Sara Cardona Henao

Medicine Student

3rd Semester

 pro-metastasis protein

reveals mysterious link to neurodegeneration and RNA

that regulates cell death identified

INTRODUCTION

the discovery of this protein involved in metastasis and its relation with blocking proteins linked to neurodegeneration is a great aid for the person interested in studying these phenomena and to those affected by cancer

the identification of the INXS has been of great hope for the activation of apoptosis in tumor cells through the expression of BCL -XS gene located on chromosome 21

the researchers have identified a protein that active metastasis and inhibit two proteins neurodegeneratives

Discovery of pro-metastasis protein reveals mysterious link to

neurodegeneration

Discovery of pro-metastasis protein reveals mysterious link to

neurodegeneration 

TARBP2 binds various sites

of ARN and generates

changes including

destruccion of RNA

TARBP2 binds various sites

of ARN and generates

changes including

destruccion of RNA

Discovery of pro-metastasis protein reveals mysterious link to

neurodegeneration 

Gene APP: produces one protein associated with

Alzheimer's disease

Gene ZNF395: is associated with Huntington's

disease

Discovery of pro-metastasis protein reveals mysterious link to neurodegeneration 

Discovery of pro-metastasis protein reveals mysterious link

to neurodegeneration 

This work bring to us hope that in the future after many studies we can use drugs that inhibit the metastatic in various types of cancer.

Student observation

RNA that regulates cell death identified

the investigators discovered one ARN know as INXS that modulate the action of a gene important in apoptosis.

RNA that regulates cell death identifiedthe Researchers experiment with mouses subcutaneously implanted human kidney cancer cells and then divided into two groups, one receive injections of the plasmid containing INXS at the site of the tumor the other group was the controlafter 15 days of treatment the tumors of control group grow up and the tumors in the group treated with INXS decreased in size.

RNA that regulates cell death identified

the gene BCL-X regulated the apoptosis and is

present in cells in two different forms:

BCL-XL inhibits apoptosis

BCL-XS induced apoptosis activating

caspases, which are required for the activation

of other genes important for apoptosis.

RNA that regulates cell death identified

In a healthy and normally cell there is

a equilibrium between the two BCL-X

isoforms but in tumor cell there is less

BCL-X and less INXS.

In a healthy and normally cell there is

a equilibrium between the two BCL-X

isoforms but in tumor cell there is less

BCL-X and less INXS.

RNA that regulates cell death identified

In this news we can see the importance of apoptosis and I think we should investigate more about genes to regulate apoptosis because in the future we can use therapies to fight cancer

Student observation

Medical utility

both studies are breakthrough for molecular biology and medicine and represents great benefit for the future treatment of such a common disease in the community such as the cancer and metastasis of this.First study raises hopes of future therapeutic focuses that to inhibit the genes which causes metastasis of cancer cells. 

Medical utility

in the other study is present the importance of useful the expression of INXS because this reduces and inhibits apoptosis then will be used for activate the process of programmed cell death with only increase INXS

Medical utility

the increase of INXS may also be used in the future as a treatment for differents tissue degeneration

Medical utility

The study can delve deeper into the regulatory role of intronic non-protein-coding genes and its utility when inhibits or activate various processes.

BIBLIOGRAPHY  Rockefeller University. "Discovery of pro-metastasis protein

reveals mysterious link to neurodegeneration." ScienceDaily. www.sciencedaily.com/releases/2014/07/140729115113.htm (accessed August 22, 2014).

  Fundação de Amparo à Pesquisa do Estado de São Paulo. "RNA

that regulates cell death identified." ScienceDaily. www.sciencedaily.com/releases/2014/07/140730094306.htm (accessed August 22, 2014).

MARTINEZ SÁNCHEZ, Lina María. Biología molecular. 7 ed. Medellín: UPB. Fac. de Medicina, 2012.