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Personal CarePRESERVATIVES

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Your preservation isIn good HAndS.

Leveraging a long history with Nipa® preservative products, Clariant continues to unite Personal Care expertise, innovation, preservative competence and worldwide presence.

All this makes us a market leader in cosmetic preservation. We are your trustworthy partner for effective preservation.

Our core-competence is also clearly shown through our Secret Code of Beauty. By combining essential knowledge, expertise and new innovations we are able to provide you with a broad preservative portfolio to fulfill your cosmetic preservation needs.

Derived from our Secret Code of Beauty and four of our codes we offer you:

Innovative solutions to meet current and future market needs.

A range of preservation solutions developed, tested and based on our extensive experience.

Deep knowledge about consumer and market needs and upcoming trends.

Preservatives based on partly or fully natural, renewable resources.

Through our broad portfolio of single acti-ves and optimized blends that includes well-known brands like Phenonip®, nipagin® or nipaguard®, Clariant stands for perfor-mance, reliability, value and expertise.

All our products are extensively tested to prove their safe and effective preservation results. Microbiology laboratories all around the world provide you with application sup-port and advice on regulatory requirements in your target markets.

We deliver you confidence in preservation.

With over 70 years of combined expertise in effective preservation, we provide you the solutions you need to preserve your formulations.

nipaguard® Zero blends are new paraben alternatives that provide comparable cost and performance to parabens. Velsan® SC (Sorbitan Caprylate) is the basis for the development of these blends. Velsan® SC is a novel, highly effective synergistic booster developed and patented by Clariant to redu-ce the amount of preservatives in cosmetics. One of its main raw materials, called Sor-bitol is produced from the sugar of wheat and corn, while the other, Caprylic Acid, is derived from palm or coconut oil.

nipaguard® Po blends are highly effective blends for Personal Care formulations that deliver broad spectrum efficacy over a wide pH range. More than 30 years of experience with octopirox® (Piroctone Olamine) have been used to develop these blends. Octo-pirox® is a highly reliable and well known preservative and anti-dandruff agent.

our expertise is based on:

• Challenge tests according to different market requirements

• Ability to perform challenge tests according to Ph. Eur. for leave-on and rinse-off products

• Minimum Inhibitory Concentration (MIC) tests • Total viable count measurement via membrane

filtration and plate-count methods according to European Pharmacopoeia, USP and ISO 11930

• Identification of bacteria and molds• Disinfection tests according to ISO 1275/1276

and 1040• Advice and experience in Plant Hygiene Con-

sultation

We present you two key pillars of Clariant’s preservation product range:nipaguard® Zero blends based on Velsan® SC (Sorbitan Caprylate) and nipaguard® Po blends based on octopirox® (Piroctone Olamine).

Sorbitan Caprylate

100% renewable preservative booster, ECOCERT®*² approved

Blends based on Velsan® SC, comparable performance and cost to parabens

Piroctone Olamine

Single active; excellentcompatibility, even with cationic surfactants

Highly efficient blends; formula and head-space preservation in one

ClARIAnTPERSonAl CAREProduct portfolio

Anisic Acid

Multifunctional, suitable also for natural formulations

Silver Chloride

Patented silver chloride/titanium dioxide composite; stable over a wide pH range and high temperature; broad spectrum antimicrobial efficacy, release of active on demand

Safe andEffective

Broad line of actives, blends and synergists

PRESERVATIVES

oCToPIRoX®

nIPAgUARd® Po

VElSAn® AS JM ACTICARE®VElSAn® SC

nIPAgUARd® ZERo

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A wide range of solutionsFoR yoUR PERSonAl CARE PRESERVATIon nEEdS

Formaldehyde Donors

Broad spectrum single actives and blends; provide high water solubility and particularly good activity against bacteria

Halogenated Compounds

Liquid blends of MIT/CMIT with parabens; highly water soluble

Alcohols

Solubility at typical use concentrations; low volatility, broad spectrum activity

Parabens

Single actives with broad spectrum of activity

Liquid and powder blends

nIPABUTyl

nIPAgIn®

nIPASol®

nIPASTAT®

PHEnonIP®

nIPASEPT®

nIPAgUARd®dMdMH / PdU

nIPA® BIoPURE

nIPAgUARd® Cg / CMB PHEnoXETol®

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Our portfolio provides you with a range of solutions to meet most cosmetic preservation needs – from innovative specialty blends to highly efficient traditional chemistries. All of our products are desi-gned to be safe and effective.

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FlexibilityAnd CHoICE

In addition to single actives and synergistic boosters, we offer a broad variety of proprietary blends, combining single actives into preservative systems to meet nearly every personal care formulation need.

All blends have been carefully developed and are optimized in respect of their concentration and efficacy by extensive testing in order to achieve excellent preservation results with lowest possible concentrations.

We focus on developing innovative preservation solutions to im-prove performance and efficiency while meeting new regulatory requirements and your needs for safety and sustainability. We present you a range of innovative specialties – to meet current and future market needs as well as classic preservative products.

WE PRoVIdE PRESERVATIVES FoR A RAngE oF CoSMETIC APPlICATIonS:

- Leave-on- Rinse-off- Including: Wet wipes and

difficult to preserve formulations

The following chart lists the composition of each blend to enable you to choose the one that's right for you.

InCI Ble

nds

Phe

noni

p®

Phe

noni

p®

P

4

Phe

noni

p®

X

B

Phe

noni

p®

M

E

Nip

asta

t®

Nip

asep

t®

Nip

agua

rd®

PD

U

Nip

agua

rd®

CG

Nip

agua

rd®

CM

B

Nip

agua

rd®

BP

X

Nip

agua

rd®

MPA

Nip

agua

rd®

SC

P

Nip

agua

rd®

SC

E

Nip

agua

rd®

SC

V

Nip

agua

rd®

SC

M

Nip

agua

rd®

PO

5

Nip

agua

rd®

PO

B

Nip

agua

rd®

PO

M

Sorbitan Caprylate

Benzoic Acid

Benzyl Alcohol

Propanediol

Piroctone Olamine

Phenoxyethanol

Methylparaben

Ethylparaben

Propylparaben

Butylparaben

Isobutylparaben

Methylisothiazolinone

Methylchloroisothiazolinone

Diazolidinyl Urea

2-Bromo-2-nitropropane- 1,3-diol

BlEnd SElECTIon CHART

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: Leave-on / : Rinse-off / : Wet wipesG-: Gram- Bacteria / G+: Gram+ Bacteria / Y: Yeast / M: Mold

++: good / +: medium / 0: none NA: Not Applicable

VElSAn® SCECOCERT®*2 approved, 100% renewable, nature-based preservative booster. Preserve more with less.A synergistic efficacy booster for preservative systems which is not listed as a preservative*** and can be used globally. A multifunctional ingredient, it is also a co-emulsifying agent for cosmetic formulations.

Product InCI Form Applications pH range Max. Temp. rec. use level (%)

EU (%)

US (%)

JP (%)

Microbiology efficacy

Single Active G- G+ Y M

Velsan® SC (Ecocert®*2 approved)

Sorbitan Caprylate Liquid 4.0 – 8.0 < 80 °C 0.5 – 2.0 NA NA NA 0 ++ + +

nIPAgUARd® ZERo BlEndS0% parabens, 100% performance

Preservative blends based on 100% renewable Velsan® SC synergistic booster to efficiently protect your formulation. Nipaguard® Zero blends represent a trusted alternative to parabens, halogenated preservatives and formaldehyde-donors and provide comparable cost and performance. They provide you efficient use of consumer accepted preservatives at low concentrations, broad spectrum preservation and are more effective.

Product InCI Form Applications pH range Max. Temp.

rec. use level (%)

EU (%)

US (%)

JP (%)


Blends-liquid G- G+ Y M

Nipaguard® SCE(Ecocert®*2 approved)

Sorbitan Caprylate (and) Propanediol (and) Benzoic Acid

Liquid 4.0 – 8.0 < 80 °C 0.5 – 1.5 3.1 no restrictions

1.25 ++ ++ ++ ++

Nipaguard® SCM Sorbitan Caprylate (and) Propylene Glycol (and) Methylisothiazolinone

Liquid 4.5 – 8.0 < 40 °C 0.5 – 1.5 1.82 no restrictions

1.82 ++ ++ ++ ++

Nipaguard® SCP Phenoxyethanol (and) Sorbitan Caprylate

Liquid 4.5 – 8.5 < 80 °C 0.5 – 1.0 1.39 considered safe

1.39 ++ ++ ++ ++

Nipaguard® SCV Sorbitan Caprylate (and) Phenoxyethanol (and) Benzyl Alcohol (and) Benzoic Acid

Liquid 4.0 – 8.0 < 40 °C 0.5 – 1.0 3.33 considered safe

1.53 ++ ++ ++ ++

** The regulations of China, ASEAN and Brazil state the same maximum allowed use levels as EU in most cases. Please check local regulations as needed.

* Maximum allowed use concen-tration for blends are calculated according to requirements of the listed ingredient at highest concentration in the blend.

*** per Cosmetic Regulation (EC) no. 1223/2009 Annex V

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oCToPIRoX®A reliable well-known source.

Piroctone Olamine is known under the trade name Octopirox® as a highly effective preservative and anti-dandruff agent. It has been successfully used for over 30 years for its good compatibility, its antimicrobial functionality and its long shelf life. It is generally considered safe, non-irritating, and non-allergenic.

*Rinse-off **All others


EU (%)

US (%)

JP (%)



Octopirox® Piroctone Olamine Powder 4.0 – 10.0 < 80 °C 0.05 – 0.1 1.0* 0.5**

no restrictions

0.05 ++ ++ ++ ++

nIPAgUARd® Po BlEndSBroad spectrum efficacy over a wide pH range.

Nipaguard® PO blends deliver superior performance compared to other market standards. Derived from Piroctone Olamine, these highly efficient blends provide you with an all-in-one preservation – from formula to headspace. They are easy to handle and process.


EU (%)

US (%)

JP (%)



Nipaguard® PO5 Phenoxyethanol (and) Piroctone Olamine

Liquid 4.0 – 10.0 < 80 °C 0.3 – 1.0 1.0 1.0 1.0 ++ ++ ++ ++

Nipaguard® POB Phenoxyethanol (and) Benzoic Acid (and) Piroctone Olamine

Liquid 4.0 – 10.0 < 80 °C 0.3 – 1.0 1.2 1.2 1.0 ++ ++ ++ ++

Nipaguard® POM Phenoxyethanol (and) Methylparaben (and) Piroctone Olamine

Liquid 4.0 – 8.0 < 80 °C 0.3 – 1.0 1.2 1.2 1.0 ++ ++ ++ ++

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VElSAn® ASMulti-functional ingredient suitable for natural formulations.p-Anisic acid is an organic acid found in nature which has antiseptic properties and therefore provides a microbial effect. It is a known fragrance ingredient that is not listed as preservative, yet offers anti-micro-bial efficacy. It shows excellent performance in rinse-off and leave-on cosmetics at pH < 5.5. It is readily biodegradable.


rec. use level (%)

EU (%)

US (%)

JP (%)



Velsan® AS p-Anisic Acid Powder < 6.0 < 80 °C 0.2 – 0.4 NA NA NA + + + +

JM ACTICARE®Patented silver preservation with broad spectrum antimicrobial efficacy.JM ActiCare®‘s activity derives from an inorganic composite which allows the slow release of antimicrobial silver ions on demand. It is highly stable over a wide pH range and effective at temperatures up to 100 °C.


rec. use level (%)

EU (%)

US (%)

JP (%)


Blends G- G+ Y M

JM ActiCare® Silver Chloride (and) Titanium Dioxide (and)Diethylhexyl Sodium Sulfosuccinate (and)Propylene Glycol

Liquid 3.0 – 12.0 100 °C 0.05 – 0.18 0.19 listed TSCA

not per-mitted

++ ++ ++ ++

JM ActiCare® P Silver Chloride (and) Titanium Dioxide

Powder 3.0 – 12.0 100 °C 0.05 – 0.18 0.19 listed TSCA

not per-mitted

++ ++ ++ ++



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PARABEnS Quality and effectiveness

Clariant offers a wide range of parabens for all personal care applications. Their well-known solubility, their broad spectrum of activity against bacteria and fungi as well as their effectiveness at low concentra-tions still make them the most widely used preservatives in personal care products. Single actives Nipagin® and Nipasol® also available as sodium salts to enable introduction without heating or pre-dissolving in solvents.


rec. use level (%)

EU (%)

US (%)

JP (%)


Single Actives G- G+ Y M

Nipagin® M(also sodium salt and 200 mesh)

Methylparaben Powder 4.0 – 8.0 < 80 °C 0.1 – 0.3 0.4 0.4 1.0 0 + ++ ++

Nipagin® A (also sodium salt and 200 mesh)

Ethylparaben Powder 4.0 – 8.0 < 80 °C 0.1 – 0.3 0.4 0.4 1.0 0 + ++ ++

Nipasol® M (also sodium salt and 200 mesh)

Propylparaben Powder 4.0 – 8.0 < 80 °C 0.1 – 0.3 0.4 0.4 1.0 0 + ++ ++

Nipabutyl Butylparaben Powder 4.0 – 8.0 < 80 °C 0.1 – 0.3 0.4 0.4 1.0 0 + ++ ++

Blends

Nipastat® Methylparaben (and) Ethylparaben (and) Propylparaben (and) Butylparaben (and) Isobutylparaben

Powder 4.0 – 8.0 < 80 °C 0.05 – 0.3 0.8 cons. safe

1.0 0 + ++ ++

Nipasept® Methylparaben (and) Ethylparaben (and) Propylparaben

Powder 4.0 – 8.0 < 80 °C 0.05 – 0.3 0.8 cons. safe

1.0 0 + ++ ++

Nipaguard® MPA Benzyl Alcohol (and) Methylparaben (and) Propylparaben

Liquid 4.5 – 8.0 40 °C 0.3 – 0.8 1.32 6.5 not per-mitted

++ ++ ++ ++

Phenonip® Phenoxyethanol (and) Methylparaben (and) Ethylparaben (and) Propylparaben (and) Butylparaben (and) Isobutylparaben

Liquid 3.0 – 8.0 < 80 °C 0.25 – 1.0 1.33 cons. safe

1.33 ++ ++ ++ ++

Phenonip® P4 Phenoxyethanol (and) Methylparaben (and) Ethylparaben (and) Propylparaben (and) Butylparaben


1.33 ++ ++ ++ ++

Phenonip® XB Phenoxyethanol (and) Methylparaben (and) Ethylparaben (and) Propylparaben


1.35 ++ ++ ++ ++

Phenonip® ME Phenoxyethanol (and) Methylparaben (and) Ethylparaben


1.29 ++ ++ ++ ++

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AlCoHolSVersatile preservative over a wide range of applications

Phenoxetol® has particularly good performance on gram-negative and gram-positive bacteria, but also against yeast and molds. It is typically non-irritating to the skin at use concentrations, low volatility at ambi-ent temperatures and soluble at typical use concentrations (approximately 2.4 % soluble in water).


rec. use level (%)

EU (%)

US (%)

JP (%)



Phenoxetol® 2-Phenoxyethanol Liquid 3.5 – 8.0 < 80 °C 0.5 – 1.0 1.0 cons. safe

1.0 ++ + 0 0



FoRMAldEHydE donoRSHighly effective at very low concentrations

The following broad spectrum formaldehyde donor products provide high water solubility and particularly good activity against bacteria.


rec. use level (%)

EU (%)

US (%)

JP (%)


Single Actives G- G+ Y M

Nipaguard® DMDMH DMDM Hydantoin Liquid 3.0 – 8.0 < 60 °C 0.15 – 0.4 1.07 cons. safe

0.53 ++ ++ + +

Nipa® Biopure 100 Imidazolidinyl Urea Powder 3.0 – 8.5 < 40 °C 0.1 – 0.3 0.6 cons. safe

0.3 ++ ++ + +

Nipa® Biopure 200 Diazolidinyl Urea Powder 3.0 – 8.5 < 40 °C 0.1 – 0.3 0.5 0.5 not per-mitted

++ ++ + +

Blend-liquid

Nipaguard® PDU Propylene Glycol (and) Methylparaben (and) Propylparaben (and) Diazolidinyl Urea

Liquid 3.0 – 8.0 < 40 °C 0.3 – 1.0 1.54 1.42 not per-mitted

++ ++ ++ ++

HAlogEnATEd CoMPoUndSBroad spectrum blends

Clariant’s offerings are optimized blends that deliver broad spectrum efficacy with the lowest possible concentrations of listed preservatives.

*Rinse-off only

Product InCI Form Applications pH range

Max. Temp.

rec. use level (%)

EU (%)

US (%)

JP (%)



Nipaguard® CG Methylchloroisothiazolinone (and) Methylisothiazolinone

Liquid < 9.0 < 50 °C 0.05 – 0.1 0.1 0.1 0.1* ++ ++ ++ ++

Nipaguard® CMB Triethylene Glycol, Benzyl Alcohol, Propylene Glycol, Methylchloroisothiazolinone and Methylisothiazolinone

Liquid < 8.0 < 40 °C 0.03 – 0.15 0.2 0.2 not per-mitted

++ ++ ++ ++

Nipaguard® BPX Phenoxyethanol (and) Methylparaben (and) Propylparaben (and) 2-Bromo-2-nitropropane-1,3-diol

Liquid 4.5 – 8.5 0.3 – 0.7 1.33 2.0 not per-mitted

++ ++ ++ ++

www.personalcare.clariant.com [email protected]

Clariant International LtdBU Industrial & Consumer SpecialtiesRothausstrasse 61, CH-4132 Muttenz

CommercialPhone: +41 61 469 5351

Application DevelopmentPhone: +49 69 305 18594

This information corresponds to the present state of our knowledge and is intended as a general description of our products and their possible applications. Clariant makes no warranties, express or implied, as to the information’s accuracy, adequacy, sufficiency or freedom from defect and assumes no liability in connection with any use of this information. Any user of this product is responsible for determining the suitability of Clariant’s products for its particular application. * Nothing included in this information waives any of Clariant’s General Terms and Conditions of Sale, which control unless it agrees otherwise in writing. Any existing intellectual/industrial property rights must be observed. Due to possible changes in our products and applicable national and international regulations and laws, the status of our products could change. Material Safety Data Sheets providing safety precautions, that should be observed when handling or storing Clariant products, are available upon request and are provided in compliance with applicable law. You should obtain and re-view the applicable Material Safety Data Sheet information before handling any of these products. For additional information, please contact Clariant.

* For sales to customers located within the United States and Canada the following applies in addition: NO EXPRESS OR IMPLIED WARRANTY IS MADE OF THE MERCHANTABILITY, SUITABILITY, FITNESS FOR A PARTICULAR PURPOSE OR OTHERWISE OF ANY PRODUCT OR SERVICE.

® Trademark of Clariant registered in many countries © 2014 Clariant International Ltd

*2 Registered trademark of ECOCERT, F-32600 L'ISLE JOURDAIN (FR)

Latin AmericaClariant S.A.

Av. Das NaçõesUnidas, 18.001

São Paulo 04795-900Brazil

Phone +55 11 568 372 33

North AmericaClariant Corporation625 E Catawba Ave.Chalotte 28120North CarolinaUSAPhone +1 800 942 7239

EMEAClariant International LtdRothausstrasse 614132 MuttenzSwitzerlandPhone +41 61 469 5111

AsiaClariant Chemicals(China) Ltd.No.2, Lane 168Linghong RoadChangning DistrictShanghai 200335P.R. ChinaPhone +86 21 2248 3000

Providing you support All ARoUnd THE WoRld

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