pre conditioning exercise
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Pre-Conditioning exercise
New concept of balance indynamic stress response
Bambang Purwanto
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Human body organization!function
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Human body organization!function
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Human body organization!function
Each level has it own balance
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Human body organization!function
Each level has it own balance
One to another are connected dynamically!balancing system
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Human body organization!function
Each level has it own balance
One to another are connected dynamically!balancing system
Function is a result of balancing system
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Human body organization!function
Each level has it own balance
One to another are connected dynamically!balancing system
Function is a result of balancing system Mall- & dysfunction is result of balancing
disorder/ failures!clinical features
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Stress: challenge on balancing system
Stress disturb balancing system; if
It meet a new (re-)balance!eustress
Its failed!imbalance!distress; if
It is reversible!compensated
Its not!de-compensated
Response to stress
Acute!survival & repairing Chronic!adaptation & conditioning
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Example: muscle contraction
O2
O2
O2*
O2* ROS Ca
Ca
Troponin C
Xanthin oxidase
AMPK
Cathepsin
Calpain
Caspase
NOX
SR
Membrane depolarization
AchAch-R
Chemistry
Stretch
Electrical
Reflex
ROS
RyR
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Other perspective
Muscle contraction isnt independentmechanism in order to locomotive, butalso co- with
Defense mechanism!prevent myofibrildetachment
Energy reproduction!glucose uptake viaAMPK & Glut-1 expression
Last scenario!suicide/ apoptosis
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Muscle contraction: could be danger..?!
Yes, if the balancing system disturb!
.. How can we control the radical oxidant effect?
How can we sure that Ca is only bound troponin C?
Thats why Allah create!
. SERCA, activated by ATP from energy reproduction!limit SRCa release
Na/K ATP pump, activated by ATP!limit depolarization
Hsp 27/72, activated by p38MAPK, MAPKAP & akt!preventapoptosis & myofibril repair
Antioxidant system, as target and neutralize oxidative stress
These molecules controls intracellular environment keep in balance
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Also, supports are given by
Hormone, especially GH!stimulate akt,prevent apoptosis, muscle repair
Macrophage!cytokine release!stimulate
akt, prevent apoptosis, muscle repair Satellite cells!pro genitor in situ stem cells,
replace & regenerate a new muscle tissue
These are back up plan when muscle destruction occur
Distress imbalance redirect to reversible repair
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Now, are u afraid to move!?
U should not!
..
There is another scenario!
What if we could increase
the defense stress response
fitness capacity & stress threshold
Than, we will able to defense againststress, not only in similar magnitude butalso bigger than before
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Make sure that u always ready!
Pre-conditioning is specific intervention before atruly stress coming
Specific intervention Specific target
Mimic with the truly stress
Pre-conditioning let our body adapt to the stress
Pre-conditioning needs times, depends on the
target Seconds to minutes
Minute to hours
Days to weeks
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Pre-conditioning
Various, depends on it modalities Physical, exercise, chemistry, medicine, radiation,
ionized
Evidences:
2ndbout exercise isnt given any stress as seen atsimilar 1stbout exercise a week before
Allopurinol which is taken orally an hour beforeexercise increases endurance two fold at maximum
stress test 11 minutes of stretching and/ or 5 minutes treadmill
(static cycling) reduce muscle injury at maximumstress test
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Pre-conditioning exercise
Goals : increasing the amount of stress the body can endure before
experiencing injury
preventing injury because they get the body to become moretolerant of sustained effort
Targets: Strength, maintain control and keeps it from stretching to the
injury point
Flexibility, accommodate more stretching before reaching itslimits and tearing
Molecular defense: block the XO, increase (hsp27, Glut-1,antioxidant system) expression,!!
Modalities, Exercise, physical activities
Medicines, supplements 12
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Exercises used for conditioning
Mimic with the actual stress activity Include these programs
Weight training
Aerobic exercise
Anaerobic exercise plyometrics
Response are vary
2ndbout with a week interval in anaerobic strenuous
exercise More than 30 minutes, 3-5 times a week needs minimum
3 weeks in low intensity aerobic exercise
Do not took any NSAIDs such as diclofenac during conditioning programs13
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Exercise!(cont)
High intensity interval exercise induce muscleinjury Needs 4-7 days to recover
Satellite cells differentiate to the muscle cells
Increase number of muscle fiber
Hypertrophy is a result in adaptation to similarstrenuous activity
Conditioning is a recovery phase after destruction
Do not pre conditioning with prolonged strenuous exercise
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Supplements used for conditioning
Specific target, a certain predicted mechanism
Dose dependent, time exposure dependent
Example:
Allopurinol which is given half until an hour priorincrease endurance in strenous exercise!helpsathlete to maintain his/her top perform duringcompetition
When allopurinol is given more than hour prior thecompetition !muscle lost it strength
When allopurinol is taken more than 100 mg, causingabdominal discomfort
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Supplement & strategy to win
the pre conditioning exercise has done Use it to protect muscle from injury before
having exercise for very first time
Joining competition in sport
Strategy in feeding is important key to win We should check pre treatment data such as
(Resting, maximum and target) heart rate, glucose level (min2 hours before start), blood uric acid, blood lactic acid
Consider to check also muscle injury marker, such as serumCK, sTnI
Creatine, vitamins, allopurinol,!!!
Be careful, use only legal supplements
(look at WADA & IOC anti doping regulation)16
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Summary
Allah create our body always able to adapt inevery condition
We must be prepared before stress coming
Pre-conditioning exercise is a method to beprepared
Please choose your suitable modalities:physical, exercise or supplement
Pay attention the protocol, rules & forbidden
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Become a winner
against stress is a must
----the end----
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