polymerase δ and ε in colon cancer
DESCRIPTION
Polymerase δ and ε in colon cancer. Aaron Stevens. Polymerase δ and ε contain both polymerase and exonuclease domains . Polymerase δ and ε are the major replicative polymerases. Pol δ and ε help repair damage. Mutating the exonuclease domain leads to decreased survival rates. - PowerPoint PPT PresentationTRANSCRIPT
![Page 1: Polymerase δ and ε in colon cancer](https://reader035.vdocuments.site/reader035/viewer/2022081418/56816592550346895dd85edc/html5/thumbnails/1.jpg)
Polymerase δ and εin colon cancer
Aaron Stevens
![Page 2: Polymerase δ and ε in colon cancer](https://reader035.vdocuments.site/reader035/viewer/2022081418/56816592550346895dd85edc/html5/thumbnails/2.jpg)
Polymerase δ and ε contain both polymerase and exonuclease domains
![Page 3: Polymerase δ and ε in colon cancer](https://reader035.vdocuments.site/reader035/viewer/2022081418/56816592550346895dd85edc/html5/thumbnails/3.jpg)
Polymerase δ and ε are the major replicative polymerases
![Page 4: Polymerase δ and ε in colon cancer](https://reader035.vdocuments.site/reader035/viewer/2022081418/56816592550346895dd85edc/html5/thumbnails/4.jpg)
Pol δ and ε help repair damage
![Page 5: Polymerase δ and ε in colon cancer](https://reader035.vdocuments.site/reader035/viewer/2022081418/56816592550346895dd85edc/html5/thumbnails/5.jpg)
Mutating the exonuclease domain leads to decreased survival rates
![Page 6: Polymerase δ and ε in colon cancer](https://reader035.vdocuments.site/reader035/viewer/2022081418/56816592550346895dd85edc/html5/thumbnails/6.jpg)
Point mutations in Pol δ are found in colon cancer
![Page 7: Polymerase δ and ε in colon cancer](https://reader035.vdocuments.site/reader035/viewer/2022081418/56816592550346895dd85edc/html5/thumbnails/7.jpg)
Mutating the exonuclease domain of Polymerase δ leads to cancer
![Page 8: Polymerase δ and ε in colon cancer](https://reader035.vdocuments.site/reader035/viewer/2022081418/56816592550346895dd85edc/html5/thumbnails/8.jpg)
![Page 9: Polymerase δ and ε in colon cancer](https://reader035.vdocuments.site/reader035/viewer/2022081418/56816592550346895dd85edc/html5/thumbnails/9.jpg)
References Biard Denis S.F. (2011). New Insight on Entangled DNA Repair Pathways: Stable
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Prindle, M. J. and Loeb, L. A. (2012), DNA polymerase delta in dna replication and genome maintenance. Environ. Mol. Mutagen., 53: 666–682. doi: 10.1002/em.21745
Goldsby RE, Hays LE, Chen X, Olmsted EA, Slayton WB, Spangrude GJ, Preston BD. High incidence of epithelial cancers in mice deficient for DNA polymerase δ proofreading. PNAS.2002;99(24):15560–15565. doi: 10.1073/pnas.232340999.
Burgers P. M. (2009) Polymerase dynamics at the eukaryotic DNA replication fork. J. Biol. Chem. 284, 4041–4045
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Helmut Pospiech and Juhani E. Syväoja, “DNA Polymerase ε - More Than a Polymerase,”TheScientificWorldJOURNAL, vol. 3, pp. 87-104, 2003. doi:10.1100/tsw.2003.08
Cancer Genome Atlas Network (2012) Comprehensive molecular characterization of human colon and rectal cancer. Nature 487: 330–337
Q. Zhou, R. Effati, K. Talvinen, H. Pospiech, J.E. Syväoja, Y. Collan. Genomic changes of the 55 kDa subunit of DNA polymerase epsilon in human breast cancer. Cancer Genomics Proteomics, 5 (2008), pp. 287–292