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POVIDONE & EUDRAGIT

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POVIDONE

´ Povidone is a synthetic polymer consisting of 

linear 1-Vinyl-2-pyrroldionone groups.

´

The degree of polymerization results inmaterials of various molecular weight range.

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POVIDONE

´ Povidone is usually available in four viscositygrades identified by their K values, whichapproximate K-15, K-30, K-60 and K-90.

´ The average molecular weight of these gradesare 10,000 40,000, 160,000 and 360,000

respectively.

´

The most common uses of Povidone inpharmaceuticals (frequently K-30) are as atablet binder and a tablet coating.

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ACRYLATE POLYMERS

´ A series of acrylate polymer is marketed under

Eudragit. Eudragit is trademark of Rohm GmbH

& Co. KG. Darmstadt in Germany, first

marketed in 1950s.

´ Eudragit is prepared by the polymerization of 

acrylic and methacrylic acids or their esters,

e.g., butyl ester or dimethylaminoethyl ester.

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EUDRAGIT

´ Eudragit is prepared by the polymerization of acrylic and methacrylic acids or their esters, e.g.,butyl ester or dimethylaminoethyl ester.

´ Eudragit RL and RS are copolymer synthesizedfrom acrylic and methacrlic acid esters with a lowcontent of quaternary ammonium groups.

´ These polymers produce films for the delayed

action preparations.

´ Eudragit L and Eudragit S are the two forms of commercially available enteric acrylic resins.

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µK¶ IN POVIDONE-K 15 ETC

´ The K value is greatly influenced by the

molecular weight distribution of the polymersample used in the determination.

´ M= molecular weight

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µK¶ IN POVIDONE-K 15 ETC

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Substance T (K)

Acetylene 192.40

Ammonia 195.40

Argon 83.81Butane 134.60

Carbon (graphite) 4765.00

Carbon ioxi e 216.55

Carbon monoxi e 68.10

Neon 24.57

Nitric oxi e 109.50

Nitrogen 63.18

Nitrous oxi e 182.34

Oxygen 54.36

Palla ium 1825

Platinum 2045

Sulfur ioxi e 197.69

Titanium 1941.00

Uranium hexafluori e 337.17

Water 273.16

Xenon 161.30

Zinc 692.65