pleural disease - pneumonologia.gr · pleural disease • accumulation of ... main causes of...
TRANSCRIPT
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Pleural disease
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Chest X-ray
• Most important imaging technique–Demonstration–Follow-up
• PA and lateral view (erect)• Expiratory chest x-ray in case of
suspicion of (small) pneumothorax• Lateral decubitus (?) and lateral supine
film• Pleura only visible at fissures
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Ultrasound
• Evaluate and guide aspiration and drain insertion
• Normal pleura presents as echogenic stripe comprising both parietal and visceral pleura
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CT
• Can play a role in specific situations• Thin slice CT for detailed view of small
pleural changes• Standard slice CT with IV contrast
–20-60 seconds after contrast injection–Differentiate pleural thickening from
pleural fluid• Normal pleura only visualised at the
fissures
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Magnetic Resonance
• Limited role• High contrast between pleural
abnormalities and extra-pleural fat• respiration artifacts:
–respiratory gating–ultra fast acquisition
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Positron Emission Tomography (PET) and integrated PET-CT
• Limited role• Diagnosis and staging of tumor
(malignant mesothelioma)
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Pleural disease
• Accumulation of fluid• Accumulation of air• Pleural thickening and fibrothorax (with
and without calcification)• Pleural tumors
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Accumulation of Pleural Fluid:Pleural Effusion
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Pleural Effusion: Goals of diagnostic imaging
1) Detection of the effusion and differentiation from other pathological pleural (and non pleural) processes
2) Detection of underlying pulmonary, cardiac, mediastinal or abdominal pathology
3) When possible, trying to make a specific diagnosis
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Main causes of pleural effusion• Hypoproteinemia
– hepatic cirrhosis– nephrotic syndrome
• Cardiovascular disease– constrictive pericarditis– SVC obstruction– post cardiac injury syndrome– PE
• Neoplasm– bronchial carcinoma– metastases (lung, pleura)– pleural tumor (benign, malignant)– lymphoma
• Infectionbacterial (tbc), viral, chlamydial, protozoal, metazoal, fungal
• Trauma– ruptured esophagus– post surgical (thorax/abdomen)– open/closed chest trauma– CVP line insertion, ventriculopleural shunt, – radiation
• Inhalation asbestos exposure
• Inflammatory (non– RA infectious)– SLE– Wegener’s
• Drug toxicity methotrexate
• Subdiaphragmatic disease– ascites - uremic pleurisy– pancreatitis - splenic infarction– subphrenic/ hepatic abscess
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Chest radiograph
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Pleural effusion: Typical findings
• Upright position: –Obliteration of post. costophrenic
angle (lat view) (> 100ml)–Obliteration of lateral costophrenic
angels (pa view) (> 175ml)–Superiorly concave meniscus
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Pleural effusion: Typical findings
• Supine position: (> 500ml)–Obliteration diaphragmatic contour–Opacification lateral costophrenic
angles–Decreased translucency of (lower part
of) hemithorax
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Upright
Supine
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Pleural effusion: Atypical findings
1.Loculated effusion:– Ill-defined opacity en face–Semicircular opacity tangentially–Obtuse angle with the chest wall
2.Interlobar effusion:– In minor and major fissures–Biconvex–Sharply defined tangentially
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Pleural effusion: atypical findings
3. Subpulmonic effusion:–Accumulation of pleural fluid between
the diaphragm and the lung–Sharp costophrenic angle–Up to 1000 ml–Left sided: distance between inferior
lung and gastric bubble > 2cm
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Pleural effusion: atypical findings
4. Apical effusion:–Accumulation of pleural fluid at the
apex of the chest– In supine body position– Increased opacity at the lung apex– Ill or sharply defined
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Ultrasound (US)
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US
• Distinguish between pleural fluid and solid pleural and extrapleural lesions
»Doppler examination»opaque hemithorax
• Identify small amounts of pleural fluid, pleural fluid in unusual locations (subpulmonary)
• Localize pleural fluid for aspiration, and identify solid components for biopsy
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US
• Can suggest type of pleural fluid–Transudate: echo-free, fluid-lung
interface is highly echogenic» Lymphoma and neurogenic tumors may
also be hypoechoic–Exudate and hemorrhagic effusion:
more echogenic with mobile strands of fibrin and accompanied by pleural thickening
» Differential diagnosis with solid pleural thickening can be difficult
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Computed Tomography (CT)
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CT
• Not indicated in every patient presenting with pleural effusion on chest X-ray
• CT density measurement cannot distinguish between exudate and transudate, clotted blood can sometimes be identified
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CT
• Can characterize the morphology of the pleural thickening that often accompanies a pleural effusion and in this way help to differentiate between benign and malignant pleural effusion
• Identify underlying lung disease that might have provoked the effusion
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Pleural thickening and Pleural Fluid
1. Empyema2. Organised (encapsulated) pleural
effusion3. Malignant pleural effusion
Metastatic diseaseMalignant mesothelioma
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1.Empyema
• Thickening is uniform/smooth• Thickening and enhancement: specificity
of 96% in predicting presence of (infectious) exudate
• Often thickening and increased attenuation of the extrapleural fat
• Split pleura sign: thickening and enhancement of visceral and parietal pleura
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2.Organised (encapsulated) pleural effusion
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3.Malignant pleural effusion
• CT may only show pleural fluid• Malignant pleural effusion associated
with malignant pleural thickening–nodular pleural thickening–parietal pleural thickening >1cm–often additional features in lung,
mediastinum, chest wall that suggest malignancy
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Magnetic Resonance Imaging (MRI)
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MRI
• Low T1 and T2 signal intensity• Does not allow to differentiate between
exudates and transudates• Subacute and chronic haemorrhage may
be recognised by the high signal intensity on both T1 and T2 weighted images
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Accumulation of Air: Pneumothorax
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Main Causes of Pneumothorax• Traumatic:
– Rib fracture– Stab wound
• Iatrogenic:– Thoracentesis (eg
subclav. catheder– Percut. Lung biopsy– Pos.press. Ventilation– Tracheostomy
• Spontaneous– Subpleural bulla– Pneumatocoele– “Cystic” lung disease
(eg. Histiocytosis, LAM,…)
– Cystic fibrosis– Pneumonia and abcess
• Esophageal rupture• Pneumoperitoneum• Pneumomediastinum• Catamenial
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Chest RadiographTypical Signs
• Pleural line parallel to the chest wall• Vascular markings absent lateral to this
hairline shadow• In upright position: air accumulates at
the apex• Pneumothorax increase on expiratory
view (occasionally useful in case of doubt)
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Skin folds
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(Bullous) Emphysema
Orientation of lines
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Chest radiographAtypical Signs
In supine patients and when the pleural space is partially obliterated
• Ipsilateral transradiancy• Deep finger-like costophrenic sulcus
laterally• Visible anterior costophrenic recess as
an oblique line or interface in the hypochondrium (“ double diaphragm sign”)
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CT ?
• In case of doubt even when a repeat chest film and an expiratory chest film have not been helpful
• To distinguish between bullae and pneumothorax
• To reveal clues to the underlying causeof the pneumothorax
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Hydropneumothorax
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Pleural thickening
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Pleural Thickening
• Focal (localised) pleural thickening• Multifocal pleural thickening• Diffuse pleural thickening
• Benign• Malignant
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Benign vs Malignant Pleural Thickening
Benign• Smooth Regular• “small”• “Plateau” like• No chest wall
invasion
Malignant• Irregular• “large”• Nodular• Chest wall invasion
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Benign Pleural Thickening
• Focal (localised):–Fibrous thickening (scarring)*–Tumor: lipoma, fibroma
• Multifocal: –Pleural plaques related to asbestos
exposure*
• Diffuse: Fibrothorax* * May contain calcifications
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Benign focal pleural thickening: 1. Focal fibrous thickening
• Usually a sequel of pleural inflammation–Delayed complication of hemothorax,
pleural empyema or recurrent pneumothorax
–Often basal• “Apical pleural cap”
–Unilateral or bilateral–Age related fibrous thickening (?)–Differential diagnosis with superior
sulcus tumor
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Benign focal pleural thickening:2. Lipoma
• Benign pleural tumor• Incidental finding on chest X-ray• Sharply defined pleural mass• CT: homogeneous fat density
When heterogeneous and soft tissue attenuation: suspected for liposarcomaor infarction
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Benign focal pleural thickening: 3. Fibrous mesothelioma
• Middle age• Half of patients are asymptomatic• 10 – 30 % develop hypertrophic
osteoarthropathy• Pleural based, well-demarcated rounded
(slightly lobulated) mass• Sometimes pedunculated (variable
position) • 2 – 20 cm
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Benign focal pleural thickening: 3. Fibrous mesothelioma
• CT: –Enhancing soft tissue mass–Heterogeneous (necrosis)–Rarely calcified
• MRI: low signal on both T1 and T2
> 10 cm may indicate malignancy
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Benign Diffuse pleural thickeningFibrothorax
• A smooth uninterrupted pleural thickening extending over at least a fourth of the chest wall (chest x-ray) or extends more than 8cm in craniocaudaldirection, 5 cm laterally and with a thickness > 3mm (CT) but less than 1cm
• Sequel of empyema, tbc, haemorrhagic effusion (may be calcified) and rarely induced by asbestos exposure (often bilateral)
• To be differentiated from malignant pleural thickening
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Malignant pleural thickening
• Can be focal, multifocal, diffuse• Malignant mesothelioma or metastasis
(usually indistinguishable)• Irregular nodular thickening
–With or without pleural effusion–May extent into the fissures–Often associated with lymphnode
metastasis (50% of cases)• CT very helpful in diagnosis and staging• MRI, PET and PET-CT: limited role
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Diseases of the Pleura
• Chest radiograph is basic imaging modality to study pleural and chest wall disease
• CT can be performed in selected cases especially when there is suspicion for tumor aetiology
• US: evaluate and guide biopsy, aspiration, drain insertion
• MR: selected cases where high contrast detail is needed
• PET and PET/CT: role not defined yet