plasma proteins table
DESCRIPTION
just put it in table form. makes studying easier for me. :)TRANSCRIPT
PLASMA PROTEINSGLOBULINS
Prealbumin (transthyretin) Albumin Αlpha-1 Antitrypsin Α-1 Acid Glycoprotein Transport thyroxine&triiodothyronine Indicator of nutritional status
Highest concentration in the serum
Maintains colloid osmotic pressure of the IVF—resp for nearly 80% of this pressure
Neutralize trypsin-like enzymes that cause hydrolytic damage to structural protein
90% of the dreaction of serum proteins
Assoc w/ severe, degenerative, emphysematous pulmonary dss, juvenile hepatic cirrhosis
Inactivate progesterone Formation of certain
membranes&fibers in assoc w/ collagen
Decreased:inflammation&malignancy, hepatic damage
malnutrition, cirrhosis, viral hepatitis, GI inflammation, renal dss
Increased:steroids, alcoholism, chronic renal failure
dehydration inflammatory reaction, pregnancy, contraceptive use
(-) acute phase reactant (-) acute phase reactant acute phase reactant acute phase reactantContinuation of GLOBULINS
Αlpha-1 Fetoprotein Α-2 Macroglobulin Haptoglobin Ceruloplasmin Protects the fetus from immunolytic
attack by its mother Modulates cell growth For dev’t of the female reproductive
system Screen fetuses: neural tube defects,
Down’s syndrome
Protease inhibitor Α-2 glycoprotein Transport free Hgb in the
plasma to the RES where Hgb is degraded
Copper containing α-2 globulin
Decreased: hemolytic anemias, megaloblastic anemia, sickle cell anemia
Wilson’s dss (hepatoenticular degeneration), malnutrition, chronic hepatitis
Increased: hemolytic dss of the newborn (HDN), presence of twin pregnancy
diabetes, liver dss, use of contraceptive medications, pregnancy
Tumor marker: hepatocellular carcinoma
Acute phase protein—infection, neoplasia, trauma, MI
acute phase reactant
Hemopexin Transferrin C-Reactive Protein Fibrinogen Beta-1 globulin Transport protein that bind free
heme after hemoglobin has been catabolized to its component parts
Beta glycoprotein-funx’ns as iron transport protein
Involved with the immune system Plays a role in complement
activation
1 of the larges proteins in blood plasma
Form a fibrin clot when activated by thrombin (clottable protein)
Decreased: liver disease, malnutrition, nephritic syndrome
Increased: infections, tissue damage or necrosis(-) acute phase protein—dec in inflammation
acute phase protein (most sensitive)
acute phase protein; glycoprotein
All plasma proteins are synthesized in the liver except: Immunoglobulins Produced by plasma cells from B lymphocyte lineage in the bone marrow
IgG IgM IgA IgE Highest concentration in adults Capable of crossing the placenta Neutralize toxins, bind
antigens&activate complement
1st Ig to be produced during the immune response (primary response to an antigen)
1st Ig produced by the fetus during dev’t
Present in the respiratory&gastrointestinal mucosa, saliva, tears, sweat
Provides external surface protection against microorganisms
Formly bound to mast cells Associated w/
allergic&anaphylactic reactions
Increased:liver dss, infections, collagen dss
rubella, herpes, syphilis
Miscellaneous ProteinsMyoglobin Troponin
Heme protein found in striated skeletal and cardiac muscles Acute myocardial infarction (AMI)-- seen within 1-3 hours of
onset, peak concentration in 5-12 hours Degree of elevation indicates the size of infarct Not cardiac specific
Consists of Troponin T,I and C Complex of proteins that bind to the filaments of striated muscle but
are not present in smooth muscle
Troponin I—highly specific for myocardial tissue; sensitive indicator of even minor amt of cardiac necrosis
TnI: 3-6 hours of onset; peak 14-20 hours
TnT: rise within 3-4 hours; peak 10-24 hours