonAnalyticalChemistry,Turkey,Trabzon,September2013,BookofAbstract2013:228

VALIDATIONOFAMETHODFORDETERMINATIONOFPHTHALATESINCOMMONUSEOBJECTS(TOYSANDCHILDCAREARTICLES)BYGASCHROMA-TOGRAPHYMASSSPECTROMETRY(GCMS)

MandićAndačićI,RanogajecA,SmitZ.AndrijaStamparInstituteofPublicHealthivana.mandic@stampar.hr

Phthalicacidesters (phthalates)are themost commonlyusedplasticizer inpolyvinylchloride(PVC)basedproductsduetotheircompatibilityandsofteningcapability.Theirprimarlyroleistosoftenpolyvinylchlorid(PVC),andthereforetheiruseiswidespreadinproductionof commonuseobject.Theneedfordeterminationofphthalatesintoysandchildcarearticles is related to the fact that theyarepotential cancerous.According todirective 2005/84/EC, phthalates (bis(2-ethylhexyl) phthalte, dibutyl phthalate andbenzylbuthylphthalate)mustnotbeusedassubstancesorasconstituentsofpreparationatconcentrationgreaterthan0,1%bymassoftheplasticmaterialintoysandchildcarearticles.Thesameconditionsareapplicablefordiisononylphthalate,diisodecylphthalteanddi-n-octylphthalateintoysandchildcarearticleswhichcanbeplacedinmouthbychildren.Method for determination of phthalates in toys and childcare articles is based onextraction of sample (1g), with dichloromethane on Soxtherm, followed by gaschromatographymass spectrometry analysesof resultig extracts.Method is validatedaccordingtoNormHRNEN14372:2004,withsomeimprovementsofextractiontime(4hinstead6h)andsamplequantity(1ginstead2g).Duringvalidationofmethodfollowingvalueshavebeenachived:recovery(83%-107%),limitofdetection(0,05%and0,01%),limitofquantification(0,01%and0,02%),linearityrange(0,015-0,15%).Obtainedresultssatisfygivencriteriaofacceptability.Method isaccredited in flexiblearea,andcanbeusedfordeterminationofphthalatesincommonuseobjects.

Keywords:phalates,GCMS,commonuseobjects

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Broj2.

2ndInternationalConferenceonEnvironment,ChemistryandBiology(ICECB2013)Stockholm,Sweden,13.-14.December2013.

COMPARASIONOFFINEPARTICULATECONCENTRATIONSINURBANAREATRAFFICEXPOSED

AREAANDLANDFILLINTHEZAGREBCITY

MajićI,KrivohlavekA,ŠikićS,ŠostarZ.AndrijaStamparInstituteofPublicHealthivona.majic@stampar.hr

ThispaperpresentstheresultsofmeasurementoffineparticulatePM10inZagrebair,atthreedifferentlocations,duringtheyearsof2011and2012.Air quality monitoring in Dr Andrija Stampar Institute of Public Health, began inDecemberof2003.Themonitorsarelocatedatsitescharacterizedbydifferentexposuretoemissionsources:residentialurbanarea,areamainlyexposedtotrafficemissions,andlandfillareaalsocharacterizedbyhightrafficdensity.Weeklybehaviorsofconcentrationlevelsareseparatelypresentedforthecoldandwarmseasonsof theyear.Thereductionofconcentration levels isalsoobservedduring theweekendscomparedtoworkingdays.Concentration levelsarequiteuniformover theentirecity,with the lowestvalues forresidentialareaofZagreb,highervaluesforsitewithhightrafficdensityandthehighestforlandfillsite.Workday behaviors generally show a progressive increase of the daily concentration,reachingamaximuminthemiddleoftheweekfollowedbyadownwardtrendtowardstheminimum always observed on weekends. The reduction in concentration level isconsistent with observed reductions of the traffic volume between weekends andworkdaysandsignificanttrafficdecreaseonthe1stofNovember.

Keywords: PM10, urban air pollution, descriptive statistics, traffic emission, weeklybehavior,trafficdecreasingeffect

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Broj3.

SEBValencia2013abstracts,Dempster,Talja(ed),Valencia,Spain.SocietyofExperimentalBiology2013:165.

OXIDATIVESTRESSRESPONSEINTOBACCOEXPERIMENTALLYEXPOSEDTOCADMIUMANDZINC

CvjetkoP,ŠikićS,Peharec-ŠtefanićP,TolićS,PavlicaM,BalenB.AndrijaStamparInstituteofPublicHealthsandra.sikic@stampar.hr

Abstract

Becauseoftheirpersistence,heavymetalsofeithernaturaloranthropogenicoriginareconsideredtobethemostcommonenvironmentalpollutants.Therefore,theeffectsof10and15μMcadmium(Cd),anonessentialtoxicelementand25and50μMzinc(Zn),anessentialmicronutrient,wasinvestigatedintobaccoplantsafterexposuretoeachmetalaloneortotheircombinations.TheassessmentofCdandZncontents,inbothshootsandrootoftobaccoplants,showedthatbothmetalsaccumulatewithtime,butwhenpresentincombination, they reduced uptake of each other. As result, leaves exhibited oxidativestress in all treatments except the one with individual Zn concentrations. In roots,increasedMDAandproteincarbonylcontentwasrecordedaftertreatmentwitheither10or15μMCd,althoughincombinedtreatments25and50μMZnsignificantlyreducedmeasuredvalues.Amongtheinvestigatedantioxidativeenzymes,activityofSOD,PPXandAPXwaselevated inboth leavesand roots after exposure to eitherCd concentration,whoseeffectwas substantially alleviatedbyadditionofZn. Interestingly,CATactivityfailedtoshowanydifferencebetweenappliedtreatmentsinleaves,whileinrootsCATactivitywassignificantlyreducedinalltreatmentscomparedtocontrol.Inconclusion,combinedtreatmentsshowedlowervaluesofoxidativestressparametersincomparisontotreatmentswitheithermetalalone,whichindicatesalleviatingeffectofZnonoxidativestressinCd-treatedplants.

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Pregled2013.

Broj4.

Congress:Breakingdownthebarriers,London27-29June2013.Abstractbook42.

REGIONALDIFFERENCIESINDRINKINGHABITSAMONGCROATIANADOLESCENTS

1 1 1KuzmanM1,Pavic-SimetinI ,MarkelicM ,Pejnovic-FranelicI .1CroatianNationalInstituteofPublicHealthmarina.kuzman@stampar.hr

Foryoungpeoplecontextualfactorsasbehaviourofadultsandpeersmakemodelsandinfluencemanyhabits,drinkinghabitsincluded.Especiallyvulnerableperiodisearlyandmiddleadolescence.DatafrominternationalsurveyESPAD1995-2011wereanalysed(studentsaged15-16,nationallyrepresentativesample).Variablesofdrinkinghabitsandselectedproblemsorconsequencesofriskydrinkingwereanalysed.The frequency of drinking among Croatian adolescents is increasing in the surveyedperiod,moreamong females than inmales.Selectedvariableswereanalysed forbothgendersregionally(northern,eastern,southern,western,middleregionandtheCityofZagreb).All drinking parameters were highest in the northern Croatian region, exceptdrunkennessinthepast12months(higherforbothgendersinthewesternregion-OR1,5,CI1,096-1,984fortheboys;OR1,3,CI1,004-1,754forthegirls)anddrunkennessinthepast30daysforthegirls(OR1,5;CI1,064-2,087).Adolescentsfromsouthernregionhadlessriskydrinkinghabitsforthegirlsaswellfortheboys.Thelowestprobabilityfortheyoungageofthefirstdrunkenness(13yrsorless)hadgirlsfromeasternregion.Boysformthe City of Zagreb had less probability for risky drinking for three, and girls for twovariables.Forthosewhohaddrunkalcoholtheconsequencesasproblemsinschoolwerelessprobableinthesouthernregion(OR0,58,CI0,443-0,752).Problemswiththepoliceweremoreprobableinthewesternregion(OR1,53,CI1,149-2,037)andnecessityofthehospital treatment more probable in the western region (OR 1,83, CI 1,072-3,121)Drinkinghabitsamongadolescentsareinfluencedbythepeergroupbutreflectedalsothecontextualenvironment.Preventiveprogramsshouldthereforebeencreatedaimingatallstakeholdersinvolvedinthebehaviouralprocess,includingeducation,availability,trafficmeasures,advertisementandpricingpolicy.

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Pregled2013.

Broj5.

IIndInternationalScientificandScienceConference„TrendsineducationandrehabilitationofPersonswithDisabilities”,Šabac,Serbia,25-27October2013.

QUALITYLIFEIMPROVEMENTOFPEOPLEWITHINTELLECTUALDISABILITIESTHROUGHOUTARTTHERAPYANDMOVEMENTREHABILITA