phenotype annotation at tair

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Phenotype Annotation at TAIR Tanya Berardini

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Phenotype Annotation at TAIR. Tanya Berardini. Current Status. Phenotypes are associated to organisms (germplasms) and linked to references Curation is mainly done in unstructured full text Pilot study of structured annotation completed PaTO not yet implemented. papillae:abnormal - PowerPoint PPT Presentation

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Page 1: Phenotype Annotation at TAIR

Phenotype Annotation at TAIR

Tanya Berardini

Page 2: Phenotype Annotation at TAIR

Current Status

• Phenotypes are associated to organisms (germplasms) and linked to references

• Curation is mainly done in unstructured full text

• Pilot study of structured annotation completed

• PaTO not yet implemented

Page 3: Phenotype Annotation at TAIR
Page 4: Phenotype Annotation at TAIR
Page 5: Phenotype Annotation at TAIR

papillae:abnormalstyle:abnormalseptum development:incompleteleaf:serrate

Page 6: Phenotype Annotation at TAIR

Same challenges as other databases

• Large corpus of literature

• Set number of curators with many diverse responsibilities

• Different ways of paper prioritization

Page 7: Phenotype Annotation at TAIR

Capturing phenotypes from the literature

• Single paper, describing single aspect of phenotype

• Single paper, describing multiple aspects of the organism’s phenotype

• Multiple papers describing different aspects of the organism’s phenotype

• Multiple papers, describing the same phenotype

Page 8: Phenotype Annotation at TAIR

Storing complex annotations in the database

• Right now, GO as a model for assocations:– 1 association = 1 gene product + 1 CV term

• How do we deal with multiple ontologies in one association?– 1 association = 1 germplasm + 1 anatomy term

+ 1 PATO term (+ others)