plegable final
TRANSCRIPT
BLOCKING DNA REPAIR ENZYME AND LEAD TO
CANCER THERAPY AND A NEW GENERATION OF
TUBERCULOSIS DRUGS
Felipe Osorio Ospina
Medicine Student
2012
FOLDING
FOLDING
INTRODUCTION
Science news line (Feb. 11,2012)
BLOCKING DNA REPAIR ENZYME
COULD EVENTUALLY
LEAD TO CANCER
THERAPY.
Blocking DNA repair enzyme could eventually lead to cancer therapy. Science news line (Feb. 11,2012)
They solved the structure of a DNA
repair enzyme called PNKP.
It could one day be used to develop
new therapies that target certain types
of cancersTaken of http://es.wikipedia.org/wiki/Archivo:DNA_Repair.jpg
Damaging DNA in cancer cells is a useful way to kill them blocking
PNKP from doing its repair work in cancer
cells as a possible new cancer therapy.
Blocking DNA repair enzyme could eventually lead to cancer therapy. Science news line (Feb. 11,2012)
Taken of http://publicacionescirculodaikon.wordpress.com/page/2/
The holy grail of cancer therapy is to find drugs that we
could give to people that would sensitize
their tumours to these therapies, one of the ideas is that we could specifically inhibit this
PNKP enzyme.
Taken of http://docente.ucol.mx/al018752/public_html/imagen.htm
Blocking DNA repair enzyme could eventually lead to cancer therapy. Science news line (Feb. 11,2012)
A different way to attack cancer´s cells is a great opportunity to
obtain a succesful treatment and reduce secundary effects, like obtains with chemotherapy. I
think if it can be used for differents cancer´s types it will be
the way to solve this patology.
Observation
A NEW GENERATION OF
TUBERCULOSIS
DRUGS. RSC (FEB. 9,
2012)
Targeting enzymes responsible for catalysing the formation of bonds to
repair of DNA, DNA ligases, allows the ever-
growing health concern of multi-drug resistant
bacteria
Taken of http://ecodiario.eleconomista.es/ciencia/noticias/3608278/12/11/Descubre-por-que-las-celulas-de-tuberculosis-son-resistentes-a-los-antibioticos.html
A NEW GENERATION OF TUBERCULOSIS DRUGS.
RSC (FEB. 9, 2012)
Humans only have the DNA ligases that utilise ATP.
NAD+-dependent ligase is indispensable in several bacterial, including Mycobacterium tuberculosis and Escherichia coli, making them attractive drug targets.
A NEW GENERATION OF TUBERCULOSIS DRUGS.
RSC (FEB. 9, 2012)
Taken of http://www.health-healths.com/usually-mycobacterium-tuberculosis/usually-mycobacterium-tuberculosis.php
Finally developing new small molecule compounds that
are able to distinguish between ATP- and NAD+-
dependent ligases, is important for engineering molecules with increased
levels of specificity.
A NEW GENERATION OF TUBERCULOSIS DRUGS.
RSC (FEB. 9, 2012)
Taken of http://www.corbisimages.com/stock-photo/rights-managed/HU010984/pharmacist-creating-streptomycin?popup=1
The identification of drug targets is very important to improve de efficiency of tuberculosis therapy and other disseases. Also it brinds the oporttunity to attack differents moleculars targets and avoid the antibiotic resistance.
OBSERVATION
Medical Utiliy
The investigation in infected cells give a new opporttunity for treatment and more eficciency of them in mutated cells.
Medical Utiliy
Taken of http://blogdecienciassocialesyhumanas.blogspot.com/2010/06/algo-sobre-la-investigacion-social-y.html
The comprehension of the structure in some virus, give us the tools to attack the drugs resistance.Taken
of http://www.corbisimages.com/stock-photo/rights-managed/SF21876/dr-kochs-treatment-for-consumption?popup=1
Medical Utiliy
The replication and the damage reparation are
essencial procces to the conservation of DNA, so damage in the structure could be reparated or modified to attack the
virus and microorganisms
providing to people quality life.
Medical Utiliy
Taken of http://www.vivirsalud.com/2010/06/23/7-habitos-de-personas-felices
Bibliography• Martínez Sánchez LM, Vargas Grisales N, Toro
Montoya AE, Pamplona Sierra AP, Quevedo Orrego E. Biología molecular. 6. ed. Medellín: UPB. Fac. de Medicina; 2011.
Newton J. A new generation of tuberculosis drugs. Royal Society of Chemestry; 2012.
Blocking DNA repair enzyme could eventually lead to cancer therapy. Science news line; 2012
THANKS!