BY:DR.SAFA BAKR KARIMM.B.CH.B.,H.D.A.,F.I.B.M.S.

OPIOIDS1.Define general anesthesia.2.Define Opioid drugs.3.Give examples of Opioid agonist, Opioid

antagonist, and Opioid agonist-antagonist.4.What are endogenous Opioids, in which

system they are important.

5.What are Opioid receptors.6.What are the central depressant actions and

side effects of Morphine.7.What are the central excitatory actions and

side effects of Morphine.8.What are the peripheral actions and side

effects of Morphine.

9.What are the actions and side effects of Pethidine.

10.What are the actions and side effects of Fentanyl.

11.What are the actions and side effects of Alfentanil.

12.What are the actions of Naloxone.

INTRA-VENOUS AND INHALATIONAL ANESTHETICS

1.Classify I.V. anesthetic drugs, give the name of the group and example.

2.What are the phases of G.A.3.What are the stages of G.A.

4.What are the clinical effects of Benzodiazepines.

5.What are the side effects of Nitrous Oxide.6.What are the clinical effects of Halothane.7.What are the side effects of Halothane.

LOCAL ANESTHETICS1.Difine L.A. agents.2.What are the factors which influence activity

of L.A. agents.3.What are the toxic CNS effects of L.A. agents.4.What are the toxic CVS effects of L.A. agents.

5.What are the toxic RS effects of L.A. agents.6.The toxicity of L.A. is influenced by what.7.What are the factors which affect L.A.

toxicity.8.Classify L.A. agents, give examples.

9.Toxicity of Bupivacaine can be minimized by what.

10.What is the metabolite of Prilocaine and its side effects and treatment.

11.What is the Emla cream and its use.12.What are the additives in L.A. and their use.13.What are the effects of Adrenaline with L.A.

MUSCLE RELAXANTS (M.R.)1.What is the definition of M.R., and their

actions.2.Classify M.R., give examples.3.What are the clinical effects of

Suxamethonium.4.What are the side effects of

Suxamethonium and its contraindications.5.What do you know about Scholine Apnea.

6.Give five causes of plasma cholinesterase deficiency.

7.What are the clinical effects of Atracurium.8.What are the side effects of Atracurium.9.What are the clinical effects of Pancuronium.10.What are the clinical effects of Rocuronium.

11.What are the clinical effects of Vecuronium.12.What are the factors which affect the

duration of action of non depolarizing M.R.13.Classify Anti-Cholinesterases, give example.14.What are the clinical effects of Anti-

Cholinesterase.15.What are the clinical effects of Neostigmin.

Sedative-Hypnotic and Anxiolytic Drugs1.Classify Sedative-Hypnotic drugs.2.What is the mechanism of action of

Benzodiazepines and its antagonist.3.What are the clinical uses of Sedative-

Hypnotics.

4.Define tolerance,psychological dependence and physiological dependence.

5.What are the signs and symptoms of withdrawal (abstinence) syndrome.

6.What is the treatment of toxicity or overdosage from Sedative-Hypnotics.

7.Enumerate the atypical Sedative-Hypnotics and give two side effects for each.

Non Steroidal Anti-Inflammatory Drugs and Acetaminophen

1.What are the three therapeutic dose ranges of Aspirin.

2.Describe REYE “S syndrome. 3.Mention the adverse effects of

Acetaminophen toxicity or overdose and its therapy.

4.Give two examples of COX-2 selective inhibitors and mention two adverse effects.

5.Mention two examples of the older non selective NSAIDS and mention two adverse effects.

6.What is the mechanism of action of Aspirin and NSAIDS.

7.Mention three adverse effects from Aspirin toxicity.

8.Mention three clinical uses for NSAIDS.