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PHOSPHATE AND MINERAL HOMEOSTASIS
ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY
Editorial Board:
NATHAN BACK, State University of New York at Buffalo
NICHOLAS R. DI LUZIO, Tulane University School of Medicine
EPHRAIM KATCHALSKI-KATZIR, The Weizmann Institute of Science
DAVID KRITCHEVSKY, Wistar Institute
ABEL LAJTHA, Rockland Research Institute
RODOLFO PAOLETTI, University of Milan
Recent Volumes in this Series
Volume 201 LIPOPROTEIN DEFICIENCY SYNDROMES
Edited by Aubie Angel and Jiri Frohlich
Volume 202 INFECTIONS IN THE IMMUNOCOMPROMISED HOST Laboratory Diagnosis and Treatment
Edited by Paul Actor, Alan Evangelista, James Poupard, and Eileen Hinks
Volume 203 EXCITATORY AMINO ACIDS AND EPILEPSY
Edited by Robert Schwarcz and Yehezkel Ben-Ari
Volume 204 NEUROBIOLOGY OF CENTRAL D1-DOPMAINE RECEPTORS
Edited by George R. Breese and Ian Creese
Volume 205 MOLECULAR AND CELLULAR ASPECTS OF REPRODUCTION
Edited by Dharam S. Dhindsa and Om P. Bahl
Volume 206 ESSENTIAL NUTRIENTS IN CARCINOGENESIS
Edited by Lionel A. Poirier, Paul Newberne, and Michael W. Pariza
Volume 207 THE MOLECULAR AND CELLULAR BIOLOGY OF FERTILIZATION
Edited by Jerry L. Hedrick
Volume 208 PHOSPHATE AND MINERAL HOMEOSTASIS
Edited by Shaul G. Massry, Michel Olmer, and Eberhard Ritz
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PHOSPHATE AND MINERAL HOMEOSTASIS
Edited by
Sha ul G. Massry University of Southern California Los Angeles, California
Michel Olmer University of Aix-Marseille Marseille, France
and
Eberhard Ritz University of Heidelberg Heidelberg, Federal Republic of Germany
PLENUM PRESS • NEW YORK AND LONDON
Library of Congress Cataloging in Publication Data
International Workshop on Phosphate and Other Minerals (7th: 1985: Marseille, France)
Phosphate and mineral homeostasis.
(Advances in experimental medicine and biology; v. 208) "Proceedings of the Seventh International Workshop on Phosphate Metabolism, held
September 1-4, 1985, in Marseille, France"-T.p. verso. Bibliography: p. Includes index. 1. Phosphates-Metabolism-Congresses. 2. Calcium-Metabolism-Congresses. 3.
Magnesium - Membolism - Congresses. 4. Homeostasis - Congresses. I. Massry, Shaul G. 11. Olmer, Michael. III. Ritz, Eberhard. IV. Title. V. Series. QP535.PIIS7 1985 599'.0133 86-30431 ISBN 978-1-4684-5208-2 ISBN 978-1-4684-5206-8 (eBook) DOI 10.1007/978-1-4684-5206-8
Proceedings of the Seventh International Workshop on Phosphate Metabolism, held September 1-4, 1985, in Marseille, France
© 1986 Plenum Press, New York Softcover reprint of the hardcover 1st edition 1986 A Division of Plenum Publishing Corporation 233 Spring Street, New York, N.Y. 10013
All rights reserved
No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher
Library of Congress Cataloging in Publication Data
International Workshop on Phosphate and Other Minerals (7th: 1985: Marseille, France)
Phosphate and mineral homeostasis.
(Advances in experimental medicine and biology; v. 208) "Proceedings of the Seventh International Workshop on Phosphate Metabolism, held
September 1-4, 1985, in Marseille, France"-T.p. verso. Bibliography: p. Includes index. 1. Phosphates-Metabolism-Congresses. 2. Calcium-Metabolism-Congresses. 3.
Magnesium - Membolism - Congresses. 4. Homeostasis - Congresses. I. Massry, Shaul G. 11. Olmer, Michael. III. Ritz, Eberhard. IV. Title. V. Series. QP535.PIIS7 1985 599'.0133 86-30431 ISBN 978-1-4684-5208-2 ISBN 978-1-4684-5206-8 (eBook) DOI 10.1007/978-1-4684-5206-8
Proceedings of the Seventh International Workshop on Phosphate Metabolism, held September 1-4, 1985, in Marseille, France
© 1986 Plenum Press, New York Softcover reprint of the hardcover 1st edition 1986 A Division of Plenum Publishing Corporation 233 Spring Street, New York, N.Y. 10013
All rights reserved
No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher
TO OUR WIVES
Meira Massry Helene Olmer Christina Ritz
AND TO OUR CHILDREN
PREFACE
We are pleased to present to our readers the proceedings of the Seventh Internat ional Workshop on Phosphate and other Minerals which was held in Marsielle, France during September 1-4, 1985. It was hosted by Professor Michel Olmer, the Chief of the Divison of Nephrology in Hopital de la Conception of the University of D'AixMarsielle II.
The workshop was attended by 250 scientists from 17 countries including Algeria, Austria, Belgium, Canada, Czechoslovakia, Democratic Republic of C'.ermany, Egypt, England, France, Israel, Italy, Japan, Spain, Switzerland and the United States of America. There were 28 invited presentations by leading scientists and 40 oral and 75 poster presentations selected from over 200 abstracts submitted to the Organizing Commi ttee. This meet ing provided an excellent opportuni ty for interested scientists from interrelated disciplines including nephrology, endcrinology, physiology, biochemistry and nutrition to get together and discuss recent advances in the field of phosphate and mineral metabolism.
We would like to express our thanks and gratitude to all those who stimulated, encouraged an~ supported us to hold the Seventh International ~~rkshop in Marsi~lle. This endeavor could not have been possible without the generous financial support of many companies and agencies in France including Bayer Pharma, Boehringer Ingelheim, Ciba, Cobe, Conseil general des Bouches du Rhone, Conseil Regional ProvenceAlpes-Cote d'Azur, Eaux Minerales D'Evian, Fournier-Dijon, Gambro, Hemofrance, Hoechst, Hospal, I.C.I. Pharma, LEO, Merck Sharp &: DohmeChibret, Municipalite de Marseille, Organon Teknika, Robert Et Carriere, Roussel, Sandoz, Servier Medical, Theraplix, Travenol, WyethByla and of others in the United States of America including Hoffman LaRoche, Inc., Marion Laboratories, Inc., Plenum Publishing Corp., Proctor and Gamble Company, Salt Institute.
We would 1 ike to express our deepest appreciation to Ms. Lilian Neel for her tremendous and valuable contribution to the organization of the Workshop and to Ms. Haidi Samouha for her important organizational assistance during the workshop.
Shaul G. Massry Mi che 1 Olmer Eberhard Ri tz
vii
CONTENTS
I. SPECIAL PRESENTATIONS
High Energy Phosphate, Phospholipids and Calcium in Ischemic Renal Tubular Cell Injury .
H.D. Humes, V.D. Nguyen, and D.A. Hunt
Calcium, Cell Function and Cell Death L. V. Avioli
Primary Hyperparathyroidism (PHP) Revisited C.R. Kleeman, S. Salehmoghaddam, and G. Hertz
II. RENAL HANDLING OF PHOSPHATE
Mechanisms of Ion Transport Regulation by Parathyroid Hormone: cAMP/Ca2+/Calmodulin and Phospholipid Dependent Phosphorylation .................. .
K. Hruska, J. ScobIe, D. Moskowitz, and M. Goligorsky
Mechanisms of NAD Action in Regulation of Renal Brush Border Membrane Transport of Phosphate . . . . .
S.A. Kempson and T.P. Dousa
Interactions between Inorganic Phosphate and Energy Metabolism in Renal Cortical Tubules . . . . .
V.W. Dennis and P.C. Brazy
Regulation of Na-Phosphate Cotransport in Cultured Renal Epithelial Cells: Protein-Synthesis-Dependent and Protein-Synthesis-Independent Pathways . . .
H. Murer, J. Biber, K. Malmstrom, I. Mohrmann, and M. Coady
Phosphorin, A Phosphate-Binding Hydrophobic Protein Isolated from Renal Brush Border Membranes . . . . . . .
R.J. Kessler, D.A. Vaughn, C. Schali, and D.D. Fanestil
3
9
17
49
59
67
73
83
Intrarenal Phosphate Reabsorption: Role of Nephron Heterogeneity. 93 A. Haramati
Resistance to the Phosphaturic Effects of Parathyroid Hormone during Phosphate Conservation is Due to Enhanced Phosphate Reabsorption by the Pars Recta .
F.G. Knox, T.J. Berndt, and J.A. Haas . .. 101
ix
Brush Border Membrane Phosphate Transport Effects of Volume Expansion . • . • . . . . • . . . .. •.•.•.... 109
J.B. Puschett, J. Liput, and C. Galya
The Direct Effect of l,25-Dihydroxycholecalciferol on Membrane Phospholipid Composition and Phosphate Transport ... 115
B.R.C.Kurnik, M. Huskey, and K.A. Hruska
Possible Role of Calcium in Parathyroid Hormone Action on Phosphate Transport in Rabbit Renal Proximal Tubules • . . • 125
N. Yanagawa and O.D. Jo
Calcium Stimulates Sodium-Dependent Phosphate Absorption in Rabbit Proximal Convoluted Tubules Perfused In Vitro • . . • • • 133
D. Rouse and W. Suki
Characteristics of Phosphate Transport Across the Basolateral Membrane of the Proximal Tubule: An In Vivo Study . • . . • • • 137
T.S. Yan and G.A. Quamme
Renal Proximal Tubular Brush-Border Membrane Transport of Phosphate with Acute Acidosis . . • • . . . . . . • . • . • • 145
B.S. Levine, J.A. Kraut, and D.R. Mishler
Effects of Glucagon on Renal and Extrarenal Handling of Pi in Rodents: Evidence for Pi Mobilizing Activity •...•. 155
R.C. MUhlbauer, J.P. Bonjour, and H. Fleisch
III. RENAL HANDLING OF CALCIUM AND MAGNESIUM
Calcium Transport by the Proximal Tubule • . . . . •.•. 165 F.S. Wright and K. Bomsztyk
Mechanisms of Calcium Transport in the Thick Ascending Limb of the Loop Henle ..•••••.•••.......... 171
Z.S. Agus, F.N. Ziyadeh, and E. Kelepouris
Calcium Transport in the Distal Convoluted Tubule ••...•..•. 177 L.S. Costanzo
Renal Membrane Transport of Calcium . . • • . . . . . . . • . • . • • 183 Y. Tsukamoto and W.N. Suki
Renal Tubular Disorders Associated with Hypocalciuria • • • . • • • . 187 R.A.L. Sutton
Renal ~1agnesium Wasting Disorders •. • • • • . . . • • • • . • . • • 193 J.H. Dirks and N.L.M. Wong
Role of PTH, Vitamin D and Bone Metabolism in Low Protein-Induced Hypercalciuria • • . • • . • . • . • • • • . • • 199
E. Fernandez-Repo11et and M. Martinez-Maldonado
IV. INTESTINAL ABSORPTION OF PHOSPHATE AND CALCIUM
Mechanism and Regulation of Intestinal Phosphate Transport D.B.N. Lee
x
• 207
Intestinal Absorption of Phosphate in Man: Effect of Drugs .. . . . 213 C. Gennari, R. Nardi, and L. Fusi
Mechanism of Phosphate Transport Adaptation in Rat Intestinal and Renal Brush Border Membranes ...•.••. 223
G. Danisi, J. Caverzasio, J-Ph. Bonjour, H. Murer, and R.W. Straub
Analysis of Calcium Transport in Rat Intestine . . • . • . . • . . • . 227 F. Bronner, D. Pansu, and W.D. Stein
Calcium Absorption in the Rat Colon Measured In Vivo • . . • . . . . . 235 P. Ammann, R. Rizzo1i, and H. Fleisch
Impaired Intestinal Calcium Transport in the Spontaneously Hypertensi ve Rat . . • . . .. ............... 239
P.A. Lucas, T. Drueke, B. Lacour, R.C. Brown, and D.A. McCarron
V. BONE METABOLISM
Cellular Mechanisms of Bone Remodeling Evaluated at the Intermediary Level of Organization of Bone . . . . . . . . . . . 247
P.J. Meunier
The Local Regulation of Bone Remodeling . . . . . . . . . . . . 255 W.A. Peck, L. Rifas, S. Cheng, and V. Shen
Immune Cells and Bone Resorption . • . . . . . . . . . . . 261 ~I. Gowen, B.R. MacDonald, D.E. Hughes, H. Skjodt,
and R.G.G. Russell
Bisphosphonates Can Reduce Osteoclastic Bone Resorption by Two Different Mechanisms . . . . . . . . " ....... 275
C.W.G.M. Lowik, P.M. Bonnekamp, G. van de Pluym, L. van de Wee-Pals, H.B. van Treslong-de Groot, and O.L.H. Bijvoet
Comparison of Aluminum Related with Vitamin D Related Osteomalacia by Tetracycline Based Bone Histomorphometry . . . . 283
A.M. Parfitt, D. Rao, J. Stanciu, and A.R. Villanueva
Parathyroid Hormone and 1.25 Vitamin D3 Exert Opposite Effects on Bone . • . . ..•..... 289
H.H. Mulluche, C. Matthews, ~1. Faugere, P. Fanti, and R.M. Friedler
Serunl Bone GLA-Protein Compared to Bone Histomorphometry in Hemodialyzed Patients . . . . . . . . . . . ., ..... 291
S.A. Charhon, P.D. Delmas, L. Malaval, P.M. Chavassieux, M.C. Chapuy, and P.J. Meunier
Effects of l,25(OH)2D3 Administration on Serum Bone GLA Protein in Predia1ysis Chronic Renal Failure . .•..... 297
G. Coen, S. 1.lazzaferro, G. Donato, C. Massimetti, P. Ballanti, F. Bondatti, C. Della Rocca, A. Smacchi, F. Mantazzoli, and G.A. Cinotti
xi
Skeletal Mass in Long Term Hemodialysis Patients . . . . • • . • • . . 305 J. Letteri, P. Nagwani, and S. Cohn
VI. PARATHYROID HORMONE
Parathyroid Hormone Antagonists Effective In Vivo . . . . • . . . . • 315 L.H. Caporale and M. Rosenblatt
Solubilization of a Guanine Nucleotide-Sensitive Parathyroid Hormone-Receptor Complex from Canine Renal Cortex • • • . . 329
R.A. Nissenson, E. Mann, J. Winer, A. Teitelbaum, and C. D. Arnaud
Parathyroid Hormone Secretory Responses to Peroral Phosphate and Stimulability of Serum Levels of Carboxyl-Terminal Flanking Peptide (PDN-2l) of the Human Calcitonin Gene by Calcium in NOrmal and Osteoporotic Patients •. .••.. 345
M.A. Dambacher, J. Ittner, R. Muff, and J.A. Fischer
Renal Adenylate Cyclase Stimulating Action of Normal and Oxidized Parathyroid Hormone (1-34). . . . . ....•. 351
J.J. Helwig, N. Burgmeier, A. Gairard, M.C.M. Yang, and P.K.T. Pang
Hypercalcemia of Malignancy ..............•....• 357 J.W. Jacobs and E. Simpson
Mechanism of the Hypocalcemic Agent WR-272l and Its Acute and Chronic Application in Eu- and Hyperparathyroidism . • • • . 367
S. Hirschel-Scholz, J. Caverzasio, and J.P. Bonjour
Determinants of Circulating Levels of 1.25(OH)2D3 (Calcitriol) in Primary Hyperparathyroidism (PHPT) .•..•..•..•.• 371
M. Paillard. P. Patron, and J.P. Gardin
Mechanism of Nephrocalcinosis in Primary Hyperparathyroidism • . • . . 379 Ph. Jaeger, W. Jones, M. Kashgarian, G.V. Segre, and
J.P. Hayslett
Changes in Serum Calcium and Phosphorus Induced by Chronic Renal Failure in the Absence of Parathyroid Hormone . . . • . . 383
M. Rodriguez, V. Lorenzo, A.J. Felsenfeld, and F. Llach
VII. MINERALS AND BLOOD PRESSURE
Theoretical Mechanisms of Dietary Calcium's Antihypertensive Action. . • .. . .•.................... 389
R. Bukoski, P. Lucas, T. Drueke, and D. McCarron
Calcium as a Mediator of Salt Sensitive Hypertension . • • • . . • . . 397 L.M. Resnick
The Effect of Calcium on Renin, Aldosterone and Prostaglandin Release . • . . . . . . . . . . . . . . . . 405
J.L. Nadler and I. Antonipillai
Disturbed Phosphate Metabolism in Spontaneously Hypertensive Rats •.•...•.•.•......••..• 417
R.J.M. Bindels and C.H. van Os
xii
Participation of Various Brain Nuclei in the Altered Time Course of Genetic Hypertension in SHR Dependent on Changes in Calcium Metabolism . . . . . . • • • . • • . • . • 423
H. Geiger, M. Palkovits, U. Bahner, G. Schmid, and A. Heidland
Dissociation Between the Hypotensive Effect of Thiazides and Plasma Divalent Cations. . • . . . . . . . ..... 433
D.C. Batlle, W-C. Yang, A. Von Riotte, and S.K. Mujais
VIII. NEPHROLITHIASIS
Urine Citrate and Calcium in Calcium Nephrolithiasis . . . . . . . • • 445 J .H. Parks and F. L. Coe
Influence of Oxalate on Calcium Oxalate Crystals Formation in Urine Oversaturation . . . . . . . • 451
M. Olmer, Y. Berland, ~I. Grandvuil1emin, L. Madsen, and R. Boistel1e
Therapeutic Hodalities for the Prevention of Nephrolithiasis . • . • . 459 I\'. Tschope, R. Horsch, and E. Ritz
IX. MISCELLANEOUS
Factors Controlling the Intracellular Concentration of Orthophosphate (Pi) in Mammalian Cells . . . . • . . . • • . . . 469
A. Bevington, G.J. Kemp, and R.G.G. Russell
Phosphate Transfer and 3lp Nuclear Magnetic Resonance (NMR) Spectroscopy Pre and Post Hemofiltration (HF) ....... 479
T. Haas, Ph. Jehenson, D. Hillion, S. Tran Dinh, E. de Vie1, J. Verrier, and A. Syrota
Effects of Aldosterone Regulation of Renal Na-K-ATPase: in Phosphate Depletion
S.K. Mujais •.•.•.. 485
Effects of the Impairment of Renal Function and of the pH of Gastric Secretion on the Efficacy of AI(OH)3 to Reduce Serum Inorganic Phosphorus . . • . . . . • . . . . • . . . . • . 493
G. Barsotti, ~1. Lazzeri, A. Polloni, E. Morelli, E. Giovannetti, S. Lupetti, A. Cupisti, L. Dani, and S. Giovannetti
Effects of Different Insulin Administration Modalities on Vitamin D ~Ietabolism of Insulin-Dependent Diabetic Patients . . 501
C. Colette, L. Monnier, J. Arnal, J-L. Selam, and J. Mirouze
Influence of Inorganic Phosphate on Glucose-Induced Insulin Release In Vitro . . • • . . . . . . . . . . . .• •.•.. 509
J.I. Osuna, M. Castillo, E. Rodriguez. J.E. Campil10, and C. Osorio
Mechanist! of Inhibition of Glycolysis by Vanadate . • . . • . • • . • 517 J.E. Benabe, L.A. Echegoyen, and M. Martinez-Maldonado
Regulation of Na+/H+ Antiport in the Intact Renal Proximal Tubular Cell ..••.........•.•.••. 529
E.P. Nord, D. Goldfarb, and L.G. Fine
xiii
Interaction of Vitamin D-Metabolites with Adenylate Cyclase/ Cyclic AMP System: A Biological Model of Controlled Regulation . . . . . . . . . . . . . .. ......... 533
M.M. Popovtzer, H. Wald, M.M. Friedlaender, and D. Rubinger
Dibutryladenosine 3 1 ,5 1 -Cyclic Monophosphate (dBcAMP) Does Not Mimic the Action of Parathyroid Hormone (PTH) on Canine Proximal Tubular Basolateral Membrane Na+:Ca2+ ..... 537
J.E. ScobIe, D. Moskowitz, and K.A. Hruska
Phosphate Transport Through Placenta Brush Border Membrane . . . • . . 543 M.G. Brunette, S. Letendre, and S. Allard
INDEX •••••••••.••••..•••.••••.••••••• 549
xiv